ENSMUSG00000069539


Mus musculus

Features
Gene ID: ENSMUSG00000069539
  
Biological name :Scyl2
  
Synonyms : Mus musculus SCY1-like 2 (S. cerevisiae) (Scyl2), transcript variant 3, mRNA. / Q8CFE4 / Scyl2
  
Possible biological names infered from orthology : Q6P3W7 / SCY1 like pseudokinase 2
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: C2
Gene start: 89638721
Gene end: 89686285
  
Corresponding Affymetrix probe sets: 10371811 (MoGene1.0st)   1436313_at (Mouse Genome 430 2.0 Array)   1436314_at (Mouse Genome 430 2.0 Array)   1440269_at (Mouse Genome 430 2.0 Array)   1446528_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000089874
Ensembl peptide - ENSMUSP00000133992
Ensembl peptide - ENSMUSP00000134366
NCBI entrez gene - 213326     See in Manteia.
MGI - MGI:1289172
RefSeq - XM_011243394
RefSeq - NM_001310704
RefSeq - NM_001358843
RefSeq - NM_198021
RefSeq - XM_006513458
RefSeq Peptide - NP_001345772
RefSeq Peptide - NP_932138
RefSeq Peptide - NP_001297633
swissprot - Q80UY7
swissprot - Q8CFE4
swissprot - G5E8J9
Ensembl - ENSMUSG00000069539
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SCYL2ENSDARG00000032627Danio rerio
 SCYL2ENSGALG00000011569Gallus gallus
 SCYL2ENSG00000136021Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR011009  Protein kinase-like domain superfamily
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002092 positive regulation of receptor internalization ISO
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0008333 endosome to lysosome transport ISO
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway ISO
 biological_processGO:2000286 receptor internalization involved in canonical Wnt signaling pathway ISO
 biological_processGO:2000370 positive regulation of clathrin-dependent endocytosis ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030136 clathrin-coated vesicle IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0005102 signaling receptor binding ISO
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Tbr1tm1Jlr/Tbr1+
Genetic Background: B6.129X1-Tbr1tm1Jlr

 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
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Allelic Composition: Tbr1tm1Jlr/Tbr1+
Genetic Background: B6.129X1-Tbr1tm1Jlr

 MP:0000811 hippocampal neuron degeneration "a retrogressive impairment of function or destruction of the neuronal cells in the hippocampus" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:72427]
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Allelic Composition: Tbr1tm1Jlr/Tbr1+
Genetic Background: B6.129X1-Tbr1tm1Jlr

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Tbr1tm1Jlr/Tbr1+
Genetic Background: B6.129X1-Tbr1tm1Jlr

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Baxtm2Sjk/Baxtm2Sjk,Scyl2tm1.1Spel/Scyl2tm1.1Spel,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * SJL

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Tbr1tm1Jlr/Tbr1+
Genetic Background: B6.129X1-Tbr1tm1Jlr

Allelic Composition: Scyl2tm1.2Spel/Scyl2tm1.2Spel
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tbr1tm1Jlr/Tbr1+
Genetic Background: B6.129X1-Tbr1tm1Jlr

Allelic Composition: Scyl2tm1.2Spel/Scyl2tm1.2Spel
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tbr1tm1Jlr/Tbr1+
Genetic Background: B6.129X1-Tbr1tm1Jlr

 MP:0002912 abnormal excitatory postsynaptic potential "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Tbr1tm1Jlr/Tbr1+
Genetic Background: B6.129X1-Tbr1tm1Jlr

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Tbr1tm1Jlr/Tbr1+
Genetic Background: B6.129X1-Tbr1tm1Jlr

 MP:0003354 astrocytosis "a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tbr1tm1Jlr/Tbr1+
Genetic Background: B6.129X1-Tbr1tm1Jlr

 MP:0003360 depression-related behavior 
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Allelic Composition: Tbr1tm1Jlr/Tbr1+
Genetic Background: B6.129X1-Tbr1tm1Jlr

 MP:0003415 priapism "prolonged penile erection, often painful and without sexual desire " [smb:Susan M Bello, Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tbr1tm1Jlr/Tbr1+
Genetic Background: B6.129X1-Tbr1tm1Jlr

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tbr1tm1Jlr/Tbr1+
Genetic Background: B6.129X1-Tbr1tm1Jlr

Allelic Composition: Scyl2tm1.2Spel/Scyl2tm1.2Spel
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0008283 small hippocampus "reduced size of the deep lying structure of the cerebrum involved with memory storage and spatial navigation" [ISBN:0-12-402035-6 "Kaufman, MH The Atlas of Mouse Development", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tbr1tm1Jlr/Tbr1+
Genetic Background: B6.129X1-Tbr1tm1Jlr

 MP:0008918 microgliosis "a proliferation or spread of microglia in the area of a degenerative lesion or damaged tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tbr1tm1Jlr/Tbr1+
Genetic Background: B6.129X1-Tbr1tm1Jlr

 MP:0009546 absent gastric milk in neonates "failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Scyl2tm1.2Spel/Scyl2tm1.2Spel
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0009971 decreased hippocampus pyramidal cell number "decreased number of the projection neurons in the pyramidal layer of the hippocampus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tbr1tm1Jlr/Tbr1+
Genetic Background: B6.129X1-Tbr1tm1Jlr

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Tbr1tm1Jlr/Tbr1+
Genetic Background: B6.129X1-Tbr1tm1Jlr

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Tbr1tm1Jlr/Tbr1+
Genetic Background: B6.129X1-Tbr1tm1Jlr

Allelic Composition: Scyl2tm1.2Spel/Scyl2tm1.2Spel
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Baxtm2Sjk/Baxtm2Sjk,Scyl2tm1.1Spel/Scyl2tm1.1Spel,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * SJL

 MP:0012460 decreased dentate gyrus size "reduced size of one of two interlocking gyri of the hippocampus formation that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [MGI:csmith]
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Allelic Composition: Tbr1tm1Jlr/Tbr1+
Genetic Background: B6.129X1-Tbr1tm1Jlr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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