Manteia - Molecule gene

ENSMUSG00000063931

Mus musculus

Features

Gene ID:	ENSMUSG00000063931

Biological name :	Pepd

Synonyms :	Pepd / peptidase D / Q11136

Possible biological names infered from orthology :	P12955

Species:	Mus musculus

Chr. number:	7
Strand:	1
Band:	B2
Gene start:	34912379
Gene end:	35044708

Corresponding Affymetrix probe sets:	10552125 (MoGene1.0st) 1416712_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000133634 Ensembl peptide - ENSMUSP00000075683 NCBI entrez gene - 18624 See in Manteia. MGI - MGI:97542 RefSeq - NM_008820 RefSeq - XM_006539622 RefSeq Peptide - NP_032846 swissprot - G3UXC5 swissprot - A2RS23 swissprot - Q11136 Ensembl - ENSMUSG00000063931

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
PEPD	ENSDARG00000102249	Danio rerio
PEPD	ENSGALG00000004899	Gallus gallus
PEPD	ENSG00000124299	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name

ID

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR000994	Peptidase M24
IPR001131	Peptidase M24B, X-Pro dipeptidase/aminopeptidase P, conserved site
IPR007865	Aminopeptidase P, N-terminal
IPR029149	Creatinase/Aminopeptidase P/Spt16, N-terminal
IPR036005	Creatinase/aminopeptidase-like

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006508	proteolysis	IEA
biological_process	GO:0030574	collagen catabolic process	IEA
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005654	nucleoplasm	IEA
molecular_function	GO:0004177	aminopeptidase activity	IEA
molecular_function	GO:0008233	peptidase activity	IDA
molecular_function	GO:0008237	metallopeptidase activity	IEA
molecular_function	GO:0016787	hydrolase activity	IEA
molecular_function	GO:0016805	dipeptidase activity	IEA
molecular_function	GO:0030145	manganese ion binding	IEA
molecular_function	GO:0046872	metal ion binding	IEA
molecular_function	GO:0102009	proline dipeptidase activity	IEA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000266	abnormal cardiac morphology	"anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Esr2^tm1.1Ksk/Esr2^tm1.1Ksk Genetic Background: involves: C57BL/6
MP:0000278	abnormal myocardial fiber morphology	"malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]	Show Allelic Composition: Esr2^tm1.1Ksk/Esr2^tm1.1Ksk Genetic Background: involves: C57BL/6
MP:0000372	irregular coat pigmentation	"uneven coloration of the hair" [J:65030]	Show Allelic Composition: Stat3^tm1Flv/Stat3^tm1Flv,Tg(Tek-cre)1Xyfu/0 Genetic Background: involves: C57BL/6
MP:0001146	abnormal testis morphology	"anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Esr2^tm1.1Ksk/Esr2^tm1.1Ksk Genetic Background: involves: C57BL/6 Allelic Composition: Atrn^mg-3J/Atrn⁺,Pepd^dal/Pepd^dal Genetic Background: involves: C3H/HeJ * C3HeB/FeJ * CBA/J Allelic Composition: Atrn^mg-3J/Atrn⁺,Pepd^dal/Pepd⁺ Genetic Background: involves: C3H/HeJ * C3HeB/FeJ * CBA/J Allelic Composition: Pepd^dal/Pepd^dal Genetic Background: involves: C3H/HeJ * C3HeB/FeJ * CBA/J Allelic Composition: Pepd^dal/Pepd^dal,Tg(ACTB-Atrnl1)B4Tmg/0 Genetic Background: involves: C57BL/6 * CBA/J * DBA/J
MP:0001147	small testis	"reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]	Show Allelic Composition: Esr2^tm1.1Ksk/Esr2^tm1.1Ksk Genetic Background: involves: C57BL/6
MP:0001261	obese	"excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]	Show Allelic Composition: A^y/A,Pepd^dal/Pepd^dal Genetic Background: involves: C3H/HeJ * CBA/J
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Stat3^tm1Flv/Stat3^tm1Flv,Tg(Tek-cre)1Xyfu/0 Genetic Background: involves: C57BL/6 Allelic Composition: Pepd^dal/Pepd^dal Genetic Background: involves: CAST/EiJ * CBA/J Allelic Composition: Mc1r^e/Mc1r^e,Pepd^dal/Pepd^dal Genetic Background: involves: C57BL/6J * CBA/J
MP:0002216	abnormal seminiferous tubule morphology	"malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Esr2^tm1.1Ksk/Esr2^tm1.1Ksk Genetic Background: involves: C57BL/6
MP:0002780	decreased circulating testosterone level	"less than the normal blood concentration of this most potent androgen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Esr2^tm1.1Ksk/Esr2^tm1.1Ksk Genetic Background: involves: C57BL/6
MP:0002953	thick ventricular wall	"increased depth of the cardiac wall of the heart ventricles" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]	Show Allelic Composition: Pepd^dal/Pepd^dal Genetic Background: involves: C3H/HeJ * CBA/J
MP:0003136	yellow coat color	"amount and distribution of yellow pigment (phaeomelanin) relative to black or brown pigment (eumelanin) is increased compared to wild-type agouti" [llw2:Linda L. Washburn, Mouse Genome Informatics Curator]	Show Allelic Composition: Mc1r^e/Mc1r^e,Pepd^dal/Pepd^dal Genetic Background: involves: C57BL/6J * CBA/J
MP:0003808	enlarged endocardial cushions	"larger than normal mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal" [mac:Megan A. Cassell, Mouse Genome Informatics Curator]	Show Allelic Composition: Pepd^dal/Pepd^dal Genetic Background: involves: C3H/HeJ * CBA/J
MP:0003984	embryonic growth retardation	"slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Pepd^dal/Pepd^dal Genetic Background: involves: C3H/HeJ * CBA/J
MP:0005014	increased B cell number	"greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Padi6^{tm1b(KOMP)Wtsi}/Padi6^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Padi6^{tm1b(KOMP)Wtsi}/Ucd
MP:0005015	increased T cell number	"greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Padi6^{tm1b(KOMP)Wtsi}/Padi6^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Padi6^{tm1b(KOMP)Wtsi}/Ucd
MP:0005409	darkened coat color	"amount and distribution of yellow pigment (phaeomelanin) relative to black or brown pigment (eumelanin) is decreasesd when compared to wild-type agouti" [llw2:Linda Washburn , Mouse Genome Informatics Curator]	Show Allelic Composition: Stat3^tm1Flv/Stat3^tm1Flv,Tg(Tek-cre)1Xyfu/0 Genetic Background: involves: C57BL/6 Allelic Composition: Pepd^dal/Pepd^dal Genetic Background: involves: C3H/HeJ * CBA/J Allelic Composition: Pepd^dal/Pepd^dal Genetic Background: involves: CAST/EiJ * CBA/J Allelic Composition: A^y/A,Pepd^dal/Pepd^dal Genetic Background: involves: C3H/HeJ * CBA/J Allelic Composition: Atrn^mg-3J/Atrn⁺,Pepd^dal/Pepd^dal Genetic Background: involves: C3H/HeJ * C3HeB/FeJ * CBA/J Allelic Composition: Pepd^dal/Pepd^dal,Tg(ACTB-Atrnl1)B4Tmg/0 Genetic Background: involves: C57BL/6 * CBA/J * DBA/J
MP:0005431	oocyte depletion	"reduced numbers or absence of germ cells in the female" [llw2:Linda Washburn , Mouse Genome Informatics Curator, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Stat3^tm1Flv/Stat3^tm1Flv,Tg(Tek-cre)1Xyfu/0 Genetic Background: involves: C57BL/6
MP:0006113	abnormal heart septum morphology	"abnormality in the wall between the atria or ventricles of the heart, usually incomplete closure" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Pepd^dal/Pepd^dal Genetic Background: involves: C3H/HeJ * CBA/J
MP:0008025	brain vacuoles	"the abnormal presence of cavities or fluid-filled vesicles in the soma of brain cells, often indicative of spongiosis or other pathological states" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pepd^dal/Pepd^dal Genetic Background: involves: C3H/HeJ * CBA/J Allelic Composition: Atrn^mg-3J/Atrn⁺,Pepd^dal/Pepd^dal Genetic Background: involves: C3H/HeJ * C3HeB/FeJ * CBA/J Allelic Composition: Pepd^dal/Pepd^dal Genetic Background: involves: C3H/HeJ * C3HeB/FeJ * CBA/J
MP:0008044	increased NK cell number	"greater number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]	Show Allelic Composition: Padi6^{tm1b(KOMP)Wtsi}/Padi6^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Padi6^{tm1b(KOMP)Wtsi}/Ucd
MP:0008074	increased CD4-positive T cell number	"greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Padi6^{tm1b(KOMP)Wtsi}/Padi6^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Padi6^{tm1b(KOMP)Wtsi}/Ucd
MP:0008078	increased CD8-positive T cell number	"greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Padi6^{tm1b(KOMP)Wtsi}/Padi6^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Padi6^{tm1b(KOMP)Wtsi}/Ucd
MP:0008346	increased gamma-delta T cell number	"greater number of immature or mature T cells expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]	Show Allelic Composition: Padi6^{tm1b(KOMP)Wtsi}/Padi6^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Padi6^{tm1b(KOMP)Wtsi}/Ucd
MP:0008347	decreased gamma-delta T cell number	"reduced number of immature or mature T cells expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]	Show Allelic Composition: Padi6^{tm1b(KOMP)Wtsi}/Padi6^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Padi6^{tm1b(KOMP)Wtsi}/Ucd
MP:0008788	abnormal fetal cardiomyocyte morphology	"any structural anomaly of fetal and neonatal heart cells that undergo proliferation and are not yet terminally differentiated into binucleate or multinucleate cardiac myocytes" [PMID:17429040]	Show Allelic Composition: Pepd^dal/Pepd^dal Genetic Background: involves: C3H/HeJ * CBA/J
MP:0009643	abnormal urine homeostasis	"anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Stat3^tm1Flv/Stat3^tm1Flv,Tg(Tek-cre)1Xyfu/0 Genetic Background: involves: C57BL/6
MP:0009925	increased transitional stage T2 B cell number	"greater number of a type of a transitional stage B cell that has the phenotype surface IgM-positive, surface IgD-postive, CD21-positive, CD23-positive, CD62L-negative, and is located in the splenic B follicles" [PMID:12810111]	Show Allelic Composition: Padi6^{tm1b(KOMP)Wtsi}/Padi6^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Padi6^{tm1b(KOMP)Wtsi}/Ucd
MP:0010168	increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number	"a greater number of the CD4-positive, CD25-positive T cell subset which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release" [ISBN:0781735149]	Show Allelic Composition: Padi6^{tm1b(KOMP)Wtsi}/Padi6^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Padi6^{tm1b(KOMP)Wtsi}/Ucd
MP:0010402	ventricular septal defect	"abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]	Show Allelic Composition: Pepd^dal/Pepd^dal Genetic Background: involves: C3H/HeJ * CBA/J
MP:0010412	atrioventricular septal defect	"defects in the thin membranous structure between the right atrium and left ventricle that arise from faulty development of the embryonic endocardial cushions; the spectrum ranges from a primum atrial septal defect and cleft mitral valve, known as a partial atrioventricular septal defect (partial AVSD), to defects of both the primum atrial septum and inlet ventricular septum and the presence of a common atrioventricular valve, referred to as complete atrioventricular septal defect (complete AVSD)" [http://emedicine.medscape.com]	Show Allelic Composition: Pepd^dal/Pepd^dal Genetic Background: involves: C3H/HeJ * CBA/J
MP:0010630	abnormal cardiac muscle tissue morphology	"any structural anomaly of the involuntary muscle comprising the myocardium of the heart and the walls of the pulmonary veins and superior vena cava; cardiac muscle is striated and multinucleate, and the cardiomyocytes branch and are joined to one another via intercalated discs" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Pepd^dal/Pepd^dal Genetic Background: involves: C3H/HeJ * CBA/J
MP:0010633	myocardial hypertrophy	"an increase in size of the myocardium, not due to increased cell number" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pepd^dal/Pepd^dal Genetic Background: involves: C3H/HeJ * CBA/J
MP:0010724	thick interventricular septum	"increased thickness of the wall between the two lower chambers of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pepd^dal/Pepd^dal Genetic Background: involves: C3H/HeJ * CBA/J
MP:0010770	preweaning lethality	"death anytime between fertilization and weaning (Mus: approximately 3-4 weeks of age)" [MGI:Sanger_Karp "Submission from Natasha Karp"]	Show Allelic Composition: Pepd^dal/Pepd^dal Genetic Background: involves: CAST/EiJ * CBA/J
MP:0011086	partial postnatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Pepd^dal/Pepd^dal Genetic Background: involves: C3H/HeJ * CBA/J
MP:0011101	partial prenatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Pepd^dal/Pepd^dal Genetic Background: involves: C3H/HeJ * CBA/J
MP:0011390	abnormal fetal cardiomyocyte physiology	"any functional anomaly of fetal and neonatal heart cells that undergo proliferation and are not yet terminally differentiated into binucleate or multinucleate cardiac myocytes" [MGI:csmith, PMID:17429040]	Show Allelic Composition: Pepd^dal/Pepd^dal Genetic Background: involves: CAST/EiJ * CBA/J
MP:0011416	abnormal testis interstitial tissue morphology	"any structural anomaly of the delicate connective tissue stroma that separates the seminiferous tubules and contains clusters of endocrine Leydig cells which secrete testosterone" [ISBN:0-683-40008-8]	Show Allelic Composition: Pepd^dal/Pepd^dal Genetic Background: involves: C3H/HeJ * CBA/J
MP:0011640	abnormal aorta collagen fibril morphology	"any structural anomaly of the connective tissue bundles in the extracellular matrix of aorta tissue that are composed of collagen, and play a role in tissue strength and elasticity" [MGI:csmith]	Show Allelic Composition: Pepd^dal/Pepd^dal Genetic Background: involves: C3H/HeJ * CBA/J
MP:0012076	abnormal agouti pigmentation	"amount and distribution of yellow pigment (phaeomelanin) relative to black or brown pigment (eumelanin) is variably increased or decreased compared with a wild-type agouti pattern resulting in a range of coat color from yellow to almost black" [MGI:llw2]	Show Allelic Composition: Pepd^dal/Pepd^dal Genetic Background: involves: CAST/EiJ * CBA/J
MP:0012764	increased alpha-beta T cell number	"greater number of T cells that expresses an alpha-beta T cell receptor complex" [CL:0000789]	Show Allelic Composition: Padi6^{tm1b(KOMP)Wtsi}/Padi6^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Padi6^{tm1b(KOMP)Wtsi}/Ucd
MP:0012767	increased KLRG1-positive NK cell number	"increase in the number of KLRG1 positive NK cells that represent a maturation subset of NK cells and is linked to NK cell proliferation" [MGI:Annie_Speak, PMID:19479342]	Show Allelic Composition: Padi6^{tm1b(KOMP)Wtsi}/Padi6^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Padi6^{tm1b(KOMP)Wtsi}/Ucd
MP:0013691	decreased CD5-positive Ly6C-positive T cell number	"reduction in the number of CD5-positive T cells expressing the memory marker Ly6C" [MGI:Saran]	Show Allelic Composition: Padi6^{tm1b(KOMP)Wtsi}/Padi6^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Padi6^{tm1b(KOMP)Wtsi}/Ucd
MP:0020254	decreased collagen level	"decreased level of the main structural protein of the various connective tissues in animals" [GOC:NV, PMID:11704682]	Show Allelic Composition: Pepd^dal/Pepd^dal Genetic Background: involves: C3H/HeJ * CBA/J

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

1 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr