ENSMUSG00000066892


Mus musculus

Features
Gene ID: ENSMUSG00000066892
  
Biological name :Fbxl12
  
Synonyms : F-box/LRR-repeat protein 12 / Fbxl12 / Q9EPX5
  
Possible biological names infered from orthology : F-box and leucine rich repeat protein 12 / Q9NXK8
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: A3
Gene start: 20618118
Gene end: 20644767
  
Corresponding Affymetrix probe sets: 10591263 (MoGene1.0st)   1448420_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000115058
Ensembl peptide - ENSMUSP00000118369
Ensembl peptide - ENSMUSP00000121429
Ensembl peptide - ENSMUSP00000119124
Ensembl peptide - ENSMUSP00000118873
Ensembl peptide - ENSMUSP00000083649
Ensembl peptide - ENSMUSP00000083650
Ensembl peptide - ENSMUSP00000114466
NCBI entrez gene - 30843     See in Manteia.
MGI - MGI:1354738
RefSeq - NM_013911
RefSeq - XM_006510399
RefSeq - XM_006510398
RefSeq - XM_006510397
RefSeq - NM_001002846
RefSeq - NM_001286529
RefSeq - NM_001286530
RefSeq Peptide - NP_001002846
RefSeq Peptide - NP_001273458
RefSeq Peptide - NP_001273459
RefSeq Peptide - NP_038939
swissprot - D3YWZ8
swissprot - Q9EPX5
swissprot - D3YY70
swissprot - A0A0R4J1Q8
swissprot - A0A0R4J1W2
Ensembl - ENSMUSG00000066892
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FBXL12ENSG00000127452Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001810  F-box domain
 IPR032675  Leucine-rich repeat domain superfamily
 IPR036047  F-box-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IPI
 biological_processGO:0016567 protein ubiquitination IEA
 cellular_componentGO:0000151 ubiquitin ligase complex IPI
 cellular_componentGO:0005737 cytoplasm IDA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity ISO
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Atp1b1tm1.1Zboro/Atp1b1tm1.1Zboro,Tg(Sftpc-cre)1Blh/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Atp1b1tm1.1Zboro/Atp1b1tm1.1Zboro,Tg(Sftpc-cre)1Blh/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0004201 fetal growth retardation "slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atp1b1tm1.1Zboro/Atp1b1tm1.1Zboro,Tg(Sftpc-cre)1Blh/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0004259 small placenta "reduced size of the size or shape of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atp1b1tm1.1Zboro/Atp1b1tm1.1Zboro,Tg(Sftpc-cre)1Blh/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0008803 abnormal placental labyrinth vasculature morphology "any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atp1b1tm1.1Zboro/Atp1b1tm1.1Zboro,Tg(Sftpc-cre)1Blh/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0008957 abnormal placenta junctional zone morphology "fetally derived placental region that separates the maternal uterine tissue from the placenta labyrinth" [PMID:16367805]
Show

Allelic Composition: Atp1b1tm1.1Zboro/Atp1b1tm1.1Zboro,Tg(Sftpc-cre)1Blh/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0009546 absent gastric milk in neonates "failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atp1b1tm1.1Zboro/Atp1b1tm1.1Zboro,Tg(Sftpc-cre)1Blh/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atp1b1tm1.1Zboro/Atp1b1tm1.1Zboro,Tg(Sftpc-cre)1Blh/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Atp1b1tm1.1Zboro/Atp1b1tm1.1Zboro,Tg(Sftpc-cre)1Blh/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Atp1b1tm1.1Zboro/Atp1b1tm1.1Zboro,Tg(Sftpc-cre)1Blh/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * DBA/2

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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