ENSMUSG00000062007


Mus musculus

Features
Gene ID: ENSMUSG00000062007
  
Biological name :Hsh2d
  
Synonyms : Hematopoietic SH2 domain-containing protein / Hsh2d / Q6VYH9
  
Possible biological names infered from orthology : hematopoietic SH2 domain containing / Q96JZ2
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: B3.3
Gene start: 72189638
Gene end: 72201527
  
Corresponding Affymetrix probe sets: 10572772 (MoGene1.0st)   1442130_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000071970
Ensembl peptide - ENSMUSP00000127575
NCBI entrez gene - 209488     See in Manteia.
MGI - MGI:2676364
RefSeq - NM_197944
RefSeq Peptide - NP_922935
swissprot - Q6VYH9
Ensembl - ENSMUSG00000062007
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hsh2dENSDARG00000042908Danio rerio
 HSH2DENSG00000196684Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9QXK9 / Sh2d2a / SH2 domain containing 2A / Q9NP31*ENSMUSG0000002807119
A6X942 / Sh2d4b / SH2 domain-containing protein 4B / Q5SQS7* / SH2 domain containing 4B*ENSMUSG0000003783316
Q9D7V1 / Sh2d4a / SH2 domain-containing protein 4A / Q9H788* / SH2 domain containing 4A*ENSMUSG0000005388614
Sh2d7 / Q8BI17 / SH2 domain-containing protein 7 ENSMUSG000000464604


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR035047  Hematopoietic SH2 domain-containing protein
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002903 negative regulation of B cell apoptotic process IDA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0009967 positive regulation of signal transduction IEA
 biological_processGO:0042110 T cell activation IDA
 biological_processGO:0051902 negative regulation of mitochondrial depolarization IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005829 cytosol IDA
 molecular_functionGO:0005070 SH3/SH2 adaptor activity IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0004392 abnormal CD8-positive T cell physiology "abnormal function of the subset of T lymphocytes that express the CD8 marker on the cell surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Foxd3tm1Lby/Foxd3tm1Lby
Genetic Background: involves: 129S6/SvEvTac * CD-1

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Foxd3tm1Lby/Foxd3tm1Lby
Genetic Background: involves: 129S6/SvEvTac * CD-1

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Foxd3tm1Lby/Foxd3tm1Lby
Genetic Background: involves: 129S6/SvEvTac * CD-1

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Foxd3tm1Lby/Foxd3tm1Lby
Genetic Background: involves: 129S6/SvEvTac * CD-1

 MP:0008687 increased interleukin-2 secretion "increase in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
Show

Allelic Composition: Foxd3tm1Lby/Foxd3tm1Lby
Genetic Background: involves: 129S6/SvEvTac * CD-1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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