ENSMUSG00000057637


Mus musculus

Features
Gene ID: ENSMUSG00000057637
  
Biological name :Prdm2
  
Synonyms : Prdm2 / PR domain containing 2, with ZNF domain
  
Possible biological names infered from orthology : PR/SET domain 2 / Q13029
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: E1
Gene start: 143107391
Gene end: 143212995
  
Corresponding Affymetrix probe sets: 10518132 (MoGene1.0st)   1429251_at (Mouse Genome 430 2.0 Array)   1444123_at (Mouse Genome 430 2.0 Array)   1453068_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000117741
Ensembl peptide - ENSMUSP00000101404
Ensembl peptide - ENSMUSP00000116458
NCBI entrez gene - 110593     See in Manteia.
MGI - MGI:107628
RefSeq - XM_017319918
RefSeq - XM_006538485
RefSeq - XM_006538486
RefSeq - XM_006538488
RefSeq - XM_011250174
RefSeq - XM_011250175
RefSeq - NM_001081355
RefSeq - NM_001256380
RefSeq Peptide - NP_001074824
RefSeq Peptide - NP_001243309
swissprot - A2A7B7
swissprot - Q8C2W5
swissprot - A2A7B5
Ensembl - ENSMUSG00000057637
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prdm2aENSDARG00000090721Danio rerio
 prdm2bENSDARG00000076451Danio rerio
 PRDM2ENSGALG00000038780Gallus gallus
 PRDM2ENSG00000116731Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001214  SET domain
 IPR009170  Predicted retinoblastoma binding protein (RIZ)
 IPR013087  Zinc finger C2H2-type
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0008340 determination of adult lifespan IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005794 Golgi apparatus ISO
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding ISO
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
Show

Allelic Composition: Nos3tm1Weo/Nos3tm1Weo
Genetic Background: B6.129S7-Nos3tm1Weo

Allelic Composition: Prdm2tm1Shg/Prdm2+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Prdm2tm1Shg/Prdm2tm1Shg,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002023 B cell derived lymphoma "heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Nos3tm1Weo/Nos3tm1Weo
Genetic Background: B6.129S7-Nos3tm1Weo

Allelic Composition: Prdm2tm1Shg/Prdm2+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002027 lung adenocarcinoma "malignant neoplasm of epithelial cells in the lung" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:18542]
Show

Allelic Composition: Nos3tm1Weo/Nos3tm1Weo
Genetic Background: B6.129S7-Nos3tm1Weo

Allelic Composition: Prdm2tm1Shg/Prdm2+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002041 pituitary adenoma "appearance of benign neoplasms of the pituitary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33042]
Show

Allelic Composition: Nos3tm1Weo/Nos3tm1Weo
Genetic Background: B6.129S7-Nos3tm1Weo

Allelic Composition: Prdm2tm1Shg/Prdm2+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nos3tm1Weo/Nos3tm1Weo
Genetic Background: B6.129S7-Nos3tm1Weo

Allelic Composition: Prdm2tm1Shg/Prdm2+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Prdm2tm1Shg/Prdm2tm1Shg,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003667 hemangiosarcoma "a malignant tumor characterized by rapidly proliferating, extensively infiltrating, anaplastic cells derived from blood vessels and appear as irregular blood-filled or lumpy sacs that are typically filled with blood; rupture of the tumor can cause rapid death from bleeding" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:53511]
Show

Allelic Composition: Nos3tm1Weo/Nos3tm1Weo
Genetic Background: B6.129S7-Nos3tm1Weo

Allelic Composition: Prdm2tm1Shg/Prdm2+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
Show

Allelic Composition: Nos3tm1Weo/Nos3tm1Weo
Genetic Background: B6.129S7-Nos3tm1Weo

Allelic Composition: Prdm2tm1Shg/Prdm2+
Genetic Background: involves: 129S2/SvPas * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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