ENSMUSG00000069833


Mus musculus

Features
Gene ID: ENSMUSG00000069833
  
Biological name :Ahnak
  
Synonyms : Ahnak / AHNAK nucleoprotein (desmoyokin)
  
Possible biological names infered from orthology : AHNAK nucleoprotein / Q09666
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: A
Gene start: 8989284
Gene end: 9076919
  
Corresponding Affymetrix probe sets: 10461369 (MoGene1.0st)   1428057_a_at (Mouse Genome 430 2.0 Array)   1428058_at (Mouse Genome 430 2.0 Array)   1429866_at (Mouse Genome 430 2.0 Array)   1452217_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000090632
Ensembl peptide - ENSMUSP00000090633
NCBI entrez gene - 66395     See in Manteia.
MGI - MGI:1316648
RefSeq - XM_017318272
RefSeq - NM_001039959
RefSeq - NM_001286518
RefSeq - NM_009643
RefSeq - XM_006527253
RefSeq - XM_006527256
RefSeq Peptide - NP_001273447
RefSeq Peptide - NP_033773
RefSeq Peptide - NP_001035048
swissprot - G5E8K8
swissprot - E9Q616
Ensembl - ENSMUSG00000069833
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ahnakENSDARG00000061764Danio rerio
 AHNAKENSG00000124942Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ahnak2 / AHNAK nucleoprotein 2 / Q8IVF2*ENSMUSG000000728126
Prx / O55103 / Periaxin / Q9BXM0*ENSMUSG000000531986


Protein motifs (from Interpro)
Interpro ID Name
 IPR001478  PDZ domain
 IPR036034  PDZ superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0043484 regulation of RNA splicing IDA
 biological_processGO:0051259 protein complex oligomerization IMP
 biological_processGO:1901385 regulation of voltage-gated calcium channel activity IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005911 cell-cell junction ISS
 cellular_componentGO:0015629 actin cytoskeleton IEA
 cellular_componentGO:0031982 vesicle IEA
 cellular_componentGO:0042383 sarcolemma IEA
 cellular_componentGO:0043034 costamere IDA
 cellular_componentGO:0044291 cell-cell contact zone ISS
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0070062 extracellular exosome IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0044548 S100 protein binding IEA
 molecular_functionGO:0045296 cadherin binding IEA
 molecular_functionGO:0097493 structural molecule activity conferring elasticity IMP


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Cflartm1.1Pope/Cflartm1.2Pope,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Prkar2btm1Gsm/Prkar2btm1Gsm
Genetic Background: B6.129-Prkar2btm1Gsm

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lamp1tm1Psa/Lamp1tm1Psa,Lamp2tm1Psa/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Prkar2btm1Gsm/Prkar2btm1Gsm
Genetic Background: B6.129-Prkar2btm1Gsm

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Prkar2btm1Gsm/Prkar2btm1Gsm
Genetic Background: B6.129-Prkar2btm1Gsm

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Adipor1tm1b(EUCOMM)Hmgu/Adipor1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Adipor1tm1b(EUCOMM)Hmgu/H

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Adipor1tm1b(EUCOMM)Hmgu/Adipor1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Adipor1tm1b(EUCOMM)Hmgu/H

 MP:0005465 abnormal T helper 1 physiology "anomalous response of the subset of helper T cells that enhance cell-mediated immune responses; these cells secrete IL-1 and gamma-IFN and are generally involved in inflammatory responses" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Prkar2btm1Gsm/Prkar2btm1Gsm
Genetic Background: B6.129-Prkar2btm1Gsm

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
Show

Allelic Composition: Cflartm1.1Pope/Cflartm1.2Pope,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Prkar2btm1Gsm/Prkar2btm1Gsm
Genetic Background: B6.129-Prkar2btm1Gsm

 MP:0008688 decreased interleukin-2 secretion "reduction in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
Show

Allelic Composition: Prkar2btm1Gsm/Prkar2btm1Gsm
Genetic Background: B6.129-Prkar2btm1Gsm

 MP:0008699 increased interleukin-4 secretion "increase in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
Show

Allelic Composition: Prkar2btm1Gsm/Prkar2btm1Gsm
Genetic Background: B6.129-Prkar2btm1Gsm

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cflartm1.1Pope/Cflartm1.2Pope,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Adipor1tm1b(EUCOMM)Hmgu/Adipor1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Adipor1tm1b(EUCOMM)Hmgu/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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