ENSMUSG00000069516


Mus musculus

Features
Gene ID: ENSMUSG00000069516
  
Biological name :Lyz2
  
Synonyms : lysozyme 2 / Lyz2 / P08905
  
Possible biological names infered from orthology : lysozyme / LYZ / P61626
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: D2
Gene start: 117277331
Gene end: 117282321
  
Corresponding Affymetrix probe sets: 10372648 (MoGene1.0st)   1423547_at (Mouse Genome 430 2.0 Array)   1436996_x_at (Mouse Genome 430 2.0 Array)   1439426_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000089801
NCBI entrez gene - 17105     See in Manteia.
MGI - MGI:96897
RefSeq - NM_017372
RefSeq Peptide - NP_059068
swissprot - A0A077S2U6
swissprot - P08905
Ensembl - ENSMUSG00000069516
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LYZENSGALG00000009963Gallus gallus
 LYZENSG00000090382Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lyz1 / P17897 / Lysozyme C-1 / LYZ* / P61626* / lysozyme*ENSMUSG0000006951592
9530003J23Rik / RIKEN cDNA 9530003J23 gene / LYZ* / P61626* / lysozyme*ENSMUSG0000002017761
Lyzl1 / Q9CPX3 / Lysozyme-like protein 1 / LYZL2* / Q6UWQ5* / Q7Z4W2* / lysozyme like 2* / lysozyme like 1*ENSMUSG0000002423343
Q9D9X8 / Spaca3 / Mus musculus sperm acrosome associated 3 (Spaca3), transcript variant 1, mRNA. / Q8IXA5* / sperm acrosome associated 3*ENSMUSG0000005318443
Lyzl6 / Q9DA11 / Mus musculus lysozyme-like 6 (Lyzl6), transcript variant 2, mRNA. / O75951* / lysozyme like 6*ENSMUSG0000002094541
Spaca5 / A2AE20 / sperm acrosome associated 5 / Q96QH8* / SPACA5B* / sperm acrosome associated 5B*ENSMUSG0000003716740
Lyzl4 / Q9D925 / lysozyme-like 4 / Q96KX0*ENSMUSG0000003253035
Lalba / P29752 / Alpha-lactalbumin / P00709* / lactalbumin alpha*ENSMUSG0000002299134


Protein motifs (from Interpro)
Interpro ID Name
 IPR000974  Glycoside hydrolase, family 22, lysozyme
 IPR001916  Glycoside hydrolase, family 22
 IPR019799  Glycoside hydrolase, family 22, conserved site
 IPR023346  Lysozyme-like domain superfamily
 IPR030056  Lysozyme C


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0016998 cell wall macromolecule catabolic process IBA
 biological_processGO:0019835 cytolysis IEA
 biological_processGO:0042742 defense response to bacterium IMP
 biological_processGO:0050829 defense response to Gram-negative bacterium IDA
 biological_processGO:0050830 defense response to Gram-positive bacterium IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space ISO
 molecular_functionGO:0003796 lysozyme activity IDA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016798 hydrolase activity, acting on glycosyl bonds IEA
 molecular_functionGO:0042802 identical protein binding ISO


Pathways (from Reactome)
Pathway description
Neutrophil degranulation
Antimicrobial peptides


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000062 increased bone density "increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
Show

Allelic Composition: Itgb3tm1.1Wlbcr/Itgb3tm1.1Wlbcr
Genetic Background: involves: C57BL/6

 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Arhgap29em1(IMPC)J/Arhgap29+
Genetic Background: C57BL/6NJ-Arhgap29em1(IMPC)J/J

 MP:0000066 osteoporosis "reduction in bone mass or atrophy of skeletal tissue; may lead to skeletal fragility" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0000067 osteopetrosis "excessive formation of dense trabecular bone and excessive calcified cartilage formation; may lead to anemia and extramedullary hematopoiesis " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Itgb3tm1.1Wlbcr/Itgb3tm1.1Wlbcr
Genetic Background: involves: C57BL/6

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ednratm1Ywa/Ednratm1Ywa
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

Allelic Composition: Esr1tm1.1Scma/Esr1tm1.1Scma,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

 MP:0000135 reduced cortical bone thickness "thinner than normal superficial layer of compact bone " [J:61509]
Show

Allelic Composition: Arhgap29em1(IMPC)J/Arhgap29+
Genetic Background: C57BL/6NJ-Arhgap29em1(IMPC)J/J

 MP:0000172 abnormal bone marrow cell number "Increased or decreased number of cells that make up the core cavities of bones when compared to the norm" [MGI:tc]
Show

Allelic Composition: Cflartm1.1Pope/Cflartm1.2Pope,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Idh1tm1Mak/Idh1tm1Mak,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Idh1tm2Mak/Idh1tm2Mak,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Nlrp3tm1Hhf/Nlrp3+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Cflartm1.1Pope/Cflartm1.2Pope,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Ptgestm1.1Gaf/Ptgestm1.1Gaf,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129 * C57BL/6

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1b+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Mef2ctm1Jjs/Mef2ctm1Jjs,Mir223tm1Fcam/Mir223tm1Fcam,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Nlrp3tm1Hhf/Nlrp3+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Cflartm1.1Pope/Cflartm1.2Pope,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Cxcr4tm2Yzo/Cxcr4tm2Yzo,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Trip13Gt(CH0621)Wtsi/Trip13Gt(CH0621)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cflartm1.1Pope/Cflartm1.2Pope,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Elavl1tm1.1Dkon/Elavl1tm1.1Dkon,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: B6.129P2-Elavl1tm1.1Dkon Lyz2tm1(cre)Ifo

Allelic Composition: Cxcr4tm2Yzo/Cxcr4tm2Yzo,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Pdgfratm9(Pdgfra/Fgfr1)Sor/Pdgfratm11(EGFP)Sor
Genetic Background: either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)

 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pdgfratm9(Pdgfra/Fgfr1)Sor/Pdgfratm11(EGFP)Sor
Genetic Background: either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)

Allelic Composition: Mcl1tm1Ywh/Mcl1tm1Ywh,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: P4hbtm1.1Geno/P4hbtm1.2Geno,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0000230 abnormal blood pressure "altered tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Tg(Camk2a-cre)1Szi/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Idh1tm1Mak/Idh1tm1Mak,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Idh1tm2Mak/Idh1tm2Mak,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cflartm1.1Pope/Cflartm1.2Pope,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0000316 cellular necrosis "pathologic death of cells, usually from irreversible damage" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Leprdb/Leprdb,Rock1tm1Leiw/Rock1tm1Leiw
Genetic Background: involves: 129S7/SvEvBrd * C57BLKS/J * FVB/N

 MP:0000322 increased granulocyte number "greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Bmp5cfe-se6J/Bmp5cfe-se6J
Genetic Background: BALB/cByJ Agtpbp1pcd-3J-Bmp5cfe-se6J/GrsrJ

Allelic Composition: Cflartm1.1Pope/Cflartm1.2Pope,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
Show

Allelic Composition: Idh1tm1Mak/Idh1tm1Mak,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Idh1tm2Mak/Idh1tm2Mak,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0000334 decreased granulocyte number "fewer than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Kat2btm1Roth/Kat2btm1Roth
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0000420 ruffled hair "fuzzy, irregular appearance of the hair" [J:50844]
Show

Allelic Composition: Lyz2tm1(DTR)Mtka/Lyz2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000477 abnormal intestine morphology "malformation of the digestive tube passing from the stomach to the anus" [J:48968]
Show

Allelic Composition: Nlrp3tm1Hhf/Nlrp3+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0000495 abnormal colon morphology "malformation of the portion of the large intestine between the cecum and the rectum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Stat3tm2Aki/Stat3tm2Aki,Tlr4tm1Aki/Tlr4tm1Aki,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Stat1tm1Rds/Stat1tm1Rds,Stat3tm2Aki/Stat3tm2Aki,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0000496 abnormal small intestine morphology "structural or developmental anomalies of the intestinum tenue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Zfp36tm1.1Xen/Zfp36tm1.1Xen,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
Show

Allelic Composition: Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1btm1Mbrg,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Lyz2tm1(DTR)Mtka/Lyz2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
Show

Allelic Composition: Kmt2atm1.1(Sh3gl1)Lcc/Kmt2a+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
Show

Allelic Composition: Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1btm1Mbrg,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Cflartm1.1Pope/Cflartm1.2Pope,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Idh1tm1Mak/Idh1tm1Mak,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Idh1tm2Mak/Idh1tm2Mak,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lrp6Cd/Lrp6+
Genetic Background: involves: A * 129/Sv

Allelic Composition: Cflartm1.1Pope/Cflartm1.2Pope,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Idh1tm1Mak/Idh1tm1Mak,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Idh1tm2Mak/Idh1tm2Mak,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Zfp36tm1.1Xen/Zfp36tm1.1Xen,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N

Allelic Composition: Kmt2atm1.1(Sh3gl1)Lcc/Kmt2a+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Zfp36tm1.1Xen/Zfp36tm1.1Xen,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N

Allelic Composition: Kmt2atm1.1(Sh3gl1)Lcc/Kmt2a+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

 MP:0000703 abnormal thymus morphology "anomalous structure or development of the primary lymphoid organ; required for immune system development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55400]
Show

Allelic Composition: Cflartm1.1Pope/Cflartm1.2Pope,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0000717 abnormal lymphocyte number "deviation from the normal number of white blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cflartm1.1Pope/Cflartm1.2Pope,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
Show

Allelic Composition: Rpl13atm1.1Mazu/Rpl13atm1.1Mazu,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: C57BL/6

 MP:0001182 lung hemorrhage "bleeding in the respiratory organs" [J:66345]
Show

Allelic Composition: Lyz2tm1(DTR)Mtka/Lyz2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001190 reddish skin "skin has a more intense ruddy appearance than normal, often due to capillary congestion" [J:65038]
Show

Allelic Composition: Nlrp3tm1Hhf/Nlrp3+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Nlrp3tm1Hhf/Nlrp3+,Rag1tm1Mom/Rag1tm1Mom,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0001192 scaly skin "skin covered with shedding scales or flakes" [J:65146]
Show

Allelic Composition: Nlrp3tm1Hhf/Nlrp3+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Nlrp3tm1Hhf/Nlrp3+,Rag1tm1Mom/Rag1tm1Mom,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Zfp36tm1.1Xen/Zfp36tm1.1Xen,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
Show

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts,Tnftm2Gkl/Tnf+
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Tnftm2.1Gkl/Tnf+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Il4ratm1Fbb/Il4ratm2Fbb,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1b+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Lmnatm3Lgf/Lmnatm3Lgf
Genetic Background: involves: 129P2/OlaHsd

 MP:0001273 decreased metastatic potential 
Show

Allelic Composition: Krastm4Tyj/Kras+,Myod1tm1.1(cre/ERT,TVA)Gcg/Myod1+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Lyz2tm1(DTR)Mtka/Lyz2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Rpl13atm1.1Mazu/Rpl13atm1.1Mazu,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: C57BL/6

 MP:0001492 piloerection "the involuntary bristling of hairs" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Atp6v0a4tm1.1Fekf/Atp6v0a4+
Genetic Background: involves: C57BL/6

 MP:0001505 hunched posture "stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404]
Show

Allelic Composition: Lyz2tm1(DTR)Mtka/Lyz2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001541 abnormal osteoclast function "reduced ability or inability of osteoclasts to absorb and remove osseous tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
Show

Allelic Composition: Esr1tm1.1Scma/Esr1tm1.1Scma,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Cflartm1.1Pope/Cflartm1.2Pope,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Idh1tm1Mak/Idh1tm1Mak,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Idh1tm2Mak/Idh1tm2Mak,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001601 abnormal myelopoiesis "atypical process of bone marrow cell formation and/or bone marrow-derived blood cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
Show

Allelic Composition: Cflartm1.1Pope/Cflartm1.2Pope,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0001654 hepatic necrosis "pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mybpc3tm1Rmos/Mybpc3tm1Rmos
Genetic Background: either: (involves: 129) or (involves: 129 * C57BL/6)

 MP:0001656 focal hepatic necrosis "a localized area of pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Zfp36tm1.1Xen/Zfp36tm1.1Xen,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pggt1btm1Mbrg/Pggt1btm1Mbrg,Krastm4Tyj/Kras+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cacna2d4lob/Cacna2d4lob
Genetic Background: involves: A/J * C57BL/10

Allelic Composition: Il15ratm1Ama/Il15ratm2.1Ama,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J

Allelic Composition: Il15ratm1Ama/Il15ratm2.1Ama,Lyz2tm1(cre)Ifo/0,Tg(Itgax-cre)1-1Reiz/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * CBA

 MP:0001798 impaired macrophage phagocytosis "reduced ability of these phagocytic cells to internalize particulate matter" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Il10tm1Cgn/Il10tm1Cgn
Genetic Background: B6.129P2-Il10tm1Cgn/J

Allelic Composition: Ppargtm1.1Gonz/Ppargtm1.1Gonz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

Allelic Composition: Rxratm1Krc/Rxratm1Krc,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Lrp1tm2Her/Lrp1tm2Her,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

Allelic Composition: Slc3a2tm1.1Yait/Slc3a2tm1.1Yait,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrSlc

Allelic Composition: Clec7atm1.1Bpip/Clec7atm1.1Bpip,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Hmgb1tm1.1Ttg/Hmgb1tm1.1Ttg,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0001819 abnormal immune cell physiology "abnormal function of the cells of the immune system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fbxw4Dac-2J/Fbxw4Dac-2J
Genetic Background: CBy.MRL-Fbxw4Dac-2J/J

 MP:0001845 abnormal inflammatory response "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]
Show

Allelic Composition: Il10tm2Roer/Il10tm2Roer,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Hsp90b1tm1Zhli/Hsp90b1tm1.1Zhli,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Il1r1tm1Quan/Il1r1tm1Quan,Lyz2tm1(cre)Ifo/Lyz2tm1(cre)Ifo
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rag2tm1.1Cgn/Rag2tm1.1Cgn
Genetic Background: C57BL/6-Rag2tm1.1Cgn

Allelic Composition: Nlrp3tm1Hhf/Nlrp3+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Nlrp3tm1Flv/Nlrp3tm1Hhf,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Vhltm1Jae/Vhltm1Jae,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Zfp36tm1.1Xen/Zfp36tm1.1Xen,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N

Allelic Composition: Map3k7tm1.1Gkl/Map3k7tm1.1Gkl,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Il4ratm1Fbb/Il4ratm2Fbb,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: at/A,As/As+
Genetic Background: Not Specified

Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Hmox1tm1.1Hes/Hmox1tm1.1Hes,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N

Allelic Composition: Mapk8tm1Rjd/Mapk8tm1Rjd,Mapk9tm2.1Rjd/Mapk9tm2.1Rjd,Lyz2tm1(cre)Ifo/0
Genetic Background: B6J.Cg-Lyz2tm1(cre)Ifo Mapk9tm2.1Rjd Mapk8tm1Rjd

 MP:0001879 abnormal lymphatic vessel morphology "malformation of the network of vessels which carries lymph around the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dgcr8Gt(XG058)Byg/Dgcr8+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
Show

Allelic Composition: Lyz2tm1(DTR)Mtka/Lyz2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1b+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0002026 leukemia "progressive proliferation of abnormal leukocytes in hematopoietic tissues, organs and blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18542]
Show

Allelic Composition: Pmltm1(PML/RARA)Ley/Pml+,Tg(CMV-cre)1Cgn/0
Genetic Background: involves: BALB/cJ * C57BL/6

Allelic Composition: Kmt2atm1.1(Sh3gl1)Lcc/Kmt2a+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

 MP:0002027 lung adenocarcinoma "malignant neoplasm of epithelial cells in the lung" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:18542]
Show

Allelic Composition: Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1b+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0002044 colonic adenoma "benign tumors of the large intestine" [J:38772]
Show

Allelic Composition: Htttm5Mem/Htttm5Mem
Genetic Background: STOCK Htttm5Mem/J

 MP:0002048 lung adenoma "benign epithelial neoplasm of the lung" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:57631]
Show

Allelic Composition: Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1btm1Mbrg,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1b+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mapk8tm1Rjd/Mapk8tm1Rjd,Mapk9tm2.1Rjd/Mapk9tm2.1Rjd,Lyz2tm1(cre)Ifo/0
Genetic Background: B6J.Cg-Lyz2tm1(cre)Ifo Mapk9tm2.1Rjd Mapk8tm1Rjd

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cacna2d4lob/Cacna2d4lob
Genetic Background: involves: A/J * C57BL/10

Allelic Composition: Hsp90b1tm1Zhli/Hsp90b1tm1.1Zhli,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

Allelic Composition: n-TUtca2tm2Mym/n-TUtca2tm2.1Mym,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Lyz2tm1(DTR)Mtka/Lyz2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Fntbtm1.1Mbrg/Fntbtm1.2Mbrg,Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1btm1.1Mbrg,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N

Allelic Composition: Fntbtm1.1Mbrg/Fntbtm1.2Mbrg,Krastm4Tyj/Kras+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N

Allelic Composition: Cflartm1.1Pope/Cflartm1.2Pope,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Ptpn11tm1Ckq/Ptpn11+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Rpl13atm1.1Mazu/Rpl13atm1.1Mazu,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: C57BL/6

Allelic Composition: Kmt2atm1.1(Sh3gl1)Lcc/Kmt2a+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

 MP:0002113 abnormal skeleton development "anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Esr1tm1.1Scma/Esr1tm1.1Scma,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mapk8tm1Rjd/Mapk8tm1Rjd,Mapk9tm2.1Rjd/Mapk9tm2.1Rjd,Lyz2tm1(cre)Ifo/0
Genetic Background: B6J.Cg-Lyz2tm1(cre)Ifo Mapk9tm2.1Rjd Mapk8tm1Rjd

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1b+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Cflartm1.1Pope/Cflartm1.2Pope,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0002128 abnormal blood circulation "failure or atypical movement in the flow of blood from the heart to the vasculature and back to the heart" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Leprdb/Leprdb,Rock1tm1Leiw/Rock1tm1Leiw
Genetic Background: involves: 129S7/SvEvBrd * C57BLKS/J * FVB/N

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Neurod1tm1Mjts/Neurod1tm1Mjts,Neurod6tm1Kan/Neurod6tm1Kan
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J

Allelic Composition: Ppargtm1.1Gonz/Ppargtm1.1Gonz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

Allelic Composition: Rxratm1Krc/Rxratm1Krc,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0002166 altered tumor susceptibility/resistance "greater than or less than the average number of tumors, usually a specific type, arising in a given strain when compared to controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Itgb3tm1.1Wlbcr/Itgb3tm1.1Wlbcr
Genetic Background: involves: C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nlrp3tm1Hhf/Nlrp3+,Rag1tm1Mom/Rag1tm1Mom,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lyz2tm1(DTR)Mtka/Lyz2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002276 abnormal lung interstitium morphology "any structural anomaly of the lung tissue, but not including the conducting airways (bronchi, bronchioles, alveoli) " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]
Show

Allelic Composition: Lyz2tm1(DTR)Mtka/Lyz2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002310 resistance to fatty liver development "less likely than the norm to to develop hepatic steatosis " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hmox1tm1.1Hes/Hmox1tm1.1Hes,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N

 MP:0002356 abnormal spleen red pulp morphology "anomalous structure of the area of the spleen that screens and eliminates defective or foreign cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]
Show

Allelic Composition: Cflartm1.1Pope/Cflartm1.2Pope,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0002362 abnormal spleen marginal zone morphology "anomalous structure of the area surrounding the marginal sinus and containing lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Cflartm1.1Pope/Cflartm1.2Pope,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Idh1tm1Mak/Idh1tm1Mak,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Idh1tm2Mak/Idh1tm2Mak,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Abca1tm1Jp/Abca1tm1Jp,Abcg1tm1Tall/Abcg1tm1Tall,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

 MP:0002410 decreased susceptibility to viral infection "reduced likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Bmp5cfe-se6J/Bmp5cfe-se6J
Genetic Background: BALB/cByJ Agtpbp1pcd-3J-Bmp5cfe-se6J/GrsrJ

 MP:0002411 decreased susceptibility to bacterial infection "reduced likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Ifnb1tm2.1Lien/Ifnb1tm2.1Lien,Tyrc-2J/Tyrc-2J,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Thbdtm1.1Hlwu/Thbdtm1.1Hlwu,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: B6.129-Thbdtm1.1Hlwu Lyz2tm1(cre)Ifo

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mybpc3tm1Rmos/Mybpc3tm1Rmos
Genetic Background: either: (involves: 129) or (involves: 129 * C57BL/6)

Allelic Composition: Hsp90b1tm1Zhli/Hsp90b1tm1.1Zhli,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Ltbrtm1Avt/Ltbrtm1Avt,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Hmgb1tm1.1Ttg/Hmgb1tm1.1Ttg,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0002413 abnormal megakaryoblast morphology/development "anomalous structure or development of the progenitor cells of the thrombocytic (platelet) line of cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Trip13Gt(CH0621)Wtsi/Trip13Gt(CH0621)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002414 abnormal myeloblast morphology/development "anomalous structure, formation, or numbers of the cells found in the bone marrow that give rise to the granulocyte line of blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Idh1tm1Mak/Idh1tm1Mak,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Idh1tm2Mak/Idh1tm2Mak,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002415 abnormal neutrophil morphology/development "anomalous structure, differentiation, or number of the granular leukocytes that have a three- to five-lobed nucleus and a cytoplasm that contains inconspicuous granules stainable by neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mef2ctm1Jjs/Mef2ctm1Jjs,Mir223tm1Fcam/Mir223tm1Fcam,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129 * C57BL/6

 MP:0002442 abnormal leukocyte physiology "abnormal function of any of the white blood cells (basophils, eosinophils, neutrophils, lymphocytes, or monocytes) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Vhltm1Jae/Vhltm1Jae,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Ptgestm1.1Gaf/Ptgestm1.1Gaf,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129 * C57BL/6

 MP:0002446 abnormal macrophage morphology "anomalous structure, number, or composition of the large mononuclear phagocytic cells found in most tissues of the body" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Slc3a2tm1.1Yait/Slc3a2tm1.1Yait,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrSlc

Allelic Composition: Fmnl1tm1.2Sdb/Fmnl1tm1.2Sdb,Lyz2tm1(cre)Ifo/Lyz2tm1(cre)Ifo
Genetic Background: involves: C3H * C57BL/6 * FVB/N

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fbxw4Dac-2J/Fbxw4Dac-2J
Genetic Background: CBy.MRL-Fbxw4Dac-2J/J

Allelic Composition: Ube2ntm1Aki/Ube2ntm1Aki,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il4ratm1Fbb/Il4ratm2Fbb,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Hsp90b1tm1Zhli/Hsp90b1tm1.1Zhli,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Adam17tm1Bbl/Adam17tm1Bbl,Lyz2tm1(cre)Ifo/0
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Socs3tm1Wsa/Socs3tm2Wsa,Lyz2tm1(cre)Ifo/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ltbrtm1.1Thhe/Ltbrtm1.1Thhe,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Slc3a2tm1.1Yait/Slc3a2tm1.1Yait,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrSlc

Allelic Composition: Clec7atm1.1Bpip/Clec7atm1.1Bpip,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Hmgb1tm1.1Ttg/Hmgb1tm1.1Ttg,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Mapk8tm1Rjd/Mapk8tm1Rjd,Mapk9tm2.1Rjd/Mapk9tm2.1Rjd,Lyz2tm1(cre)Ifo/0
Genetic Background: B6J.Cg-Lyz2tm1(cre)Ifo Mapk9tm2.1Rjd Mapk8tm1Rjd

Allelic Composition: Fmnl1tm1.2Sdb/Fmnl1tm1.2Sdb,Lyz2tm1(cre)Ifo/Lyz2tm1(cre)Ifo
Genetic Background: involves: C3H * C57BL/6 * FVB/N

 MP:0002454 abnormal macrophage antigen presentation "impairment of these phagocytic cells to process and present antigen to T lymphocytes" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Foxp4tm1Eem/Foxp4tm1Eem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002458 abnormal B cell number "deviation from the normal number of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cflartm1.1Pope/Cflartm1.2Pope,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Kat2btm1Roth/Kat2btm1Roth
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Mef2ctm1Jjs/Mef2ctm1Jjs,Mir223tm1Fcam/Mir223tm1Fcam,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Syktm1Tyb/Syktm1.2Tara,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Lyz2tm1(cre)Ifo/Lyz2+,Pdcd10tm1Wami/Pdcd10tm1Wami
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

 MP:0002472 impaired complement alternative pathway "abnormal function of the plasma protein cascade triggered by direct contact with pathogen surfaces" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Cfptm2.1Song/Cfptm2.1Song,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL

 MP:0002493 increased IgG "greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ppargtm1.1Gonz/Ppargtm1.1Gonz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

Allelic Composition: Rxratm1Krc/Rxratm1Krc,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ppargtm1.1Gonz/Ppargtm1.1Gonz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

Allelic Composition: Rxratm1Krc/Rxratm1Krc,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0002500 granulomatous inflammation "chronic inflammation resulting from the failure of the acute inflammatory response and persistance of the injurious agent; characterized by a central area of marcophages, often fused into giant cells, and surrounded by T cells " [Pathology:ISBN 0-397-51047-0, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Il4ratm1Fbb/Il4ratm2Fbb,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0002702 decreased circulating free fatty acid level "lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hmox1tm1.1Hes/Hmox1tm1.1Hes,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mapk8tm1Rjd/Mapk8tm1Rjd,Mapk9tm2.1Rjd/Mapk9tm2.1Rjd,Lyz2tm1(cre)Ifo/0
Genetic Background: B6J.Cg-Lyz2tm1(cre)Ifo Mapk9tm2.1Rjd Mapk8tm1Rjd

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ppargtm1.1Gonz/Ppargtm1.1Gonz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

Allelic Composition: Rxratm1Krc/Rxratm1Krc,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0002816 colitis "local accumulation of fluid, plasma proteins, and leukocytes in the colon region of the large intestine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Il10tm1Cgn/Il10tm1Cgn
Genetic Background: B6.129P2-Il10tm1Cgn/J

Allelic Composition: Stat3tm2Aki/Stat3tm2Aki,Tlr4tm1Aki/Tlr4tm1Aki,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Stat3tm2Aki/Stat3tm2Aki,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Stat3tm2Aki/Stat3tm2Aki,Tnftm1Sek/Tnftm1Sek,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Stat1tm1Rds/Stat1tm1Rds,Stat3tm2Aki/Stat3tm2Aki,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0002871 albuminuria "presence of excess albumin in the urine" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ppargtm1.1Gonz/Ppargtm1.1Gonz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

Allelic Composition: Rxratm1Krc/Rxratm1Krc,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Idh1tm1Mak/Idh1tm1Mak,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Idh1tm2Mak/Idh1tm2Mak,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Hmox1tm1.1Hes/Hmox1tm1.1Hes,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N

Allelic Composition: Mapk8tm1Rjd/Mapk8tm1Rjd,Mapk9tm2.1Rjd/Mapk9tm2.1Rjd,Lyz2tm1(cre)Ifo/0
Genetic Background: B6J.Cg-Lyz2tm1(cre)Ifo Mapk9tm2.1Rjd Mapk8tm1Rjd

 MP:0002908 delayed wound healing "longer time requirement for the ability to self-repair and close wounds than normal" [J:63037]
Show

Allelic Composition: Esr2tm1.1Pcn/Esr2tm1.1Pcn,Tg(KRT14-cre)1Ipc/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Zfp36tm1.1Xen/Zfp36tm1.1Xen,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N

Allelic Composition: Myd88tm1Hlz/Myd88tm1Hlz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: B6.129P2-Myd88tm1Hlz Lyz2tm1(cre)Ifo

 MP:0002944 increased lactate dehydrogenase level "greater than the normal concentration of this enzyme, which catalyzes the interconversion of lactate and pyruvate" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:87714]
Show

Allelic Composition: Lyz2tm1(DTR)Mtka/Lyz2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Zfp36tm1.1Xen/Zfp36tm1.1Xen,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N

 MP:0002962 increased protein excretion "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Ppargtm1.1Gonz/Ppargtm1.1Gonz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

Allelic Composition: Rxratm1Krc/Rxratm1Krc,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0002993 arthritis "joint inflammation, marked by changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Zfp36tm1.1Xen/Zfp36tm1.1Xen,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
Show

Allelic Composition: Il10tm2Roer/Il10tm2Roer,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Hsp90b1tm1Zhli/Hsp90b1tm1.1Zhli,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

 MP:0003058 increased insulin secretion "greater than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Mapk8tm1Rjd/Mapk8tm1Rjd,Mapk9tm2.1Rjd/Mapk9tm2.1Rjd,Lyz2tm1(cre)Ifo/0
Genetic Background: B6J.Cg-Lyz2tm1(cre)Ifo Mapk9tm2.1Rjd Mapk8tm1Rjd

 MP:0003068 enlarged kidney "larger than average size of the kidney" [J:86005, pvb:Pierre Vanden Borre, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ppargtm1.1Gonz/Ppargtm1.1Gonz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

Allelic Composition: Rxratm1Krc/Rxratm1Krc,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0003075 response to CNS ischemic injury 
Show

Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Lrp1tm2Her/Lrp1tm2Her,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

Allelic Composition: Nr3c1tm2.1Ljm/Nr3c1tm2.1Ljm,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0003186 abnormal redox activity "defect in the processes that maintain the redox environment of a cell or compartment within a cell " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hmox1tm1.1Hes/Hmox1tm1.1Hes,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N

 MP:0003303 peritoneal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the membrane that lines the abdominal cavity and covers most of the viscera" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Zfp335tm1.1Caw/Zfp335+,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6

 MP:0003333 liver fibrosis "invasion of fibrous connective tissue into the liver, often resulting from inflammation or injury " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Il4ratm1Fbb/Il4ratm2Fbb,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0003383 abnormal gluconeogenesis "anomaly in the formation of glucose from noncarbohydrates, such as proteins or fat" [J:93896]
Show

Allelic Composition: Mapk8tm1Rjd/Mapk8tm1Rjd,Mapk9tm2.1Rjd/Mapk9tm2.1Rjd,Lyz2tm1(cre)Ifo/0
Genetic Background: B6J.Cg-Lyz2tm1(cre)Ifo Mapk9tm2.1Rjd Mapk8tm1Rjd

 MP:0003436 resistance to induced arthritis "less likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:75303]
Show

Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Cfptm2.1Song/Cfptm2.1Song,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * SJL

 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
Show

Allelic Composition: Fntbtm1.1Mbrg/Fntbtm1.2Mbrg,Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1btm1.1Mbrg,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N

Allelic Composition: Fntbtm1.1Mbrg/Fntbtm1.2Mbrg,Krastm4Tyj/Kras+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N

 MP:0003449 abnormal intestinal goblet cells "malformation of the unicellular mucin-secreting glands" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95282]
Show

Allelic Composition: Il4ratm1Fbb/Il4ratm2Fbb,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0003658 abnormal capillaries "malformation in the minute blood vessels that connect arterioles and venules" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96775]
Show

Allelic Composition: Leprdb/Leprdb,Rock1tm1Leiw/Rock1tm1Leiw
Genetic Background: involves: 129S7/SvEvBrd * C57BLKS/J * FVB/N

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ncr1m1J/Ncr1m1J,Pepcb/Pepcb,Ptprca/Ptprca
Genetic Background: B6.SJL-Ptprca Pepcb/BoyJ

 MP:0003691 abnormal microglial cell function "anomalous activity of the small neuroglial cells, possibly of mesodermal origin, which may become phagocytic, in areas of neural damage or inflammation" [hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Lrp1tm2Her/Lrp1tm2Her,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

 MP:0003710 abnormal physiological neovascularization "anomalies in the development of new blood vessels in restoration of blood circulation during the healing process " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Leprdb/Leprdb,Rock1tm1Leiw/Rock1tm1Leiw
Genetic Background: involves: 129S7/SvEvBrd * C57BLKS/J * FVB/N

 MP:0003721 increased tumor growth/size "greater than expected development of tumorous growth when compared to controls" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Elavl1tm1.1Dkon/Elavl1tm1.1Dkon,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: B6.129P2-Elavl1tm1.1Dkon Lyz2tm1(cre)Ifo

 MP:0003724 susceptibility to induced arthritis "more likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [acv:Alicia Valenzuela, Genetic Resources Curator]
Show

Allelic Composition: Spta1sph/Spta1sph
Genetic Background: B6.C3-Spta1sph/BrkJ

 MP:0003725 increased autoantibody level "elevated level of antibodies to self-antigens present in the sera; often indicative of autoimmune disease" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, acv:Alicia Valenzuela, Genetic Resources Curator]
Show

Allelic Composition: Il10tm1Cgn/Il10tm1Cgn
Genetic Background: B6.129P2-Il10tm1Cgn/J

Allelic Composition: Ppargtm1.1Gonz/Ppargtm1.1Gonz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

Allelic Composition: Rxratm1Krc/Rxratm1Krc,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0003797 abnormal compact bone morphology "structural anomaly of the outer layers of solid, hard bone that covers spongy bone; consists of parallel osteons containing mineral deposits and interstitial lamellae" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Arhgap29em1(IMPC)J/Arhgap29+
Genetic Background: C57BL/6NJ-Arhgap29em1(IMPC)J/J

 MP:0003799 impaired macrophage migration "defect in the ability of macrophages to move up a chemotactic gradient" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Chuktm1Lex/Chuktm1Lex,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEvBrd

Allelic Composition: Ikbkbtm1Lex/Ikbkbtm1Lex,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEvBrd

Allelic Composition: Mapk8tm1Rjd/Mapk8tm1Rjd,Mapk9tm2.1Rjd/Mapk9tm2.1Rjd,Lyz2tm1(cre)Ifo/0
Genetic Background: B6J.Cg-Lyz2tm1(cre)Ifo Mapk9tm2.1Rjd Mapk8tm1Rjd

Allelic Composition: Fmnl1tm1.2Sdb/Fmnl1tm1.2Sdb,Lyz2tm1(cre)Ifo/Lyz2tm1(cre)Ifo
Genetic Background: involves: C3H * C57BL/6 * FVB/N

 MP:0003815 nude "having no hair at some time during or throughout lifespan, generally referring to primary genetic hairlessness" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nlrp3tm1Hhf/Nlrp3+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0003828 pulmonary edema "an accumulation of an excessive amount of watery fluid in the lung " [J:44108, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0003881 abnormal nephron morphology "malformation of the filtering unit of the kidney that includes the renal corpuscle, proximal and distal convoluted tubules, and loop of henle" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:71588]
Show

Allelic Composition: Ppargtm1.1Gonz/Ppargtm1.1Gonz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

Allelic Composition: Rxratm1Krc/Rxratm1Krc,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0003884 decreased macrophage count "fewer than the normal numbers of macrophages" [acv:Alicia Valenzuela, Genetic Resources Curator]
Show

Allelic Composition: Cflartm1.1Pope/Cflartm1.2Pope,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Ccr2tm1Mpa/Ccr2tm1Mpa,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Hmgb1tm1.1Ttg/Hmgb1tm1.1Ttg,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Mapk8tm1Rjd/Mapk8tm1Rjd,Mapk9tm2.1Rjd/Mapk9tm2.1Rjd,Lyz2tm1(cre)Ifo/0
Genetic Background: B6J.Cg-Lyz2tm1(cre)Ifo Mapk9tm2.1Rjd Mapk8tm1Rjd

Allelic Composition: Fmnl1tm1.2Sdb/Fmnl1tm1.2Sdb,Lyz2tm1(cre)Ifo/Lyz2tm1(cre)Ifo
Genetic Background: involves: C3H * C57BL/6 * FVB/N

 MP:0003917 increased kidney weight "greater heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Ppargtm1.1Gonz/Ppargtm1.1Gonz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

Allelic Composition: Rxratm1Krc/Rxratm1Krc,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Mapk8tm1Rjd/Mapk8tm1Rjd,Mapk9tm2.1Rjd/Mapk9tm2.1Rjd,Lyz2tm1(cre)Ifo/0
Genetic Background: B6J.Cg-Lyz2tm1(cre)Ifo Mapk9tm2.1Rjd Mapk8tm1Rjd

 MP:0004049 acute promyelocytic leukemia "rapid onset of abnormal leukocyte proliferation, manifesting as a severe bleeding disorder from coagulation abnormalities, and bone marrow infiltration of abnormal promyelocytes and myelocytes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ptpn11tm1Ckq/Ptpn11+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

 MP:0004154 renal tubular necrosis "pathological cell death in the proximal and/or distal renal tubules, usually due to irreversible damage " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Lyz2tm1(cre)Ifo/Lyz2+,Pdcd10tm1Wami/Pdcd10tm1Wami
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Elavl1tm1.1Dkon/Elavl1tm1.1Dkon,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: B6.129P2-Elavl1tm1.1Dkon Lyz2tm1(cre)Ifo

 MP:0004502 decreased incidence of chemically-induced tumors "lower than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(Osr1-cre)4Mrt/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004762 increased anti-double stranded DNA antibody level "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ppargtm1.1Gonz/Ppargtm1.1Gonz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

Allelic Composition: Rxratm1Krc/Rxratm1Krc,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0004771 increased anti-single stranded DNA antibody level "increase in the level of antibodies that recognize single stranded DNA" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ppargtm1.1Gonz/Ppargtm1.1Gonz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

Allelic Composition: Rxratm1Krc/Rxratm1Krc,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0004780 abnormal surfactant secretion "anomaly in the production or release from pneumocytes of surfactant, a phospholipid present in the lungs that controls surface tension in the alveoli" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lyz2tm1(DTR)Mtka/Lyz2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004794 increased anti-nuclear antigen antibody level "elevated level of antibodies to nuclear antigens present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ppargtm1.1Gonz/Ppargtm1.1Gonz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

Allelic Composition: Rxratm1Krc/Rxratm1Krc,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0004799 increased susceptibility to experimental autoimmune encephalomyelitis "greater likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hmox1tm1.1Gkl/Hmox1tm1.1Gkl,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129 * 129P2/OlaHsd * BALB/cJ * C57BL/6

Allelic Composition: Lyz2tm1(cre)Ifo/Lyz2tm1(cre)Ifo,Nrrostm1Wouy/Nrrostm1Wouy
Genetic Background: involves: 129P2/OlaHsd

 MP:0004809 increased hematopoietic stem cell number "greater cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Idh1tm1Mak/Idh1tm1Mak,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Idh1tm2Mak/Idh1tm2Mak,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004875 increased mean arterial blood pressure "increase in the average arterial pressure during a single cardiac cycle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dgcr8Gt(XG058)Byg/Dgcr8+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004883 abnormal blood vessel healing "anomaly in the repair process of blood vessels after injury" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptgestm1.1Gaf/Ptgestm1.1Gaf,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129 * C57BL/6

 MP:0004889 increased energy expenditure "increase in the number of calories used per unit time or decrease in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hmox1tm1.1Hes/Hmox1tm1.1Hes,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N

 MP:0004947 skin inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nlrp3tm2Hhf/Nlrp3+,Tg(CAG-cre/Esr1*)5Amc/?
Genetic Background: involves: 129/Sv * C57BL/6 * CBA

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Zfp36tm1.1Xen/Zfp36tm1.1Xen,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N

 MP:0004974 decreased regulatory T cell number "reduced number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lyz2tm1(cre)Ifo/Lyz2+,Pikfyvetm1b(EUCOMM)Hmgu/Pikfyvetm1b(EUCOMM)Hmgu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0004982 abnormal osteoclast morphology "any structural anomaly of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ednratm1Ywa/Ednratm1Ywa
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

Allelic Composition: Itgb3tm1Hyn/Itgb3tm1.1Wlbcr,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0004984 increased osteoclast cell number "greater than average number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Esr1tm1.1Scma/Esr1tm1.1Scma,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Rnf146tm1.1Rtpl/Rnf146tm1.1Rtpl,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004985 decreased osteoclast cell number "reduced number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Itgb3tm1Hyn/Itgb3tm1.1Wlbcr,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0004992 increased bone resorption "greater than average amount of degradation of the organic and inorganic phases of bone by absorption, usually by the abnormal function or number of osteoclasts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0004993 decreased bone resorption "reduced amount of degradation of the organic and inorganic phases of bone by absorption, usually by the abnormal function or number of osteoclasts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0005011 increased eosinophil count "greater than normal eosinophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mcl1tm1Ywh/Mcl1tm1Ywh,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Cflartm1.1Pope/Cflartm1.2Pope,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Lyz2tm1(cre)Ifo/Lyz2+,Pikfyvetm1b(EUCOMM)Hmgu/Pikfyvetm1b(EUCOMM)Hmgu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0005013 increased lymphocyte number "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cxcr4tm2Yzo/Cxcr4tm2Yzo,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Bmp5cfe-se6J/Bmp5cfe-se6J
Genetic Background: BALB/cByJ Agtpbp1pcd-3J-Bmp5cfe-se6J/GrsrJ

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1b+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Idh1tm1Mak/Idh1tm1Mak,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Idh1tm2Mak/Idh1tm2Mak,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005023 abnormal wound healing "aberrant process of repair of trauma to any tissues of the body, especially that caused by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ccr2tm1Mpa/Ccr2tm1Mpa,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Vegfatm2Gne/Vegfatm2Gne,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * FVB/N

Allelic Composition: Vegfatm2Gne/Vegfatm2Gne,Lyz2tm1(cre)Ifo/Lyz2+,Tg(KRT14-cre)1Cgn/0
Genetic Background: involves: 129 * C57BL/6 * CBA * FVB/N

 MP:0005026 decreased susceptibility to parasitic infection "reduced likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Il4ratm1Fbb/Il4ratm2Fbb,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Arg1tm1Pmu/Arg1tm1Pmu,Lyz2tm1(cre)Ifo/?
Genetic Background: B6.Cg-Arg1tm1Pmu Lyz2tm1(cre)Ifo

Allelic Composition: Il6ratm1.1Jcbr/Il6ratm1.1Jcbr,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Il4ratm1Fbb/Il4ratm2Fbb,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Il10ratm1.1Jack/Il10ratm1.1Jack,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0005040 abnormal MHC II cell surface expression on macrophages "anomaly in the ability of macrophages to express major histocompatibility complex class II at the cell surface" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31326]
Show

Allelic Composition: H2-Oatm1Dma/H2-Oatm1Dma
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005065 abnormal neutrophil morphology "structural anomaly of the granular leukocytes that have a three- to five-lobed nucleus and a cytoplasm that contains inconspicuous granules stainable by neutral dyes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lyz2tm1(cre)Ifo/Lyz2+,Pdcd10tm1Wami/Pdcd10tm1Wami
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

 MP:0005074 defective granulocyte bactericidal activity "inability or reduced ability of neutrophils, eosinophils, or basophils to kill bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:5405]
Show

Allelic Composition: Syktm1Tyb/Syktm1.2Tara,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Itgamtm1Myd/Itgamtm1Myd,Syktm1Tyb/Syktm1.2Tara,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0005087 reduced acute inflammation "less than the expected early reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into extravascular tissues; initiated by injury, infection, or local immune response " [Pathology:ISBN 0-397-51047-0, J:74478]
Show

Allelic Composition: Pdgfratm9(Pdgfra/Fgfr1)Sor/Pdgfratm11(EGFP)Sor
Genetic Background: either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)

 MP:0005165 increased susceptibility to injury "greater than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Myd88tm1Hlz/Myd88tm1Hlz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: B6.129P2-Myd88tm1Hlz Lyz2tm1(cre)Ifo

 MP:0005166 decreased susceptiblity to injury "less than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Il6sttm1Ard/Il6sttm1Ard
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Adora2btm1Msit/Adora2btm1Msit,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Thbdtm1.1Hlwu/Thbdtm1.1Hlwu,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: B6.129-Thbdtm1.1Hlwu Lyz2tm1(cre)Ifo

 MP:0005202 lethargy "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Zfp36tm1.1Xen/Zfp36tm1.1Xen,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N

 MP:0005266 abnormal metabolism "anomalous chemical and physical changes occurring in tissue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hmox1tm1.1Hes/Hmox1tm1.1Hes,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N

 MP:0005282 decreased fatty acid level "less than normal non-circulating level of organic, monobasic acids derived from hydrocarbons; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Fbn1Tsk/Fbn1+,Tg(Tcra2C,Tcrb2C)1Dlo/?
Genetic Background: involves: C57BL/10 * DBA/2

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Hmox1tm1.1Hes/Hmox1tm1.1Hes,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N

Allelic Composition: Mapk8tm1Rjd/Mapk8tm1Rjd,Mapk9tm2.1Rjd/Mapk9tm2.1Rjd,Lyz2tm1(cre)Ifo/0
Genetic Background: B6J.Cg-Lyz2tm1(cre)Ifo Mapk9tm2.1Rjd Mapk8tm1Rjd

 MP:0005319 abnormal enzyme/ coenzyme level "altered concentration of any of these proteins, or their cofactors, that act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rag2tm1.1Cgn/Rag2tm1.1Cgn
Genetic Background: C57BL/6-Rag2tm1.1Cgn

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ppargtm1.1Gonz/Ppargtm1.1Gonz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

Allelic Composition: Rxratm1Krc/Rxratm1Krc,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Zfp36tm1.1Xen/Zfp36tm1.1Xen,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N

 MP:0005329 abnormal cardiac muscle morphology "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Zfp36tm1.1Xen/Zfp36tm1.1Xen,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N

 MP:0005338 atherosclerotic lesions "thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ptpn3Gt(RRS555)Byg/Ptpn3Gt(RRS555)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apoetm1Lmh/Apoetm1Lmh,Ldlrtm1Her/Ldlrtm1Her,Lrp1tm2Her/Lrp1tm2Her,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

 MP:0005339 increased susceptibility to atherosclerosis "more likely than the norm to develop thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Apoetm1Lmh/Apoetm1Lmh,Ldlrtm1Her/Ldlrtm1Her,Lrp1tm2Her/Lrp1tm2Her,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

 MP:0005343 increased circulating aspartate transaminase level "greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
Show

Allelic Composition: Myd88tm1Hlz/Myd88tm1Hlz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: B6.129P2-Myd88tm1Hlz Lyz2tm1(cre)Ifo

Allelic Composition: Rpl13atm1.1Mazu/Rpl13atm1.1Mazu,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: C57BL/6

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Spta1sph/Spta1sph
Genetic Background: B6.C3-Spta1sph/BrkJ

 MP:0005351 decreased susceptibility to autoimmune disorders "reduced likelihood that an organism will develop disease characterized by production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tnftm1.1Sned/Tnftm1.1Sned,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

 MP:0005399 increased susceptibility to fungal infection "greater likelihood that an organism will develop ill effects from infection by a yeast or mold, or from components of, or toxins produced by, these organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Clec7atm1.1Bpip/Clec7atm1.1Bpip,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005416 abnormal circulating protein level "anomalous blood concentration of any of the macromolecules consisting of long chains of amino acids in peptide linkage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tfpitm1.1Rdsi/Tfpitm1.1Rdsi,Tg(Tek-cre)12Flv/0
Genetic Background: B6.Cg-Tfpitm1.1Rdsi Tg(Tek-cre)12Flv

 MP:0005425 increased macrophage count "greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]
Show

Allelic Composition: Stat3tm2Aki/Stat3tm2Aki,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Hmox1tm1.1Gkl/Hmox1tm1.1Gkl,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129 * 129P2/OlaHsd * BALB/cJ * C57BL/6

Allelic Composition: Elavl1tm1.1Dkon/Elavl1tm1.1Dkon,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: B6.129P2-Elavl1tm1.1Dkon Lyz2tm1(cre)Ifo

 MP:0005426 tachypnea "rapid breathing" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Zfp36tm1.1Xen/Zfp36tm1.1Xen,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N

Allelic Composition: Rpl13atm1.1Mazu/Rpl13atm1.1Mazu,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: C57BL/6

 MP:0005438 abnormal glycogen homeostasis "abnormal processing and or utilization of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mapk8tm1Rjd/Mapk8tm1Rjd,Mapk9tm2.1Rjd/Mapk9tm2.1Rjd,Lyz2tm1(cre)Ifo/0
Genetic Background: B6J.Cg-Lyz2tm1(cre)Ifo Mapk9tm2.1Rjd Mapk8tm1Rjd

 MP:0005505 increased platelet count "greater than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nlrp3tm1Hhf/Nlrp3+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Cflartm1.1Pope/Cflartm1.2Pope,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0005534 decreased body temperature "less than the level of heat natural to a living being" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Zfp36tm1.1Xen/Zfp36tm1.1Xen,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N

 MP:0005535 abnormal body temperature "deviation in the level of heat natural to a living being" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Tg(Camk2a-cre)1Szi/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0005553 increased circulating creatinine level "greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Lyz2tm1(cre)Ifo/Lyz2+,Pdcd10tm1Wami/Pdcd10tm1Wami
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mapk8tm1Rjd/Mapk8tm1Rjd,Mapk9tm2.1Rjd/Mapk9tm2.1Rjd,Lyz2tm1(cre)Ifo/0
Genetic Background: B6J.Cg-Lyz2tm1(cre)Ifo Mapk9tm2.1Rjd Mapk8tm1Rjd

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Zfp36tm1.1Xen/Zfp36tm1.1Xen,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N

Allelic Composition: Rpl13atm1.1Mazu/Rpl13atm1.1Mazu,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: C57BL/6

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gbatm1Clk/Gbatm1.1Clk,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005596 increased susceptibility to type I hypersensitvity reaction "greater likelihood of developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lyz2tm1(cre)Ifo/Lyz2+,Pikfyvetm1b(EUCOMM)Hmgu/Pikfyvetm1b(EUCOMM)Hmgu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0005630 increased lung weight "greater than the normal state of the physical heaviness of the lung" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1btm1Mbrg,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1b+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Krastm4Tyj/Kras+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Fntbtm1.1Mbrg/Fntbtm1.2Mbrg,Krastm4Tyj/Kras+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N

 MP:0006036 abnormal mitochondrial physiology 
Show

Allelic Composition: Hmox1tm1.1Hes/Hmox1tm1.1Hes,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: n-TUtca2tm2Mym/n-TUtca2tm2.1Mym,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Nfe2l2tm1Mym/Nfe2l2tm1Mym,n-TUtca2tm2Mym/n-TUtca2tm2.1Mym,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0006058 decreased cerebral infarction size "decreased size of necrotic area of the cerebrum resulting from a sudden insufficiency of arterial or venous blood supply " [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Lrp1tm2Her/Lrp1tm2Her,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

 MP:0006059 decreased susceptibility to ischemic brain injury "decreased lesion size following loss of circulation in a region of the brain; may be induced or spontaneous" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Lrp1tm2Her/Lrp1tm2Her,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

 MP:0006410 abnormal common myeloid progenitor cell morphology "anomaly in the structure of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trip13Gt(CH0621)Wtsi/Trip13Gt(CH0621)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008014 lung tumor "presence of abnormal, rapidly proliferating cells on the lung usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1btm1Mbrg,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1b+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Fntbtm1.1Mbrg/Fntbtm1.2Mbrg,Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1btm1.1Mbrg,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N

Allelic Composition: Krastm4Tyj/Kras+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Fntbtm1.1Mbrg/Fntbtm1.2Mbrg,Krastm4Tyj/Kras+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N

 MP:0008045 decreased NK cell number "reduction in the number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
Show

Allelic Composition: Il15ratm1Ama/Il15ratm2.1Ama,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J

Allelic Composition: Il15ratm1Ama/Il15ratm2.1Ama,Lyz2tm1(cre)Ifo/0,Tg(Itgax-cre)1-1Reiz/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * CBA

 MP:0008050 decreased memory T cell number "reduced number of the set of long-lived T cells differentiated from T cells activated by a specific antigen encountered during a past immune response" [adiehl:Alex Diehl_MGI GO curator, Biology-Online.org:http://www.biology-online.org/, MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il15ratm1Ama/Il15ratm2.1Ama,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J

Allelic Composition: Il15ratm1Ama/Il15ratm2.1Ama,Lyz2tm1(cre)Ifo/0,Tg(Itgax-cre)1-1Reiz/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * CBA

 MP:0008053 abnormal NK cell differentiation "atypical production of or inability to produce the non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
Show

Allelic Composition: Il15ratm1Ama/Il15ratm2.1Ama,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J

 MP:0008059 abnormal podocyte foot process morphology "any structural anomaly of the footlike extension of podocytes that interdigitate with one another to form the walls of the glomerular capillaries" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Ppargtm1.1Gonz/Ppargtm1.1Gonz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

Allelic Composition: Rxratm1Krc/Rxratm1Krc,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0008070 absent T cells "absence of the lymphocytes that are responsible for cell-mediated immunity and immune system regulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nlrp3tm1Hhf/Nlrp3+,Rag1tm1Mom/Rag1tm1Mom,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0008071 absent B cells "absence of lymphocytes that expresses membrane-bound antibody, and differentiate into antibody-secreting plasma cells and memory cells upon interaction with antigen; B cells are the primary lymphocyte responsible for humoral immunity, and are most effective against extracellular pathogens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nlrp3tm1Hhf/Nlrp3+,Rag1tm1Mom/Rag1tm1Mom,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0008073 abnormal CD4-positive T cell number "anomaly in the number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cflartm1.1Pope/Cflartm1.2Pope,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Stat3tm2Aki/Stat3tm2Aki,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Stat1tm1Rds/Stat1tm1Rds,Stat3tm2Aki/Stat3tm2Aki,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Hmox1tm1.1Gkl/Hmox1tm1.1Gkl,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129 * 129P2/OlaHsd * BALB/cJ * C57BL/6

Allelic Composition: Idh1tm1Mak/Idh1tm1Mak,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Idh1tm2Mak/Idh1tm2Mak,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Idh1tm1Mak/Idh1tm1Mak,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Idh1tm2Mak/Idh1tm2Mak,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008077 abnormal CD8-positive T cell number "anomaly in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cflartm1.1Pope/Cflartm1.2Pope,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hmox1tm1.1Gkl/Hmox1tm1.1Gkl,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129 * 129P2/OlaHsd * BALB/cJ * C57BL/6

Allelic Composition: Cflartm1.1Pope/Cflartm1.2Pope,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il15ratm1Ama/Il15ratm2.1Ama,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J

Allelic Composition: Il15ratm1Ama/Il15ratm2.1Ama,Lyz2tm1(cre)Ifo/0,Tg(Itgax-cre)1-1Reiz/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Idh1tm1Mak/Idh1tm1Mak,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Idh1tm2Mak/Idh1tm2Mak,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008113 abnormal macrophage differentiation "atypical production of or inability to produce the large mononuclear phagocytes which differentiate from monocytes, are typically resident in a particular tissue, and capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells" [CL:0000235, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Casp8tm1Wll/Casp8tm1.1Yuan,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * MF1

Allelic Composition: Slc3a2tm1.1Yait/Slc3a2tm1.1Yait,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrSlc

Allelic Composition: Mapk8tm1Rjd/Mapk8tm1Rjd,Mapk9tm2.1Rjd/Mapk9tm2.1Rjd,Lyz2tm1(cre)Ifo/0
Genetic Background: B6J.Cg-Lyz2tm1(cre)Ifo Mapk9tm2.1Rjd Mapk8tm1Rjd

 MP:0008114 abnormal Kupffer cell morphology "any structural anomaly of the phagocytic macrophages residing on the luminal surface of the hepatic sinusoids" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fmnl1tm1.2Sdb/Fmnl1tm1.2Sdb,Lyz2tm1(cre)Ifo/Lyz2tm1(cre)Ifo
Genetic Background: involves: C3H * C57BL/6 * FVB/N

 MP:0008126 increased dendritic cell number "greater number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Stat3tm2Aki/Stat3tm2Aki,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008139 fused podocyte foot processes "coalescence of the footlike extension of podocytes that interdigitate with one another to form the walls of the glomerular capillaries " [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Ppargtm1.1Gonz/Ppargtm1.1Gonz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

Allelic Composition: Rxratm1Krc/Rxratm1Krc,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0008183 absent marginal zone B cells "absence of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
Show

Allelic Composition: Lrp6Cd/Lrp6+
Genetic Background: involves: A * 129/Sv

 MP:0008236 decreased susceptibility to neuronal excitotoxicity "less than normal amount of neuronal cell death following exposure to a neurotoxic compound, such as kaniate-induced neuronal cell death mediated via a glutamate excitotoxic process" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nr3c1tm2.1Ljm/Nr3c1tm2.1Ljm,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0008240 abnormal spleen marginal zone macrophage morphology "any structural anomaly of the cells present in the splenic marginal zone and are involved in the recognition and clearance of material, such as pathogen-derived material, from the splenic circulation" [PMID:16322748]
Show

Allelic Composition: Lrp6Cd/Lrp6+
Genetic Background: involves: A * 129/Sv

 MP:0008244 abnormal peritoneal macrophage morphology "any structural anomaly of a mononuclear phagocyte that develops from bone marrow precursors but is resident in the peritoneum" [CL:0000581, MESH:A.11.329.372.630]
Show

Allelic Composition: Ppargtm1.1Gonz/Ppargtm1.1Gonz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

Allelic Composition: Rxratm1Krc/Rxratm1Krc,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0008245 abnormal alveolar macrophage morphology "any structural anomaly of the round, granular, mononuclear phagocytes found in the alveoli of the lungs which ingest small inhaled particles resulting in degradation and presentation of the antigen to immunocompetent cells" [CL:0000583, MESH:A.11.329.372.600]
Show

Allelic Composition: Lyz2tm1(DTR)Mtka/Lyz2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Lyz2tm1(cre)Ifo/Lyz2+,Pikfyvetm1b(EUCOMM)Hmgu/Pikfyvetm1b(EUCOMM)Hmgu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0008260 abnormal autophagy "abnormal catabolic process involving the degradation of a cell s own components through the lysosomal machinery" [MGI:honda "Hiraoki Onda, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atg16l1tm2.1Mvlc/Atg16l1tm2.1Mvlc,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008271 abnormal bone ossification "any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]
Show

Allelic Composition: Ednratm1Ywa/Ednratm1Ywa
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

 MP:0008396 abnormal osteoclast differentiation "atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fosl2tm2Wag/Fosl2tm2Wag,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

Allelic Composition: Itgb3tm1Hyn/Itgb3tm1.1Wlbcr,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Rnf146tm1.1Rtpl/Rnf146tm1.1Rtpl,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008406 increased cellular sensitivity to hydrogen peroxide "greater incidence of cell death following exposure to hydrogen peroxide" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nfe2l2tm1Mym/Nfe2l2tm1Mym,n-TUtca2tm2Mym/n-TUtca2tm2.1Mym,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0008412 increased cellular sensitivity to oxidative stress "greater incidence of cell death or enhanced production of reactive oxygen species after exposure to a variety of stress conditions including ionizing radiation, exposure to xenobiotics, inflammation, and phagocytosis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: n-TUtca2tm2Mym/n-TUtca2tm2.1Mym,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Nfe2l2tm1Mym/Nfe2l2tm1Mym,n-TUtca2tm2Mym/n-TUtca2tm2.1Mym,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0008470 abnormal spleen B cell follicle morphology "any structural anomaly of the area of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur" [PMID:17495967]
Show

Allelic Composition: Cflartm1.1Pope/Cflartm1.2Pope,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nlrp3tm1Hhf/Nlrp3+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Nlrp3tm1Hhf/Nlrp3+,Rag1tm1Mom/Rag1tm1Mom,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0008537 increased susceptibility to induced colitis "increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Elavl1tm1.1Dkon/Elavl1tm1.1Dkon,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: B6.129P2-Elavl1tm1.1Dkon Lyz2tm1(cre)Ifo

 MP:0008539 decreased susceptibility to induced colitis "decreased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fpr2tm1.2Jimw/Fpr2tm1.2Jimw
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Naipctm1Kmma/Naipctm1Kmma,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: B6.Cg-Lyz2tm1(cre)Ifo Naipctm1Kmma

 MP:0008553 increased circulating tumor necrosis factor level "greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Hmox1tm1.1Gkl/Hmox1tm1.1Gkl,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129 * 129P2/OlaHsd * BALB/cJ * C57BL/6

Allelic Composition: Nlrp3tm1Hhf/Nlrp3+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Il10ratm1.1Jack/Il10ratm1.1Jack,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

Allelic Composition: Fostm7Wag/Fostm7Wag,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Elavl1tm1.1Dkon/Elavl1tm1.1Dkon,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: B6.129P2-Elavl1tm1.1Dkon Lyz2tm1(cre)Ifo

Allelic Composition: Elavl1tm1.1Dkon/Elavl1tm1.1Dkon,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Zfp36tm1.1Xen/Zfp36tm1.1Xen,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N

Allelic Composition: Myd88tm1Hlz/Myd88tm1Hlz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: B6.129P2-Myd88tm1Hlz Lyz2tm1(cre)Ifo

Allelic Composition: Rpl13atm1.1Mazu/Rpl13atm1.1Mazu,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: C57BL/6

Allelic Composition: Map3k7tm1.1Gkl/Map3k7tm1.1Gkl,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Rnf146tm1.1Rtpl/Rnf146tm1.1Rtpl,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008554 decreased circulating tumor necrosis factor level "reduction in the amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Tnftm1.1Sned/Tnftm1.1Sned,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

Allelic Composition: Adam17tm1Bbl/Adam17tm1Bbl,Lyz2tm1(cre)Ifo/0
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Thbdtm1.1Hlwu/Thbdtm1.1Hlwu,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: B6.129-Thbdtm1.1Hlwu Lyz2tm1(cre)Ifo

Allelic Composition: Il6ratm1.1Jcbr/Il6ratm1.1Jcbr,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008560 increased tumor necrosis factor secretion "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Stat1tm1Rds/Stat1tm1Rds,Stat3tm2Aki/Stat3tm2Aki,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Fostm7Wag/Fostm7Wag,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Adcy7tm1.1Pcst/Adcy7tm1.1Pcst,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Map3k7tm1.1Gkl/Map3k7tm1.1Gkl,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Thbdtm1.1Hlwu/Thbdtm1.1Hlwu,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: B6.129-Thbdtm1.1Hlwu Lyz2tm1(cre)Ifo

Allelic Composition: Pycardtm1Ayaz/Pycardtm1Ayaz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Clec7atm1.1Bpip/Clec7atm1.1Bpip,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Hmox1tm1.1Hes/Hmox1tm1.1Hes,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N

 MP:0008565 decreased interferon-beta secretion "reduction in the production or release of one of the type I interferons produced by fibroblasts in response to stimulation by live or inactivated virus or by double-stranded RNA with antiviral, antiproliferative, and immunomodulating activity" [MESH:D12.644.276.374.440.890.275]
Show

Allelic Composition: Hmox1tm1.1Gkl/Hmox1tm1.1Gkl,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129 * 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Stat3tm2Aki/Stat3tm2Aki,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Stat3tm2Aki/Stat3tm2Aki,Tnftm1Sek/Tnftm1Sek,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Stat1tm1Rds/Stat1tm1Rds,Stat3tm2Aki/Stat3tm2Aki,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Hmox1tm1.1Gkl/Hmox1tm1.1Gkl,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129 * 129P2/OlaHsd * BALB/cJ * C57BL/6

Allelic Composition: Il1rntm1.1Cga/Il1rntm1.1Cga,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: D1.Cg-Il1rntm1.1Cga Lyz2tm1(cre)Ifo

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Stat3tm2Aki/Stat3tm2Aki,Tlr4tm1Aki/Tlr4tm1Aki,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd1d1tm1.1Aben/Cd1d1tm1.1Aben,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: B6.Cg-Cd1d1tm1.1Aben Lyz2tm1(cre)Ifo

 MP:0008574 decreased circulating interferon-alpha level "reduction in the amount in the blood of one of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells that has antiviral activity and activates natural killer cells and B cells" [MESH:D12.644.276.374.440.890.250]
Show

Allelic Composition: Ifnb1tm2.1Lien/Ifnb1tm2.1Lien,Tyrc-2J/Tyrc-2J,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008576 decreased circulating interferon-beta level "reduction in the amount in the blood of one of the type I interferons produced by fibroblasts in response to stimulation by live or inactivated virus or by double-stranded RNA with antiviral, antiproliferative, and immunomodulating activity" [MESH:D12.644.276.374.440.890.275]
Show

Allelic Composition: Ifnb1tm2.1Lien/Ifnb1tm2.1Lien,Tyrc-2J/Tyrc-2J,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008577 increased circulating interferon-gamma level "increase in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Il10ratm1.1Jack/Il10ratm1.1Jack,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0008593 increased circulating interleukin-10 level "increase in the amount in the blood of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
Show

Allelic Composition: Fostm7Wag/Fostm7Wag,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Stk11tm1Keis/Stk11tm1Keis,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0008594 decreased circulating interleukin-10 level "reduction in the amount in the blood of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
Show

Allelic Composition: Map3k7tm1.1Gkl/Map3k7tm1.1Gkl,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008596 increased circulating interleukin-6 level "increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Nlrp3tm1Hhf/Nlrp3+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Fostm7Wag/Fostm7Wag,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Elavl1tm1.1Dkon/Elavl1tm1.1Dkon,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: B6.129P2-Elavl1tm1.1Dkon Lyz2tm1(cre)Ifo

Allelic Composition: Elavl1tm1.1Dkon/Elavl1tm1.1Dkon,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008597 decreased circulating interleukin-6 level "reduction in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Il6sttm1Ard/Il6sttm1Ard
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Thbdtm1.1Hlwu/Thbdtm1.1Hlwu,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: B6.129-Thbdtm1.1Hlwu Lyz2tm1(cre)Ifo

 MP:0008599 increased circulating interleukin-2 level "increase in the amount in the blood of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
Show

Allelic Composition: Il10ratm1.1Jack/Il10ratm1.1Jack,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0008614 increased circulating interleukin-17 level "increase in the amount in the blood of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
Show

Allelic Composition: Il10ratm1.1Jack/Il10ratm1.1Jack,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0008617 increased circulating interleukin-12 level "increase in the amount in the blood of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
Show

Allelic Composition: Il10ratm1.1Jack/Il10ratm1.1Jack,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

Allelic Composition: Elavl1tm1.1Dkon/Elavl1tm1.1Dkon,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: B6.129P2-Elavl1tm1.1Dkon Lyz2tm1(cre)Ifo

Allelic Composition: Elavl1tm1.1Dkon/Elavl1tm1.1Dkon,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008635 increased circulating interleukin-18 level "increase in the amount in the blood of a cytokine which enhances the cytotoxic activity of NK cells and cytotoxic T-cells and appears to play a role both as neuroimmunomodulator and in the induction of mucosal immunity" [MESH:D12.644.276.374.465.518]
Show

Allelic Composition: Nlrp3tm1Hhf/Nlrp3+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Hmgb1tm1.1Ttg/Hmgb1tm1.1Ttg,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0008638 increased circulating interleukin-1 alpha level "increase in the amount in the blood of an interleukin-1 subtype that occurs as a membrane-bound pro-protein form that is cleaved by proteases to form a secreted mature form; both membrane-bound and secreted forms of interleukin-1alpha are biologically active" [MESH:D12.644.276.374.465.501.300]
Show

Allelic Composition: Il10ratm1.1Jack/Il10ratm1.1Jack,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0008641 increased circulating interleukin-1 beta level "increased in the amount in the blood of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
Show

Allelic Composition: Nlrp3tm1Hhf/Nlrp3+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Il10ratm1.1Jack/Il10ratm1.1Jack,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

Allelic Composition: Elavl1tm1.1Dkon/Elavl1tm1.1Dkon,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: B6.129P2-Elavl1tm1.1Dkon Lyz2tm1(cre)Ifo

Allelic Composition: Elavl1tm1.1Dkon/Elavl1tm1.1Dkon,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Hmgb1tm1.1Ttg/Hmgb1tm1.1Ttg,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Map3k7tm1.1Gkl/Map3k7tm1.1Gkl,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008642 decreased circulating interleukin-1 beta level "reduction in the amount in the blood of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
Show

Allelic Composition: Il6ratm1.1Jcbr/Il6ratm1.1Jcbr,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008655 decreased interleukin-1 alpha secretion "reduction in the production or release of an interleukin-1 subtype that occurs as a membrane-bound pro-protein form that is cleaved by proteases to form a secreted mature form; both membrane-bound and secreted forms of interleukin-1alpha are biologically active" [MESH:D12.644.276.374.465.501.300]
Show

Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Pycardtm1Ayaz/Pycardtm1Ayaz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008657 increased interleukin-1 beta secretion "increase in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
Show

Allelic Composition: Il1rntm1.1Cga/Il1rntm1.1Cga,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: D1.Cg-Il1rntm1.1Cga Lyz2tm1(cre)Ifo

Allelic Composition: Hmgb1tm1.1Ttg/Hmgb1tm1.1Ttg,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Map3k7tm1.1Gkl/Map3k7tm1.1Gkl,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Nr3c1tm2.1Ljm/Nr3c1tm2.1Ljm,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0008658 decreased interleukin-1 beta secretion "reduction in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
Show

Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Pycardtm1Ayaz/Pycardtm1Ayaz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Hmox1tm1.1Hes/Hmox1tm1.1Hes,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N

 MP:0008660 increased interleukin-10 secretion "increase in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
Show

Allelic Composition: Map3k7tm1.1Gkl/Map3k7tm1.1Gkl,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008661 decreased interleukin-10 secretion "reduction in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
Show

Allelic Composition: Fostm7Wag/Fostm7Wag,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Map3k7tm1.1Gkl/Map3k7tm1.1Gkl,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008663 increased interleukin-12 secretion "increase in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
Show

Allelic Composition: Stat3tm2Aki/Stat3tm2Aki,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008664 decreased interleukin-12 secretion "reduction in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
Show

Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008669 increased interleukin-12b secretion "increase in the production or release of the p40 cytokine subunit that is a component of both interleukin-12 and interleukin-23" [MESH:D12.644.276.374.465.512.500]
Show

Allelic Composition: Stat3tm2Aki/Stat3tm2Aki,Tnftm1Sek/Tnftm1Sek,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0008672 increased interleukin-13 secretion "increase in the production or release of a cytokine synthesized by T-cells that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-cells, and appears to play a role in regulating inflammatory and immune responses" [MESH:D12.644.276.374.465.513]
Show

Allelic Composition: Lyz2tm1(cre)Ifo/Lyz2+,Pikfyvetm1b(EUCOMM)Hmgu/Pikfyvetm1b(EUCOMM)Hmgu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0008681 increased interleukin-17 secretion "increase in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
Show

Allelic Composition: Il1rntm1.1Cga/Il1rntm1.1Cga,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: D1.Cg-Il1rntm1.1Cga Lyz2tm1(cre)Ifo

Allelic Composition: Abca1tm1Jp/Abca1tm1Jp,Abcg1tm1Tall/Abcg1tm1Tall,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

 MP:0008684 increased interleukin-18 secretion "increase in the production or release of a cytokine which enhances the cytotoxic activity of NK cells and cytotoxic T-cells and appears to play a role both as neuroimmunomodulator and in the induction of mucosal immunity" [MESH:D12.644.276.374.465.518]
Show

Allelic Composition: Hmgb1tm1.1Ttg/Hmgb1tm1.1Ttg,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0008690 increased interleukin-23 secretion "increase in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells" [MESH:D12.644.276.374.465.759]
Show

Allelic Composition: Abca1tm1Jp/Abca1tm1Jp,Abcg1tm1Tall/Abcg1tm1Tall,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

 MP:0008699 increased interleukin-4 secretion "increase in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
Show

Allelic Composition: Lyz2tm1(cre)Ifo/Lyz2+,Pikfyvetm1b(EUCOMM)Hmgu/Pikfyvetm1b(EUCOMM)Hmgu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0008700 decreased interleukin-4 secretion "reduction in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
Show

Allelic Composition: Cd1d1tm1.1Aben/Cd1d1tm1.1Aben,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: B6.Cg-Cd1d1tm1.1Aben Lyz2tm1(cre)Ifo

 MP:0008704 abnormal interleukin-6 secretion "anomaly in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Nr3c1tm2.1Ljm/Nr3c1tm2.1Ljm,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0008705 increased interleukin-6 secretion "increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Stat3tm2Aki/Stat3tm2Aki,Tnftm1Sek/Tnftm1Sek,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Stat1tm1Rds/Stat1tm1Rds,Stat3tm2Aki/Stat3tm2Aki,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Il1rntm1.1Cga/Il1rntm1.1Cga,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: D1.Cg-Il1rntm1.1Cga Lyz2tm1(cre)Ifo

Allelic Composition: Fostm7Wag/Fostm7Wag,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Map3k7tm1.1Gkl/Map3k7tm1.1Gkl,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008706 decreased interleukin-6 secretion "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Pycardtm1Ayaz/Pycardtm1Ayaz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Hmox1tm1.1Hes/Hmox1tm1.1Hes,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N

 MP:0008713 abnormal cytokine level "deviation from the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il10ratm1.1Jack/Il10ratm1.1Jack,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Rpl13atm1.1Mazu/Rpl13atm1.1Mazu,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: C57BL/6

 MP:0008719 impaired neutrophil recruitment "reduced diffusion or accumulation of neutrophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pdgfratm9(Pdgfra/Fgfr1)Sor/Pdgfratm11(EGFP)Sor
Genetic Background: either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)

Allelic Composition: Mcl1tm1Ywh/Mcl1tm1Ywh,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Chuktm1Lex/Chuktm1Lex,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEvBrd

Allelic Composition: Ikbkbtm1Lex/Ikbkbtm1Lex,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEvBrd

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: P4hbtm1.1Geno/P4hbtm1.2Geno,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0008720 impaired neutrophil migration "defect in the ability of neutrophils to move along a chemotactic gradient" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pdgfratm9(Pdgfra/Fgfr1)Sor/Pdgfratm11(EGFP)Sor
Genetic Background: either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)

Allelic Composition: Chuktm1Lex/Chuktm1Lex,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEvBrd

Allelic Composition: Ikbkbtm1Lex/Ikbkbtm1Lex,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEvBrd

 MP:0008721 abnormal chemokine level "deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
Show

Allelic Composition: Il10ratm1.1Jack/Il10ratm1.1Jack,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

Allelic Composition: Myd88tm1Hlz/Myd88tm1Hlz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: B6.129P2-Myd88tm1Hlz Lyz2tm1(cre)Ifo

Allelic Composition: Mapk8tm1Rjd/Mapk8tm1Rjd,Mapk9tm2.1Rjd/Mapk9tm2.1Rjd,Lyz2tm1(cre)Ifo/0
Genetic Background: B6J.Cg-Lyz2tm1(cre)Ifo Mapk9tm2.1Rjd Mapk8tm1Rjd

 MP:0008722 abnormal chemokine secretion "anomaly in the production or cellular release of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
Show

Allelic Composition: Tnftm1.1Sned/Tnftm1.1Sned,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

Allelic Composition: Il1rntm1.1Cga/Il1rntm1.1Cga,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: D1.Cg-Il1rntm1.1Cga Lyz2tm1(cre)Ifo

 MP:0008734 decreased susceptibility to endotoxin shock "less than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Btn1a1tm2Ihm/Btn1a1tm2Ihm
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Tnftm1.1Sned/Tnftm1.1Sned,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

Allelic Composition: Stat3tm2Aki/Stat3tm2Aki,Tlr4tm1Aki/Tlr4tm1Aki,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Adam17tm1Bbl/Adam17tm1Bbl,Lyz2tm1(cre)Ifo/0
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Apba3tm1.1Ski/Apba3tm1.1Ski,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: B6.129-Apba3tm1.1Ski Lyz2tm1(cre)Ifo

 MP:0008735 increased susceptibility to endotoxin shock "more than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il10tm2Roer/Il10tm2Roer,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Fostm7Wag/Fostm7Wag,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Elavl1tm1.1Dkon/Elavl1tm1.1Dkon,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: B6.129P2-Elavl1tm1.1Dkon Lyz2tm1(cre)Ifo

Allelic Composition: Elavl1tm1.1Dkon/Elavl1tm1.1Dkon,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Zfp36tm1.1Xen/Zfp36tm1.1Xen,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N

Allelic Composition: Hmgb1tm1.1Ttg/Hmgb1tm1.1Ttg,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Map3k7tm1.1Gkl/Map3k7tm1.1Gkl,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008813 decreased common myeloid progenitor cell number "reduced number of progenitor cells committed to myeloid lineage, including the megakaryocyte and erythroid lineages" [CL:0000049, MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Idh1tm1Mak/Idh1tm1Mak,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Idh1tm2Mak/Idh1tm2Mak,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008943 increased sensitivity to induced cell death "decrease in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hmgb1tm1.1Ttg/Hmgb1tm1.1Ttg,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0008973 decreased erythroid progenitor cell number "reduced numbers of progenitors of the erythrocyte lineage" [CL:0000038, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trip13Gt(CH0621)Wtsi/Trip13Gt(CH0621)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009172 small pancreatic islets "decrease in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
Show

Allelic Composition: Mapk8tm1Rjd/Mapk8tm1Rjd,Mapk9tm2.1Rjd/Mapk9tm2.1Rjd,Lyz2tm1(cre)Ifo/0
Genetic Background: B6J.Cg-Lyz2tm1(cre)Ifo Mapk9tm2.1Rjd Mapk8tm1Rjd

 MP:0009269 decreased fat cell size "reduction in the size of fat-storing cells found mostly in the abdominal cavity and subcutaneous tissue of mammals" [CL:0000449]
Show

Allelic Composition: Hmox1tm1.1Hes/Hmox1tm1.1Hes,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N

 MP:0009278 abnormal bone marrow cell physiology "any functional anomaly of any of the cells found in the blood" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Idh1tm1Mak/Idh1tm1Mak,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Idh1tm2Mak/Idh1tm2Mak,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009314 colon adenocarcinoma "malignant neoplasm of epithelial cells in the colon" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Elavl1tm1.1Dkon/Elavl1tm1.1Dkon,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: B6.129P2-Elavl1tm1.1Dkon Lyz2tm1(cre)Ifo

 MP:0009336 increased splenocyte proliferation "increase in the expansion rate of a splenocyte cell population by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hmox1tm1.1Gkl/Hmox1tm1.1Gkl,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129 * 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0009543 abnormal thymus corticomedullary boundary morphology "any structural anomaly of the dense region demarcating the thymus medulla from the surrounding cortex that is characterized by numerous blood vessels (predominantly arterioles) with some perivascular connective tissue, mature and immature T lymphocytes, dendritic cells, variable numbers of perivascular B-lymphocytes and plasma cells; site of entry of bone marrow stem cells and exit of mature, functional T cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:17067941]
Show

Allelic Composition: Cflartm1.1Pope/Cflartm1.2Pope,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0009625 abnormal abdominal lymph node morphology 
Show

Allelic Composition: Cflartm1.1Pope/Cflartm1.2Pope,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Idh1tm1Mak/Idh1tm1Mak,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Idh1tm2Mak/Idh1tm2Mak,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tnftm1.1Sned/Tnftm1.1Sned,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

Allelic Composition: Map3k7tm1.1Gkl/Map3k7tm1.1Gkl,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009764 decreased sensitivity to induced morbidity/mortality "increase in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Thbdtm1.1Hlwu/Thbdtm1.1Hlwu,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: B6.129-Thbdtm1.1Hlwu Lyz2tm1(cre)Ifo

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Elavl1tm1.1Dkon/Elavl1tm1.1Dkon,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: B6.129P2-Elavl1tm1.1Dkon Lyz2tm1(cre)Ifo

Allelic Composition: Elavl1tm1.1Dkon/Elavl1tm1.1Dkon,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0009767 decreased sensitivity to xenobiotic induced morbidity/mortality "increase in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Apba3tm1.1Ski/Apba3tm1.1Ski,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: B6.129-Apba3tm1.1Ski Lyz2tm1(cre)Ifo

 MP:0009788 increased susceptibility to bacterial infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0009789 decreased susceptibility to bacterial infection induced morbidity/mortality "reduced likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hmox1tm1.1Gkl/Hmox1tm1.1Gkl,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129 * 129P2/OlaHsd * BALB/cJ * C57BL/6

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Thbdtm1.1Hlwu/Thbdtm1.1Hlwu,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: B6.129-Thbdtm1.1Hlwu Lyz2tm1(cre)Ifo

 MP:0009814 increased prostaglandin level "increase in the amount in the body of any of a class of mediators with effects of vasodilation, vasoconstriction, and smooth muscle stimulation" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Ptgestm1.1Gaf/Ptgestm1.1Gaf,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129 * C57BL/6

 MP:0009815 decreased prostaglandin level "reduction in the amount in the body of any of a class of mediators with effects of vasodilation, vasoconstriction, and smooth muscle stimulation" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Ptgestm1.1Gaf/Ptgestm1.1Gaf,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129 * C57BL/6

 MP:0009858 abnormal cellular extravasation "any anomaly in the migration of leukocytes from the blood vessels into the surrounding tissue" [GO:0045123]
Show

Allelic Composition: Lyz2tm1(cre)Ifo/Lyz2tm1(cre)Ifo,Nrrostm1Wouy/Nrrostm1Wouy
Genetic Background: involves: 129P2/OlaHsd

 MP:0010064 increased circulating creatine level "increase in the amount per unit of blood of an amino acid that is found in muscle tissue of vertebrates as phosphocreatine and supplies energy for muscle contraction when metabolized" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ppargtm1.1Gonz/Ppargtm1.1Gonz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

Allelic Composition: Rxratm1Krc/Rxratm1Krc,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0010182 decreased susceptibility to weight gain "smaller increase in body weight over time when compared to the average increase in weight on the same diet, with equal energy (calorie) intake" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hmox1tm1.1Hes/Hmox1tm1.1Hes,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N

 MP:0010209 abnormal circulating chemokine level "deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes in the circulation" [MESH:D12.644.276.374.200, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nlrp3tm1Hhf/Nlrp3+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Mapk8tm1Rjd/Mapk8tm1Rjd,Mapk9tm2.1Rjd/Mapk9tm2.1Rjd,Lyz2tm1(cre)Ifo/0
Genetic Background: B6J.Cg-Lyz2tm1(cre)Ifo Mapk9tm2.1Rjd Mapk8tm1Rjd

 MP:0010210 abnormal circulating cytokine level "deviation from the normal levels in the blood of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nlrp3tm1Hhf/Nlrp3+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Mapk8tm1Rjd/Mapk8tm1Rjd,Mapk9tm2.1Rjd/Mapk9tm2.1Rjd,Lyz2tm1(cre)Ifo/0
Genetic Background: B6J.Cg-Lyz2tm1(cre)Ifo Mapk9tm2.1Rjd Mapk8tm1Rjd

 MP:0010373 myeloid hyperplasia "greater than normal number of nucleated cells of the myeloid lineage (a monocyte, granulocyte, or mast cell), found in blood or other tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trip13Gt(CH0621)Wtsi/Trip13Gt(CH0621)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ptpn11tm1Ckq/Ptpn11+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Kmt2atm1.1(Sh3gl1)Lcc/Kmt2a+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

 MP:0010639 altered tumor pathology "any changes associated with the chemistry, immunohistology, cellular alterations or environmental interactions of tumors compared to the expected state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Itgb3tm1Hyn/Itgb3tm1.1Wlbcr,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0010760 abnormal macrophage chemotaxis "anomaly in the movement of a macrophage guided by a specific chemical concentration gradient" [GO:0048246]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Elavl1tm1.1Dkon/Elavl1tm1.1Dkon,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: B6.129P2-Elavl1tm1.1Dkon Lyz2tm1(cre)Ifo

Allelic Composition: Rpl13atm1.1Mazu/Rpl13atm1.1Mazu,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: C57BL/6

 MP:0010762 abnormal microglial cell activation "any anomaly in change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, during the maturation to the fully active phagocytic form" [GO:0001774, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il1r1tm1Quan/Il1r1tm1Quan,Lyz2tm1(cre)Ifo/Lyz2tm1(cre)Ifo
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010766 abnormal NK cell physiology "any functional anomaly of a lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells" [GOC:add, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15771571]
Show

Allelic Composition: Il15ratm1Ama/Il15ratm2.1Ama,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J

 MP:0010812 absent type II pneumocytes "absence of the granular and roughly cuboidal cells typically found at the alveolar-septal junction that modulate the fluid surrounding the alveolar epithelium by secreting and recycling surfactants, and also contribute to tissue repair and can differentiate after injury into a type I pneumocyte; type II cells cover a much smaller surface area than type I cells (less than 5 percent), but are much more numerous and contain lamellar bodies on the apical surface where surfactant is stored" [ISBN:0412046911, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", PMID:8540632]
Show

Allelic Composition: Lyz2tm1(DTR)Mtka/Lyz2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010869 decreased bone trabecula number "decreased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rnf146tm1.1Rtpl/Rnf146tm1.1Rtpl,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0010873 decreased trabecular bone mass "reduced total amount of trabecular bone tissue contained in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rnf146tm1.1Rtpl/Rnf146tm1.1Rtpl,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0010875 increased bone volume "increased amount of space occupied by bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0010878 increased trabecular bone volume "increase in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Itgb3tm1Hyn/Itgb3tm1.1Wlbcr,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0010879 decreased trabecular bone volume "decrease in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Rnf146tm1.1Rtpl/Rnf146tm1.1Rtpl,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0010922 alveolitis "inflammation of the small sac-like dilations of the distal airspace of the lung; acute pulmonary alveolitis involves exudate into the pulmonary alveoli and impaired gas exchange" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Zfp36tm1.1Xen/Zfp36tm1.1Xen,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N

 MP:0010954 abnormal cellular respiration "anomaly in the enzymatic release of energy from organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration)" [GO:0045333]
Show

Allelic Composition: Hmox1tm1.1Hes/Hmox1tm1.1Hes,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N

 MP:0010957 abnormal aerobic respiration "any anomaly in the process of enzymatic release of energy from organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor" [GO:0009060]
Show

Allelic Composition: Ptpmt1tm2.1Ckq/Ptpmt1tm2.1Ckq,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0010962 decreased compact bone mass 
Show

Allelic Composition: Esr1tm1.1Scma/Esr1tm1.1Scma,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

 MP:0011014 decreased core body temperature "reduced degree of heat natural to the internal center of a living being" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fbn1Tsk/Fbn1+,Tg(Tcra2C,Tcrb2C)1Dlo/?
Genetic Background: involves: C57BL/10 * DBA/2

 MP:0011075 abnormal macrophage activation involved in immune response "anomaly in the process in which a change in morphology and behavior of a macrophage results from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response" [GO:0002281]
Show

Allelic Composition: Ppargtm1.1Gonz/Ppargtm1.1Gonz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

Allelic Composition: Rxratm1Krc/Rxratm1Krc,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0011079 decreased macrophage cytokine production "reduced production of macrophage-derived cytokine(s) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mapk8tm1Rjd/Mapk8tm1Rjd,Mapk9tm2.1Rjd/Mapk9tm2.1Rjd,Lyz2tm1(cre)Ifo/0
Genetic Background: B6J.Cg-Lyz2tm1(cre)Ifo Mapk9tm2.1Rjd Mapk8tm1Rjd

 MP:0011080 increased macrophage apoptosis "greater incidence of cell death in macrophages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tymptm1Mihi/Tymptm1Mihi,Upp1tm1Gp/Upp1tm1Gp
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6J

Allelic Composition: Apoetm1Bres/Apoetm1Bres,Bcl2tm1Irt/Bcl2tm1Irt,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ikbkbtm2Mka/Ikbkbtm2Mka,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd

Allelic Composition: Hmgb1tm1.1Ttg/Hmgb1tm1.1Ttg,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Nlrp3tm1Hhf/Nlrp3+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Nlrp3tm1Hhf/Nlrp3+,Rag1tm1Mom/Rag1tm1Mom,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Nlrp3tm1Flv/Nlrp3tm1Hhf,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Krastm4Tyj/Kras+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1btm1Mbrg,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1b+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Nlrp3tm1Hhf/Nlrp3+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0011294 renal glomerulus hypertrophy "increase in the bulk size of the capillary loops of the kidney that normally function as a filtration unit, due to cell enlargement" [MGI:anna]
Show

Allelic Composition: Ppargtm1.1Gonz/Ppargtm1.1Gonz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

Allelic Composition: Rxratm1Krc/Rxratm1Krc,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0011353 expanded mesangial matrix "increase in the amount of mesangial matrix present in the basement membrane surrounding the glomerular capillaries that also contain the intraglomerular mesangial cells" [MGI:csmith]
Show

Allelic Composition: Ppargtm1.1Gonz/Ppargtm1.1Gonz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

Allelic Composition: Rxratm1Krc/Rxratm1Krc,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0011369 increased renal glomerulus apoptosis "increase in the number of cells of the kidney glomerulus undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Ppargtm1.1Gonz/Ppargtm1.1Gonz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

Allelic Composition: Rxratm1Krc/Rxratm1Krc,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0011409 increased renal glomerulus basement membrane thickness "increased width of the layer of extracellular matrix that lies between the endothelium of the glomerular capillaries and the podocytes of the inner or visceral layer of the Bowman capsule" [MGI:anna]
Show

Allelic Composition: Ppargtm1.1Gonz/Ppargtm1.1Gonz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

Allelic Composition: Rxratm1Krc/Rxratm1Krc,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0011427 mesangial cell hyperplasia "increased number of the phagocytic cells in the capillary tuft of the renal glomerulus, interposed between endothelial cells and the basement membrane in the central or stalk region of the tuft" [MGI:anna]
Show

Allelic Composition: Ppargtm1.1Gonz/Ppargtm1.1Gonz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

Allelic Composition: Rxratm1Krc/Rxratm1Krc,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0011820 decreased pancreatic beta cell proliferation "reduction in the ability of the cells that secrete insulin and are located towards the center of the islets of Langerhans in the pancreas to undergo expansion by cell division" [CL:0000169]
Show

Allelic Composition: Mapk8tm1Rjd/Mapk8tm1Rjd,Mapk9tm2.1Rjd/Mapk9tm2.1Rjd,Lyz2tm1(cre)Ifo/0
Genetic Background: B6J.Cg-Lyz2tm1(cre)Ifo Mapk9tm2.1Rjd Mapk8tm1Rjd

 MP:0012007 abnormal chloride level "any change in the amount of chloride, the major extracellular anion in mammals; it plays roles in tissue fluid homeostasis and also helps maintain proper blood volume, blood pressure, and body fluid pH" [MGI:csmith]
Show

Allelic Composition: Dgcr8Gt(XG058)Byg/Dgcr8+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0012441 abnormal monocyte cell number "any deviation in the count of the large, phagocytic mononuclear leukocytes produced in the vertebrate bone marrow and released into the blood" [CL:0000576, MGI:csmith]
Show

Allelic Composition: Nr3c1tm2.1Ljm/Nr3c1tm2.1Ljm,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0013026 decreased Ly6C low monocyte number "decrease in the number of monocytes that express low levels of Ly6C and low MHC class II that represent a subset of patrolling monocytes" [MGI:Annie_Speak]
Show

Allelic Composition: Atmtm1Awb/Atmtm1Awb,Paxxem1Spj/Paxxem1Spj
Genetic Background: involves: A/J * C57BL/6NTac

Allelic Composition: Klf4tm1Khk/Klf4tm1Khk,Lyz2tm1(cre)Ifo/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0013630 increased bone trabecular spacing "increase in the amount of space between trabeculae in cancellous bone" [MGI:jwhite]
Show

Allelic Composition: Rnf146tm1.1Rtpl/Rnf146tm1.1Rtpl,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0014226 abnormal alveolar macrophage physiology 
Show

Allelic Composition: Lyz2tm1(cre)Ifo/Lyz2+,Pikfyvetm1b(EUCOMM)Hmgu/Pikfyvetm1b(EUCOMM)Hmgu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0014229 decreased alveolar macrophage number 
Show

Allelic Composition: Lyz2tm1(cre)Ifo/Lyz2+,Pikfyvetm1b(EUCOMM)Hmgu/Pikfyvetm1b(EUCOMM)Hmgu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0020254 decreased collagen level "decreased level of the main structural protein of the various connective tissues in animals" [GOC:NV, PMID:11704682]
Show

Allelic Composition: Itgb3tm1Hyn/Itgb3tm1.1Wlbcr,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr