ENSMUSG00000055639


Mus musculus

Features
Gene ID: ENSMUSG00000055639
  
Biological name :Dach1
  
Synonyms : Dach1 / Dachshund homolog 1 / Q9QYB2
  
Possible biological names infered from orthology : dachshund family transcription factor 1 / Q9UI36
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: E2.1
Gene start: 97786853
Gene end: 98169765
  
Corresponding Affymetrix probe sets: 10421950 (MoGene1.0st)   1420694_a_at (Mouse Genome 430 2.0 Array)   1420695_at (Mouse Genome 430 2.0 Array)   1433743_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000064970
Ensembl peptide - ENSMUSP00000071464
NCBI entrez gene - 13134     See in Manteia.
MGI - MGI:1277991
RefSeq - NM_001038610
RefSeq - NM_007826
RefSeq Peptide - NP_001033699
RefSeq Peptide - NP_031852
swissprot - Q9QYB2
Ensembl - ENSMUSG00000055639
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dachcENSDARG00000003142Danio rerio
 dachdENSDARG00000069440Danio rerio
 DACH1ENSGALG00000037015Gallus gallus
 DACH1ENSG00000276644Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dach2 / Q925Q8 / Dachshund homolog 2 / Q96NX9* / dachshund family transcription factor 2*ENSMUSG0000002559246


Protein motifs (from Interpro)
Interpro ID Name
 IPR003380  SKI/SNO/DAC domain
 IPR009061  Putative DNA-binding domain superfamily
 IPR037000  Ski-like, DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0001967 suckling behavior IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IMP
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007585 respiratory gaseous exchange IMP
 biological_processGO:0008283 cell proliferation IMP
 biological_processGO:0010944 negative regulation of transcription by competitive promoter binding ISO
 biological_processGO:0030336 negative regulation of cell migration ISO
 biological_processGO:0033262 regulation of nuclear cell cycle DNA replication IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISO
 biological_processGO:0046545 development of primary female sexual characteristics IGI
 biological_processGO:0048147 negative regulation of fibroblast proliferation IGI
 biological_processGO:0051123 RNA polymerase II transcriptional preinitiation complex assembly IEA
 biological_processGO:0060244 negative regulation of cell proliferation involved in contact inhibition IGI
 biological_processGO:2000279 negative regulation of DNA biosynthetic process ISO
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005667 transcription factor complex IPI
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle ISO
 molecular_functionGO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly IDA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001436 abnormal suckling behavior "reduced ability or inability to exert suction by the mouth, or atypical suckling pattern" [J:16461]
Show

Allelic Composition: MitfMi-wh/Mitfmi-x
Genetic Background: NZB/Mac

Allelic Composition: Dach1tm1Mrd/Dach1tm1Mrd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001488 increased startle reflex "reduced threshold or more severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Daam2tm1b(KOMP)Wtsi/Daam2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Daam2tm1b(KOMP)Wtsi/Wtsi

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
Show

Allelic Composition: MitfMi-wh/Mitfmi-x
Genetic Background: NZB/Mac

Allelic Composition: Dach1tm1Mrd/Dach1tm1Mrd
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Dach1tm1Mrd/Dach1tm1Mrd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: MitfMi-wh/Mitfmi-x
Genetic Background: NZB/Mac

Allelic Composition: Dach1tm1Mrd/Dach1tm1Mrd
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Dach1tm1Mrd/Dach1tm1Mrd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003019 increased circulating chloride level "elevated concentration of chlorine salts in the circulation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Daam2tm1b(KOMP)Wtsi/Daam2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Daam2tm1b(KOMP)Wtsi/Wtsi

 MP:0003339 decreased number of pancreatic beta cells "fewer than normal number of the cells of the pancreas that secrete insulin" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: MitfMi-wh/Mitfmi-x
Genetic Background: NZB/Mac

 MP:0009172 small pancreatic islets "decrease in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
Show

Allelic Composition: MitfMi-wh/Mitfmi-x
Genetic Background: NZB/Mac

 MP:0009177 decreased pancreatic alpha cell number "reduction in the number of the cells of the pancreas that secrete glucagon" [MESH:A03.734.414.065]
Show

Allelic Composition: MitfMi-wh/Mitfmi-x
Genetic Background: NZB/Mac

 MP:0009546 absent gastric milk in neonates "failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: MitfMi-wh/Mitfmi-x
Genetic Background: NZB/Mac

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: MitfMi-wh/Mitfmi-x
Genetic Background: NZB/Mac

Allelic Composition: Dach1tm1Mrd/Dach1tm1Mrd
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Dach1tm1Mrd/Dach1tm1Mrd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Daam2tm1b(KOMP)Wtsi/Daam2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Daam2tm1b(KOMP)Wtsi/Wtsi

 MP:0011820 decreased pancreatic beta cell proliferation "reduction in the ability of the cells that secrete insulin and are located towards the center of the islets of Langerhans in the pancreas to undergo expansion by cell division" [CL:0000169]
Show

Allelic Composition: MitfMi-wh/Mitfmi-x
Genetic Background: NZB/Mac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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