ENSMUSG00000063281


Mus musculus

Features
Gene ID: ENSMUSG00000063281
  
Biological name :Zfp35
  
Synonyms : P15620 / Zfp35 / zinc finger protein 35
  
Possible biological names infered from orthology :
  
Species: Mus musculus
  
Chr. number: 18
Strand: 1
Band: A2
Gene start: 23989632
Gene end: 24005376
  
Corresponding Affymetrix probe sets: 10454306 (MoGene1.0st)   1417778_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000074475
NCBI entrez gene - 22694     See in Manteia.
MGI - MGI:99179
RefSeq - NM_011755
RefSeq Peptide - NP_035885
swissprot - P15620
swissprot - Q3V142
Ensembl - ENSMUSG00000063281
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CT027801.1ENSDARG00000096005Danio rerio


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Zfp420 / zinc finger protein 420 / Q86YE8* / O75290* / ZNF573* / ZNF780A* / zinc finger protein 573* / zinc finger protein 780A*ENSMUSG0000005840252
Zfp712 / Q5SXM1* / ZNF678* / zinc finger protein 678*ENSMUSG0000009064151
Q7TSH9 / Zfp184 / zinc finger protein 184 (Kruppel-like) / Q99676* / ZNF184* / zinc finger protein 184*ENSMUSG0000000672050
Gm14399ENSMUSG0000009009347
Zfp189 / zinc finger protein 189 / O75820* / ZNF189*ENSMUSG0000003963447
Q9EQB9 / Zfp287 / zinc finger protein 287 / Q9HBT7* / ZNF287*ENSMUSG0000000526743
Zfp612 / zinc finger protein 612 / ZNF23* / P17027* / zinc finger protein 23*ENSMUSG0000004467643
Q8BI99 / Zfp879 / zinc finger protein 879 / B4DU55* / ZNF879*ENSMUSG0000004429640
Zfp2 / P08043 / zinc finger protein 2 / Q6ZN57* / ZFP2 zinc finger protein*ENSMUSG0000004932139
Zfp11 / P10751 / zinc finger protein 11 / Q5SXM1* / ZNF678* / zinc finger protein 678*ENSMUSG0000005103439
Zkscan7 / zinc finger with KRAB and SCAN domains 7 / Q9P0L1*ENSMUSG0000006348838
Zfp3 / Q8BLB0 / zinc finger protein 3 / Q96NJ6* / ZFP3 zinc finger protein*ENSMUSG0000004360238


Protein motifs (from Interpro)
Interpro ID Name
 IPR013087  Zinc finger C2H2-type
 IPR017125  PR-domain zinc finger protein PRDM5-like
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002437 inflammatory response to antigenic stimulus IMP
 biological_processGO:0002829 negative regulation of type 2 immune response IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0045629 negative regulation of T-helper 2 cell differentiation IMP
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000976 transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IBA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001952 increased airway responsiveness "more easily provoked into bronchoconstriction in bronchial provocation tests" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd3gtm1.1Cage/Cd3gtm1.1Cage,Tg(TcrLCMV)318Sdz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N

 MP:0005011 increased eosinophil count "greater than normal eosinophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd3gtm1.1Cage/Cd3gtm1.1Cage,Tg(TcrLCMV)318Sdz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N

 MP:0008092 abnormal T-helper 2 cell differentiation "atypical production of or inability to produce the type of T-helper cell whose cytokine production promotes defense against extracellular parasites and humoral immune responses typical of allergy" [CL:0000546, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd3gtm1.1Cage/Cd3gtm1.1Cage,Tg(TcrLCMV)318Sdz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N

 MP:0008602 increased circulating interleukin-4 level "increase in the amount in the blood of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
Show

Allelic Composition: Cd3gtm1.1Cage/Cd3gtm1.1Cage,Tg(TcrLCMV)318Sdz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N

 MP:0008608 increased circulating interleukin-13 level "increase in the amount in the blood of a cytokine synthesized by T-cells that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-cells, and appears to play a role in regulating inflammatory and immune responses" [MESH:D12.644.276.374.465.513]
Show

Allelic Composition: Cd3gtm1.1Cage/Cd3gtm1.1Cage,Tg(TcrLCMV)318Sdz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N

 MP:0008626 increased circulating interleukin-5 level "increase in the amount in the blood of a cytokine that promotes differentiation and activation of eosinophils; it also triggers activated B-cells to differentiate into immunoglobulin-secreting cells" [MESH:D12.644.276.374.465.505]
Show

Allelic Composition: Cd3gtm1.1Cage/Cd3gtm1.1Cage,Tg(TcrLCMV)318Sdz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr