ENSMUSG00000062270


Mus musculus

Features
Gene ID: ENSMUSG00000062270
  
Biological name :Morf4l1
  
Synonyms : Morf4l1 / Mus musculus mortality factor 4 like 1 (Morf4l1), transcript variant 3, mRNA. / P60762
  
Possible biological names infered from orthology : mortality factor 4 like 1 / Q9UBU8
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: E3.1
Gene start: 90091665
Gene end: 90114774
  
Corresponding Affymetrix probe sets: 10454099 (MoGene1.0st)   10458757 (MoGene1.0st)   10463153 (MoGene1.0st)   10595673 (MoGene1.0st)   1424185_a_at (Mouse Genome 430 2.0 Array)   1437801_at (Mouse Genome 430 2.0 Array)   1437802_x_at (Mouse Genome 430 2.0 Array)   1438597_x_at (Mouse Genome 430 2.0 Array)   1455077_a_at (Mouse Genome 430 2.0 Array)   1455742_x_at (Mouse Genome 430 2.0 Array)   1456142_x_at (Mouse Genome 430 2.0 Array)   1456455_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000140023
Ensembl peptide - ENSMUSP00000082346
Ensembl peptide - ENSMUSP00000132020
Ensembl peptide - ENSMUSP00000140118
Ensembl peptide - ENSMUSP00000141091
NCBI entrez gene - 627352     See in Manteia.
NCBI entrez gene - 21761     See in Manteia.
MGI - MGI:1096551
RefSeq - XM_006511018
RefSeq - NM_001039147
RefSeq - NM_001326287
RefSeq - NM_001357780
RefSeq - NM_024431
RefSeq Peptide - NP_001034236
RefSeq Peptide - NP_001313216
RefSeq Peptide - NP_077751
RefSeq Peptide - NP_001344709
swissprot - Q569V4
swissprot - P60762
swissprot - A0A087WQ34
swissprot - A0A087WSL1
swissprot - A0A087WQB0
Ensembl - ENSMUSG00000062270
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 morf4l1ENSDARG00000041155Danio rerio
 MORF4L1ENSGALG00000008146Gallus gallus
 Q9UBU8ENSG00000185787Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9R0Q4 / Morf4l2 / Mortality factor 4-like protein 2 / Q15014* / mortality factor 4 like 2*ENSMUSG0000003142255


Protein motifs (from Interpro)
Interpro ID Name
 IPR000953  Chromo/chromo shadow domain
 IPR008676  MRG
 IPR016197  Chromo-like domain superfamily
 IPR025995  RNA binding activity-knot of a chromodomain
 IPR026541  MRG domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000724 double-strand break repair via homologous recombination ISS
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006310 DNA recombination IEA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006338 chromatin remodeling TAS
 biological_processGO:0006342 chromatin silencing IBA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0008283 cell proliferation IMP
 biological_processGO:0016575 histone deacetylation ISS
 biological_processGO:0040008 regulation of growth IEA
 biological_processGO:0043967 histone H4 acetylation IBA
 biological_processGO:0043968 histone H2A acetylation ISO
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0016580 Sin3 complex IEA
 cellular_componentGO:0016607 nuclear speck ISO
 cellular_componentGO:0035267 NuA4 histone acetyltransferase complex IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0047485 protein N-terminus binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pcgf2tm1Hko/Pcgf2tm1Hko,Bmi1tm1Brn/Bmi1tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001199 thin skin "reduced thickness of the outer protective layer of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49471]
Show

Allelic Composition: Pcgf2tm1Hko/Pcgf2tm1Hko,Bmi1tm1Brn/Bmi1tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001231 abnormal basal cell layer morphology "structural anomaly of the deepest layer of the epidermis, which is composed of dividing stem cells and anchoring cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pcgf2tm1Hko/Pcgf2tm1Hko,Bmi1tm1Brn/Bmi1tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Pcgf2tm1Hko/Pcgf2tm1Hko,Bmi1tm1Brn/Bmi1tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Morf4l2tm1.1Kto/Y
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Morf4l1tm1Kto/Morf4l1tm1Kto,Morf4l2tm1.1Kto/Y
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001786 skin edema "accumulation of an excessive amount of fluid in the skin" [J:65039]
Show

Allelic Composition: Pcgf2tm1Hko/Pcgf2tm1Hko,Bmi1tm1Brn/Bmi1tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
Show

Allelic Composition: Pcgf2tm1Hko/Pcgf2tm1Hko,Bmi1tm1Brn/Bmi1tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002190 disorganized myocardium "malformed or poorly developed cardiac muscle layers" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67044]
Show

Allelic Composition: Pcgf2tm1Hko/Pcgf2tm1Hko,Bmi1tm1Brn/Bmi1tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pcgf2tm1Hko/Pcgf2tm1Hko,Bmi1tm1Brn/Bmi1tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Pcgf2tm1Hko/Pcgf2tm1Hko,Bmi1tm1Brn/Bmi1tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pcgf2tm1Hko/Pcgf2tm1Hko,Bmi1tm1Brn/Bmi1tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010017 visceral vascular congestion "obstruction of the normal flux of blood within the blood vessel network of the internal organs enclosed within the cavity of the body, such as the thoracic, abdominal, endocrine, and pelvic organs" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pcgf2tm1Hko/Pcgf2tm1Hko,Bmi1tm1Brn/Bmi1tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010018 lung vascular congestion "obstruction of the normal flux of blood within the blood vessel network of the lung" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pcgf2tm1Hko/Pcgf2tm1Hko,Bmi1tm1Brn/Bmi1tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010019 liver vascular congestion "obstruction of the normal flux of blood within the blood vessel network of the liver" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pcgf2tm1Hko/Pcgf2tm1Hko,Bmi1tm1Brn/Bmi1tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010020 spleen vascular congestion "obstruction of the normal flux of blood within the blood vessel network of the spleen" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pcgf2tm1Hko/Pcgf2tm1Hko,Bmi1tm1Brn/Bmi1tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Pcgf2tm1Hko/Pcgf2tm1Hko,Bmi1tm1Brn/Bmi1tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Morf4l2tm1.1Kto/Y
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Morf4l1tm1Kto/Morf4l1tm1Kto,Morf4l2tm1.1Kto/Y
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Morf4l2tm1.1Kto/Y
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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