ENSMUSG00000061718


Mus musculus

Features
Gene ID: ENSMUSG00000061718
  
Biological name :Ppp1r1b
  
Synonyms : Ppp1r1b / Protein phosphatase 1 regulatory subunit 1B / Q60829
  
Possible biological names infered from orthology : protein phosphatase 1 regulatory inhibitor subunit 1B / Q9UD71
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: D
Gene start: 98348404
Gene end: 98357796
  
Corresponding Affymetrix probe sets: 10380862 (MoGene1.0st)   1451331_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000077760
Ensembl peptide - ENSMUSP00000121147
Ensembl peptide - ENSMUSP00000123528
NCBI entrez gene - 19049     See in Manteia.
MGI - MGI:94860
RefSeq - NM_001313970
RefSeq - NM_144828
RefSeq Peptide - NP_001300899
RefSeq Peptide - NP_659077
swissprot - Q60829
Ensembl - ENSMUSG00000061718
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ppp1r1bENSDARG00000076280Danio rerio
 PPP1R1BENSGALG00000044406Gallus gallus
 Q9UD71ENSG00000131771Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR008466  Protein phosphatase inhibitor 1
 IPR015670  Protein phosphatase 1 regulatory subunit 1B


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001975 response to amphetamine IGI
 biological_processGO:0006351 transcription, DNA-templated IMP
 biological_processGO:0006469 negative regulation of protein kinase activity IBA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007621 negative regulation of female receptivity IMP
 biological_processGO:0007626 locomotory behavior IMP
 biological_processGO:0008542 visual learning IGI
 biological_processGO:0032515 negative regulation of phosphoprotein phosphatase activity ISO
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0043278 response to morphine IMP
 biological_processGO:0043987 histone H3-S10 phosphorylation IMP
 biological_processGO:0048148 behavioral response to cocaine IMP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0043025 neuronal cell body IDA
 molecular_functionGO:0004864 protein phosphatase inhibitor activity TAS
 molecular_functionGO:0004865 protein serine/threonine phosphatase inhibitor activity TAS
 molecular_functionGO:0031748 D1 dopamine receptor binding IEA
 molecular_functionGO:0031749 D2 dopamine receptor binding IEA
 molecular_functionGO:0031750 D3 dopamine receptor binding IEA
 molecular_functionGO:0031751 D4 dopamine receptor binding IEA
 molecular_functionGO:0031752 D5 dopamine receptor binding IEA


Pathways (from Reactome)
Pathway description
DARPP-32 events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Ppp1r1btm5.1Pggd/Ppp1r1btm5.1Pggd,Tg(Drd1-cre)EY262Gsat/0,Tg(Drd1-EGFP)X60Gsat/0
Genetic Background: involves: C57BL/6 * FVB/N * FVB/NTac

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Mafbkr/Mafbkr
Genetic Background: CBA.Cg-Mafbkr

 MP:0001425 alcohol consumption 
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Allelic Composition: Ppp1r1btm1Aaf/Ppp1r1btm1Aaf
Genetic Background: Not Specified

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Mafbkr/Mafbkr
Genetic Background: CBA.Cg-Mafbkr

Allelic Composition: Ppp1r1btm5.1Pggd/Ppp1r1btm5.1Pggd,Tg(Drd2-cre)ER44Gsat/0,Tg(Drd2-EGFP)S118Gsat/0
Genetic Background: involves: C57BL/6 * FVB/N * FVB/NTac

 MP:0002629 hyperactivity elicited by ethanol administration 
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Allelic Composition: Ppp1r1btm1Aaf/Ppp1r1btm1Aaf
Genetic Background: Not Specified

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stim1Gt(RRS558)Byg/Stim1Gt(RRS558)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008872 abnormal response to xenobiotics "any anomaly in the physiological or morphological changes induced by a foreign compound, such as changes in blood pressure, changes in hormone or protein levels or hypertrophy or hypotrophy of an organ" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gja1tm1Kdr/Gja1tm1Kwi,Tg(Tek-cre)5326Sato/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA/J

Allelic Composition: Ppp1r1btm3Pggd/Ppp1r1btm3Pggd
Genetic Background: involves: 129 * C57BL/6

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnfsf14tm1Ddy/Tnfsf14tm1Ddy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Ppp1r1btm1Aaf/Ppp1r1btm1Aaf
Genetic Background: Not Specified

 MP:0009712 impaired conditioned place preference behavior "decrease in the ability of an animal to learn and remember an association between a putative rewarding internal state produced by a xenobiotic or drug with a neutral, unchanging environment" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ppp1r1btm1Aaf/Ppp1r1btm1Aaf
Genetic Background: Not Specified

Allelic Composition: Ppp1r1btm4Pggd/Ppp1r1btm4Pggd
Genetic Background: Not Specified

 MP:0009747 impaired behavioral response to xenobiotic "decreased sensitivity to a foreign compound capable of inducing the appearance of behavioral response, such as consumption preference, induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mafbkr/Mafbkr
Genetic Background: CBA.Cg-Mafbkr

Allelic Composition: Ppp1r1btm5.1Pggd/Ppp1r1btm5.1Pggd,Tg(Drd2-cre)ER44Gsat/0,Tg(Drd2-EGFP)S118Gsat/0
Genetic Background: involves: C57BL/6 * FVB/N * FVB/NTac

 MP:0009750 impaired behavioral response to addictive substance "decreased sensitivity to an addictive substance capable of inducing the appearance of behavioral response, such as induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnfsf14tm1Ddy/Tnfsf14tm1Ddy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Ppp1r1btm1Pggd/Ppp1r1btm1Pggd
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Ppp1r1btm3Pggd/Ppp1r1btm3Pggd
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Ppp1r1btm1Aaf/Ppp1r1btm1Aaf
Genetic Background: B6.129P2-Ppp1r1btm1Aaf

Allelic Composition: Ppp1r1btm2Pggd/Ppp1r1btm2Pggd
Genetic Background: involves: 129 * C57BL/6

 MP:0009754 enhanced behavioral response to cocaine "increased sensitivity to cocaine resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or decreased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ppp1r1btm1Aaf/Ppp1r1btm1Aaf
Genetic Background: Not Specified

Allelic Composition: Ppp1r1btm5.1Pggd/Ppp1r1btm5.1Pggd,Tg(Drd2-cre)ER44Gsat/0,Tg(Drd2-EGFP)S118Gsat/0
Genetic Background: involves: C57BL/6 * FVB/N * FVB/NTac

 MP:0009757 impaired behavioral response to morphine "decreased sensitivity to morphine resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ppp1r1btm4Pggd/Ppp1r1btm4Pggd
Genetic Background: Not Specified

 MP:0009758 impaired behavioral response to cocaine "decreased sensitivity to cocaine resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tnfsf14tm1Ddy/Tnfsf14tm1Ddy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Ppp1r1btm1Pggd/Ppp1r1btm1Pggd
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Ppp1r1btm3Pggd/Ppp1r1btm3Pggd
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Ppp1r1btm4Pggd/Ppp1r1btm4Pggd
Genetic Background: Not Specified

Allelic Composition: Ppp1r1btm5.1Pggd/Ppp1r1btm5.1Pggd,Tg(Drd1-cre)EY262Gsat/0,Tg(Drd1-EGFP)X60Gsat/0
Genetic Background: involves: C57BL/6 * FVB/N * FVB/NTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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