ENSMUSG00000056832


Mus musculus

Features
Gene ID: ENSMUSG00000056832
  
Biological name :Ttc26
  
Synonyms : Q8BS45 / tetratricopeptide repeat domain 26 / Ttc26
  
Possible biological names infered from orthology : A0AVF1
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: B1
Gene start: 38381469
Gene end: 38427647
  
Corresponding Affymetrix probe sets: 10537353 (MoGene1.0st)   1435401_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000124271
Ensembl peptide - ENSMUSP00000125097
Ensembl peptide - ENSMUSP00000124873
Ensembl peptide - ENSMUSP00000124369
NCBI entrez gene - 264134     See in Manteia.
MGI - MGI:2444853
RefSeq - XM_006506152
RefSeq - NM_153600
RefSeq Peptide - NP_705828
swissprot - E0CXQ7
swissprot - E0CYE0
swissprot - Q8BS45
swissprot - E0CX73
Ensembl - ENSMUSG00000056832
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ttc26ENSDARG00000012039Danio rerio
 TTC26ENSGALG00000011847Gallus gallus
 TTC26ENSG00000105948Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR013026  Tetratricopeptide repeat-containing domain
 IPR030511  Tetratricopeptide repeat protein 26


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007224 smoothened signaling pathway IMP
 biological_processGO:0007286 spermatid development IMP
 biological_processGO:0008594 photoreceptor cell morphogenesis ISO
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0042073 intraciliary transport IMP
 biological_processGO:0046530 photoreceptor cell differentiation ISO
 biological_processGO:0060271 cilium assembly ISO
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005929 cilium IEA
 cellular_componentGO:0030992 intraciliary transport particle B IDA
 cellular_componentGO:0036064 ciliary basal body IDA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Intraflagellar transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000161 scoliosis "lateral and rotational curvature of the spine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53770, J:66943]
Show

Allelic Composition: Ttc26hop-hpy/Ttc26hop-hpy
Genetic Background: Not Specified

 MP:0000562 polydactyly "greater than 5 digits on one or more autopods" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ttc26hop-hpy/Ttc26hop-hpy
Genetic Background: Not Specified

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Inpp5btm2.1Nbm/Inpp5btm2.1Nbm
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Prdm2tm1Shg/Prdm2tm1Shg,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Ttc26hop/Ttc26hop
Genetic Background: CByJ.Cg-Ttc26hop/J

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Inpp5btm2.1Nbm/Inpp5btm2.1Nbm
Genetic Background: involves: 129S6/SvEvTac * FVB/N

Allelic Composition: Ttc26hop-hpy/Ttc26hop-hpy
Genetic Background: Not Specified

 MP:0001504 abnormal posture "atypical position of the limbs or carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]
Show

Allelic Composition: Inpp5btm2.1Nbm/Inpp5btm2.1Nbm
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0001522 impaired swimming "reduced ability or inability to swim" [J:45446, J:39081]
Show

Allelic Composition: Inpp5btm2.1Nbm/Inpp5btm2.1Nbm
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Ttc26hop-hpy/Ttc26hop-hpy
Genetic Background: Not Specified

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Inpp5btm2.1Nbm/Inpp5btm2.1Nbm
Genetic Background: involves: 129S6/SvEvTac * FVB/N

Allelic Composition: Ttc26hop-hpy/Ttc26hop-hpy
Genetic Background: Not Specified

Allelic Composition: Ttc26hop-hpy/Ttc26hop-hpy,Oca2p-s/Oca2p-s
Genetic Background: Not Specified

 MP:0001932 abnormal spermiogenesis "failure of sperm cells to form or differentiate" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Inpp5btm2.1Nbm/Inpp5btm2.1Nbm
Genetic Background: involves: 129S6/SvEvTac * FVB/N

Allelic Composition: Ttc26hop-hpy/Ttc26hop-hpy
Genetic Background: Not Specified

Allelic Composition: Ttc26hop-hpy/Ttc26hop-hpy,Oca2p-s/Oca2p-s
Genetic Background: Not Specified

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prdm2tm1Shg/Prdm2tm1Shg,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Ttc26hop-hpy/Ttc26hop-hpy,Oca2p-s/Oca2p-s
Genetic Background: Not Specified

 MP:0002084 abnormal developmental patterning "abnormal systematic arrangement of the developing body along an axis" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ttc26hop/Ttc26hop
Genetic Background: CByJ.Cg-Ttc26hop/J

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ttc26hop/Ttc26hop
Genetic Background: CByJ.Cg-Ttc26hop/J

 MP:0002784 abnormal Sertoli cell morphology "malformation of the cells of the seminiferous tubules that create the blood-testes barrier and enable spermatogenesis" [J:65900, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ttc26hop-hpy/Ttc26hop-hpy
Genetic Background: Not Specified

 MP:0002948 abnormal neuronal specification "defects in the developmental patterning of neurons resulting in ectopic placement, decreased numbers or absence of mature neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:87948]
Show

Allelic Composition: Ttc26hop/Ttc26hop
Genetic Background: CByJ.Cg-Ttc26hop/J

 MP:0003729 abnormal photoreceptor outer segments "malformation/anomalous structure of the photoreceptor layer which contains stacks of membranous discs that are rich in the visual pigment rhodopsin " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ttc26hop/Ttc26hop
Genetic Background: CByJ.Cg-Ttc26hop/J

 MP:0004131 abnormal embryonic ciliary morphology "any structural malformation of the earliest cilia of the mouse embryo found on the cells of the embryonic node" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ttc26hop/Ttc26hop
Genetic Background: CByJ.Cg-Ttc26hop/J

 MP:0004289 abnormal bony labyrinth "any structural abnormality in the series of cavities (cochlea, vestibule, and semicircular canals) contained within the otic capsule of the petrous portion of the temporal bone; the bony labyrinth is filled with perilymph, in which the delicate, endolymph-filled membranous labyrinth is suspended" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ttc26hop/Ttc26hop
Genetic Background: CByJ.Cg-Ttc26hop/J

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Inpp5btm2.1Nbm/Inpp5btm2.1Nbm
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0005169 abnormal male meiosis "malfunction in the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Inpp5btm2.1Nbm/Inpp5btm2.1Nbm
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0005578 teratozoospermia "presence of malformed spermatozoa in the semen; malformations include the physical bending of the sperm to produce kinks or bends" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ttc26hop-hpy/Ttc26hop-hpy
Genetic Background: Not Specified

Allelic Composition: Ttc26hop-hpy/Ttc26hop-hpy,Oca2p-s/Oca2p-s
Genetic Background: Not Specified

 MP:0006325 impaired hearing "reduced ability to percieve auditory stimuli" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ttc26hop/Ttc26hop
Genetic Background: CByJ.Cg-Ttc26hop/J

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Inpp5btm2.1Nbm/Inpp5btm2.1Nbm
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0008545 absent sperm flagella "mature spermatozoa lack a flagella" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Inpp5btm2.1Nbm/Inpp5btm2.1Nbm
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0008892 abnormal sperm flagellum "any strucutral anomaly of the whiplike posterior filiform portion of the spermatozoon that provides sperm motility" [MESH:A05.360.490.890.840]
Show

Allelic Composition: Inpp5btm2.1Nbm/Inpp5btm2.1Nbm
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0009376 abnormal manchette morphology "any structural abnormality of the conic array of microtubules that invests the posterior nucleus of a spermatid, and is believed to play a role in definitive posterior head-shaping events during spermiogenesis" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Inpp5btm2.1Nbm/Inpp5btm2.1Nbm
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0009743 preaxial polydactyly "duplication of all or part of the first ray on one or more of the autopods" [PMID:19125433]
Show

Allelic Composition: Inpp5btm2.1Nbm/Inpp5btm2.1Nbm
Genetic Background: involves: 129S6/SvEvTac * FVB/N

Allelic Composition: Ttc26hop/Ttc26hop
Genetic Background: CByJ.Cg-Ttc26hop/J

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Ttc26hop-hpy/Ttc26hop-hpy
Genetic Background: Not Specified

Allelic Composition: Ttc26hop-hpy/Ttc26hop-hpy,Oca2p-s/Oca2p-s
Genetic Background: Not Specified

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Ttc26hop/Ttc26hop
Genetic Background: CByJ.Cg-Ttc26hop/J

 MP:0011965 decreased total retina thickness "decreased width of the retina through the center plane" [MGI:csmith]
Show

Allelic Composition: Ttc26hop/Ttc26hop
Genetic Background: CByJ.Cg-Ttc26hop/J

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
Show

Allelic Composition: Ttc26hop/Ttc26hop
Genetic Background: CByJ.Cg-Ttc26hop/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr