ENSG00000130159


Homo sapiens

Features
Gene ID: ENSG00000130159
  
Biological name :ECSIT
  
Synonyms : ECSIT / ECSIT signalling integrator / Q9BQ95
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: p13.2
Gene start: 11505916
Gene end: 11529174
  
Corresponding Affymetrix probe sets: 218225_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000465181
Ensembl peptide - ENSP00000466559
Ensembl peptide - ENSP00000466762
Ensembl peptide - ENSP00000467436
Ensembl peptide - ENSP00000468783
Ensembl peptide - ENSP00000252440
Ensembl peptide - ENSP00000270517
Ensembl peptide - ENSP00000412712
Ensembl peptide - ENSP00000462957
Ensembl peptide - ENSP00000464783
Ensembl peptide - ENSP00000465162
Ensembl peptide - ENSP00000466415
NCBI entrez gene - 51295     See in Manteia.
OMIM - 608388
RefSeq - NM_016581
RefSeq - NM_001142465
RefSeq - NM_001243204
RefSeq - NM_001142464
RefSeq Peptide - NP_057665
RefSeq Peptide - NP_001135937
RefSeq Peptide - NP_001135936
RefSeq Peptide - NP_001230133
swissprot - Q9BQ95
swissprot - J3KTF5
swissprot - K7EIK2
swissprot - K7EJG5
swissprot - K7EJI1
swissprot - K7EM98
swissprot - K7EN32
swissprot - K7EPL5
swissprot - K7ESM8
Ensembl - ENSG00000130159
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ecsitENSDARG00000062834Danio rerio
 EcsitENSMUSG00000066839Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR010418  ECSIT
 IPR029342  ECSIT, C-terminal domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0032981 mitochondrial respiratory chain complex I assembly TAS
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0051341 regulation of oxidoreductase activity IDA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005743 mitochondrial inner membrane TAS
 cellular_componentGO:0005829 cytosol IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016651 oxidoreductase activity, acting on NAD(P)H IDA


Pathways (from Reactome)
Pathway description
MyD88:Mal cascade initiated on plasma membrane
Complex I biogenesis
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
MyD88 cascade initiated on plasma membrane


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000177646 ACAD9 / Q9H845 / acyl-CoA dehydrogenase family member 9  / complex
 ENSG00000137806 Q9Y375 / NDUFAF1 / NADH:ubiquinone oxidoreductase complex assembly factor 1  / complex
 ENSG00000171204 Q8IUX1 / TMEM126B / transmembrane protein 126B  / complex






 

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contact: otassy@igbmc.fr