ENSMUSG00000061603


Mus musculus

Features
Gene ID: ENSMUSG00000061603
  
Biological name :Akap6
  
Synonyms : Akap6 / A kinase (PRKA) anchor protein 6
  
Possible biological names infered from orthology : A-kinase anchoring protein 6 / Q13023
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: C1
Gene start: 52699383
Gene end: 53155599
  
Corresponding Affymetrix probe sets: 10395702 (MoGene1.0st)   1440859_at (Mouse Genome 430 2.0 Array)   1444357_at (Mouse Genome 430 2.0 Array)   1444444_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000093406
Ensembl peptide - ENSMUSP00000151871
NCBI entrez gene - 238161     See in Manteia.
MGI - MGI:3050566
RefSeq - XM_017315055
RefSeq - NM_198111
RefSeq - XM_006515827
RefSeq - XM_006515828
RefSeq - XM_006515829
RefSeq - XM_006515821
RefSeq - XM_006515822
RefSeq - XM_006515824
RefSeq - XM_006515825
RefSeq - XM_006515826
RefSeq Peptide - NP_932779
swissprot - Q6PGB9
swissprot - E9Q9K8
Ensembl - ENSMUSG00000061603
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 akap6ENSDARG00000077295Danio rerio
 AKAP6ENSGALG00000009995Gallus gallus
 AKAP6ENSG00000151320Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cep68 / Q8C0D9 / Centrosomal protein of 68 kDa / Q76N32* / centrosomal protein 68*ENSMUSG000000440665


Protein motifs (from Interpro)
Interpro ID Name
 IPR002017  Spectrin repeat
 IPR018159  Spectrin/alpha-actinin
 IPR026696  A-kinase anchor protein 6/Centrosomal protein of 68kDa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0060306 regulation of membrane repolarization ISO
 biological_processGO:0071320 cellular response to cAMP ISO
 biological_processGO:1901381 positive regulation of potassium ion transmembrane transport ISO
 biological_processGO:1902261 positive regulation of delayed rectifier potassium channel activity ISO
 cellular_componentGO:0005635 nuclear envelope ISO
 cellular_componentGO:0016529 sarcoplasmic reticulum ISO
 cellular_componentGO:0031965 nuclear membrane IDA
 cellular_componentGO:0034704 calcium channel complex ISO
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008179 adenylate cyclase binding IPI
 molecular_functionGO:0044325 ion channel binding ISO
 molecular_functionGO:0051018 protein kinase A binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000428 abnormal craniofacial morphology "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Elovl4tm1Wked/Elovl4+
Genetic Background: involves: 129S/SvEv * 129S1/Sv

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Elovl4tm1Wked/Elovl4+
Genetic Background: involves: 129S/SvEv * 129S1/Sv

 MP:0002058 neonatal lethality "death of animal within one day after birth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm75.1(CAG-tdTomato*)Hze/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm75.1(CAG-tdTomato*)Hze/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6

 MP:0002625 left ventricle hypertrophy "increased size of the left ventricle" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Akap6tm1.1Mskf/Akap6tm1.1Mskf,Nkx2-5tm1(cre)Rjs/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0002953 thick ventricular wall "increased depth of the cardiac wall of the heart ventricles" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
Show

Allelic Composition: Akap6tm1.1Mskf/Akap6tm1.1Mskf,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL

 MP:0003222 increased cardiomyocyte apoptosis "increase in the number of cardiac muscle cells undergoing programmed cell death" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Akap6tm1.1Mskf/Akap6tm1.1Mskf,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL

 MP:0003915 increased left ventricle weight "greater than average weight of the left ventricle compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Akap6tm1.1Mskf/Akap6tm1.1Mskf,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL

 MP:0004564 enlarged myocardial fiber "increased size of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Akap6tm1.1Mskf/Akap6tm1.1Mskf,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
Show

Allelic Composition: Akap6tm1.1Mskf/Akap6tm1.1Mskf,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL

 MP:0005608 cardiac interstitial fibrosis "formation of fibrous tissue within the interstices of the heart as a result of repair or a reactive process" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Akap6tm1.1Mskf/Akap6tm1.1Mskf,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Elovl4tm1Wked/Elovl4+
Genetic Background: involves: 129S/SvEv * 129S1/Sv

 MP:0011915 increased heart left atrium weight "more than average weight of the left atrium" [MPD:Molly]
Show

Allelic Composition: Akap6tm1.1Mskf/Akap6tm1.1Mskf,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL

 MP:0012688 abnormal heart ventricles weight "abnormal average weight of both the left and right ventricles together" [MPD:Molly]
Show

Allelic Composition: Akap6tm1.1Mskf/Akap6tm1.1Mskf,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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