ENSMUSG00000053198


Mus musculus

Features
Gene ID: ENSMUSG00000053198
  
Biological name :Prx
  
Synonyms : O55103 / Periaxin / Prx
  
Possible biological names infered from orthology : Q9BXM0
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: A3
Gene start: 27499324
Gene end: 27520214
  
Corresponding Affymetrix probe sets: 10551365 (MoGene1.0st)   1423292_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000103992
Ensembl peptide - ENSMUSP00000145598
Ensembl peptide - ENSMUSP00000066110
Ensembl peptide - ENSMUSP00000096241
NCBI entrez gene - 19153     See in Manteia.
MGI - MGI:108176
RefSeq - NM_198048
RefSeq - XM_006539666
RefSeq - NM_019412
RefSeq Peptide - NP_062285
RefSeq Peptide - NP_932165
swissprot - A0A0U1RNK1
swissprot - O55103
swissprot - Q6NVF7
swissprot - E9QQ57
Ensembl - ENSMUSG00000053198
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prxENSDARG00000017246Danio rerio
 PRXENSG00000105227Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ahnak / AHNAK nucleoprotein (desmoyokin) / Q09666* / AHNAK nucleoprotein*ENSMUSG0000006983324
Ahnak2 / AHNAK nucleoprotein 2 / Q8IVF2*ENSMUSG0000007281222


Protein motifs (from Interpro)
Interpro ID Name
 IPR001478  PDZ domain
 IPR036034  PDZ superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0019226 transmission of nerve impulse IMP
 biological_processGO:0019233 sensory perception of pain IMP
 biological_processGO:0032287 peripheral nervous system myelin maintenance IMP
 biological_processGO:0032290 peripheral nervous system myelin formation IMP
 biological_processGO:0043484 regulation of RNA splicing IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000344 absent Cajal-Retzius cell "the absence of a distinct population of large, bipolar cells, distributed in a continuous band along the marginal zone of the cortex extending to the molecular layer of the dentate gyrus" [J:60896, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Pip5k1ctm1.2Ref/Pip5k1ctm1.2Ref
Genetic Background: involves: 129

 MP:0000920 abnormal myelination "atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Plectm2Gwi/Plectm2Gwi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Prxtm2.1Brp/Prxtm2.1Brp
Genetic Background: B6.129P2-Prxtm2.1Brp

Allelic Composition: Prxtm1Brp/Prxtm1Brp
Genetic Background: involves: 129P2/OlaHsd

 MP:0001106 abnormal Schwann cell "malformed or absent cells which form the insulating myelin sheaths of peripheral axons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Plectm2Gwi/Plectm2Gwi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Prxtm1Brp/Prxtm1Brp,Tg(Mpz/GJB1-Prx*)#Brp/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Prxtm2.1Brp/Prxtm2.1Brp
Genetic Background: B6.129P2-Prxtm2.1Brp

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Plectm2Gwi/Plectm2Gwi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Pip5k1ctm1.2Ref/Pip5k1ctm1.2Ref
Genetic Background: involves: 129

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Plectm2Gwi/Plectm2Gwi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001438 aphagia "inability to eat " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:30404]
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Allelic Composition: Plectm2Gwi/Plectm2Gwi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Plectm2Gwi/Plectm2Gwi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001968 abnormal touch/ nociception "change in the ability to sense contact with objects or in the ability to sense pain, most often registered by mechanoreceptors in the skin and mucous membranes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Plectm2Gwi/Plectm2Gwi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Plectm2Gwi/Plectm2Gwi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002314 abnormal respiratory mechanics "anomaly in the action of the lungs, diaphragm, ribs and chest wall during respiration" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Plectm2Gwi/Plectm2Gwi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003998 decreased thermal nociceptive threshold "a lower than average point at which thermal pain sensation is first detectable" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Plectm2Gwi/Plectm2Gwi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005402 abnormal action potential "change in the electric response of a nerve or other excitable tissue to its stimulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Plectm2Gwi/Plectm2Gwi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005403 abnormal nerve conduction "anomaly in the act of transmitting electricity along a single nerve" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Plectm2Gwi/Plectm2Gwi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Prxtm2.1Brp/Prxtm2.1Brp
Genetic Background: B6.129P2-Prxtm2.1Brp

 MP:0005498 hyporesponsive to tactile stimuli "reduced reflex action normally induced by touch or pain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Plectm2Gwi/Plectm2Gwi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008814 reduced nerve conduction velocity "decrease in the rate at which an eletrical impulse travels through a nerve" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Prxtm2.1Brp/Prxtm2.1Brp
Genetic Background: B6.129P2-Prxtm2.1Brp

Allelic Composition: Prxtm1Brp/Prxtm1Brp
Genetic Background: involves: 129P2/OlaHsd

 MP:0010738 abnormal internode morphology "any structrual anomaly of the intervening axon segment that is located between the juxtaparanodes and is surrounded by a single compact myelin sheath" [PMID:18929652]
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Allelic Composition: Prxtm2.1Brp/Prxtm2.1Brp
Genetic Background: B6.129P2-Prxtm2.1Brp

Allelic Composition: Prxtm1Brp/Prxtm1Brp
Genetic Background: involves: 129P2/OlaHsd

 MP:0010742 increased Schwann cell number "greater than normal number of cells that sheath the axons of the peripheral nervous system" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prxtm2.1Brp/Prxtm2.1Brp
Genetic Background: B6.129P2-Prxtm2.1Brp

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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