ENSMUSG00000063015


Mus musculus

Features
Gene ID: ENSMUSG00000063015
  
Biological name :Ccni
  
Synonyms : Ccni / Cyclin-I / Q9Z2V9
  
Possible biological names infered from orthology : Q14094
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: E2
Gene start: 93181933
Gene end: 93206495
  
Corresponding Affymetrix probe sets: 10415574 (MoGene1.0st)   10531488 (MoGene1.0st)   1416427_at (Mouse Genome 430 2.0 Array)   1448334_a_at (Mouse Genome 430 2.0 Array)   1448335_s_at (Mouse Genome 430 2.0 Array)   1459602_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000050189
Ensembl peptide - ENSMUSP00000143972
Ensembl peptide - ENSMUSP00000122434
Ensembl peptide - ENSMUSP00000116224
NCBI entrez gene - 12453     See in Manteia.
MGI - MGI:1341077
RefSeq - XM_006534736
RefSeq - NM_017367
RefSeq Peptide - NP_059063
swissprot - D3Z602
swissprot - D3Z680
swissprot - Q9Z2V9
swissprot - A0A0J9YU25
Ensembl - ENSMUSG00000063015
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ccniENSDARG00000068214Danio rerio
 CCNIENSGALG00000011457Gallus gallus
 CCNIENSG00000118816Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ccng2 / O08918 / Cyclin-G2 / Q16589*ENSMUSG0000002938524
Ccng1 / P51945 / Cyclin-G1 / P51959*ENSMUSG0000002032621


Protein motifs (from Interpro)
Interpro ID Name
 IPR006671  Cyclin, N-terminal
 IPR013763  Cyclin-like
 IPR028856  Cyclin I
 IPR036915  Cyclin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0045859 regulation of protein kinase activity IEA
 biological_processGO:0051726 regulation of cell cycle IEA
 molecular_functionGO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity ISS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002962 increased protein excretion "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]
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Allelic Composition: Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003606 kidney failure "cessation of renal function" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005264 glomerulosclerosis "hyaline deposits or scarring within the renal glomeruli, often occurring with renal arteriosclerosis or diabetes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005553 increased circulating creatinine level "greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011282 increased podocyte apoptosis "increase in the number of podocytes undergoing programmed cell death; podocyte apoptosis is an early step in the pathophysiological progression to proteinuria and glomerulosclerosis" [MGI:anna]
Show

Allelic Composition: Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011369 increased renal glomerulus apoptosis "increase in the number of cells of the kidney glomerulus undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011753 decreased podocyte number "reduced number of the modified epithelial cells of the visceral layer of the Bowman capsule in the renal corpuscle" [MGI:anna]
Show

Allelic Composition: Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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