ENSMUSG00000059834


Mus musculus

Features
Gene ID: ENSMUSG00000059834
  
Biological name :Sclt1
  
Synonyms : G5E861 / Sclt1 / Sodium channel and clathrin linker 1
  
Possible biological names infered from orthology : Q96NL6
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: B
Gene start: 41626720
Gene end: 41742514
  
Corresponding Affymetrix probe sets: 10497971 (MoGene1.0st)   1427493_at (Mouse Genome 430 2.0 Array)   1455608_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000026866
Ensembl peptide - ENSMUSP00000117608
Ensembl peptide - ENSMUSP00000120108
Ensembl peptide - ENSMUSP00000123392
NCBI entrez gene - 67161     See in Manteia.
MGI - MGI:1914411
RefSeq - XM_011239970
RefSeq - NM_001081411
RefSeq - XM_006500786
RefSeq - XM_006500787
RefSeq Peptide - NP_001074880
swissprot - G5E861
swissprot - F6X8R3
swissprot - D6REI8
Ensembl - ENSMUSG00000059834
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sclt1ENSDARG00000057248Danio rerio
 SCLT1ENSG00000151466Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
No match


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0045162 clustering of voltage-gated sodium channels IEA
 biological_processGO:0060271 cilium assembly ISO
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome ISO
 cellular_componentGO:0005814 centriole ISS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0071439 clathrin complex IEA
 cellular_componentGO:0097539 ciliary transition fiber ISO
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0017080 sodium channel regulator activity IEA
 molecular_functionGO:0030276 clathrin binding IEA


Pathways (from Reactome)
Pathway description
Anchoring of the basal body to the plasma membrane


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Tg(CAG-Bmp4,-EGFP)1Ypc/0,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: C57BL/6J * CBA/J * CD-1

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
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Allelic Composition: Cdkn2atm1Cjs/Cdkn2atm1Cjs,Sclt1Tg(CAG-sb10)1Dla/0,TgTn(sb-T2/Onc)76Dla/0
Genetic Background: involves: 129X1/SvJ * FVB/N

Allelic Composition: Cdkn2atm1Cjs/Cdkn2atm1Cjs,Sclt1Tg(CAG-sb10)1Dla/0,TgTn(sb-T2/Onc)68Dla/0
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0002026 leukemia "progressive proliferation of abnormal leukocytes in hematopoietic tissues, organs and blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Cdkn2atm1Cjs/Cdkn2atm1Cjs,Sclt1Tg(CAG-sb10)1Dla/0,TgTn(sb-T2/Onc)76Dla/0
Genetic Background: involves: 129X1/SvJ * FVB/N

Allelic Composition: Cdkn2atm1Cjs/Cdkn2atm1Cjs,Sclt1Tg(CAG-sb10)1Dla/0,TgTn(sb-T2/Onc)68Dla/0
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0002027 lung adenocarcinoma "malignant neoplasm of epithelial cells in the lung" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Cdkn2atm1Cjs/Cdkn2atm1Cjs,Sclt1Tg(CAG-sb10)1Dla/0,TgTn(sb-T2/Onc)76Dla/0
Genetic Background: involves: 129X1/SvJ * FVB/N

Allelic Composition: Cdkn2atm1Cjs/Cdkn2atm1Cjs,Sclt1Tg(CAG-sb10)1Dla/0,TgTn(sb-T2/Onc)68Dla/0
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0002032 sarcoma "connective tissue neoplasm associated with the proliferation of mesodermal cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: Cdkn2atm1Cjs/Cdkn2atm1Cjs,Sclt1Tg(CAG-sb10)1Dla/0,TgTn(sb-T2/Onc)76Dla/0
Genetic Background: involves: 129X1/SvJ * FVB/N

Allelic Composition: Cdkn2atm1Cjs/Cdkn2atm1Cjs,Sclt1Tg(CAG-sb10)1Dla/0,TgTn(sb-T2/Onc)68Dla/0
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn2atm1Cjs/Cdkn2atm1Cjs,Sclt1Tg(CAG-sb10)1Dla/0,TgTn(sb-T2/Onc)76Dla/0
Genetic Background: involves: 129X1/SvJ * FVB/N

Allelic Composition: Cdkn2atm1Cjs/Cdkn2atm1Cjs,Sclt1Tg(CAG-sb10)1Dla/0,TgTn(sb-T2/Onc)68Dla/0
Genetic Background: involves: 129X1/SvJ * FVB/N

Allelic Composition: Sclt1Tg(CAG-sb10)1Dla/Sclt1Tg(CAG-sb10)1Dla
Genetic Background: FVB/N-Sclt1Tg(CAG-sb10)1Dla

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tg(CAG-Bmp4,-EGFP)1Ypc/0,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: C57BL/6J * CBA/J * CD-1

 MP:0003068 enlarged kidney "larger than average size of the kidney" [J:86005, pvb:Pierre Vanden Borre, Mouse Genome Informatics Curator]
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Allelic Composition: Sclt1Tg(CAG-sb10)1Dla/Sclt1Tg(CAG-sb10)1Dla
Genetic Background: FVB/N-Sclt1Tg(CAG-sb10)1Dla

 MP:0003789 osteosarcoma "malignant neoplasm derived from bone" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn2atm1Cjs/Cdkn2atm1Cjs,Sclt1Tg(CAG-sb10)1Dla/0,TgTn(sb-T2/Onc)76Dla/0
Genetic Background: involves: 129X1/SvJ * FVB/N

Allelic Composition: Cdkn2atm1Cjs/Cdkn2atm1Cjs,Sclt1Tg(CAG-sb10)1Dla/0,TgTn(sb-T2/Onc)68Dla/0
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0003985 renal fibrosis "formation of fibrous tissue in the kidney as a result of repair or a reactive process" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sclt1Tg(CAG-sb10)1Dla/Sclt1Tg(CAG-sb10)1Dla
Genetic Background: FVB/N-Sclt1Tg(CAG-sb10)1Dla

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sclt1Tg(CAG-sb10)1Dla/Sclt1Tg(CAG-sb10)1Dla
Genetic Background: FVB/N-Sclt1Tg(CAG-sb10)1Dla

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sclt1Tg(CAG-sb10)1Dla/Sclt1Tg(CAG-sb10)1Dla
Genetic Background: FVB/N-Sclt1Tg(CAG-sb10)1Dla

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sclt1Tg(CAG-sb10)1Dla/Sclt1Tg(CAG-sb10)1Dla
Genetic Background: FVB/N-Sclt1Tg(CAG-sb10)1Dla

 MP:0008528 polycystic kidney "the development of innumerable cysts in the kidneys filled with fluid replacing much of the mass of the kidneys leading to reduction in kidney function and frequently kidney failure" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Sclt1Tg(CAG-sb10)1Dla/Sclt1Tg(CAG-sb10)1Dla
Genetic Background: FVB/N-Sclt1Tg(CAG-sb10)1Dla

 MP:0009743 preaxial polydactyly "duplication of all or part of the first ray on one or more of the autopods" [PMID:19125433]
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Allelic Composition: Sclt1Tg(CAG-sb10)1Dla/Sclt1Tg(CAG-sb10)1Dla
Genetic Background: FVB/N-Sclt1Tg(CAG-sb10)1Dla

 MP:0011307 kidney medulla cysts "abnormal membranous sacs appearing in the inner portion of the kidney which consists of the renal pyramids" [MGI:anna]
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Allelic Composition: Sclt1Tg(CAG-sb10)1Dla/Sclt1Tg(CAG-sb10)1Dla
Genetic Background: FVB/N-Sclt1Tg(CAG-sb10)1Dla

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
Show

Allelic Composition: Cdkn2atm1Cjs/Cdkn2atm1Cjs,Sclt1Tg(CAG-sb10)1Dla/0,TgTn(sb-T2/Onc)76Dla/0
Genetic Background: involves: 129X1/SvJ * FVB/N

Allelic Composition: Cdkn2atm1Cjs/Cdkn2atm1Cjs,Sclt1Tg(CAG-sb10)1Dla/0,TgTn(sb-T2/Onc)68Dla/0
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0013916 decreased intestine length "reduced length of the digestive tube passing from the stomach to the anus, consisting of the small and large intestine divisions" [ISBN:0-683-40008-8]
Show

Allelic Composition: Sclt1Tg(CAG-sb10)1Dla/Sclt1Tg(CAG-sb10)1Dla
Genetic Background: FVB/N-Sclt1Tg(CAG-sb10)1Dla

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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