ENSMUSG00000060510


Mus musculus

Features
Gene ID: ENSMUSG00000060510
  
Biological name :Zfp266
  
Synonyms : Zfp266 / zinc finger protein 266
  
Possible biological names infered from orthology : Q6V9R5 / Q8N587 / zinc finger protein 561 / zinc finger protein 562 / ZNF561 / ZNF562
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: A3
Gene start: 20495068
Gene end: 20521417
  
Corresponding Affymetrix probe sets: 10591253 (MoGene1.0st)   1431206_at (Mouse Genome 430 2.0 Array)   1434084_at (Mouse Genome 430 2.0 Array)   1454812_at (Mouse Genome 430 2.0 Array)   1457913_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000134217
Ensembl peptide - ENSMUSP00000150538
Ensembl peptide - ENSMUSP00000149315
Ensembl peptide - ENSMUSP00000066012
NCBI entrez gene - 77519     See in Manteia.
MGI - MGI:1924769
RefSeq - XM_011242622
RefSeq - XM_011242624
RefSeq - XM_011242623
RefSeq - NM_001082485
RefSeq - NM_001135019
RefSeq Peptide - NP_001075954
RefSeq Peptide - NP_001128491
swissprot - E9Q2S7
swissprot - A0A1L1SR49
swissprot - A0A1L1SU03
Ensembl - ENSMUSG00000060510
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q6V9R5ENSG00000171466Homo sapiens
 Q8N587ENSG00000171469Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Zfp560 / zinc finger protein 560 / Q96MR9* / ZNF560*ENSMUSG0000004551944
Zfp26 / zinc finger protein 26 / Q96MR9* / ZNF560* / zinc finger protein 560*ENSMUSG0000006310843
Q8R1D1 / Zfp426 / zinc finger protein 426 / Q9BUY5* / ZNF426*ENSMUSG0000005947535
Zfp846 / zinc finger protein 846ENSMUSG0000005819235
BC025920 / cDNA sequence BC025920ENSMUSG000000748627


Protein motifs (from Interpro)
Interpro ID Name
 IPR001909  Krueppel-associated box
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013087  Zinc finger C2H2-type
 IPR029037  YfgJ-like
 IPR036051  KRAB domain superfamily
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0008150 biological_process ND
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Generic Transcription Pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0005015 increased T cell number "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Zfp260tm1b(NCOM)Mfgc/Zfp260tm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Zfp260tm1b(NCOM)Mfgc/Tcp

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Zfp260tm1b(NCOM)Mfgc/Zfp260tm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Zfp260tm1b(NCOM)Mfgc/Tcp

 MP:0010169 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number "a reduction in the number of the CD4-positive, CD25-positive T cell subset which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release" [ISBN:0781735149]
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Allelic Composition: Zfp260tm1b(NCOM)Mfgc/Zfp260tm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Zfp260tm1b(NCOM)Mfgc/Tcp

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Zfp260tm1b(NCOM)Mfgc/Zfp260tm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Zfp260tm1b(NCOM)Mfgc/Tcp

 MP:0012764 increased alpha-beta T cell number "greater number of T cells that expresses an alpha-beta T cell receptor complex" [CL:0000789]
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Allelic Composition: Zfp260tm1b(NCOM)Mfgc/Zfp260tm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Zfp260tm1b(NCOM)Mfgc/Tcp

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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