ENSMUSG00000060261


Mus musculus

Features
Gene ID: ENSMUSG00000060261
  
Biological name :Gtf2i
  
Synonyms : Gtf2i / Mus musculusral transcription factor II I (Gtf2i), transcript variant 7, mRNA. / Q9ESZ8
  
Possible biological names infered from orthology : general transcription factor IIi / P78347
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: G2
Gene start: 134237834
Gene end: 134314760
  
Corresponding Affymetrix probe sets: 10534216 (MoGene1.0st)   1425628_a_at (Mouse Genome 430 2.0 Array)   1431675_a_at (Mouse Genome 430 2.0 Array)   1431676_x_at (Mouse Genome 430 2.0 Array)   1460279_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000134636
Ensembl peptide - ENSMUSP00000049625
Ensembl peptide - ENSMUSP00000080714
Ensembl peptide - ENSMUSP00000106892
Ensembl peptide - ENSMUSP00000133375
Ensembl peptide - ENSMUSP00000133435
Ensembl peptide - ENSMUSP00000133444
Ensembl peptide - ENSMUSP00000133489
Ensembl peptide - ENSMUSP00000133526
Ensembl peptide - ENSMUSP00000133566
Ensembl peptide - ENSMUSP00000133740
Ensembl peptide - ENSMUSP00000133905
Ensembl peptide - ENSMUSP00000133969
Ensembl peptide - ENSMUSP00000134035
Ensembl peptide - ENSMUSP00000134042
Ensembl peptide - ENSMUSP00000134111
Ensembl peptide - ENSMUSP00000134440
NCBI entrez gene - 14886     See in Manteia.
MGI - MGI:1202722
RefSeq - XM_017320682
RefSeq - NM_001359062
RefSeq - NM_001359063
RefSeq - NM_001359064
RefSeq - NM_001359065
RefSeq - NM_001359066
RefSeq - NM_001359067
RefSeq - NM_010365
RefSeq - XM_006504384
RefSeq - XM_006504385
RefSeq - XM_006504386
RefSeq - XM_006504389
RefSeq - XM_006504391
RefSeq - XM_017320673
RefSeq - XM_017320674
RefSeq - XM_017320675
RefSeq - XM_017320676
RefSeq - XM_017320677
RefSeq - XM_017320678
RefSeq - XM_017320679
RefSeq - XM_017320680
RefSeq - XM_017320681
RefSeq - NM_001080746
RefSeq - NM_001080747
RefSeq - NM_001080748
RefSeq - NM_001080749
RefSeq Peptide - NP_001074217
RefSeq Peptide - NP_001074218
RefSeq Peptide - NP_001345991
RefSeq Peptide - NP_001345992
RefSeq Peptide - NP_001345993
RefSeq Peptide - NP_001345994
RefSeq Peptide - NP_001345995
RefSeq Peptide - NP_001345996
RefSeq Peptide - NP_034495
RefSeq Peptide - NP_001074215
RefSeq Peptide - NP_001074216
swissprot - G3UY14
swissprot - G3UYD0
swissprot - G3UYD7
swissprot - G3UYJ6
swissprot - G3UZU4
swissprot - G3UWV2
swissprot - Q3UHU8
swissprot - Q9ESZ8
swissprot - G3UWP6
swissprot - G3UX27
Ensembl - ENSMUSG00000060261
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GTF2IENSGALG00000021665Gallus gallus
 GTF2IENSG00000263001Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9JI57 / Gtf2ird1 / ral transcription factor II-I repeat domain-containing protein 1 / Q9UHL9* / GTF2I repeat domain containing 1*ENSMUSG0000002307927


Protein motifs (from Interpro)
Interpro ID Name
 IPR004212  GTF2I-like repeat
 IPR016659  Transcription factor II-I
 IPR036647  GTF2I-like repeat superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0014886 transition between slow and fast fiber IDA
 biological_processGO:0016525 negative regulation of angiogenesis ISO
 biological_processGO:0051481 negative regulation of cytosolic calcium ion concentration IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IBA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0042995 cell projection IDA
 cellular_componentGO:0043025 neuronal cell body IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0003677 DNA binding IBA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0051019 mitogen-activated protein kinase binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000108 midline facial cleft "incomplete merging or fusion of the tissues normally uniting to form the face" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Sac3d1tm1Hnaka/Sac3d1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0000292 distended pericardial sacs "stretched outer parietal layer of the pericardium" [J:25248]
Show

Allelic Composition: Sac3d1tm1Hnaka/Sac3d1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0000428 abnormal craniofacial morphology "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Brca2tm1Mak/Brca2tm2Mak,Trp53tm1Brd/Trp53tm1Brd,Tg(Lck-cre)548Jxm/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * CBA

Allelic Composition: Gtf2itm1Vcam/Gtf2itm1Vcam
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0000445 short snout "reduced length of the anterior facial part of the muzzle" [J:53370]
Show

Allelic Composition: Gtf2itm1Vcam/Gtf2itm1Vcam
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0000449 broad nasal bridge "wider than normal upper part of the ridge of the nose" [J:53370]
Show

Allelic Composition: Gtf2itm1Vcam/Gtf2itm1Vcam
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0000913 abnormal brain development "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]
Show

Allelic Composition: Sac3d1tm1Hnaka/Sac3d1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Sac3d1tm1Hnaka/Sac3d1+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Gtf2iGt(XE029)Byg/Gtf2i+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Gtf2itm1Vcam/Gtf2itm1Vcam
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Brca2tm1Mak/Brca2tm2Mak,Trp53tm1Brd/Trp53tm1Brd,Tg(Lck-cre)548Jxm/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * CBA

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
Show

Allelic Composition: Gtf2itm1Vcam/Gtf2itm1Vcam
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0001417 decreased exploration in new environment "less amount of time spent investigating a new location" [J:79870]
Show

Allelic Composition: Gtf2itm1Vcam/Gtf2itm1Vcam
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0001634 internal hemorrhage "blood loss in the interior of the body due to vessel rupture or dysmorphology " [J:23170]
Show

Allelic Composition: Sac3d1tm1Hnaka/Sac3d1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gtf2itm1Vcam/Gtf2itm1Vcam
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Sac3d1tm1Hnaka/Sac3d1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Gtf2itm1Vcam/Gtf2itm1Vcam
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Gtf2itm1Vcam/Gtf2itm1Vcam
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gtf2itm1Vcam/Gtf2itm1Vcam
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0003205 testicular atrophy "wasting of the male reproductive glands resulting in reduced size" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Gtf2itm1Vcam/Gtf2itm1Vcam
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0003742 narrow head "a shorter ear- to -ear distance resulting in the appearance of a thin face and a protruding nasal region" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Gtf2iGt(XE029)Byg/Gtf2i+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003873 branchial arch hypoplasia "reduced size of the transient structures of the embryo that develop into regions of the head, neck and ears, due to reduced cell number" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Sac3d1tm1Hnaka/Sac3d1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sac3d1tm1Hnaka/Sac3d1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0004251 failure of looping morphogenesis "failure of the primitive heart tube to initiate or complete looping" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sac3d1tm1Hnaka/Sac3d1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0004557 dilated allantois "an expansion in the volume of the fetal membrane which contributes to the formation of the umbilical cord and placental blood vessels, as by stretching or distention" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sac3d1tm1Hnaka/Sac3d1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gtf2itm1Vcam/Gtf2itm1Vcam
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0009657 failure of chorioallantoic fusion "failure to initiate and/or complete the formation of a highly vascularized extra-embryonic fetal membrane by fusion of the chorion and allantois" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sac3d1tm1Hnaka/Sac3d1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Sac3d1tm1Hnaka/Sac3d1+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Gtf2iGt(XC455)Byg/Gtf2iGt(XC455)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gtf2iGt(RRI105)Byg/Gtf2iGt(RRI105)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gtf2iGt(YTA365)Byg/Gtf2iGt(YTA365)Byg
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Gtf2itm1Vcam/Gtf2itm1Vcam
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0011102 partial embryonic lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Gtf2itm1Vcam/Gtf2itm1Vcam
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0011184 absent embryonic epiblast "absence of the tissue derived from the inner cell mass that gives rise to the ectoderm, endoderm and mesoderm of the embryo proper and to the extraembryonic mesoderm" [PMID:21123814]
Show

Allelic Composition: Gtf2itm1Vcam/Gtf2itm1Vcam
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0011192 decreased embryonic epiblast cell proliferation "reduction in the expansion rate of the embryonic epiblast cells by cell division" [MGI:anna]
Show

Allelic Composition: Gtf2itm1Vcam/Gtf2itm1Vcam
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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