ENSMUSG00000062115


Mus musculus

Features
Gene ID: ENSMUSG00000062115
  
Biological name :Rai1
  
Synonyms : Q61818 / Rai1 / retinoic acid induced 1
  
Possible biological names infered from orthology : Q7Z5J4
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B1.3
Gene start: 60105013
Gene end: 60199197
  
Corresponding Affymetrix probe sets: 10376568 (MoGene1.0st)   1420454_at (Mouse Genome 430 2.0 Array)   1453200_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000118543
Ensembl peptide - ENSMUSP00000126183
Ensembl peptide - ENSMUSP00000070896
Ensembl peptide - ENSMUSP00000088315
Ensembl peptide - ENSMUSP00000099749
NCBI entrez gene - 19377     See in Manteia.
MGI - MGI:103291
RefSeq - NM_001037764
RefSeq - NM_009021
RefSeq Peptide - NP_001032853
RefSeq Peptide - NP_033047
swissprot - B1AU85
swissprot - Q61818
Ensembl - ENSMUSG00000062115
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rai1ENSDARG00000076679Danio rerio
 RAI1ENSGALG00000004888Gallus gallus
 RAI1ENSG00000108557Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tcf20 / Q9EPQ8 / Transcription factor 20 / Q9UGU0*ENSMUSG0000004185222
Zfp957 / zinc finger protein 957 / TCF20* / Q9UGU0* / transcription factor 20*ENSMUSG000000712626


Protein motifs (from Interpro)
Interpro ID Name
 IPR001965  Zinc finger, PHD-type
 IPR034732  Extended PHD (ePHD) domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001501 skeletal system development IMP
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IDA
 biological_processGO:0032922 circadian regulation of gene expression ISO
 biological_processGO:0040015 negative regulation of multicellular organism growth IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IBA
 biological_processGO:0048511 rhythmic process IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion ISO
 molecular_functionGO:0003700 DNA-binding transcription factor activity IBA
 molecular_functionGO:0035326 enhancer binding ISS
 molecular_functionGO:0044212 transcription regulatory region DNA binding IBA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000008 increased white fat amount "increased quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fosl2tm2Wag/Fosl2tm2Wag,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000102 abnormal nasal bone morphology "malformed elongated rectangular bone that forms part of the nasal bridge" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17489]
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Allelic Composition: Gzmbtm2.1Ley/Gzmbtm2.1Ley
Genetic Background: 129X1/SvJ-Gzmbtm2.1Ley

Allelic Composition: Rai1tm1Jrl/Rai1+
Genetic Background: involves: 129S/SvEvBrd * C57BL/6

 MP:0000120 malocclusion "perturbations in the normal patterned arrangement of the teeth or alignment of the jaw, resulting in the incorrect position of biting or chewing surfaces of the upper and lower teeth" [J:61509]
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Allelic Composition: Gzmbtm2.1Ley/Gzmbtm2.1Ley
Genetic Background: 129X1/SvJ-Gzmbtm2.1Ley

 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Gzmbtm2.1Ley/Gzmbtm2.1Ley
Genetic Background: 129X1/SvJ-Gzmbtm2.1Ley

Allelic Composition: Rai1tm2.1Luo/Rai1tm2.1Luo,Tg(Nes-cre)1Kln/?
Genetic Background: either: (involves: 129S1/Sv * C57BL/6 * SJL) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL)

 MP:0000182 increased circulating LDL cholesterol level "greater than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rai1tm2.1Luo/Rai1tm2.1Luo,Tg(Sim1-cre)1Lowl/?
Genetic Background: either: (involves: 129S1/Sv * C57BL/6 * FVB) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB)

 MP:0000413 polyphalangy "increased number of phalanges in any of the digits" [J:13069, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Gzmbtm2.1Ley/Gzmbtm2.1Ley
Genetic Background: 129X1/SvJ-Gzmbtm2.1Ley

 MP:0000443 abnormal snout morphology "anomalous structure or development of the anterior facial part of the muzzle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gzmbtm2.1Ley/Gzmbtm2.1Ley
Genetic Background: 129X1/SvJ-Gzmbtm2.1Ley

Allelic Composition: Rai1tm1Jrl/Rai1+
Genetic Background: involves: 129S/SvEvBrd * C57BL/6

 MP:0000445 short snout "reduced length of the anterior facial part of the muzzle" [J:53370]
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Allelic Composition: Gzmbtm2.1Ley/Gzmbtm2.1Ley
Genetic Background: 129X1/SvJ-Gzmbtm2.1Ley

Allelic Composition: Rai1tm1Jrl/Rai1+
Genetic Background: involves: 129S/SvEvBrd * C57BL/6

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Rai1tm2.1Luo/Rai1+,Slc17a6tm2(cre)Lowl/?
Genetic Background: either: (involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6) or (involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6)

Allelic Composition: Rai1tm2.1Luo/Rai1+,Tg(Sim1-cre)1Lowl/?
Genetic Background: either: (involves: 129S1/Sv * C57BL/6 * FVB) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB)

Allelic Composition: Rai1tm2.1Luo/Rai1tm2.1Luo,Tg(Nr5a1-cre)7Lowl/?
Genetic Background: either: (involves: 129S1/Sv * C57BL/6 * FVB) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB)

Allelic Composition: Rai1tm2.1Luo/Rai1+,Tg(Nr5a1-cre)7Lowl/?
Genetic Background: either: (involves: 129S1/Sv * C57BL/6 * FVB) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB)

 MP:0001261 obese "excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Rai1tm1Jrl/Rai1+
Genetic Background: involves: 129S/SvEvBrd * C57BL/6

Allelic Composition: Rai1tm1Jrl/Rai1+
Genetic Background: B6.129S7-Rai1tm1Jrl/J

Allelic Composition: Rai1tm2.1Luo/Rai1tm2.1Luo,Tg(Nes-cre)1Kln/?
Genetic Background: either: (involves: 129S1/Sv * C57BL/6 * SJL) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL)

Allelic Composition: Rai1tm2.1Luo/Rai1+,Tg(Nes-cre)1Kln/?
Genetic Background: either: (involves: 129S1/Sv * C57BL/6 * SJL) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL)

Allelic Composition: Rai1tm2.2Luo/Rai1tm2.1Luo,Tg(Nes-cre)1Kln/?
Genetic Background: either: (involves: 129S1/Sv * C57BL/6 * SJL) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL)

Allelic Composition: Rai1tm2.1Luo/Rai1tm2.1Luo,Slc17a6tm2(cre)Lowl/?
Genetic Background: either: (involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6) or (involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6)

Allelic Composition: Rai1tm2.1Luo/Rai1tm2.1Luo,Tg(Sim1-cre)1Lowl/?
Genetic Background: either: (involves: 129S1/Sv * C57BL/6 * FVB) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB)

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Rai1tm1Jrl/Rai1+
Genetic Background: involves: 129S/SvEvBrd * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Cfap54Gt(IST10309B2)Tigm/Cfap54Gt(IST10309B2)Tigm
Genetic Background: (B6J.B6N-Cfap54Gt(IST10309B2)Tigm x 129S6.B6N-Cfap54Gt(IST10309B2)Tigm)F1

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
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Allelic Composition: Gzmbtm2.1Ley/Gzmbtm2.1Ley
Genetic Background: 129X1/SvJ-Gzmbtm2.1Ley

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Gusbmps/Gusbmps
Genetic Background: B6.C-H2-Kbm1/ByBir-Gusbmps/J

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Rai1tm2.1Luo/Rai1tm2.1Luo,Tg(Sim1-cre)1Lowl/?
Genetic Background: either: (involves: 129S1/Sv * C57BL/6 * FVB) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB)

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gzmbtm2.1Ley/Gzmbtm2.1Ley
Genetic Background: 129X1/SvJ-Gzmbtm2.1Ley

Allelic Composition: Rai1tm2.1Luo/Rai1tm2.1Luo,Tg(Nes-cre)1Kln/?
Genetic Background: either: (involves: 129S1/Sv * C57BL/6 * SJL) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL)

Allelic Composition: Rai1tm2.2Luo/Rai1+,Tg(Nes-cre)1Kln/?
Genetic Background: either: (involves: 129S1/Sv * C57BL/6 * SJL) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL)

Allelic Composition: Rai1tm2.1Luo/Rai1+,Tg(Nes-cre)1Kln/?
Genetic Background: either: (involves: 129S1/Sv * C57BL/6 * SJL) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL)

Allelic Composition: Rai1tm2.1Luo/Rai1tm2.1Luo,Slc17a6tm2(cre)Lowl/?
Genetic Background: either: (involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6) or (involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6)

Allelic Composition: Rai1tm2.1Luo/Rai1+,Slc17a6tm2(cre)Lowl/?
Genetic Background: either: (involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6) or (involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6)

 MP:0001433 polyphagia "eating to excess" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fosl2tm2Wag/Fosl2tm2Wag,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Rai1tm2.1Luo/Rai1tm2.1Luo,Tg(Sim1-cre)1Lowl/?
Genetic Background: either: (involves: 129S1/Sv * C57BL/6 * FVB) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB)

 MP:0001454 abnormal cued conditioning behavior "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light)" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Gzmbtm2.1Ley/Gzmbtm2.1Ley
Genetic Background: 129X1/SvJ-Gzmbtm2.1Ley

 MP:0001469 abnormal contextual conditioning "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), or the environmental context in this case)" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Gzmbtm2.1Ley/Gzmbtm2.1Ley
Genetic Background: 129X1/SvJ-Gzmbtm2.1Ley

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Gzmbtm2.1Ley/Gzmbtm2.1Ley
Genetic Background: 129X1/SvJ-Gzmbtm2.1Ley

Allelic Composition: Rai1tm2.1Luo/Rai1tm2.1Luo,Tg(Nes-cre)1Kln/?
Genetic Background: either: (involves: 129S1/Sv * C57BL/6 * SJL) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL)

 MP:0001556 increased circulating HDL cholesterol level "higher than average level of high density lipoprotein in the blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47439]
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Allelic Composition: Rai1tm2.1Luo/Rai1tm2.1Luo,Tg(Sim1-cre)1Lowl/?
Genetic Background: either: (involves: 129S1/Sv * C57BL/6 * FVB) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB)

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gzmbtm2.1Ley/Gzmbtm2.1Ley
Genetic Background: 129X1/SvJ-Gzmbtm2.1Ley

Allelic Composition: Rai1tm1Jrl/Rai1+
Genetic Background: involves: 129S/SvEvBrd * C57BL/6

 MP:0001745 increased circulating corticosterone level "greater than the normal concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:54931]
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Allelic Composition: Rai1tm1Jrl/Rai1+
Genetic Background: B6.129S7-Rai1tm1Jrl/J

 MP:0002062 abnormal conditioning behavior "inability to change the frequency or form of a behavior as a result of the influence of the environment " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cfap54Gt(IST10309B2)Tigm/Cfap54Gt(IST10309B2)Tigm
Genetic Background: (B6J.B6N-Cfap54Gt(IST10309B2)Tigm x 129S6.B6N-Cfap54Gt(IST10309B2)Tigm)F1

Allelic Composition: Rai1tm2.1Luo/Rai1tm2.1Luo,Slc17a6tm2(cre)Lowl/?
Genetic Background: either: (involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6) or (involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6)

Allelic Composition: Gad2tm2(cre)Zjh/?,Rai1tm2.1Luo/Rai1tm2.1Luo
Genetic Background: either: (involves: 129S1/Sv * 129S4/SvJae * C57BL/6) or (involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6)

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gzmbtm2.1Ley/Gzmbtm2.1Ley
Genetic Background: 129X1/SvJ-Gzmbtm2.1Ley

Allelic Composition: Rai1tm1Jrl/Rai1+
Genetic Background: involves: 129S/SvEvBrd * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cfap54Gt(IST10309B2)Tigm/Cfap54Gt(IST10309B2)Tigm
Genetic Background: (B6J.B6N-Cfap54Gt(IST10309B2)Tigm x 129S6.B6N-Cfap54Gt(IST10309B2)Tigm)F1

 MP:0002114 abnormal axial skeleton morphology "abnormal development of vertebral, spinal or sternal bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gzmbtm2.1Ley/Gzmbtm2.1Ley
Genetic Background: 129X1/SvJ-Gzmbtm2.1Ley

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rai1tm2.1Luo/Rai1+,Tg(Nr5a1-cre)7Lowl/?
Genetic Background: either: (involves: 129S1/Sv * C57BL/6 * FVB) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB)

Allelic Composition: Rai1tm2.1Luo/Rai1tm2.1Luo,Tg(Gfap-cre)73.12Mvs/?
Genetic Background: either: (involves: 129S1/Sv * BALB/c * C57BL/6 * C57BL/6NHsd) or (involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * C57BL/6NHsd)

 MP:0002260 abnormal thyroid cartilage morphology "any structural anomaly of the largest of the laryngeal cartilages " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]
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Allelic Composition: Gzmbtm2.1Ley/Gzmbtm2.1Ley
Genetic Background: 129X1/SvJ-Gzmbtm2.1Ley

 MP:0002574 increased vertical activity "greater than average time spent jumping or rearing " [J:72576, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Rai1tm1Jrl/Rai1+
Genetic Background: involves: 129S/SvEvBrd * C57BL/6

 MP:0002823 abnormal rib development "anomalous formation of the bones forming the bony wall of the chest" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84754]
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Allelic Composition: Gzmbtm2.1Ley/Gzmbtm2.1Ley
Genetic Background: 129X1/SvJ-Gzmbtm2.1Ley

 MP:0003047 abnormal thoracic vertebrae morphology "malformation of any or all of the thirteen bony segments of the spine located anterior to the lumbar vertebrae and posterior to the cervical vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Gzmbtm2.1Ley/Gzmbtm2.1Ley
Genetic Background: 129X1/SvJ-Gzmbtm2.1Ley

 MP:0003048 abnormal cervical vertebrae morphology "malformation of any or all of the seven bony segments of the spine located anterior to the thoracic vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Gzmbtm2.1Ley/Gzmbtm2.1Ley
Genetic Background: 129X1/SvJ-Gzmbtm2.1Ley

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Rai1tm2.1Luo/Rai1tm2.1Luo,Tg(Sim1-cre)1Lowl/?
Genetic Background: either: (involves: 129S1/Sv * C57BL/6 * FVB) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB)

 MP:0003982 increased cholesterol level "greater than normal concentration in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Rai1tm2.1Luo/Rai1tm2.1Luo,Tg(Sim1-cre)1Lowl/?
Genetic Background: either: (involves: 129S1/Sv * C57BL/6 * FVB) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB)

 MP:0003997 tonic-clonic seizures "increased number or decreased threshold for the induction of a seizure characterized by initial rigidity followed by rhythmic jerking movements" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gzmbtm2.1Ley/Gzmbtm2.1Ley
Genetic Background: 129X1/SvJ-Gzmbtm2.1Ley

 MP:0004471 short nasal bone "reduced length of either of two rectangular bone plates forming the bridge of the nose" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Gzmbtm2.1Ley/Gzmbtm2.1Ley
Genetic Background: 129X1/SvJ-Gzmbtm2.1Ley

Allelic Composition: Rai1tm1Jrl/Rai1+
Genetic Background: involves: 129S/SvEvBrd * C57BL/6

 MP:0004472 broad nasal bone "increased width of either of two rectangular bone plates forming the bridge of the nose" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Gzmbtm2.1Ley/Gzmbtm2.1Ley
Genetic Background: 129X1/SvJ-Gzmbtm2.1Ley

Allelic Composition: Rai1tm1Jrl/Rai1+
Genetic Background: involves: 129S/SvEvBrd * C57BL/6

 MP:0004994 abnormal brain wave pattern "any anomaly in the standard pattern of rhythmic and rapid fluctuation of electrical potential between parts of the brain, often visualized on an electroencephalogram (EEG); the pattern is often measured to diagnose neurological conditions such as seizure disorders (epilepsy)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gzmbtm2.1Ley/Gzmbtm2.1Ley
Genetic Background: 129X1/SvJ-Gzmbtm2.1Ley

Allelic Composition: Rai1tm1Jrl/Rai1+
Genetic Background: involves: 129S/SvEvBrd * C57BL/6

 MP:0005145 increased circulating VLDL cholesterol level "greater than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rai1tm2.1Luo/Rai1tm2.1Luo,Tg(Sim1-cre)1Lowl/?
Genetic Background: either: (involves: 129S1/Sv * C57BL/6 * FVB) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB)

 MP:0005226 abnormal vertebral arch development "anomalous formation of the posterior projection from the body of a vertebra that encloses the vertebral foramen " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gzmbtm2.1Ley/Gzmbtm2.1Ley
Genetic Background: 129X1/SvJ-Gzmbtm2.1Ley

 MP:0005317 increased triglyceride level "higher than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rai1tm2.1Luo/Rai1tm2.1Luo,Tg(Sim1-cre)1Lowl/?
Genetic Background: either: (involves: 129S1/Sv * C57BL/6 * FVB) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB)

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Rai1tm1Jrl/Rai1+
Genetic Background: B6.129S7-Rai1tm1Jrl/J

 MP:0008428 abnormal spatial working memory "anomaly in the ability to spontaneously process spatial location information in order to naviagate or perform other behavior using such locational cues, without previous encounters or training at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rai1tm2.1Luo/Rai1tm2.1Luo,Tg(Nes-cre)1Kln/?
Genetic Background: either: (involves: 129S1/Sv * C57BL/6 * SJL) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL)

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Gzmbtm2.1Ley/Gzmbtm2.1Ley
Genetic Background: 129X1/SvJ-Gzmbtm2.1Ley

 MP:0008908 increased total fat pad weight "greater than average weight of the fat pads" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rai1tm2.1Luo/Rai1tm2.1Luo,Tg(Sim1-cre)1Lowl/?
Genetic Background: either: (involves: 129S1/Sv * C57BL/6 * FVB) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB)

 MP:0009454 impaired contextual conditioning "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Rai1tm2.1Luo/Rai1tm2.1Luo,Tg(Nes-cre)1Kln/?
Genetic Background: either: (involves: 129S1/Sv * C57BL/6 * SJL) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL)

Allelic Composition: Rai1tm2.1Luo/Rai1tm2.1Luo,Slc17a6tm2(cre)Lowl/?
Genetic Background: either: (involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6) or (involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6)

Allelic Composition: Gad2tm2(cre)Zjh/?,Rai1tm2.1Luo/Rai1tm2.1Luo
Genetic Background: either: (involves: 129S1/Sv * 129S4/SvJae * C57BL/6) or (involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6)

 MP:0009456 impaired cued conditioning behavior "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light flash)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Rai1tm2.1Luo/Rai1tm2.1Luo,Tg(Nes-cre)1Kln/?
Genetic Background: either: (involves: 129S1/Sv * C57BL/6 * SJL) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL)

Allelic Composition: Rai1tm2.1Luo/Rai1tm2.1Luo,Slc17a6tm2(cre)Lowl/?
Genetic Background: either: (involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6) or (involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6)

Allelic Composition: Gad2tm2(cre)Zjh/?,Rai1tm2.1Luo/Rai1tm2.1Luo
Genetic Background: either: (involves: 129S1/Sv * 129S4/SvJae * C57BL/6) or (involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6)

 MP:0010701 fusion of atlas and odontoid process "the large protuberance that projects upward from the cervical axis (C2), around which the cervical atlas normally rotates, is instead fused to elements of the atlas; the odontoid process may or may not remain attached to the axis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gzmbtm2.1Ley/Gzmbtm2.1Ley
Genetic Background: 129X1/SvJ-Gzmbtm2.1Ley

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Gzmbtm2.1Ley/Gzmbtm2.1Ley
Genetic Background: 129X1/SvJ-Gzmbtm2.1Ley

 MP:0011106 partial embryonic lethality before somite formation "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Gzmbtm2.1Ley/Gzmbtm2.1Ley
Genetic Background: 129X1/SvJ-Gzmbtm2.1Ley

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Gzmbtm2.1Ley/Gzmbtm2.1Ley
Genetic Background: 129X1/SvJ-Gzmbtm2.1Ley

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Rai1tm1Jrl/Rai1+
Genetic Background: B6.129S7-Rai1tm1Jrl/J

 MP:0014124 increased amylin secretion "greater than normal production or release of the polypeptide hormone that is normally co-secreted with insulin by the beta cells of the pancreatic islets of Langerhans and is known to inhibit glucagon secretion, delay gastric emptying, and act as a satiety agent" [http://www.ajpcr.com/Vol6Issue1/1462.pdf]
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Allelic Composition: Rai1tm1Jrl/Rai1+
Genetic Background: B6.129S7-Rai1tm1Jrl/J

 MP:0014142 increased body fat mass "increased physical bulk or volume of fat in the whole body" [MGI:csmith]
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Allelic Composition: Rai1tm2.1Luo/Rai1tm2.1Luo,Tg(Sim1-cre)1Lowl/?
Genetic Background: either: (involves: 129S1/Sv * C57BL/6 * FVB) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB)

 MP:0020411 increased abdominal adipose tissue amount "increase in amount of adipose tissue associated with internal organs" [MGI:anna]
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Allelic Composition: Rai1tm1Jrl/Rai1+
Genetic Background: B6.129S7-Rai1tm1Jrl/J

 MP:0020467 abnormal circadian behavior "any anomaly in the specific behavior of an organism that recurs with a regularity of approximately 24 hours" [GO:0048512]
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Allelic Composition: Rai1tm1Jrl/Rai1+
Genetic Background: B6.129S7-Rai1tm1Jrl/J

 MP:0030189 broad snout "increased width of the anterior facial part of the face or muzzle containing the oral and nasal regions" [MGI:anna]
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Allelic Composition: Rai1tm1Jrl/Rai1+
Genetic Background: involves: 129S/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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