ENSMUSG00000066839


Mus musculus

Features
Gene ID: ENSMUSG00000066839
  
Biological name :Ecsit
  
Synonyms : Ecsit / ECSIT signalling integrator
  
Possible biological names infered from orthology : Q9BQ95
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: A3
Gene start: 22072246
Gene end: 22085438
  
Corresponding Affymetrix probe sets: 10591726 (MoGene1.0st)   1417080_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000096537
Ensembl peptide - ENSMUSP00000135936
Ensembl peptide - ENSMUSP00000136247
Ensembl peptide - ENSMUSP00000137424
NCBI entrez gene - 26940     See in Manteia.
MGI - MGI:1349469
RefSeq - XM_011242540
RefSeq - NM_001253898
RefSeq - NM_012029
RefSeq - XM_006510370
RefSeq - XM_011242538
RefSeq - XM_011242539
RefSeq - NM_001253897
RefSeq Peptide - NP_001240827
RefSeq Peptide - NP_036159
RefSeq Peptide - NP_001240826
swissprot - J3KMM6
swissprot - A0A0R4J174
Ensembl - ENSMUSG00000066839
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ecsitENSDARG00000062834Danio rerio
 ECSITENSG00000130159Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR010418  ECSIT
 IPR029342  ECSIT, C-terminal domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0051341 regulation of oxidoreductase activity IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0016651 oxidoreductase activity, acting on NAD(P)H IEA


Pathways (from Reactome)
Pathway description
MyD88:Mal cascade initiated on plasma membrane
Complex I biogenesis
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
MyD88 cascade initiated on plasma membrane


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sox3tm1.1Lja/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001680 abnormal mesoderm development "failure or abnormality in the formation of the mesoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sox3tm1.1Lja/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001683 absent mesoderm "missing or failure to differentiate the middle primary germ layer " [J:40594]
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Allelic Composition: Sox3tm1.1Lja/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Sox3tm1.1Lja/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005330 cardiomyopathy "diseases of the heart (myocardium); may result from many causes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:80681]
Show

Allelic Composition: Bcat2mpc91H/Bcat2mpc91H
Genetic Background: involves: BALB/c * C3H/HeH * C57BL/6J

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Sox3tm1.1Lja/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011190 thick embryonic epiblast "increased thickness of the tissue derived from the inner cell mass that gives rise to the ectoderm, endoderm and mesoderm of the embryo proper and to the extraembryonic mesoderm" [PMID:21123814]
Show

Allelic Composition: Sox3tm1.1Lja/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000030614 Q9D1R1 / Tmem126b / Complex I assembly factor TMEM126B, mitochondrial / Q8IUX1* / transmembrane protein 126B*  / complex
 ENSMUSG00000027710 Acad9 / Q8JZN5 / acyl-Coenzyme A dehydrogenase family, member 9 / Q9H845* / acyl-CoA dehydrogenase family member 9*  / complex
 ENSMUSG00000027305 Ndufaf1 / NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 1 / Q9Y375* / NADH:ubiquinone oxidoreductase complex assembly factor 1*  / complex






 

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