ENSMUSG00000023079


Mus musculus

Features
Gene ID: ENSMUSG00000023079
  
Biological name :Gtf2ird1
  
Synonyms : Gtf2ird1 / Q9JI57 / ral transcription factor II-I repeat domain-containing protein 1
  
Possible biological names infered from orthology : GTF2I repeat domain containing 1 / Q9UHL9
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: G2
Gene start: 134357656
Gene end: 134456716
  
Corresponding Affymetrix probe sets: 10534253 (MoGene1.0st)   1451899_a_at (Mouse Genome 430 2.0 Array)   1460364_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000143948
Ensembl peptide - ENSMUSP00000143897
Ensembl peptide - ENSMUSP00000144003
Ensembl peptide - ENSMUSP00000144604
Ensembl peptide - ENSMUSP00000144521
Ensembl peptide - ENSMUSP00000144502
Ensembl peptide - ENSMUSP00000144447
Ensembl peptide - ENSMUSP00000144420
Ensembl peptide - ENSMUSP00000144391
Ensembl peptide - ENSMUSP00000144373
Ensembl peptide - ENSMUSP00000144222
Ensembl peptide - ENSMUSP00000144203
Ensembl peptide - ENSMUSP00000072904
Ensembl peptide - ENSMUSP00000073752
Ensembl peptide - ENSMUSP00000098215
Ensembl peptide - ENSMUSP00000098217
Ensembl peptide - ENSMUSP00000098219
Ensembl peptide - ENSMUSP00000106875
Ensembl peptide - ENSMUSP00000106876
Ensembl peptide - ENSMUSP00000129392
Ensembl peptide - ENSMUSP00000132882
Ensembl peptide - ENSMUSP00000143809
Ensembl peptide - ENSMUSP00000143848
NCBI entrez gene - 57080     See in Manteia.
MGI - MGI:1861942
RefSeq - XM_017321047
RefSeq - XM_006504466
RefSeq - XM_011240885
RefSeq - XM_011240886
RefSeq - XM_011240887
RefSeq - XM_011240888
RefSeq - XM_011240889
RefSeq - XM_011240890
RefSeq - XM_011240891
RefSeq - XM_011240892
RefSeq - XM_011240893
RefSeq - XM_011240894
RefSeq - XM_011240895
RefSeq - XM_011240896
RefSeq - XM_011240897
RefSeq - XM_011240898
RefSeq - XM_011240900
RefSeq - XM_011240901
RefSeq - XM_017321038
RefSeq - XM_017321039
RefSeq - XM_017321040
RefSeq - XM_017321041
RefSeq - XM_017321042
RefSeq - XM_017321043
RefSeq - XM_017321044
RefSeq - XM_017321045
RefSeq - XM_017321046
RefSeq - NM_001081462
RefSeq - NM_001081463
RefSeq - NM_001081464
RefSeq - NM_001081465
RefSeq - NM_001081466
RefSeq - NM_001081467
RefSeq - NM_001081468
RefSeq - NM_001081469
RefSeq - NM_001081470
RefSeq - NM_001244936
RefSeq - NM_020331
RefSeq - XM_006504462
RefSeq Peptide - NP_001074935
RefSeq Peptide - NP_001074936
RefSeq Peptide - NP_001074937
RefSeq Peptide - NP_001074938
RefSeq Peptide - NP_001074939
RefSeq Peptide - NP_001231865
RefSeq Peptide - NP_001334417
RefSeq Peptide - NP_065064
RefSeq Peptide - NP_001074931
RefSeq Peptide - NP_001074932
RefSeq Peptide - NP_001074933
RefSeq Peptide - NP_001074934
swissprot - Q6PD35
swissprot - Q80ZG9
swissprot - Q9JI57
swissprot - A0A0J9YV59
swissprot - A0A0J9YV21
swissprot - A0A0J9YV00
swissprot - A0A0J9YUX8
swissprot - A0A0J9YUW7
swissprot - A0A0J9YUK2
swissprot - A0A0J9YUI9
swissprot - A0A0J9YU48
swissprot - A0A0J9YU11
swissprot - A0A0J9YTX7
swissprot - A0A0J9YV72
Ensembl - ENSMUSG00000023079
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gtf2ird1ENSDARG00000022203Danio rerio
 GTF2IRD1ENSGALG00000001263Gallus gallus
 Q9UHL9ENSG00000006704Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gtf2i / Q9ESZ8 / Mus musculusral transcription factor II I (Gtf2i), transcript variant 7, mRNA. / P78347* / general transcription factor IIi*ENSMUSG0000006026124


Protein motifs (from Interpro)
Interpro ID Name
 IPR004212  GTF2I-like repeat
 IPR016659  Transcription factor II-I
 IPR036647  GTF2I-like repeat superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0014886 transition between slow and fast fiber IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IBA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol ISO
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0003677 DNA binding IBA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000108 midline facial cleft "incomplete merging or fusion of the tissues normally uniting to form the face" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Brca2tm1Cam/Brca2tm1Cam
Genetic Background: 129S/SvEv-Brca2tm1Cam

 MP:0000120 malocclusion "perturbations in the normal patterned arrangement of the teeth or alignment of the jaw, resulting in the incorrect position of biting or chewing surfaces of the upper and lower teeth" [J:61509]
Show

Allelic Composition: Ntf3tm1Tojo/Ntf3tm1Tojo
Genetic Background: involves: C57BL/6 * DBA/2 * ICR

 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Brca2tm1Cam/Brca2tm1Cam
Genetic Background: 129S/SvEv-Brca2tm1Cam

 MP:0000292 distended pericardial sacs "stretched outer parietal layer of the pericardium" [J:25248]
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Allelic Composition: Brca2tm1Cam/Brca2tm1Cam
Genetic Background: 129S/SvEv-Brca2tm1Cam

 MP:0000373 belly spot "the appearance of a round area of white fur on the belly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Brca2tm1Cam/Brca2tm1Cam
Genetic Background: 129S/SvEv-Brca2tm1Cam

 MP:0000428 abnormal craniofacial morphology "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Brca2tm1Cam/Brca2tm1Cam
Genetic Background: 129S/SvEv-Brca2tm1Cam

 MP:0000440 domed skull 
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Allelic Composition: Brca2tm1Cam/Brca2tm1Cam
Genetic Background: 129S/SvEv-Brca2tm1Cam

 MP:0000445 short snout "reduced length of the anterior facial part of the muzzle" [J:53370]
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Allelic Composition: Ntf3tm1Tojo/Ntf3tm1Tojo
Genetic Background: involves: C57BL/6 * DBA/2 * ICR

Allelic Composition: Gtf2ird1Tg(Alb1-Myc)166.8Sst/Gtf2ird1Tg(Alb1-Myc)166.8Sst
Genetic Background: involves: C57BL/6J * CBA/J

 MP:0000454 abnormal jaw morphology "malformation of the bony framework of the mouth where the teeth are held" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cd28tm1Huen/Cd28tm1Huen,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ebf2tm1.1Ggc/Ebf2tm1.1Ggc
Genetic Background: involves: 129S2/SvPas * C57BL/6J * FVB/N

Allelic Composition: Gtf2ird1Tg(Alb1-Myc)166.8Sst/Gtf2ird1+,Tg(MtTGFA)42Lmb/0
Genetic Background: involves: C57BL/6 * CBA * CD-1

 MP:0000913 abnormal brain development "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]
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Allelic Composition: Brca2tm1Cam/Brca2tm1Cam
Genetic Background: 129S/SvEv-Brca2tm1Cam

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Brca2tm1Cam/Brca2tm1Cam
Genetic Background: 129S/SvEv-Brca2tm1Cam

Allelic Composition: Gtf2ird1Gt(XE465)Byg/Gtf2ird1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001219 thickened epidermis "increase in the width of the epidermal cell layer in the skin" [J:65146]
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Allelic Composition: Gtf2ird1tm1Hrd/Gtf2ird1tm1Hrd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001222 epidermal hyperplasia "increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Gtf2ird1tm1Hrd/Gtf2ird1tm1Hrd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Ntf3tm1Tojo/Ntf3tm1Tojo
Genetic Background: involves: C57BL/6 * DBA/2 * ICR

Allelic Composition: Gtf2ird1tm1Hrd/Gtf2ird1tm1Hrd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Gtf2ird1Tg(Alb1-Myc)166.8Sst/Gtf2ird1Tg(Alb1-Myc)166.8Sst
Genetic Background: involves: C57BL/6J * CBA/J

Allelic Composition: Gtf2ird1Tg(Alb1-Myc)166.8Sst/Gtf2ird1+
Genetic Background: involves: C57BL/6J * CBA/J

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Brca2tm1Cam/Brca2tm1Cam
Genetic Background: 129S/SvEv-Brca2tm1Cam

Allelic Composition: Gtf2ird1tm1Lro/Gtf2ird1tm1Lro
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0001282 short vibrissae "decreased length of the vibrissae" [J:30249]
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Allelic Composition: Gtf2ird1tm1Hrd/Gtf2ird1tm1Hrd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001283 sparse vibrissae "few and widely spaced whiskers" [J:65302]
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Allelic Composition: Gtf2ird1tm1Hrd/Gtf2ird1tm1Hrd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
Show

Allelic Composition: Cd28tm1Huen/Cd28tm1Huen,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
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Allelic Composition: Grin1tm1Rpa/Grin1tm1.1Rpa
Genetic Background: Not Specified

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Gtf2ird1tm1Hrd/Gtf2ird1tm1Hrd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Gtf2ird1tm1Hrd/Gtf2ird1tm1Hrd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Tie1tm1Jpa/Tie1tm1Jpa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

Allelic Composition: Gtf2ird1tm1Hrd/Gtf2ird1tm1Hrd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Gtf2ird1Tg(Alb1-Myc)166.8Sst/Gtf2ird1Tg(Alb1-Myc)166.8Sst
Genetic Background: involves: C57BL/6J * CBA/J

Allelic Composition: Gtf2ird1Tg(Alb1-Myc)166.8Sst/Gtf2ird1+
Genetic Background: involves: C57BL/6J * CBA/J

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Gtf2ird1Tg(Alb1-Myc)166.8Sst/Gtf2ird1Tg(Alb1-Myc)166.8Sst
Genetic Background: involves: C57BL/6J * CBA/J

 MP:0001413 abnormal response to new environment "altered investigative behavior from controls in reactions associated with placing an animal in a new location" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Cd28tm1Huen/Cd28tm1Huen,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0001431 abnormal eating behavior "inability to consume or atypical consumption pattern" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:19212]
Show

Allelic Composition: Cd28tm1Huen/Cd28tm1Huen,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac

Allelic Composition: Gtf2ird1Tg(Alb1-Myc)166.8Sst/Gtf2ird1+
Genetic Background: involves: C57BL/6J * CBA/J

 MP:0001441 increased grooming behavior "increased amount of time spent cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gtf2ird1Tg(Alb1-Myc)166.8Sst/Gtf2ird1Tg(Alb1-Myc)166.8Sst
Genetic Background: involves: C57BL/6J * CBA/J

 MP:0001447 abnormal nest building behavior "deviation from the usual behavior of mice to build sleeping nests out of any available materials; also of female mice to bulid nests to protect offspring" [J:42758, What s wrong with my mouse?:ISBN 0-471-31639-3]
Show

Allelic Composition: Cd28tm1Huen/Cd28tm1Huen,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0001454 abnormal cued conditioning behavior "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light)" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Gtf2ird1tm1Lro/Gtf2ird1tm1Lro
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ntf3tm1Tojo/Ntf3tm1Tojo
Genetic Background: involves: C57BL/6 * DBA/2 * ICR

Allelic Composition: Gtf2ird1Tg(Alb1-Myc)166.8Sst/Gtf2ird1Tg(Alb1-Myc)166.8Sst
Genetic Background: involves: C57BL/6J * CBA/J

 MP:0001529 abnormal vocalization "an inability, decreased ability or altered ability to produce sound from the vocal organs; or a general increase or decrease in the production of vocal sound" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:85479]
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Allelic Composition: Hprttm1(Camk2a-APP*Swe*Lon,-MAPT*P301L*R406W)Geno/Hprt+,Tg(PSEN1)5Dbo/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0001634 internal hemorrhage "blood loss in the interior of the body due to vessel rupture or dysmorphology " [J:23170]
Show

Allelic Composition: Brca2tm1Cam/Brca2tm1Cam
Genetic Background: 129S/SvEv-Brca2tm1Cam

 MP:0001655 multifocal hepatic necrosis "multiple localized areas of pathologic death of cells within, or portions of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gtf2ird1Tg(Alb1-Myc)166.8Sst/Gtf2ird1+,Tg(MtTGFA)42Lmb/0
Genetic Background: involves: C57BL/6 * CBA * CD-1

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Brca2tm1Cam/Brca2tm1Cam
Genetic Background: 129S/SvEv-Brca2tm1Cam

 MP:0001722 pale yolk sac "bloodless yolk sac" [J:62571]
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Allelic Composition: Brca2tm1Cam/Brca2tm1Cam
Genetic Background: 129S/SvEv-Brca2tm1Cam

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Brca2tm1Cam/Brca2tm1Cam
Genetic Background: 129S/SvEv-Brca2tm1Cam

Allelic Composition: Gtf2ird1Tg(Alb1-Myc)166.8Sst/Gtf2ird1Tg(Alb1-Myc)166.8Sst
Genetic Background: involves: C57BL/6J * CBA/J

Allelic Composition: Gtf2ird1Tg(Alb1-Myc)166.8Sst/Gtf2ird1+
Genetic Background: involves: C57BL/6J * CBA/J

 MP:0001745 increased circulating corticosterone level "greater than the normal concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:54931]
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Allelic Composition: Gtf2ird1tm1Hrd/Gtf2ird1tm1Hrd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Gtf2ird1Tg(Alb1-Myc)166.8Sst/Gtf2ird1Tg(Alb1-Myc)166.8Sst
Genetic Background: involves: C57BL/6J * CBA/J

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Gtf2ird1Gt(XE465)Byg/Gtf2ird1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002065 abnormal fear/anxiety-related behavior "altered response in tests for fear or anxiety related behaviors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cd28tm1Huen/Cd28tm1Huen,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0002263 abnormal laryngeal muscle morphology "any structural anomaly of the muscles associated with the larynx " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gtf2ird1tm1Hrd/Gtf2ird1tm1Hrd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Gtf2ird1Tg(Alb1-Myc)166.8Sst/Gtf2ird1Tg(Alb1-Myc)166.8Sst
Genetic Background: involves: C57BL/6J * CBA/J

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ebf2tm1.1Ggc/Ebf2tm1.1Ggc
Genetic Background: involves: 129S2/SvPas * C57BL/6J * FVB/N

Allelic Composition: Gtf2ird1Tg(Alb1-Myc)166.8Sst/Gtf2ird1+,Tg(MtTGFA)42Lmb/0
Genetic Background: involves: C57BL/6 * CBA * CD-1

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
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Allelic Composition: Brca2tm1Cam/Brca2tm1Cam
Genetic Background: 129S/SvEv-Brca2tm1Cam

 MP:0003324 liver adenoma "benign epithelial neoplasm of the liver" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Ebf2tm1.1Ggc/Ebf2tm1.1Ggc
Genetic Background: involves: 129S2/SvPas * C57BL/6J * FVB/N

Allelic Composition: Gtf2ird1Tg(Alb1-Myc)166.8Sst/Gtf2ird1+,Tg(MtTGFA)42Lmb/0
Genetic Background: involves: C57BL/6 * CBA * CD-1

 MP:0003331 hepatocellular carcinoma "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Flt3tm1Dosm/Flt3+,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Flt3tm1Dosm Tg(Mx1-cre)1Cgn

Allelic Composition: Gtf2ird1Tg(Alb1-Myc)166.8Sst/Gtf2ird1+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Gtf2ird1Tg(Alb1-Myc)166.8Sst/Gtf2ird1+,Tg(MtTGFA)42Lmb/0
Genetic Background: involves: C57BL/6 * CBA * CD-1

Allelic Composition: Gtf2ird1Tg(Alb1-Myc)166.8Sst/Gtf2ird1+,Tg(Alb-E2F1)8Sst/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0003460 decreased fear-related response "reduced emotional response related to anticipation of specific pain or danger" [CFG:Center for Functional Genomics, Northwestern University]
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Allelic Composition: Gtf2ird1tm1Lro/Gtf2ird1tm1Lro
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0003633 abnormal nervous system physiology 
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Allelic Composition: Tie1tm1Jpa/Tie1tm1Jpa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Brca2tm1Cam/Brca2tm1Cam
Genetic Background: 129S/SvEv-Brca2tm1Cam

 MP:0003742 narrow head "a shorter ear- to -ear distance resulting in the appearance of a thin face and a protruding nasal region" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Gtf2ird1Gt(XE465)Byg/Gtf2ird1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003743 abnormal facial morphology "anomalous structure or development of the face" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Gtf2ird1tm1Hrd/Gtf2ird1tm1Hrd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003863 decreased aggression towards mice "when compared to controls, subjects exhibit less than normal level of domineering, assaultive posture and/or hostile physical action towards other mice" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Gtf2ird1tm1Lro/Gtf2ird1tm1Lro
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0003873 branchial arch hypoplasia "reduced size of the transient structures of the embryo that develop into regions of the head, neck and ears, due to reduced cell number" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Brca2tm1Cam/Brca2tm1Cam
Genetic Background: 129S/SvEv-Brca2tm1Cam

 MP:0003887 increased hepatocyte apoptosis "increase in the number of hepatocytes undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Gtf2ird1Tg(Alb1-Myc)166.8Sst/Gtf2ird1+,Tg(MtTGFA)42Lmb/0
Genetic Background: involves: C57BL/6 * CBA * CD-1

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Brca2tm1Cam/Brca2tm1Cam
Genetic Background: 129S/SvEv-Brca2tm1Cam

 MP:0004251 failure of looping morphogenesis "failure of the primitive heart tube to initiate or complete looping" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Brca2tm1Cam/Brca2tm1Cam
Genetic Background: 129S/SvEv-Brca2tm1Cam

 MP:0004376 absent frontal bone "absence of the bone forming the forehead and roof of the eye orbit" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Gtf2ird1Gt(XE465)Byg/Gtf2ird1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004383 absent interparietal bone "absence of the bone of the cranium that lies above and anterior to the occipital bone in some mammals" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gtf2ird1Gt(XE465)Byg/Gtf2ird1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004419 absent parietal bone "absence of the curved bone forming part of the vault of the cranium" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gtf2ird1Gt(XE465)Byg/Gtf2ird1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004443 absent supraoccipital bone "absence of the bone on the dorsal side of the great foramen of the skull, usually forming a part of the occipital in the adult, but distinct in the young" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gtf2ird1Gt(XE465)Byg/Gtf2ird1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004557 dilated allantois "an expansion in the volume of the fetal membrane which contributes to the formation of the umbilical cord and placental blood vessels, as by stretching or distention" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Brca2tm1Cam/Brca2tm1Cam
Genetic Background: 129S/SvEv-Brca2tm1Cam

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Gtf2ird1tm1Hrd/Gtf2ird1tm1Hrd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sh3bp2tm1Bjro/Sh3bp2tm1Bjro,Tnftm1Gkl/Tnftm1Gkl
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * BALB/cJ * C57BL/6J

 MP:0005322 abnormal serotonin level "anomalous concentration of biochemical messenger and regulator, found in the CNS, g.i. tract, and produced by platelets; it mediates neurotransmission, g.i. motility, hemostasis, and cardiovascular integrity " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gtf2ird1tm1Lro/Gtf2ird1tm1Lro
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0005352 small skull "less than the normal size of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gtf2ird1Gt(XE465)Byg/Gtf2ird1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005534 decreased body temperature "less than the level of heat natural to a living being" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gtf2ird1tm1Hrd/Gtf2ird1tm1Hrd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008019 liver tumor "presence of abnormal, rapidly proliferating cells in the liver usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Gtf2ird1Tg(Alb1-Myc)166.8Sst/Gtf2ird1+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Gtf2ird1Tg(Alb1-Myc)166.8Sst/Gtf2ird1+,Tg(Alb-E2F1)8Sst/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gtf2ird1Tg(Alb1-Myc)166.8Sst/Gtf2ird1Tg(Alb1-Myc)166.8Sst
Genetic Background: involves: C57BL/6J * CBA/J

Allelic Composition: Gtf2ird1Tg(Alb1-Myc)166.8Sst/Gtf2ird1+
Genetic Background: involves: C57BL/6J * CBA/J

 MP:0008819 abnormal mastication "any anomaly in the process of biting and mashing food with the teeth prior to swallowing" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Ntf3tm1Tojo/Ntf3tm1Tojo
Genetic Background: involves: C57BL/6 * DBA/2 * ICR

 MP:0008862 asymmetric snout "presence of a snout that lacks mirrored identity on either side of the median plane" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Ntf3tm1Tojo/Ntf3tm1Tojo
Genetic Background: involves: C57BL/6 * DBA/2 * ICR

 MP:0009657 failure of chorioallantoic fusion "failure to initiate and/or complete the formation of a highly vascularized extra-embryonic fetal membrane by fusion of the chorion and allantois" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Brca2tm1Cam/Brca2tm1Cam
Genetic Background: 129S/SvEv-Brca2tm1Cam

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gtf2ird1tm1Hrd/Gtf2ird1tm1Hrd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0010043 abnormal frontonasal suture morphology "any structural anomaly of the dense, fibrous connective tissue joint between the frontal and nasal bones" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Gtf2ird1Gt(XE465)Byg/Gtf2ird1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Gtf2ird1Tg(Alb1-Myc)166.8Sst/Gtf2ird1Tg(Alb1-Myc)166.8Sst
Genetic Background: involves: C57BL/6J * CBA/J

 MP:0010166 increased response to stress-induced hyperthermia "greater increase or faster than expected increase in core body termperature in response to stress or anticipatory anxiety" [PMID:18722480]
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Allelic Composition: Gtf2ird1Tg(Alb1-Myc)166.8Sst/Gtf2ird1Tg(Alb1-Myc)166.8Sst
Genetic Background: involves: C57BL/6J * CBA/J

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Brca2tm1Cam/Brca2tm1Cam
Genetic Background: 129S/SvEv-Brca2tm1Cam

 MP:0020427 increased hepatocyte karyomegaly "an increase in the number or proportion of liver cells with enlarged nuclei" [PMID:22733568, PMID:26980189, PMID:7731963, PMID:8701981, url:http://medical-dictionary.thefreedictionary.com/karyomegaly]
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Allelic Composition: Gtf2ird1Tg(Alb1-Myc)166.8Sst/Gtf2ird1+,Tg(MtTGFA)42Lmb/0
Genetic Background: involves: C57BL/6 * CBA * CD-1

 MP:0020467 abnormal circadian behavior "any anomaly in the specific behavior of an organism that recurs with a regularity of approximately 24 hours" [GO:0048512]
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Allelic Composition: Gtf2ird1Tg(Alb1-Myc)166.8Sst/Gtf2ird1Tg(Alb1-Myc)166.8Sst
Genetic Background: involves: C57BL/6J * CBA/J

Allelic Composition: Gtf2ird1Tg(Alb1-Myc)166.8Sst/Gtf2ird1+
Genetic Background: involves: C57BL/6J * CBA/J

 MP:0030098 periorbital fullness "increase in periorbital soft tissue" [HP:0000629]
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Allelic Composition: Ntf3tm1Tojo/Ntf3tm1Tojo
Genetic Background: involves: C57BL/6 * DBA/2 * ICR

Allelic Composition: Gtf2ird1Tg(Alb1-Myc)166.8Sst/Gtf2ird1Tg(Alb1-Myc)166.8Sst
Genetic Background: involves: C57BL/6J * CBA/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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