ENSMUSG00000056569


Mus musculus

Features
Gene ID: ENSMUSG00000056569
  
Biological name :Mpz
  
Synonyms : Mpz / myelin protein zero
  
Possible biological names infered from orthology : P25189
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: H3
Gene start: 171150711
Gene end: 171161130
  
Corresponding Affymetrix probe sets: 10351525 (MoGene1.0st)   1423253_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000066701
Ensembl peptide - ENSMUSP00000106966
NCBI entrez gene - 17528     See in Manteia.
MGI - MGI:103177
RefSeq - NM_001315499
RefSeq - NM_001315500
RefSeq - NM_008623
RefSeq Peptide - NP_032649
RefSeq Peptide - NP_001302428
RefSeq Peptide - NP_001302429
swissprot - E9QK82
Ensembl - ENSMUSG00000056569
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mpzENSDARG00000038609Danio rerio
 MPZENSG00000158887Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mpzl1 / Q3TEW6 / myelin protein zero-like 1 / O95297*ENSMUSG0000002656631
Mpzl2 / myelin protein zero-like 2 / O60487*ENSMUSG0000003209225
Mpzl3 / Q3V3F6 / Myelin protein zero-like protein 3 / Q6UWV2* / myelin protein zero like 3*ENSMUSG0000007030524


Protein motifs (from Interpro)
Interpro ID Name
 IPR000920  Myelin P0 protein-related
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013106  Immunoglobulin V-set domain
 IPR013783  Immunoglobulin-like fold
 IPR019566  Myelin-PO, C-terminal
 IPR019738  Myelin P0 protein, conserved site
 IPR021157  Cytochrome c1, transmembrane anchor, C-terminal
 IPR029869  Myelin protein P0
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0042552 myelination IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules IEA
 biological_processGO:0098743 cell aggregation IEA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005791 rough endoplasmic reticulum IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 cellular_componentGO:0043209 myelin sheath IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mpztm1Msch/Mpz+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000727 absent CD4-8+ cells "lack of the set of single-positive T cells that express CD8 on their surface" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mpztm1Msch/Mpz+,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: B6.129S7-Mpztm1Msch Rag1tm1Mom

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Chfrtm1Jc/Chfr+
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Mpzttrr/Mpzttrr
Genetic Background: B6.Cg-Mpzttrr/GrsrJ

Allelic Composition: Mpzm1Anu/?
Genetic Background: involves: BALB/c * C57BL/6 * DBA/2

 MP:0000746 weakness "state of being infirm or less strong than littermates" [J:45400]
Show

Allelic Composition: Chfrtm1Jc/Chfr+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0000753 paralysis "loss of power of voluntary movement in a muscle through injury or disease of its nerve supply" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Chfrtm1Jc/Chfr+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0000755 hindlimb paralysis "loss of power of voluntary movement in the muscles of the hindlimb through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Mpzttrr/Mpzttrr
Genetic Background: B6.Cg-Mpzttrr/GrsrJ

 MP:0000920 abnormal myelination "atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Chfrtm1Jc/Chfr+
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Csf1op/Csf1op,Mpztm1Msch/Mpz+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Mpztm1Msch/Mpz+
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Mpztm1Msch/Mpz+,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: B6.129S7-Mpztm1Msch Rag1tm1Mom

Allelic Composition: Mpztm1Msch/Mpz+
Genetic Background: B6.129S7-Mpztm1Msch

 MP:0000921 demyelination "loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mpztm1Msch/Mpz+
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Mpzttrr/Mpzttrr
Genetic Background: B6.Cg-Mpzttrr/GrsrJ

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Mpztm1Msch/Mpz+
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Ccl2tm1Rol/Ccl2+,Mpztm1Msch/Mpz+
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0001106 abnormal Schwann cell "malformed or absent cells which form the insulating myelin sheaths of peripheral axons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Chfrtm1Jc/Chfr+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Chfrtm1Jc/Chfr+
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Mpztm1Msch/Mpz+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Mpzttrr/Mpzttrr
Genetic Background: B6.Cg-Mpzttrr/GrsrJ

Allelic Composition: Mpzm1Anu/?
Genetic Background: involves: BALB/c * C57BL/6 * DBA/2

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Chfrtm1Jc/Chfr+
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Mpzm1Anu/?
Genetic Background: involves: BALB/c * C57BL/6 * DBA/2

 MP:0001522 impaired swimming "reduced ability or inability to swim" [J:45446, J:39081]
Show

Allelic Composition: Chfrtm1Jc/Chfr+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0001844 autoimmune response "condition in which cells and/or antibodies arise from and are directed against one s own tissues " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mpztm1Msch/Mpz+,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: B6.129S7-Mpztm1Msch Rag1tm1Mom

 MP:0001924 infertility "inability to produce live offspring" [J:47225]
Show

Allelic Composition: Mpzttrr/Mpzttrr
Genetic Background: B6.Cg-Mpzttrr/GrsrJ

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Mpzttrr/Mpzttrr
Genetic Background: B6.Cg-Mpzttrr/GrsrJ

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Mpzttrr/Mpzttrr
Genetic Background: B6.Cg-Mpzttrr/GrsrJ

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dab1scm-3J/Dab1scm-3J
Genetic Background: B6.Cg-Dab1scm-3J/J

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Mpztm1Msch/Mpz+,Tcratm1Mjo/Tcratm1Mjo
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * BALB/c * C57BL/6

Allelic Composition: Mpztm1Msch/Mpz+,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: B6.129S7-Mpztm1Msch Rag1tm1Mom

Allelic Composition: Mpztm1Msch/Mpz+
Genetic Background: B6.129S7-Mpztm1Msch

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mpztm1Msch/Mpz+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003224 neuron degeneration "a retrogressive impairment of function or destruction of the functional cells of the nervous system that receive, conduct, and transmit impulses " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Mpztm1Msch/Mpz+
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Mpztm1Msch/Mpz+
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Ccl2tm1Rol/Ccl2+,Mpztm1Msch/Mpz+
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0003312 abnormal locomotor coordination "reduced ability of an animal to maintain skillful and effective interaction of movements while engaging in locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Chfrtm1Jc/Chfr+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0003633 abnormal nervous system physiology 
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Allelic Composition: Mpztm1Msch/Mpz+,Tcratm1Mjo/Tcratm1Mjo
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * BALB/c * C57BL/6

Allelic Composition: Mpztm1Msch/Mpz+
Genetic Background: B6.129S7-Mpztm1Msch

 MP:0003790 absent CD4+8- cells "lack of the set of single-positive T cells that express CD4 on their surface" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, acv:Alicia Valenzuela, Genetic Resources Curator]
Show

Allelic Composition: Mpztm1Msch/Mpz+,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: B6.129S7-Mpztm1Msch Rag1tm1Mom

 MP:0003871 abnormal myelin sheath morphology "malformation of the insulating envelope that surrounds nerve fibers or axons" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Mpztm1Msch/Mpz+,Tcratm1Mjo/Tcratm1Mjo
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * BALB/c * C57BL/6

Allelic Composition: Mpztm1Msch/Mpz+,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: B6.129S7-Mpztm1Msch Rag1tm1Mom

Allelic Composition: Mpztm1Msch/Mpz+
Genetic Background: B6.129S7-Mpztm1Msch

 MP:0003884 decreased macrophage count "fewer than the normal numbers of macrophages" [acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Mpztm1Msch/Mpz+
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Ccl2tm1Rol/Ccl2+,Mpztm1Msch/Mpz+
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Efemp2tm1.2Hiya/Efemp2tm1.2Hiya
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0005403 abnormal nerve conduction "anomaly in the act of transmitting electricity along a single nerve" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Chfrtm1Jc/Chfr+
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Mpztm1Msch/Mpz+
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Mpztm1Msch/Mpz+,Tcratm1Mjo/Tcratm1Mjo
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * BALB/c * C57BL/6

Allelic Composition: Mpztm1Msch/Mpz+,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: B6.129S7-Mpztm1Msch Rag1tm1Mom

Allelic Composition: Mpztm1Msch/Mpz+
Genetic Background: B6.129S7-Mpztm1Msch

 MP:0005425 increased macrophage count "greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]
Show

Allelic Composition: Mpztm1Msch/Mpz+
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Mpztm1Msch/Mpz+
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0005465 abnormal T helper 1 physiology "anomalous response of the subset of helper T cells that enhance cell-mediated immune responses; these cells secrete IL-1 and gamma-IFN and are generally involved in inflammatory responses" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Mpztm1Msch/Mpz+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008243 abnormal foam cell morphology "any structural anomaly of a type of macrophage containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions" [CL:0000517]
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Allelic Composition: Ccl2tm1Rol/Ccl2+,Mpztm1Msch/Mpz+
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0008713 abnormal cytokine level "deviation from the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Mpztm1Msch/Mpz+
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0008814 reduced nerve conduction velocity "decrease in the rate at which an eletrical impulse travels through a nerve" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Mpztm1Msch/Mpz+,Tcratm1Mjo/Tcratm1Mjo
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * BALB/c * C57BL/6

 MP:0010742 increased Schwann cell number "greater than normal number of cells that sheath the axons of the peripheral nervous system" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mpztm1Msch/Mpz+,Tcratm1Mjo/Tcratm1Mjo
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * BALB/c * C57BL/6

Allelic Composition: Mpztm1Msch/Mpz+,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: B6.129S7-Mpztm1Msch Rag1tm1Mom

Allelic Composition: Mpztm1Msch/Mpz+
Genetic Background: B6.129S7-Mpztm1Msch

 MP:0010760 abnormal macrophage chemotaxis "anomaly in the movement of a macrophage guided by a specific chemical concentration gradient" [GO:0048246]
Show

Allelic Composition: Mpztm1Msch/Mpz+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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