| MP:0000266 | abnormal cardiac morphology | "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0000274 | enlarged heart | "increase over normal size of the heart" [J:29971] |
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0001262 | decreased body weight | "lower than normal average weight " [J:61295] |
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0001263 | weight loss | "progressive reduction of body weight below normal average for age" [J:45400] |
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0001278 | kinked vibrissae | "sharp bends in the vibrissae" [J:56641] |
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0001393 | ataxia | "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231] |
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0001680 | abnormal mesoderm development | "failure or abnormality in the formation of the mesoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0001683 | absent mesoderm | "missing or failure to differentiate the middle primary germ layer " [J:40594] |
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0001687 | thin endoderm | "reduced thickness of the innermost germ layer of the embryo" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33880] |
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0001698 | reduced embryo size | "smaller proportions of embryo compared to littermates" [J:61790] |
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0001732 | postnatal growth retardation | "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0001914 | hemorrhage | "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0002085 | abnormal embryonic tissue morphology | "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0002621 | delayed neural tube closure | "delayed fusion of the neuroepithelial layer in early development" [J:79790, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator] |
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0003065 | abnormal hepatic copper content | "anomalous level of copper present in the liver tissue" [RGD:Rat Genome Database submission] |
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0003087 | absent allantois | "missing fetal membrane which contributes to the formation of the umbilical cord and placenta" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0003952 | abnormal copper level | "anomaly in the concentration in the body with respect to this metallic element that normally occurs in a number of proteins including amine oxidases and chaperone proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Slc31a1tm1Djt/Slc31a1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0003954 | abnormal Reichert s membrane | "aberrant structure of the extraembryonic basement membrane that forms on the inner surface of the trophectoderm beginning at E6.0 and is secreted by the distal endoderm; required for the maternofetal exchange of nutrients and is important for the postgastrulation development" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0004180 | failure of initiation of embryo turning | "failure to begin the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0004261 | abnormal embryonic neuroepithelium morphology | "any structural anomaly in the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0004272 | abnormal basement membrane morphology | "anomaly in the structure, organization and/or placement of the extracellular supportive tissue adjacent to the basal surface of the epithelia, including the epithelium of muscle cells, fat cells and Schwann cells; it is comprised of type IV collagen, laminin, and sulfated proteoglycans and other components and consists of two layers, the basal lamina and the lamina reticularis" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A10.272.220] |
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0004953 | decreased spleen weight | "reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0005408 | hypopigmentation | "dilution of the pigment in the body" [llw2:Linda Washburn , Mouse Genome Informatics Curator] |
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0005421 | loose skin | "condition in which the skin hangs in folds" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0005639 | hemosiderosis | "condition in which there is a generalized increase in the iron stores of body tissues, particularly of liver and the reticuloendothelial system, without demonstrable tissue damage" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0006301 | abnormal mesenchyme morphology | "abnormality in the loosely packed, unspecialized cells that derive mostly from the mesoderm and contribute to connective tissue, bone, cartilage and circulatory and lymphatic systems." [J:120305, mnk:Michelle Knowlton_MGI Curator] |
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0006349 | decreased circulating copper level | "less than the normal concentration of copper in the blood" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator", Riken ENU:Hiroshi Masuya] |
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0008743 | decreased liver iron level | "reduction in the amount of iron present in the liver tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Slc31a1tm1Djt/Slc31a1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0011086 | partial postnatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0011098 | complete embryonic lethality during organogenesis | "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith] |
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Slc31a1tm1Djt/Slc31a1tm1Djt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0011101 | partial prenatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith] |
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0011215 | decreased brain copper level | "a reduced amount of copper in the brain tissue compared to controls" [MGI:llw2] |
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0012096 | decreased Reichert s membrane thickness | "reduced width of the extraembryonic basement membrane that forms on the inner surface of the trophectoderm during placenta morphogenesis and is secreted by the distal parietal endoderm" [MGI:anna] |
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S7/SvEvBrd
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