ENSMUSG00000061313


Mus musculus

Features
Gene ID: ENSMUSG00000061313
  
Biological name :Ddhd2
  
Synonyms : Ddhd2 / Phospholipase DDHD2 / Q80Y98
  
Possible biological names infered from orthology : DDHD domain containing 2 / O94830
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: A2
Gene start: 25725346
Gene end: 25754596
  
Corresponding Affymetrix probe sets: 10577838 (MoGene1.0st)   1435376_at (Mouse Genome 430 2.0 Array)   1444320_at (Mouse Genome 430 2.0 Array)   1444590_at (Mouse Genome 430 2.0 Array)   1457209_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000033975
Ensembl peptide - ENSMUSP00000148250
Ensembl peptide - ENSMUSP00000148084
Ensembl peptide - ENSMUSP00000147859
Ensembl peptide - ENSMUSP00000147769
Ensembl peptide - ENSMUSP00000147702
NCBI entrez gene - 72108     See in Manteia.
MGI - MGI:1919358
RefSeq - XM_011242164
RefSeq - XM_011242163
RefSeq - XM_006509197
RefSeq - XM_006509198
RefSeq - NM_028102
RefSeq - XM_011242160
RefSeq Peptide - NP_082378
swissprot - Q80Y98
swissprot - A0A1B0GT91
swissprot - A0A1B0GRX3
swissprot - A0A1B0GS27
swissprot - A0A1B0GSA5
swissprot - A0A1B0GSV3
Ensembl - ENSMUSG00000061313
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ddhd2ENSDARG00000076765Danio rerio
 DDHD2ENSGALG00000042181Gallus gallus
 DDHD2ENSG00000085788Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sec23ip / Sec23 interacting protein / Q9Y6Y8*ENSMUSG0000005531953
Ddhd1 / phospholipase DDHD1 isoform 4 / Q8NEL9* / DDHD domain containing 1*ENSMUSG0000003769724


Protein motifs (from Interpro)
Interpro ID Name
 IPR001660  Sterile alpha motif domain
 IPR004170  WWE domain
 IPR004177  DDHD domain
 IPR013761  Sterile alpha motif/pointed domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006888 ER to Golgi vesicle-mediated transport IBA
 biological_processGO:0007626 locomotory behavior IMP
 biological_processGO:0008542 visual learning IMP
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:0019433 triglyceride catabolic process IMP
 biological_processGO:0034389 lipid particle organization IMP
 biological_processGO:0090141 positive regulation of mitochondrial fission IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005793 endoplasmic reticulum-Golgi intermediate compartment IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0030134 COPII-coated ER to Golgi transport vesicle IBA
 molecular_functionGO:0004620 phospholipase activity IBA
 molecular_functionGO:0004806 triglyceride lipase activity IMP
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Synthesis of PA


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Chrna7tm2.1(cre)Swr/Chrna7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001407 short stride length "reduced average distance between steps" [J:34193]
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Chrna7tm2.1(cre)Swr/Chrna7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001516 abnormal motor coordination/ balance "altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Chrna7tm2.1(cre)Swr/Chrna7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001525 impaired balance "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Chrna7tm2.1(cre)Swr/Chrna7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001547 abnormal lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Chrna7tm2.1(cre)Swr/Chrna7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Chrna7tm2.1(cre)Swr/Chrna7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Chrna7tm2.1(cre)Swr/Chrna7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Chrna7tm2.1(cre)Swr/Chrna7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005317 increased triglyceride level "higher than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Chrna7tm2.1(cre)Swr/Chrna7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008432 abnormal long-term spatial reference memory "anomaly in long-term memory for spatial location information that is consolidated over hours and days after training or an encounter at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Chrna7tm2.1(cre)Swr/Chrna7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0012307 impaired spatial learning "impaired ability to ascertain or acquire spatial location information in order to improve navigation or other behavior using such location cues" [MGI:csmith]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Chrna7tm2.1(cre)Swr/Chrna7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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