ENSMUSG00000062729


Mus musculus

Features
Gene ID: ENSMUSG00000062729
  
Biological name :Ppox
  
Synonyms : P51175 / Ppox / Protoporphyrinogen oxidase
  
Possible biological names infered from orthology : P50336
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: H3
Gene start: 171275990
Gene end: 171281186
  
Corresponding Affymetrix probe sets: 10360090 (MoGene1.0st)   1416618_at (Mouse Genome 430 2.0 Array)   1441862_at (Mouse Genome 430 2.0 Array)   1448065_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000072863
Ensembl peptide - ENSMUSP00000141835
NCBI entrez gene - 19044     See in Manteia.
MGI - MGI:104968
RefSeq - XM_011238775
RefSeq - NM_008911
RefSeq - XM_006496709
RefSeq - XM_011238772
RefSeq - XM_011238773
RefSeq - XM_006496707
RefSeq Peptide - NP_032937
swissprot - P51175
swissprot - A0A0A6YX50
Ensembl - ENSMUSG00000062729
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ppoxENSDARG00000102167Danio rerio
 PPOXENSG00000143224Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002937  Amine oxidase
 IPR004572  Protoporphyrinogen oxidase
 IPR036188  FAD/NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006779 porphyrin-containing compound biosynthetic process IEA
 biological_processGO:0006782 protoporphyrinogen IX biosynthetic process IEA
 biological_processGO:0006783 heme biosynthetic process ISO
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0046501 protoporphyrinogen IX metabolic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005743 mitochondrial inner membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031304 intrinsic component of mitochondrial inner membrane IDA
 cellular_componentGO:0031305 integral component of mitochondrial inner membrane IEA
 cellular_componentGO:0031966 mitochondrial membrane IEA
 molecular_functionGO:0004729 oxygen-dependent protoporphyrinogen oxidase activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA


Pathways (from Reactome)
Pathway description
Heme biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003868 abnormal feces composition "increase or decrease in the amount of compunds normally found in the feces (fat, protein etc) or presence of material not normally seen in the feces" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh
Genetic Background: involves: 129P2/OlaHsd * CBA/CaJ

Allelic Composition: Ppoxtm1.1Had/Ppox+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh
Genetic Background: involves: 129P2/OlaHsd * CBA/CaJ

Allelic Composition: Ppoxtm1.1Had/Ppox+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009643 abnormal urine homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh
Genetic Background: involves: 129P2/OlaHsd * CBA/CaJ

Allelic Composition: Ppoxtm1.1Had/Ppox+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh
Genetic Background: involves: 129P2/OlaHsd * CBA/CaJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000062729 Ppox / P51175 / Protoporphyrinogen oxidase / P50336*  / complex






 

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