ENSMUSG00000062352


Mus musculus

Features
Gene ID: ENSMUSG00000062352
  
Biological name :Itgb1bp1
  
Synonyms : Integrin beta-1-binding protein 1 / Itgb1bp1 / O35671
  
Possible biological names infered from orthology : integrin subunit beta 1 binding protein 1 / O14713
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: A1.3
Gene start: 21240825
Gene end: 21286237
  
Corresponding Affymetrix probe sets: 10399593 (MoGene1.0st)   1422157_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000075609
Ensembl peptide - ENSMUSP00000133557
Ensembl peptide - ENSMUSP00000134508
Ensembl peptide - ENSMUSP00000134627
NCBI entrez gene - 16413     See in Manteia.
MGI - MGI:1306802
RefSeq - XM_011243816
RefSeq - NM_008403
RefSeq - XM_006514989
RefSeq - XM_006514990
RefSeq - XM_006514991
RefSeq Peptide - NP_001342538
RefSeq Peptide - NP_032429
swissprot - Q3UGH2
swissprot - G3UX55
swissprot - O35671
Ensembl - ENSMUSG00000062352
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 itgb1bp1ENSDARG00000007169Danio rerio
 ITGB1BP1ENSGALG00000016421Gallus gallus
 O14713ENSG00000119185Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR006020  PTB/PI domain
 IPR011993  PH-like domain superfamily
 IPR019517  Integrin binding protein, ICAP-1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis ISO
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006469 negative regulation of protein kinase activity ISO
 biological_processGO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration IDA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007160 cell-matrix adhesion ISS
 biological_processGO:0007219 Notch signaling pathway IEA
 biological_processGO:0007229 integrin-mediated signaling pathway ISO
 biological_processGO:0008284 positive regulation of cell proliferation ISS
 biological_processGO:0008285 negative regulation of cell proliferation ISS
 biological_processGO:0010595 positive regulation of endothelial cell migration ISS
 biological_processGO:0010764 negative regulation of fibroblast migration IDA
 biological_processGO:0015031 protein transport ISO
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030155 regulation of cell adhesion ISO
 biological_processGO:0031214 biomineral tissue development IEA
 biological_processGO:0032091 negative regulation of protein binding ISS
 biological_processGO:0032148 activation of protein kinase B activity ISO
 biological_processGO:0033622 integrin activation IDA
 biological_processGO:0033628 regulation of cell adhesion mediated by integrin IMP
 biological_processGO:0035148 tube formation ISO
 biological_processGO:0035924 cellular response to vascular endothelial growth factor stimulus ISO
 biological_processGO:0043087 regulation of GTPase activity ISS
 biological_processGO:0043113 receptor clustering IDA
 biological_processGO:0044344 cellular response to fibroblast growth factor stimulus ISO
 biological_processGO:0045747 positive regulation of Notch signaling pathway ISS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISS
 biological_processGO:0050880 regulation of blood vessel size ISO
 biological_processGO:0051451 myoblast migration IMP
 biological_processGO:0051496 positive regulation of stress fiber assembly IDA
 biological_processGO:0051781 positive regulation of cell division IEA
 biological_processGO:0051894 positive regulation of focal adhesion assembly IDA
 biological_processGO:0051895 negative regulation of focal adhesion assembly ISO
 biological_processGO:0051897 positive regulation of protein kinase B signaling ISS
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade ISS
 biological_processGO:0090051 negative regulation of cell migration involved in sprouting angiogenesis ISS
 biological_processGO:0090314 positive regulation of protein targeting to membrane IDA
 biological_processGO:0090315 negative regulation of protein targeting to membrane ISO
 biological_processGO:1900025 negative regulation of substrate adhesion-dependent cell spreading ISS
 biological_processGO:2001044 regulation of integrin-mediated signaling pathway IMP
 cellular_componentGO:0001726 ruffle ISS
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005815 microtubule organizing center ISO
 cellular_componentGO:0005829 cytosol ISS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016604 nuclear body ISO
 cellular_componentGO:0030027 lamellipodium ISS
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISS
 cellular_componentGO:0071944 cell periphery ISS
 molecular_functionGO:0005092 GDP-dissociation inhibitor activity ISO
 molecular_functionGO:0005178 integrin binding ISO
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008022 protein C-terminus binding ISO
 molecular_functionGO:0008565 protein transporter activity ISO
 molecular_functionGO:0019900 kinase binding IPI
 molecular_functionGO:0019901 protein kinase binding IDA
 molecular_functionGO:0044877 protein-containing complex binding ISS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000060 delayed bone ossification "late onset of the formation of bone" [J:40203]
Show

Allelic Composition: Jag1Mhdahtu/Jag1+
Genetic Background: C3HeB/FeJ-Jag1Mhdahtu

 MP:0000074 abnormal neurocranium morphology "malformed bones of the skull enclosing the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]
Show

Allelic Composition: Jag1Mhdahtu/Jag1+
Genetic Background: C3HeB/FeJ-Jag1Mhdahtu

 MP:0000085 large anterior fontanelle "enlarged diamond-shaped membranous interval at the junction of the coronal, sagittal and metopic sutures of the cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Jag1Mhdahtu/Jag1+
Genetic Background: C3HeB/FeJ-Jag1Mhdahtu

 MP:0000137 abnormal vertebrae morphology "malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Jag1Mhdahtu/Jag1+
Genetic Background: C3HeB/FeJ-Jag1Mhdahtu

 MP:0000438 abnormal skull morphology "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Jag1Mhdahtu/Jag1+
Genetic Background: C3HeB/FeJ-Jag1Mhdahtu

 MP:0000440 domed skull 
Show

Allelic Composition: Jag1Mhdahtu/Jag1+
Genetic Background: C3HeB/FeJ-Jag1Mhdahtu

 MP:0000445 short snout "reduced length of the anterior facial part of the muzzle" [J:53370]
Show

Allelic Composition: Jag1Mhdahtu/Jag1+
Genetic Background: C3HeB/FeJ-Jag1Mhdahtu

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Jag1Mhdahtu/Jag1+
Genetic Background: C3HeB/FeJ-Jag1Mhdahtu

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Jag1Mhdahtu/Jag1+
Genetic Background: C3HeB/FeJ-Jag1Mhdahtu

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Jag1Mhdahtu/Jag1+
Genetic Background: C3HeB/FeJ-Jag1Mhdahtu

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ncoa1tm1Hkaw/Ncoa1tm1Hkaw
Genetic Background: involves: C57BL/6J

 MP:0002750 exophthalmos "protrusion of one or both eyeballs" [J:47965, il:Ira Lu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Jag1Mhdahtu/Jag1+
Genetic Background: C3HeB/FeJ-Jag1Mhdahtu

 MP:0003723 abnormal long bone morphology "malformation of any of the several elongated bones of the extremities " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Jag1Mhdahtu/Jag1+
Genetic Background: C3HeB/FeJ-Jag1Mhdahtu

 MP:0003840 abnormal coronal suture morphology "malformation of the articulation between the parietal bones and the frontal bone" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99]
Show

Allelic Composition: Jag1Mhdahtu/Jag1+
Genetic Background: C3HeB/FeJ-Jag1Mhdahtu

 MP:0003843 abnormal sagittal suture morphology "malformation of the articulation between the parietal bones" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99]
Show

Allelic Composition: Jag1Mhdahtu/Jag1+
Genetic Background: C3HeB/FeJ-Jag1Mhdahtu

 MP:0004420 parietal bone hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, in the curved bone forming part of the vault of the cranium" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Jag1Mhdahtu/Jag1+
Genetic Background: C3HeB/FeJ-Jag1Mhdahtu

 MP:0004509 abnormal pelvic girdle bone morphology "any structural anomaly of the bones of the pelvis by which the limbs attach to the axial skeleton " [MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Jag1Mhdahtu/Jag1+
Genetic Background: C3HeB/FeJ-Jag1Mhdahtu

 MP:0004599 abnormal vertebral arch morphology "any structural anomaly of the dorsal part of a vertebra, consisting of a pair of pedicles, a pair of laminae, and seven processes (four articular processes, two transverse processes, and one spinous process)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Jag1Mhdahtu/Jag1+
Genetic Background: C3HeB/FeJ-Jag1Mhdahtu

 MP:0004686 decreased length of long bones "reduced end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Jag1Mhdahtu/Jag1+
Genetic Background: C3HeB/FeJ-Jag1Mhdahtu

 MP:0004989 decreased osteoblast cell number "reduction in the number of the bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Jag1Mhdahtu/Jag1+
Genetic Background: C3HeB/FeJ-Jag1Mhdahtu

 MP:0008271 abnormal bone ossification "any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]
Show

Allelic Composition: Jag1Mhdahtu/Jag1+
Genetic Background: C3HeB/FeJ-Jag1Mhdahtu

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Jag1Mhdahtu/Jag1+
Genetic Background: C3HeB/FeJ-Jag1Mhdahtu

 MP:0030189 broad snout "increased width of the anterior facial part of the face or muzzle containing the oral and nasal regions" [MGI:anna]
Show

Allelic Composition: Jag1Mhdahtu/Jag1+
Genetic Background: C3HeB/FeJ-Jag1Mhdahtu

 MP:0030387 large posterior fontanelle "an abnormally increased size of the triangle-shaped membranous interval between the pair of parietal bones and the occipital bone for age-related norms; the posterior fontanelle is located at the lambda, at the junction between the sagittal suture and the lambdoid suture" [MGI:anna]
Show

Allelic Composition: Jag1Mhdahtu/Jag1+
Genetic Background: C3HeB/FeJ-Jag1Mhdahtu

 MP:0030431 wide metopic suture "an abnormally increased width of the metopic suture for age-related norms" [MGI:anna]
Show

Allelic Composition: Jag1Mhdahtu/Jag1+
Genetic Background: C3HeB/FeJ-Jag1Mhdahtu

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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