ENSMUSG00000058440


Mus musculus

Features
Gene ID: ENSMUSG00000058440
  
Biological name :Nrf1
  
Synonyms : Nrf1 / nuclear respiratory factor 1 / Q9WU00
  
Possible biological names infered from orthology : Q16656
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: A3.3
Gene start: 30047988
Gene end: 30153458
  
Corresponding Affymetrix probe sets: 10536976 (MoGene1.0st)   1420978_at (Mouse Genome 430 2.0 Array)   1424787_a_at (Mouse Genome 430 2.0 Array)   1434627_at (Mouse Genome 430 2.0 Array)   1445914_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000114650
Ensembl peptide - ENSMUSP00000114451
Ensembl peptide - ENSMUSP00000117868
Ensembl peptide - ENSMUSP00000143957
Ensembl peptide - ENSMUSP00000132637
Ensembl peptide - ENSMUSP00000130108
Ensembl peptide - ENSMUSP00000004761
Ensembl peptide - ENSMUSP00000065568
Ensembl peptide - ENSMUSP00000067447
Ensembl peptide - ENSMUSP00000110853
Ensembl peptide - ENSMUSP00000110854
Ensembl peptide - ENSMUSP00000110858
Ensembl peptide - ENSMUSP00000110860
Ensembl peptide - ENSMUSP00000110863
Ensembl peptide - ENSMUSP00000110864
Ensembl peptide - ENSMUSP00000110866
Ensembl peptide - ENSMUSP00000110867
NCBI entrez gene - 18181     See in Manteia.
MGI - MGI:1332235
RefSeq - XM_017321445
RefSeq - NM_001164227
RefSeq - NM_001164228
RefSeq - NM_001164229
RefSeq - NM_001164230
RefSeq - NM_010938
RefSeq - XM_006505005
RefSeq - XM_006505006
RefSeq - XM_006505008
RefSeq - XM_011241044
RefSeq - XM_011241046
RefSeq - XM_011241048
RefSeq - XM_017321440
RefSeq - XM_017321441
RefSeq - XM_017321442
RefSeq - XM_017321443
RefSeq - XM_017321444
RefSeq - NM_001164226
RefSeq Peptide - NP_001157702
RefSeq Peptide - NP_035068
RefSeq Peptide - NP_001157698
RefSeq Peptide - NP_001157699
RefSeq Peptide - NP_001157700
RefSeq Peptide - NP_001157701
swissprot - E9Q7X0
swissprot - Q99K73
swissprot - Q9WU00
swissprot - A0A0J9YU17
swissprot - Q3UXF4
swissprot - D3Z3B4
swissprot - D3YVX7
swissprot - F6XZB0
swissprot - G3XA39
swissprot - D3YV66
Ensembl - ENSMUSG00000058440
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nrf1ENSDARG00000000018Danio rerio
 NRF1ENSGALG00000040060Gallus gallus
 NRF1ENSG00000106459Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR012675  Beta-grasp domain superfamily
 IPR012676  TGS-like
 IPR013029  YchF, C-terminal domain
 IPR019525  Nuclear respiratory factor 1, NLS/DNA-binding, dimerisation domain
 IPR019526  Nuclear respiratory factor-1, activation binding domain
 IPR036188  FAD/NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007005 mitochondrion organization IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005667 transcription factor complex TAS
 cellular_componentGO:0005829 cytosol ISO
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0001046 core promoter sequence-specific DNA binding ISS
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity ISS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nfe2l1tm1Mym/Nfe2l1tm1Mym,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA

 MP:0006035 abnormal mitochondrial morphology "anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Nfe2l1tm1Mym/Nfe2l1tm1Mym,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Nfe2l1tm1Mym/Nfe2l1tm1Mym,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000033871 Q8VHJ7 / Ppargc1b / Peroxisome proliferator-activated receptor gamma coactivator 1-beta / Q86YN6* / PPARG coactivator 1 beta*  / complex / reaction






 

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