ENSMUSG00000068290


Mus musculus

Features
Gene ID: ENSMUSG00000068290
  
Biological name :Ddrgk1
  
Synonyms : Ddrgk1 / DDRGK domain-containing protein 1 / Q80WW9
  
Possible biological names infered from orthology : DDRGK domain containing 1 / Q96HY6
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: F1
Gene start: 130653960
Gene end: 130664659
  
Corresponding Affymetrix probe sets: 10487711 (MoGene1.0st)   1434702_at (Mouse Genome 430 2.0 Array)   1458761_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000114535
Ensembl peptide - ENSMUSP00000121190
Ensembl peptide - ENSMUSP00000086988
NCBI entrez gene - 77006     See in Manteia.
MGI - MGI:1924256
RefSeq - NM_029832
RefSeq Peptide - NP_084108
swissprot - Q80WW9
swissprot - B0R015
swissprot - F7AIJ1
Ensembl - ENSMUSG00000068290
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ddrgk1ENSDARG00000037172Danio rerio
 DDRGK1ENSGALG00000016003Gallus gallus
 DDRGK1ENSG00000198171Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR019153  DDRGK domain containing protein
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0033146 regulation of intracellular estrogen receptor signaling pathway IEA
 biological_processGO:0034976 response to endoplasmic reticulum stress IMP
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:1901800 positive regulation of proteasomal protein catabolic process IEA
 biological_processGO:1903721 positive regulation of I-kappaB phosphorylation IEA
 biological_processGO:1905050 positive regulation of metallopeptidase activity IEA
 biological_processGO:1905552 positive regulation of protein localization to endoplasmic reticulum IDA
 biological_processGO:1905636 positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding IEA
 biological_processGO:1990592 protein K69-linked ufmylation IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 molecular_functionGO:0001103 RNA polymerase II repressing transcription factor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0044389 ubiquitin-like protein ligase binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000164 abnormal cartilage development "anomalous formation of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Aipl1tvrm119/Aipl1tvrm127
Genetic Background: C57BL/6J-Aipl1tvrm119/Aipl1tvrm127

 MP:0000223 decreased monocyte count "fewer than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ddrgk1tm1c(EUCOMM)Hmgu/Ddrgk1tm1c(EUCOMM)Hmgu,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6N

 MP:0000334 decreased granulocyte number "fewer than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ddrgk1tm1c(EUCOMM)Hmgu/Ddrgk1tm1c(EUCOMM)Hmgu,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6N

 MP:0000600 liver hypoplasia "reduced size of liver due to decreased cell number " [J:57631]
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Allelic Composition: Ddah1tm1.1Geno/Ddah1tm1.1Geno
Genetic Background: Not Specified

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Ddrgk1tm1c(EUCOMM)Hmgu/Ddrgk1tm1c(EUCOMM)Hmgu,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6N

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Ddah1tm1.1Geno/Ddah1tm1.1Geno
Genetic Background: Not Specified

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ddrgk1tm1c(EUCOMM)Hmgu/Ddrgk1tm1c(EUCOMM)Hmgu,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6N

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ddrgk1tm1c(EUCOMM)Hmgu/Ddrgk1tm1c(EUCOMM)Hmgu,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6N

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ddah1tm1.1Geno/Ddah1tm1.1Geno
Genetic Background: Not Specified

Allelic Composition: Ddrgk1tm1c(EUCOMM)Hmgu/Ddrgk1tm1c(EUCOMM)Hmgu,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6N

Allelic Composition: Ddrgk1em1Brle/Ddrgk1em1Brle
Genetic Background: C57BL/6J-Ddrgk1em1Brle

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ddah1tm1.1Geno/Ddah1tm1.1Geno
Genetic Background: Not Specified

 MP:0004229 abnormal embryonic erythropoiesis "anomaly in the development of primarily large, nucleated erythroblasts occurring in blood islands in the yolk sac, generally occurs from E7-E11 in the mouse and through 10 weeks in humans" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ddah1tm1.1Geno/Ddah1tm1.1Geno
Genetic Background: Not Specified

Allelic Composition: Ddrgk1tm1c(EUCOMM)Hmgu/Ddrgk1tm1c(EUCOMM)Hmgu,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6N

 MP:0004230 abnormal embryonic erythrocyte morphology "structural anomaly of the embryonic blood cells that carry oxygen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ddah1tm1.1Geno/Ddah1tm1.1Geno
Genetic Background: Not Specified

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ddrgk1tm1c(EUCOMM)Hmgu/Ddrgk1tm1c(EUCOMM)Hmgu,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6N

 MP:0005152 pancytopenia "reduction in the number of erythrocytes, all types of white blood cells, and platelets in the circulating blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:20450]
Show

Allelic Composition: Ddrgk1tm1c(EUCOMM)Hmgu/Ddrgk1tm1c(EUCOMM)Hmgu,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6N

 MP:0005650 abnormal limb bud morphology "aberrant structure or development of any of the swellings on the trunk of the embryo that become limbs" [hdene:Howard Dene , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:61460]
Show

Allelic Composition: Ddrgk1em1Brle/Ddrgk1em1Brle
Genetic Background: C57BL/6J-Ddrgk1em1Brle

 MP:0008813 decreased common myeloid progenitor cell number "reduced number of progenitor cells committed to myeloid lineage, including the megakaryocyte and erythroid lineages" [CL:0000049, MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ddah1tm1.1Geno/Ddah1tm1.1Geno
Genetic Background: Not Specified

 MP:0008973 decreased erythroid progenitor cell number "reduced numbers of progenitors of the erythrocyte lineage" [CL:0000038, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ddah1tm1.1Geno/Ddah1tm1.1Geno
Genetic Background: Not Specified

 MP:0010763 abnormal hematopoietic stem cell physiology "any functional anomaly or number of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; HSCs give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ddrgk1tm1c(EUCOMM)Hmgu/Ddrgk1tm1c(EUCOMM)Hmgu,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6N

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Ddah1tm1.1Geno/Ddah1tm1.1Geno
Genetic Background: Not Specified

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Pofut2tm2.2Bch/Pofut2tm2.2Bch
Genetic Background: B6.Cg-Pofut2tm2.2Bch

 MP:0011261 abnormal limb mesenchyme morphology "any structural anomaly in the primordial embryonic connective tissue of the developing limbs, autopods and digits, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to limb connective tissue, bone and musculature in conjunction with myotome cells" [ISBN:0-683-40008-8, MGI:csmith]
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Allelic Composition: Ddrgk1em1Brle/Ddrgk1em1Brle
Genetic Background: C57BL/6J-Ddrgk1em1Brle

 MP:0012556 increased cell death "increased occurrence of the cessation of function at the cellular level" [http://orcid.org/0000-0001-5208-3432]
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Allelic Composition: Ddah1tm1.1Geno/Ddah1tm1.1Geno
Genetic Background: Not Specified

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
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Allelic Composition: Ddrgk1em1Brle/Ddrgk1em1Brle
Genetic Background: C57BL/6J-Ddrgk1em1Brle

 MP:0013772 increased effector memory T-helper cell number "increase in the number of CD4-positive alpha-beta T-helper cells with a CD44-positive, CD62L-negative memory phenotype" [MGI:Saran]
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Allelic Composition: Pofut2tm2.2Bch/Pofut2tm2.2Bch
Genetic Background: B6.Cg-Pofut2tm2.2Bch

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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