ENSMUSG00000064120


Mus musculus

Features
Gene ID: ENSMUSG00000064120
  
Biological name :Mocs1
  
Synonyms : Mocs1 / Molybdenum cofactor biosynthesis protein 1 GTP 3,8-cyclase Cyclic pyranopterin monophosphate synthase / Q5RKZ7
  
Possible biological names infered from orthology : molybdenum cofactor synthesis 1 / Q9NZB8
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: C
Gene start: 49428362
Gene end: 49455435
  
Corresponding Affymetrix probe sets: 10445826 (MoGene1.0st)   1425004_s_at (Mouse Genome 430 2.0 Array)   1460520_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000134449
Ensembl peptide - ENSMUSP00000024797
Ensembl peptide - ENSMUSP00000132371
Ensembl peptide - ENSMUSP00000133694
Ensembl peptide - ENSMUSP00000133713
Ensembl peptide - ENSMUSP00000133761
Ensembl peptide - ENSMUSP00000134265
NCBI entrez gene - 56738     See in Manteia.
MGI - MGI:1928904
RefSeq - XM_006524682
RefSeq - NM_020042
RefSeq - NM_028464
RefSeq - XM_006524680
RefSeq - XM_006524681
RefSeq Peptide - NP_064426
RefSeq Peptide - NP_082740
swissprot - G3UXN5
swissprot - G3UYX9
swissprot - G3UZD4
swissprot - Q5RKZ7
swissprot - G3UXJ3
swissprot - G3UWH1
Ensembl - ENSMUSG00000064120
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mocs1ENSDARG00000078479Danio rerio
 ENSGALG00000039801Gallus gallus
 ENSGALG00000010051Gallus gallus
 MOCS1ENSG00000124615Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000385  MoaA/nifB/pqqE, iron-sulphur binding, conserved site
 IPR002820  Molybdopterin cofactor biosynthesis C (MoaC) domain
 IPR006638  Elp3/MiaB/NifB
 IPR007197  Radical SAM
 IPR010505  Molybdenum cofactor synthesis C-terminal
 IPR013483  Molybdenum cofactor biosynthesis protein A
 IPR013785  Aldolase-type TIM barrel
 IPR023045  Molybdenum cofactor biosynthesis C
 IPR034395  SPASM/twitch domain-containing
 IPR034481  Main SPASM domain-containing
 IPR036522  Molybdopterin cofactor biosynthesis C (MoaC) domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006777 Mo-molybdopterin cofactor biosynthetic process IEA
 biological_processGO:0032324 molybdopterin cofactor biosynthetic process IMP
 cellular_componentGO:0019008 molybdopterin synthase complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051536 iron-sulfur cluster binding IEA
 molecular_functionGO:0051539 4 iron, 4 sulfur cluster binding IEA
 molecular_functionGO:0061798 GTP 3",8"-cyclase activity ISO
 molecular_functionGO:0061799 cyclic pyranopterin monophosphate synthase activity ISO


Pathways (from Reactome)
Pathway description
Molybdenum cofactor biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Casp4tm1Yuan/Casp4tm1Yuan
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2

 MP:0001274 curly vibrissae "whiskers twisted into coils or spirals" [J:47620]
Show

Allelic Composition: Casp4tm1Yuan/Casp4tm1Yuan
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2

 MP:0003311 aminoaciduria "excretion of amino acids in the urine, especially in excessive amounts" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:66560]
Show

Allelic Composition: Casp4tm1Yuan/Casp4tm1Yuan
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Casp4tm1Yuan/Casp4tm1Yuan
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2

 MP:0009643 abnormal urine homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Casp4tm1Yuan/Casp4tm1Yuan
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Casp4tm1Yuan/Casp4tm1Yuan
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2

 MP:0020400 cystinuria "excretion of excessive amounts of cystine in the urine" [HP:0003131]
Show

Allelic Composition: Casp4tm1Yuan/Casp4tm1Yuan
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2

 MP:0020405 increased urine taurine level "excretion of excessive amounts of taurine in the urine" [HP:0003166]
Show

Allelic Composition: Casp4tm1Yuan/Casp4tm1Yuan
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000064120 Mocs1 / Q5RKZ7 / Molybdenum cofactor biosynthesis protein 1 GTP 3,8-cyclase Cyclic pyranopterin monophosphate synthase / Q9NZB8* / molybdenum cofactor synthesis 1*  / complex






 

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