ENSMUSG00000016346


Mus musculus

Features
Gene ID: ENSMUSG00000016346
  
Biological name :Kcnq2
  
Synonyms : Kcnq2 / potassium voltage-gated channel subfamily KQT member 2 isoform 13
  
Possible biological names infered from orthology : O43526 / potassium voltage-gated channel subfamily Q member 2
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: H4
Gene start: 181075579
Gene end: 181135300
  
Corresponding Affymetrix probe sets: 10490569 (MoGene1.0st)   1420800_a_at (Mouse Genome 430 2.0 Array)   1426006_at (Mouse Genome 430 2.0 Array)   1426080_a_at (Mouse Genome 430 2.0 Array)   1426128_a_at (Mouse Genome 430 2.0 Array)   1426335_at (Mouse Genome 430 2.0 Array)   1435942_at (Mouse Genome 430 2.0 Array)   1438260_at (Mouse Genome 430 2.0 Array)   1440141_at (Mouse Genome 430 2.0 Array)   1440258_at (Mouse Genome 430 2.0 Array)   1451595_a_at (Mouse Genome 430 2.0 Array)   1459826_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000052453
Ensembl peptide - ENSMUSP00000016491
Ensembl peptide - ENSMUSP00000080243
Ensembl peptide - ENSMUSP00000143490
Ensembl peptide - ENSMUSP00000143263
Ensembl peptide - ENSMUSP00000123488
Ensembl peptide - ENSMUSP00000122915
Ensembl peptide - ENSMUSP00000099340
Ensembl peptide - ENSMUSP00000099339
Ensembl peptide - ENSMUSP00000099338
Ensembl peptide - ENSMUSP00000099337
Ensembl peptide - ENSMUSP00000099336
NCBI entrez gene - 16536     See in Manteia.
MGI - MGI:1309503
RefSeq - XM_017315768
RefSeq - NM_010611
RefSeq - XM_006500565
RefSeq - XM_006500567
RefSeq - XM_006500568
RefSeq - XM_011239925
RefSeq - XM_017315735
RefSeq - XM_017315738
RefSeq - XM_017315740
RefSeq - XM_017315741
RefSeq - XM_017315742
RefSeq - XM_017315743
RefSeq - XM_017315744
RefSeq - XM_017315746
RefSeq - XM_017315747
RefSeq - XM_017315751
RefSeq - XM_017315753
RefSeq - XM_017315754
RefSeq - XM_017315763
RefSeq - XM_017315767
RefSeq - NM_001003824
RefSeq - NM_001003825
RefSeq - NM_001006668
RefSeq - NM_001006669
RefSeq - NM_001006674
RefSeq - NM_001302888
RefSeq Peptide - NP_001006669
RefSeq Peptide - NP_001006670
RefSeq Peptide - NP_001006675
RefSeq Peptide - NP_001289817
RefSeq Peptide - NP_034741
RefSeq Peptide - NP_001003825
RefSeq Peptide - NP_001003824
swissprot - B7ZBV4
swissprot - B7ZBV3
swissprot - B7ZBW2
swissprot - A0A0G2JGA6
swissprot - A0A0G2JFQ2
swissprot - F6UC55
swissprot - B7ZBW1
swissprot - B7ZBV9
swissprot - B7ZBV8
swissprot - B7ZBV7
swissprot - B7ZBV6
swissprot - B7ZBV5
Ensembl - ENSMUSG00000016346
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kcnq2bENSDARG00000091130Danio rerio
 KCNQ2ENSGALG00000005822Gallus gallus
 KCNQ2ENSG00000075043Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Kcnq3 / Q8K3F6 / Potassium voltage-gated channel subfamily KQT member 3 / O43525* / potassium voltage-gated channel subfamily Q member 3*ENSMUSG0000005625847
Kcnq5 / Q9JK45 / Potassium voltage-gated channel subfamily KQT member 5 / Q9NR82* / potassium voltage-gated channel subfamily Q member 5*ENSMUSG0000002803346
Kcnq4 / Q9JK97 / Potassium voltage-gated channel subfamily KQT member 4 / P56696* / potassium voltage-gated channel subfamily Q member 4*ENSMUSG0000002863142
Kcnq1 / P97414 / Potassium voltage-gated channel subfamily KQT member 1 / P51787* / potassium voltage-gated channel subfamily Q member 1*ENSMUSG0000000954528


Protein motifs (from Interpro)
Interpro ID Name
 IPR003937  Potassium channel, voltage dependent, KCNQ
 IPR003947  Potassium channel, voltage dependent, KCNQ2
 IPR005821  Ion transport domain
 IPR013821  Potassium channel, voltage dependent, KCNQ, C-terminal
 IPR020969  Ankyrin-G binding site
 IPR028325  Voltage-gated potassium channel


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006813 potassium ion transport IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0071805 potassium ion transmembrane transport IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0008076 voltage-gated potassium channel complex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005249 voltage-gated potassium channel activity IEA
 molecular_functionGO:0005267 potassium channel activity IEA
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0030506 ankyrin binding IEA


Pathways (from Reactome)
Pathway description
Voltage gated Potassium channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000807 abnormal hippocampus morphology "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]
Show

Allelic Composition: Emx1tm1(cre)Krj/?,Kcnq2tm1.1Avtz/Kcnq2tm1.1Avtz
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000947 convulsive seizures "seizures characterized by uncontrolled motor activity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Scn1atm1.1Aesc/Scn1a+,Tg(Eno2-Scn2a1*)Q54Mm/0
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0001177 atelectasis "collapse of the lung or any portion of the lung, or decreased or absent air in the lung, resulting in loss of lung volume " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd9tm1Mek/Cd9tm1Mek
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Kcnq2tm1.1Naas/Kcnq2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Kcnq2tm1.1Naas/Kcnq2tm1.1Naas
Genetic Background: FVB.129-Kcnq2tm1.1Naas

 MP:0001650 electrically induced seizures "high or low frequency electrical stimulation applied to induce seizure activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, wf:Wayne Frankel , TJL staff]
Show

Allelic Composition: Acetm1Unc/Acetm1Unc,Ace2tm1Pngr/Ace2tm1Pngr
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Kcnq2Nmf134/Kcnq2+
Genetic Background: C57BL/6J-Kcnq2Nmf134/J

Allelic Composition: Kcnq2tm1.1Naas/Kcnq2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Opn4tm1Yau/Opn4tm2(DTA)Yau
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Kcnq2tm1.1Naas/Kcnq2tm1.1Naas
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Kcnq2tm1.1Naas/Kcnq2tm1.1Naas
Genetic Background: FVB.129-Kcnq2tm1.1Naas

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Opn4tm1Yau/Opn4tm2(DTA)Yau
Genetic Background: involves: 129 * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Opn4tm1Yau/Opn4tm2(DTA)Yau
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Kcnq2tm1.1Naas/Kcnq2tm1.1Naas
Genetic Background: B6.129-Kcnq2tm1.1Naas

Allelic Composition: Kcnq2tm1.1Naas/Kcnq2tm1.1Naas
Genetic Background: FVB.129-Kcnq2tm1.1Naas

Allelic Composition: Emx1tm1(cre)Krj/?,Kcnq2tm1.1Avtz/Kcnq2tm1.1Avtz
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Emx1tm1(cre)Krj/?,Kcnq2tm1.1Avtz/Kcnq2tm1.1Avtz
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Kcnq2tm2.1Snhr/Kcnq2tm2.1Snhr
Genetic Background: B6.Cg-Kcnq2tm2.1Snhr

Allelic Composition: Kcnq2tm2.1Snhr/Kcnq2+
Genetic Background: B6.Cg-Kcnq2tm2.1Snhr

 MP:0002906 susceptibility to pharmacologically induced seizures "inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:69504]
Show

Allelic Composition: Cd9tm1Mek/Cd9tm1Mek
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Kcnq2tm1Dgen/Kcnq2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Kcnq2Nmf134/Kcnq2+
Genetic Background: C57BL/6J-Kcnq2Nmf134

 MP:0003412 abnormal afterhyperpolarization "anomaly in the currents that follow an action potential and influence firing frequency and neuronal integration" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94941]
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Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Prom1tm1(cre/ERT2)Gilb/Prom1+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

Allelic Composition: Emx1tm1(cre)Krj/?,Kcnq2tm1.1Avtz/Kcnq2tm1.1Avtz
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003996 clonic seizures "increased number or decreased threshold for the induction of a seizure characterized by unilateral or bilateral rhythmic jerking movements of the arms and legs caused by alternating contraction and relaxation of muscle" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Kcnq2tm2.1Snhr/Kcnq2tm2.1Snhr
Genetic Background: B6.Cg-Kcnq2tm2.1Snhr

Allelic Composition: Kcnq2tm2.1Snhr/Kcnq2+
Genetic Background: B6.Cg-Kcnq2tm2.1Snhr

Allelic Composition: Kcnq2tm3.1Snhr/Kcnq2+
Genetic Background: B6.Cg-Kcnq2tm3.1Snhr

 MP:0003997 tonic-clonic seizures "increased number or decreased threshold for the induction of a seizure characterized by initial rigidity followed by rhythmic jerking movements" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Opn4tm1Yau/Opn4tm2(DTA)Yau
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Kcnq2tm1.1Naas/Kcnq2tm1.1Naas
Genetic Background: B6.129-Kcnq2tm1.1Naas

Allelic Composition: Kcnq2Nmf134/Kcnq2+,Scn1atm1.1Aesc/Scn1a+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J

Allelic Composition: Emx1tm1(cre)Krj/?,Kcnq2tm1.1Avtz/Kcnq2tm1.1Avtz
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Kcnq2tm1.1Naas/Kcnq2tm1.1Naas
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004994 abnormal brain wave pattern "any anomaly in the standard pattern of rhythmic and rapid fluctuation of electrical potential between parts of the brain, often visualized on an electroencephalogram (EEG); the pattern is often measured to diagnose neurological conditions such as seizure disorders (epilepsy)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Emx1tm1(cre)Krj/?,Kcnq2tm1.1Avtz/Kcnq2tm1.1Avtz
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005402 abnormal action potential "change in the electric response of a nerve or other excitable tissue to its stimulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Emx1tm1(cre)Krj/?,Kcnq2tm1.1Avtz/Kcnq2tm1.1Avtz
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Kcnq2Nmf134/Kcnq2+,Scn1atm1.1Aesc/Scn1a+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: a/a,Tyrp1b/Tyrp1b,wad/wad
Genetic Background: Not Specified

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Kcnq2tm1.1Naas/Kcnq2tm1.1Naas
Genetic Background: FVB.129-Kcnq2tm1.1Naas

Allelic Composition: Kcnq2Nmf134/Kcnq2+,Scn1atm1.1Aesc/Scn1a+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J

Allelic Composition: Emx1tm1(cre)Krj/?,Kcnq2tm1.1Avtz/Kcnq2tm1.1Avtz
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Cd9tm1Mek/Cd9tm1Mek
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Kcnq2tm3.1Snhr/Kcnq2tm3.1Snhr
Genetic Background: B6.Cg-Kcnq2tm3.1Snhr

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Kcnq2tm1.1Naas/Kcnq2tm1.1Naas
Genetic Background: B6.129-Kcnq2tm1.1Naas

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Kcnq2tm1.1Naas/Kcnq2tm1.1Naas
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Kcnq2tm1.1Naas/Kcnq2tm1.1Naas
Genetic Background: FVB.129-Kcnq2tm1.1Naas

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Seletm2Alb/Seletm2Alb,Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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