MP:0000063 | reduced bone density | "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315] |
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Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz Genetic Background: C57BL/6-Prf1tm1Sdz/J
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MP:0000160 | kyphosis | "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator] |
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Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz Genetic Background: C57BL/6-Prf1tm1Sdz/J
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MP:0000194 | hypercalcemia | "abnormally high concentration of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz Genetic Background: C57BL/6-Prf1tm1Sdz/J
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MP:0000278 | abnormal myocardial fiber morphology | "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048] |
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Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz Genetic Background: C57BL/6-Prf1tm1Sdz/J
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MP:0000321 | increased bone marrow cell number | "increased number of cells that make up the core cavitites of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator] |
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Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz Genetic Background: C57BL/6-Prf1tm1Sdz/J
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MP:0000367 | abnormal coat/ hair morphology | "anomalous color, structure, growth, or texture of the hair" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Tcf12tm1Zhu/Tcf12+,Tcf3tm4Zhu/Tcf3tm4Zhu,Tg(Lck-cre)#Zhu/0 Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * SJL
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MP:0000377 | abnormal hair follicle | "malformed invagination of the epidermis from which the hair shaft develops" [J:65031] |
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Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz Genetic Background: C57BL/6-Prf1tm1Sdz/J
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MP:0000379 | reduced hair follicle number | "fewer number of the epidermal invaginations from which the hair shaft develops" [J:15108] |
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Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz Genetic Background: C57BL/6-Prf1tm1Sdz/J
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MP:0000382 | underdeveloped hair follicles | "arrest of or retarded differentiation of the epidermal invaginations from which the hair shaft develops" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790] |
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Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz Genetic Background: C57BL/6-Prf1tm1Sdz/J
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MP:0000414 | alopecia | "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796] |
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Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz Genetic Background: C57BL/6-Prf1tm1Sdz/J
Allelic Composition: Mpzl3tm1Tacz/Mpzl3tm1Tacz Genetic Background: B6.129P2-Mpzl3tm1Tacz
Allelic Composition: Mpzl3tm1(KOMP)Mbp/Mpzl3tm1(KOMP)Mbp Genetic Background: C57BL/6-Tyrc-Brd Mpzl3tm1(KOMP)Mbp
Allelic Composition: Mpzl3rc/Mpzl3tm1(KOMP)Mbp Genetic Background: C57BL/6-Tyrc-Brd Mpzl3rc/Mpzl3tm1(KOMP)Mbp
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MP:0000598 | abnormal liver morphology | "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170] |
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Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz Genetic Background: C57BL/6-Prf1tm1Sdz/J
Allelic Composition: Mpzl3tm1Tacz/Mpzl3tm1Tacz Genetic Background: B6.129P2-Mpzl3tm1Tacz
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MP:0000609 | abnormal liver physiology | "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Mpzl3tm1Tacz/Mpzl3tm1Tacz Genetic Background: B6.129P2-Mpzl3tm1Tacz
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MP:0000647 | abnormal sebaceous gland morphology | "malformation of the holocrine glands of the dermis that secrete sebum into the hair follicles" [MGI:tc] |
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Allelic Composition: Tcf12tm1Zhu/Tcf12+,Tcf3tm4Zhu/Tcf3tm4Zhu,Tg(Lck-cre)#Zhu/0 Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * SJL
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MP:0000652 | enlarged sebaceous gland | "increased size of the sebum secreting glands of the hair shaft" [J:30249] |
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Allelic Composition: Mpzl3ruf/Mpzl3ruf Genetic Background: C3H/HeJ-Mpzl3ruf
Allelic Composition: Mpzl3tm1Tacz/Mpzl3tm1Tacz Genetic Background: B6.129P2-Mpzl3tm1Tacz
Allelic Composition: Mpzl3tm1(KOMP)Mbp/Mpzl3tm1(KOMP)Mbp Genetic Background: C57BL/6-Tyrc-Brd Mpzl3tm1(KOMP)Mbp
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MP:0000689 | abnormal spleen morphology | "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463] |
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Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz Genetic Background: C57BL/6-Prf1tm1Sdz/J
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MP:0001194 | dermatitis | "inflammation of the skin" [J:65146] |
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Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz Genetic Background: C57BL/6-Prf1tm1Sdz/J
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MP:0001209 | spontaneous skin ulceration | "unpredictable appearance of skin lesions, usually with inflammation" [J:65302] |
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Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz Genetic Background: C57BL/6-Prf1tm1Sdz/J
Allelic Composition: Mpzl3tm1(KOMP)Mbp/Mpzl3tm1(KOMP)Mbp Genetic Background: C57BL/6-Tyrc-Brd Mpzl3tm1(KOMP)Mbp
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MP:0001212 | skin lesions | "focal patches of inflammation on the skin" [J:30162] |
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Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz Genetic Background: C57BL/6-Prf1tm1Sdz/J
Allelic Composition: Mpzl3tm1Tacz/Mpzl3tm1Tacz Genetic Background: B6.129P2-Mpzl3tm1Tacz
Allelic Composition: Mpzl3tm1(KOMP)Mbp/Mpzl3tm1(KOMP)Mbp Genetic Background: C57BL/6-Tyrc-Brd Mpzl3tm1(KOMP)Mbp
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MP:0001222 | epidermal hyperplasia | "increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146] |
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Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz Genetic Background: C57BL/6-Prf1tm1Sdz/J
Allelic Composition: Mpzl3tm1(KOMP)Mbp/Mpzl3tm1(KOMP)Mbp Genetic Background: C57BL/6-Tyrc-Brd Mpzl3tm1(KOMP)Mbp
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MP:0001240 | abnormal cornified layer morphology | "structural or developmental anomaly of the outer layer of the epidermis, consisting of several layers of flat keratinized non-nucleated cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Mpzl3ruf/Mpzl3ruf Genetic Background: C3H/HeJ-Mpzl3ruf
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MP:0001242 | hyperkeratosis | "increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133] |
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Allelic Composition: Mpzl3ruf/Mpzl3ruf Genetic Background: C3H/HeJ-Mpzl3ruf
Allelic Composition: Mpzl3tm1(KOMP)Mbp/Mpzl3tm1(KOMP)Mbp Genetic Background: C57BL/6-Tyrc-Brd Mpzl3tm1(KOMP)Mbp
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MP:0001245 | thick dermal layer | "increased depth of the dermis" [J:65033] |
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Allelic Composition: Mpzl3tm1(KOMP)Mbp/Mpzl3tm1(KOMP)Mbp Genetic Background: C57BL/6-Tyrc-Brd Mpzl3tm1(KOMP)Mbp
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MP:0001258 | decreased body length | "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator] |
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Allelic Composition: Mpzl3tm1Tacz/Mpzl3tm1Tacz Genetic Background: B6.129P2-Mpzl3tm1Tacz
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MP:0001262 | decreased body weight | "lower than normal average weight " [J:61295] |
Show
Allelic Composition: Mpzl3tm1Tacz/Mpzl3tm1Tacz Genetic Background: B6.129P2-Mpzl3tm1Tacz
Allelic Composition: Mpzl3tm1(KOMP)Mbp/Mpzl3tm1(KOMP)Mbp Genetic Background: C57BL/6-Tyrc-Brd Mpzl3tm1(KOMP)Mbp
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MP:0001263 | weight loss | "progressive reduction of body weight below normal average for age" [J:45400] |
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Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz Genetic Background: C57BL/6-Prf1tm1Sdz/J
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MP:0001280 | loss of vibrissae | "inability to retain the whiskers" [J:45400] |
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Allelic Composition: Mpzl3tm1(KOMP)Mbp/Mpzl3tm1(KOMP)Mbp Genetic Background: C57BL/6-Tyrc-Brd Mpzl3tm1(KOMP)Mbp
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MP:0001386 | abnormal maternal nurturing | "failure of mothers to tend offspring" [J:39801] |
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Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz Genetic Background: C57BL/6-Prf1tm1Sdz/J
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MP:0001399 | hyperactivity | "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125] |
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Allelic Composition: Mpzl3tm1Tacz/Mpzl3tm1Tacz Genetic Background: B6.129P2-Mpzl3tm1Tacz
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MP:0001433 | polyphagia | "eating to excess" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Mpzl3tm1Tacz/Mpzl3tm1Tacz Genetic Background: B6.129P2-Mpzl3tm1Tacz
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MP:0001510 | abnormal coat appearance | "coat that looks different from the usual state " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz Genetic Background: C57BL/6-Prf1tm1Sdz/J
Allelic Composition: Mpzl3ruf/Mpzl3ruf Genetic Background: C3H/HeJ-Mpzl3ruf
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MP:0001511 | disheveled coat | "coat that looks generally unkempt" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz Genetic Background: C57BL/6-Prf1tm1Sdz/J
Allelic Composition: Mpzl3ruf/Mpzl3ruf Genetic Background: C3H/HeJ-Mpzl3ruf
Allelic Composition: Mpzl3tm1(KOMP)Mbp/Mpzl3tm1(KOMP)Mbp Genetic Background: C57BL/6-Tyrc-Brd Mpzl3tm1(KOMP)Mbp
Allelic Composition: Mpzl3rc/Mpzl3tm1(KOMP)Mbp Genetic Background: C57BL/6-Tyrc-Brd Mpzl3rc/Mpzl3tm1(KOMP)Mbp
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MP:0001614 | abnormal vasculature | "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz Genetic Background: C57BL/6-Prf1tm1Sdz/J
Allelic Composition: Mpzl3tm1(KOMP)Mbp/Mpzl3tm1(KOMP)Mbp Genetic Background: C57BL/6-Tyrc-Brd Mpzl3tm1(KOMP)Mbp
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MP:0001732 | postnatal growth retardation | "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz Genetic Background: C57BL/6-Prf1tm1Sdz/J
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MP:0001860 | liver inflammation | "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz Genetic Background: C57BL/6-Prf1tm1Sdz/J
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MP:0001874 | acanthosis | "diffuse hyperplasia of the spinous layer of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Mpzl3tm1(KOMP)Mbp/Mpzl3tm1(KOMP)Mbp Genetic Background: C57BL/6-Tyrc-Brd Mpzl3tm1(KOMP)Mbp
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MP:0002060 | abnormal skin morphology | "malformation or atypical structure of the membranous protective covering of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:56777] |
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Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz Genetic Background: C57BL/6-Prf1tm1Sdz/J
Allelic Composition: Mpzl3ruf/Mpzl3ruf Genetic Background: C3H/HeJ-Mpzl3ruf
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MP:0002074 | abnormal hair texture | "irregular or unusual appearance of the structure of the hair" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Tcf12tm1Zhu/Tcf12+,Tcf3tm4Zhu/Tcf3tm4Zhu,Tg(Lck-cre)#Zhu/0 Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * SJL
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MP:0002075 | abnormal coat color | "irregular or unusual pigmentation pattern of the hair in relation to control animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Ola1Gt(OST312288)Lex/Ola1Gt(OST312288)Lex Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
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MP:0002106 | abnormal muscle physiology | "anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Mpzl3tm1Tacz/Mpzl3tm1Tacz Genetic Background: B6.129P2-Mpzl3tm1Tacz
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MP:0002108 | abnormal muscle morphology | "abnormal development of muscle tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Mpzl3tm1Tacz/Mpzl3tm1Tacz Genetic Background: B6.129P2-Mpzl3tm1Tacz
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MP:0002310 | resistance to fatty liver development | "less likely than the norm to to develop hepatic steatosis " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Mpzl3tm1Tacz/Mpzl3tm1Tacz Genetic Background: B6.129P2-Mpzl3tm1Tacz
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MP:0002644 | decreased circulating triglyceride level | "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Mpzl3tm1Tacz/Mpzl3tm1Tacz Genetic Background: B6.129P2-Mpzl3tm1Tacz
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MP:0002665 | decreased circulating corticosterone level | "less than the normal blood concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Mpzl3tm1Tacz/Mpzl3tm1Tacz Genetic Background: B6.129P2-Mpzl3tm1Tacz
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MP:0002702 | decreased circulating free fatty acid level | "lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Mpzl3tm1Tacz/Mpzl3tm1Tacz Genetic Background: B6.129P2-Mpzl3tm1Tacz
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MP:0002991 | abnormal sebaceous gland physiology | "anomalous fundtion of any of the small, sacculated organs found within the dermis that normally secrete sebum" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Mpzl3ruf/Mpzl3ruf Genetic Background: C3H/HeJ-Mpzl3ruf
Allelic Composition: Mpzl3tm1(KOMP)Mbp/Mpzl3tm1(KOMP)Mbp Genetic Background: C57BL/6-Tyrc-Brd Mpzl3tm1(KOMP)Mbp
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MP:0002992 | abnormal sebaceous lipid secretion | "abnormal function of the sebaceous gland resulting in changes to the lipid profile secreted onto the hair and skin" [smb:Susan M. Bello , Mouse Genome Informatics Curator] |
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Allelic Composition: Mpzl3ruf/Mpzl3ruf Genetic Background: C3H/HeJ-Mpzl3ruf
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MP:0003068 | enlarged kidney | "larger than average size of the kidney" [J:86005, pvb:Pierre Vanden Borre, Mouse Genome Informatics Curator] |
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Allelic Composition: Mpzl3tm1Tacz/Mpzl3tm1Tacz Genetic Background: B6.129P2-Mpzl3tm1Tacz
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MP:0003413 | hair follicle degeneration | "a retrogressive impairment of function or destruction of the hair follicle" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:94517] |
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Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz Genetic Background: C57BL/6-Prf1tm1Sdz/J
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MP:0003427 | parakeratosis | "abnormal retention of the nuclei of the keratinocytes in the stratum corneum of the epidermis" [smb:Susan M Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Mpzl3tm1(KOMP)Mbp/Mpzl3tm1(KOMP)Mbp Genetic Background: C57BL/6-Tyrc-Brd Mpzl3tm1(KOMP)Mbp
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MP:0003795 | abnormal bone structure | |
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Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz Genetic Background: C57BL/6-Prf1tm1Sdz/J
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MP:0003809 | abnormal hair shaft morphology | "irregular or unusual structure of the cuticle, and/or cortex and/or medulla of a hair" [llw2:Linda Washburn , Mouse Genome Informatics Curator] |
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Allelic Composition: Mpzl3ruf/Mpzl3ruf Genetic Background: C3H/HeJ-Mpzl3ruf
Allelic Composition: Mpzl3tm1(KOMP)Mbp/Mpzl3tm1(KOMP)Mbp Genetic Background: C57BL/6-Tyrc-Brd Mpzl3tm1(KOMP)Mbp
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MP:0003848 | brittle hair | "hair is susceptible to breakage " [llw2:Linda Washburn , Mouse Genome Informatics Curator] |
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Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz Genetic Background: C57BL/6-Prf1tm1Sdz/J
Allelic Composition: Mpzl3ruf/Mpzl3ruf Genetic Background: C3H/HeJ-Mpzl3ruf
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MP:0003849 | greasy coat | "fur is oily in appearance or texture" [llw2:Linda Washburn , Mouse Genome Informatics Curator] |
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Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz Genetic Background: C57BL/6-Prf1tm1Sdz/J
Allelic Composition: Mpzl3tm1(KOMP)Mbp/Mpzl3tm1(KOMP)Mbp Genetic Background: C57BL/6-Tyrc-Brd Mpzl3tm1(KOMP)Mbp
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MP:0003875 | abnormal hair follicle regresssion | "abnormal length of time for the onset of catagen phase of the cyclic trasnformation of the hair follicle
" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz Genetic Background: C57BL/6-Prf1tm1Sdz/J
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MP:0003960 | increased lean body mass | "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator] |
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Allelic Composition: Mpzl3tm1Tacz/Mpzl3tm1Tacz Genetic Background: B6.129P2-Mpzl3tm1Tacz
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MP:0003981 | decreased circulating phospholipid level | "reduced concentration in the blood of the fat derivatives in which one fatty acid has been replaced by a phosphate group" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Mpzl3tm1Tacz/Mpzl3tm1Tacz Genetic Background: B6.129P2-Mpzl3tm1Tacz
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MP:0004381 | abnormal hair follicle melanocyte morphology | "any structural anomaly of the cells that produce pigment in the hair follicles" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz Genetic Background: C57BL/6-Prf1tm1Sdz/J
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MP:0004566 | myocardial fiber degeneration | "deterioration or destruction of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz Genetic Background: C57BL/6-Prf1tm1Sdz/J
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MP:0004889 | increased energy expenditure | "increase in the number of calories used per unit time or decrease in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mpzl3tm1Tacz/Mpzl3tm1Tacz Genetic Background: B6.129P2-Mpzl3tm1Tacz
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MP:0004947 | skin inflammation | "local accumulation of fluid, plasma proteins, and leukocytes in the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mpzl3tm1(KOMP)Mbp/Mpzl3tm1(KOMP)Mbp Genetic Background: C57BL/6-Tyrc-Brd Mpzl3tm1(KOMP)Mbp
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MP:0005081 | abnormal stratum reticulare morphology | "structural anomaly of the thicker, deeper layer of the dermis, containing blood and lymph vessles, nerves and nerve endings, and hair follicles" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz Genetic Background: C57BL/6-Prf1tm1Sdz/J
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MP:0005179 | decreased total circulating cholesterol level | "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Mpzl3tm1Tacz/Mpzl3tm1Tacz Genetic Background: B6.129P2-Mpzl3tm1Tacz
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MP:0005289 | increased oxygen consumption | "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Mpzl3tm1Tacz/Mpzl3tm1Tacz Genetic Background: B6.129P2-Mpzl3tm1Tacz
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MP:0005292 | improved glucose tolerance | "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Mpzl3tm1Tacz/Mpzl3tm1Tacz Genetic Background: B6.129P2-Mpzl3tm1Tacz
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MP:0005335 | abnormal gonadal fat pad | "malformed or aberrant size of the encapsulated adipose tissue associated with the ovaries or testes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:84541] |
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Allelic Composition: Mpzl3tm1(KOMP)Mbp/Mpzl3tm1(KOMP)Mbp Genetic Background: C57BL/6-Tyrc-Brd Mpzl3tm1(KOMP)Mbp
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MP:0005534 | decreased body temperature | "less than the level of heat natural to a living being" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Mpzl3tm1Tacz/Mpzl3tm1Tacz Genetic Background: B6.129P2-Mpzl3tm1Tacz
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MP:0005620 | abnormal muscle contractility | "aberrant ability of a muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Mpzl3tm1Tacz/Mpzl3tm1Tacz Genetic Background: B6.129P2-Mpzl3tm1Tacz
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MP:0005659 | resistance to diet-induced obesity | "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator] |
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Allelic Composition: Mpzl3tm1Tacz/Mpzl3tm1Tacz Genetic Background: B6.129P2-Mpzl3tm1Tacz
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MP:0005668 | decreased circulating leptin level | "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751] |
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Allelic Composition: Mpzl3tm1Tacz/Mpzl3tm1Tacz Genetic Background: B6.129P2-Mpzl3tm1Tacz
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MP:0006319 | abnormal epididymal fat pad | "any structural anomaly of the encapsulated adipose tissue associated with the epididymis" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mpzl3tm1(KOMP)Mbp/Mpzl3tm1(KOMP)Mbp Genetic Background: C57BL/6-Tyrc-Brd Mpzl3tm1(KOMP)Mbp
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MP:0008844 | decreased subcutaneous adipose tissue amount | "reduction in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mpzl3tm1(KOMP)Mbp/Mpzl3tm1(KOMP)Mbp Genetic Background: C57BL/6-Tyrc-Brd Mpzl3tm1(KOMP)Mbp
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MP:0008965 | increased basal metabolism | "increase in heat production of an organism at the lowest level of cell chemistry in an inactive, awake, and fasting state" [MESH:E01.370.374.750.100] |
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Allelic Composition: Mpzl3tm1Tacz/Mpzl3tm1Tacz Genetic Background: B6.129P2-Mpzl3tm1Tacz
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MP:0009133 | decreased white fat cell size | "reduction in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mpzl3tm1(KOMP)Mbp/Mpzl3tm1(KOMP)Mbp Genetic Background: C57BL/6-Tyrc-Brd Mpzl3tm1(KOMP)Mbp
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MP:0009356 | decreased liver triglyceride level | "lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mpzl3tm1Tacz/Mpzl3tm1Tacz Genetic Background: B6.129P2-Mpzl3tm1Tacz
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MP:0009545 | abnormal dermis papillary layer | "any structural anomaly of the more superficial, thin layer of the dermis that interdigitates with the epidermis" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz Genetic Background: C57BL/6-Prf1tm1Sdz/J
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MP:0009600 | hypergranulosis | "increased thickness of the granular layer of the epidermis" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Mpzl3tm1(KOMP)Mbp/Mpzl3tm1(KOMP)Mbp Genetic Background: C57BL/6-Tyrc-Brd Mpzl3tm1(KOMP)Mbp
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MP:0009675 | orthokeratosis | "thickening of the stratum corneum of the epidermis (hyperkeratosis) with non-nucleated keratinocytes retained in this layer" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mpzl3tm1(KOMP)Mbp/Mpzl3tm1(KOMP)Mbp Genetic Background: C57BL/6-Tyrc-Brd Mpzl3tm1(KOMP)Mbp
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MP:0009792 | seborrheic dermatitis | "an inflammatory skin condition that causes flaky, white to yellowish scales to form on oily areas such as the scalp or inside the ear, with or without reddened skin" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mpzl3tm1(KOMP)Mbp/Mpzl3tm1(KOMP)Mbp Genetic Background: C57BL/6-Tyrc-Brd Mpzl3tm1(KOMP)Mbp
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MP:0009793 | sebaceous gland hypertrophy | "increase in the bulk size of the sebum secreting glands of the hair shaft due to cell enlargement" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz Genetic Background: C57BL/6-Prf1tm1Sdz/J
Allelic Composition: Mpzl3tm1(KOMP)Mbp/Mpzl3tm1(KOMP)Mbp Genetic Background: C57BL/6-Tyrc-Brd Mpzl3tm1(KOMP)Mbp
Allelic Composition: Mpzl3rc/Mpzl3tm1(KOMP)Mbp Genetic Background: C57BL/6-Tyrc-Brd Mpzl3rc/Mpzl3tm1(KOMP)Mbp
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MP:0010025 | decreased total body fat amount | "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz Genetic Background: C57BL/6-Prf1tm1Sdz/J
Allelic Composition: Mpzl3tm1Tacz/Mpzl3tm1Tacz Genetic Background: B6.129P2-Mpzl3tm1Tacz
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MP:0010179 | rough coat | "coat does not have the usual smooth appearance" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz Genetic Background: C57BL/6-Prf1tm1Sdz/J
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MP:0010378 | increased respiratory quotient | "increase in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mpzl3tm1Tacz/Mpzl3tm1Tacz Genetic Background: B6.129P2-Mpzl3tm1Tacz
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MP:0010699 | dilated hair follicles | "the luminal space of the hair follicle is increased in volume or area, sometimes with an increase of contained fluid or sebum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz Genetic Background: C57BL/6-Prf1tm1Sdz/J
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MP:0013373 | increased sebum secretion | "increased production and/or release of the lipid-rich substance that is produced by the sebaceous glands, acts to lubricate and waterproof the skin and hair of mammals, and provides antibacterial activity; sebum is released by disintegrating sebocytes that are continuously replaced from progenitors in the periphery of the sebaceous gland; its composition varies across species" [MGI:Anna] |
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Allelic Composition: Mpzl3tm1(KOMP)Mbp/Mpzl3tm1(KOMP)Mbp Genetic Background: C57BL/6-Tyrc-Brd Mpzl3tm1(KOMP)Mbp
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MP:0014143 | decreased body fat mass | "decreased physical bulk or volume of fat in the whole body" [MGI:csmith] |
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Allelic Composition: Mpzl3tm1Tacz/Mpzl3tm1Tacz Genetic Background: B6.129P2-Mpzl3tm1Tacz
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MP:0020010 | decreased bone mineral density of femur | "reduction in the amount of mineral per square centimeter of bone (usually g/cm2) in the long bone of the thigh" [GOC:NV] |
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Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz Genetic Background: C57BL/6-Prf1tm1Sdz/J
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MP:0030571 | dilated piliary canal | "stretched or widened aperture of the luminal space of the tubular connection that is found between the epidermal surface and the most distal part of the hair follicle inner root sheath and contains the hair shaft; the infundibulum is the opening of the hair canal to the skin surface" [MGI:anna, PMID:11171393] |
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Allelic Composition: Mpzl3tm1(KOMP)Mbp/Mpzl3tm1(KOMP)Mbp Genetic Background: C57BL/6-Tyrc-Brd Mpzl3tm1(KOMP)Mbp
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