ENSMUSG00000070327


Mus musculus

Features
Gene ID: ENSMUSG00000070327
  
Biological name :Rnf213
  
Synonyms : E9Q555 / ring finger protein 213 / Rnf213
  
Possible biological names infered from orthology : Q63HN8
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: E2
Gene start: 119393100
Gene end: 119487418
  
Corresponding Affymetrix probe sets: 10383152 (MoGene1.0st)   10383168 (MoGene1.0st)   10383192 (MoGene1.0st)   10383194 (MoGene1.0st)   10383196 (MoGene1.0st)   10383198 (MoGene1.0st)   10383200 (MoGene1.0st)   10383202 (MoGene1.0st)   10383204 (MoGene1.0st)   10383206 (MoGene1.0st)   10383208 (MoGene1.0st)   10383210 (MoGene1.0st)   10383212 (MoGene1.0st)   10383214 (MoGene1.0st)   10383233 (MoGene1.0st)   1455500_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000115063
Ensembl peptide - ENSMUSP00000130027
Ensembl peptide - ENSMUSP00000091429
NCBI entrez gene - 672511     See in Manteia.
MGI - MGI:1289196
RefSeq - XM_006534630
RefSeq - XM_006534631
RefSeq - XM_006534632
RefSeq - XM_006534633
swissprot - A0A171EBL2
swissprot - Q3U0U2
swissprot - E9Q555
Ensembl - ENSMUSG00000070327
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01058333.1ENSDARG00000113458Danio rerio
 rnf213aENSDARG00000099465Danio rerio
 RNF213ENSGALG00000039269Gallus gallus
 Q63HN8ENSG00000173821Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR003593  AAA+ ATPase domain
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR017907  Zinc finger, RING-type, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR031248  RNF213 protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis ISO
 biological_processGO:0002040 sprouting angiogenesis ISO
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process ISS
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0051260 protein homooligomerization ISS
 biological_processGO:0051865 protein autoubiquitination ISO
 biological_processGO:2000051 negative regulation of non-canonical Wnt signaling pathway ISO
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016887 ATPase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Glp1rtm1Ddr/Glp1rtm1Ddr
Genetic Background: B6.129-Glp1rtm1Ddr

Allelic Composition: Ins2Akita/Ins2+,Rnf213tm1.1Akoi/Rnf213tm1.1Akoi
Genetic Background: involves: C57BL/6N * C57BL/6NSlc

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sprtntm1Yjm/Sprtntm1.2Yjm
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Glp1rtm1Ddr/Glp1rtm1Ddr
Genetic Background: B6.129-Glp1rtm1Ddr

Allelic Composition: Ins2Akita/Ins2+,Rnf213tm1.1Akoi/Rnf213tm1.1Akoi
Genetic Background: involves: C57BL/6N * C57BL/6NSlc

 MP:0003339 decreased number of pancreatic beta cells "fewer than normal number of the cells of the pancreas that secrete insulin" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ins2Akita/Ins2+,Rnf213tm1.1Akoi/Rnf213tm1.1Akoi
Genetic Background: involves: C57BL/6N * C57BL/6NSlc

 MP:0003710 abnormal physiological neovascularization "anomalies in the development of new blood vessels in restoration of blood circulation during the healing process " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Abcb10tm1.2Tafu/Abcb10tm1.2Tafu
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0005166 decreased susceptiblity to injury "less than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Abcb10tm1.2Tafu/Abcb10tm1.2Tafu
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0005215 abnormal islet of Langerhans morphology "anomalous morphology of these structures that are scattered throughout the pancreas and comprise its endocrine portion; within each islet there are three cell types: alpha, beta, and delta " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ins2Akita/Ins2+,Rnf213tm1.1Akoi/Rnf213tm1.1Akoi
Genetic Background: involves: C57BL/6N * C57BL/6NSlc

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ins2Akita/Ins2+,Rnf213tm1.1Akoi/Rnf213tm1.1Akoi
Genetic Background: involves: C57BL/6N * C57BL/6NSlc

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Ins2Akita/Ins2+,Rnf213tm1.1Akoi/Rnf213tm1.1Akoi
Genetic Background: involves: C57BL/6N * C57BL/6NSlc

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Glp1rtm1Ddr/Glp1rtm1Ddr
Genetic Background: B6.129-Glp1rtm1Ddr

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
Show

Allelic Composition: Ins2Akita/Ins2+,Rnf213tm1.1Akoi/Rnf213tm1.1Akoi
Genetic Background: involves: C57BL/6N * C57BL/6NSlc

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Ins2Akita/Ins2+,Rnf213tm1.1Akoi/Rnf213tm1.1Akoi
Genetic Background: involves: C57BL/6N * C57BL/6NSlc

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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