ENSMUSG00000062937


Mus musculus

Features
Gene ID: ENSMUSG00000062937
  
Biological name :Mtap
  
Synonyms : Mtap / Q9CQ65 / S-methyl-5-thioadenosine phosphorylase
  
Possible biological names infered from orthology : methylthioadenosine phosphorylase / Q13126
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: C4
Gene start: 89137122
Gene end: 89181081
  
Corresponding Affymetrix probe sets: 10505894 (MoGene1.0st)   1424425_a_at (Mouse Genome 430 2.0 Array)   1424426_at (Mouse Genome 430 2.0 Array)   1451345_at (Mouse Genome 430 2.0 Array)   1451346_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000061092
NCBI entrez gene - 66902     See in Manteia.
MGI - MGI:1914152
RefSeq - NM_024433
RefSeq Peptide - NP_077753
swissprot - Q9CQ65
Ensembl - ENSMUSG00000062937
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mtapENSDARG00000037261Danio rerio
 MTAPENSGALG00000008174Gallus gallus
 MTAPENSG00000099810Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000845  Nucleoside phosphorylase domain
 IPR010044  Methylthioadenosine phosphorylase (MTAP)
 IPR018099  Purine phosphorylase, family 2, conserved site
 IPR035994  Nucleoside phosphorylase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006166 purine ribonucleoside salvage IEA
 biological_processGO:0009116 nucleoside metabolic process IEA
 biological_processGO:0019509 L-methionine salvage from methylthioadenosine IEA
 biological_processGO:0032259 methylation IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016757 transferase activity, transferring glycosyl groups IEA
 molecular_functionGO:0016763 transferase activity, transferring pentosyl groups IEA
 molecular_functionGO:0017061 S-methyl-5-thioadenosine phosphorylase activity IEA


Pathways (from Reactome)
Pathway description
Methionine salvage pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Iglc1tm2Ust/Iglc1tm2Ust
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002264 abnormal bronchus morphology "any structural anomaly of of the upper conducting airways of the lung; these airways arise from the terminus of the trachea " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Iglc1tm2Ust/Iglc1tm2Ust
Genetic Background: involves: 129S7/SvEvBrd

 MP:0010138 arteritis "inflammation of the walls of arteries, usually as a result of infection or auto-immune response" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Iglc1tm2Ust/Iglc1tm2Ust
Genetic Background: involves: 129S7/SvEvBrd

 MP:0011097 complete embryonic lethality before turning of embryo "death of all organisms of a given genotype in a population between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]
Show

Allelic Composition: Iglc1tm2Ust/Iglc1tm2Ust
Genetic Background: involves: 129S7/SvEvBrd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000062937 Mtap / Q9CQ65 / S-methyl-5-thioadenosine phosphorylase / Q13126* / methylthioadenosine phosphorylase*  / complex






 

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