ENSMUSG00000056258


Mus musculus

Features
Gene ID: ENSMUSG00000056258
  
Biological name :Kcnq3
  
Synonyms : Kcnq3 / Potassium voltage-gated channel subfamily KQT member 3 / Q8K3F6
  
Possible biological names infered from orthology : O43525 / potassium voltage-gated channel subfamily Q member 3
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: D1
Gene start: 65986387
Gene end: 66286642
  
Corresponding Affymetrix probe sets: 10429083 (MoGene1.0st)   1435957_at (Mouse Genome 430 2.0 Array)   1458421_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000063380
NCBI entrez gene - 110862     See in Manteia.
MGI - MGI:1336181
RefSeq - NM_152923
RefSeq Peptide - NP_690887
swissprot - Q8K3F6
Ensembl - ENSMUSG00000056258
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kcnq3ENSDARG00000060085Danio rerio
 KCNQ3ENSGALG00000037626Gallus gallus
 KCNQ3ENSG00000184156Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Kcnq2 / potassium voltage-gated channel subfamily KQT member 2 isoform 13 / O43526* / potassium voltage-gated channel subfamily Q member 2*ENSMUSG0000001634647
Kcnq5 / Q9JK45 / Potassium voltage-gated channel subfamily KQT member 5 / Q9NR82* / potassium voltage-gated channel subfamily Q member 5*ENSMUSG0000002803341
Kcnq4 / Q9JK97 / Potassium voltage-gated channel subfamily KQT member 4 / P56696* / potassium voltage-gated channel subfamily Q member 4*ENSMUSG0000002863136
Kcnq1 / P97414 / Potassium voltage-gated channel subfamily KQT member 1 / P51787* / potassium voltage-gated channel subfamily Q member 1*ENSMUSG0000000954527


Protein motifs (from Interpro)
Interpro ID Name
 IPR003937  Potassium channel, voltage dependent, KCNQ
 IPR003948  Potassium channel, voltage dependent, KCNQ3
 IPR005821  Ion transport domain
 IPR013821  Potassium channel, voltage dependent, KCNQ, C-terminal
 IPR020969  Ankyrin-G binding site
 IPR028325  Voltage-gated potassium channel


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006813 potassium ion transport IEA
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0060081 membrane hyperpolarization IMP
 biological_processGO:0071805 potassium ion transmembrane transport ISO
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0008076 voltage-gated potassium channel complex ISO
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0033268 node of Ranvier IDA
 cellular_componentGO:0043194 axon initial segment IDA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005244 voltage-gated ion channel activity IGI
 molecular_functionGO:0005249 voltage-gated potassium channel activity ISS
 molecular_functionGO:0005267 potassium channel activity IMP
 molecular_functionGO:0005516 calmodulin binding IEA


Pathways (from Reactome)
Pathway description
Voltage gated Potassium channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000807 abnormal hippocampus morphology "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]
Show

Allelic Composition: Kcnq3tm1.1Naas/Kcnq3tm1.1Naas
Genetic Background: FVB.129-Kcnq3tm1.1Naas

Allelic Composition: Emx1tm1(cre)Krj/?,Kcnq3tm1.1Avtz/Kcnq3tm1.1Avtz
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Kcnq3tm1.1Naas/Kcnq3tm1.1Naas
Genetic Background: B6.129-Kcnq3tm1.1Naas

Allelic Composition: Kcnq3tm1.1Naas/Kcnq3tm1.1Naas
Genetic Background: FVB.129-Kcnq3tm1.1Naas

 MP:0001650 electrically induced seizures "high or low frequency electrical stimulation applied to induce seizure activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, wf:Wayne Frankel , TJL staff]
Show

Allelic Composition: Kcnq2tm1.1Naas/Kcnq2tm1.1Naas
Genetic Background: FVB.129-Kcnq2tm1.1Naas

Allelic Composition: Kcnq3tm1.1Naas/Kcnq3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kcnq2tm1.1Naas/Kcnq2tm1.1Naas
Genetic Background: FVB.129-Kcnq2tm1.1Naas

Allelic Composition: Kcnq3tm1.1Naas/Kcnq3tm1.1Naas
Genetic Background: B6.129-Kcnq3tm1.1Naas

Allelic Composition: Kcnq3tm1.1Naas/Kcnq3tm1.1Naas
Genetic Background: FVB.129-Kcnq3tm1.1Naas

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Kcnq3tm1.1Naas/Kcnq3tm1.1Naas
Genetic Background: FVB.129-Kcnq3tm1.1Naas

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Emx1tm1(cre)Krj/?,Kcnq3tm1.1Avtz/Kcnq3tm1.1Avtz
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003354 astrocytosis "a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Kcnq3tm1.1Naas/Kcnq3tm1.1Naas
Genetic Background: FVB.129-Kcnq3tm1.1Naas

 MP:0003412 abnormal afterhyperpolarization "anomaly in the currents that follow an action potential and influence firing frequency and neuronal integration" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94941]
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Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Prom1tm1(cre/ERT2)Gilb/Prom1+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Kcnq2tm1.1Naas/Kcnq2tm1.1Naas
Genetic Background: FVB.129-Kcnq2tm1.1Naas

Allelic Composition: Kcnq3tm1.1Naas/Kcnq3tm1.1Naas
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0008872 abnormal response to xenobiotics "any anomaly in the physiological or morphological changes induced by a foreign compound, such as changes in blood pressure, changes in hormone or protein levels or hypertrophy or hypotrophy of an organ" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Prom1tm1(cre/ERT2)Gilb/Prom1+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Kcnq3tm1.1Naas/Kcnq3tm1.1Naas
Genetic Background: FVB.129-Kcnq3tm1.1Naas

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Kcnq2tm1.1Naas/Kcnq2tm1.1Naas
Genetic Background: FVB.129-Kcnq2tm1.1Naas

Allelic Composition: Kcnq3tm1.1Naas/Kcnq3tm1.1Naas
Genetic Background: B6.129-Kcnq3tm1.1Naas

Allelic Composition: Kcnq3tm1.1Naas/Kcnq3tm1.1Naas
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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