ENSMUSG00000071550


Mus musculus

Features
Gene ID: ENSMUSG00000071550
  
Biological name :Cfap44
  
Synonyms : Cfap44 / cilia and flagella associated protein 44
  
Possible biological names infered from orthology : Q96MT7
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: B4
Gene start: 44394796
Gene end: 44482428
  
Corresponding Affymetrix probe sets: 10435862 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000097331
Ensembl peptide - ENSMUSP00000113908
Ensembl peptide - ENSMUSP00000115502
NCBI entrez gene - 212517     See in Manteia.
MGI - MGI:1277238
RefSeq - XM_011245864
RefSeq - XM_006521964
RefSeq - XM_006521967
RefSeq - XM_006521968
RefSeq - NM_001033247
RefSeq - XM_006521963
RefSeq Peptide - NP_001028419
swissprot - F6THM3
swissprot - E9Q5M6
Ensembl - ENSMUSG00000071550
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CFAP44ENSGALG00000042577Gallus gallus
 CFAP44ENSG00000206530Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Eml6 / Q5SQM0 / Echinoderm microtubule-associated protein-like 6 / Q6ZMW3*ENSMUSG0000004407212
Eml5 / Q8BQM8 / Echinoderm microtubule-associated protein-like 5 / Q05BV3*ENSMUSG0000005116612
Eml2 / Q7TNG5 / Mus musculus echinoderm microtubule associated protein like 2 (Eml2), transcript variant 3, mRNA. / O95834* / echinoderm microtubule associated protein like 2*ENSMUSG000000408119
Eml4 / echinoderm microtubule-associated protein-like 4 isoform 4 / Q9HC35* / echinoderm microtubule associated protein like 4*ENSMUSG000000326249
Eml3 / Q8VC03 / Echinoderm microtubule-associated protein-like 3 / Q32P44*ENSMUSG000000716478
Eml1 / Q05BC3 / Echinoderm microtubule-associated protein-like 1 / O00423*ENSMUSG000000580708


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0060285 cilium-dependent cell motility IBA
 cellular_componentGO:0005575 cellular_component ND
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Slc12a6em1Dlp/Slc12a6em1Dlp
Genetic Background: involves: C57BL/6J

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc12a6em1Dlp/Slc12a6em1Dlp
Genetic Background: involves: C57BL/6J

 MP:0005578 teratozoospermia "presence of malformed spermatozoa in the semen; malformations include the physical bending of the sperm to produce kinks or bends" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc12a6em1Dlp/Slc12a6em1Dlp
Genetic Background: involves: C57BL/6J

Allelic Composition: Cfap44em1Pfr/Cfap44+
Genetic Background: involves: C57BL/6J

 MP:0009831 abnormal sperm midpiece morphology "any structural abnormality of the highly organized segment of the sperm flagellum which begins at the connecting piece and is characterized by the presence of 9 outer dense fibers (ODFs) that lie outside each of the 9 outer axonemal microtubule doublets and by a sheath of mitochondria that encloses the ODFs and the axoneme; the midpiece terminates about one-fourth of the way down the sperm flagellum at the annulus, which marks the beginning of the principal piece" [PMID:14581499]
Show

Allelic Composition: Slc12a6em1Dlp/Slc12a6em1Dlp
Genetic Background: involves: C57BL/6J

 MP:0009832 abnormal sperm mitochondrial sheath morphology "any structural anomaly or impairment of the tightly packed helical sheath of ATP-producing mitochondria restricted to the midpiece of the sperm flagellum" [PMID:14581499]
Show

Allelic Composition: Slc12a6em1Dlp/Slc12a6em1Dlp
Genetic Background: involves: C57BL/6J

 MP:0009836 abnormal sperm principal piece morphology "any structural abnormality in the segment of the sperm flagellum where the mitochondrial sheath ends and the outer dense fibers (ODFs) associated with outer axonemal doublets 3 and 8 are replaced by the 2 longitudinal columns of the fibrous sheath (FS) which run the length of the principal piece and are stabilized by circumferential ribs; the principal piece makes up ~2/3 of the length of the sperm flagellum and is defined by the presence of the FS and of only 7 (rather than 9) ODFs which taper and then terminate near the distal end of the principal piece" [PMID:14581499]
Show

Allelic Composition: Slc12a6em1Dlp/Slc12a6em1Dlp
Genetic Background: involves: C57BL/6J

 MP:0009838 abnormal sperm axoneme morphology "any structural abnormality of the central core of the sperm flagellum, composed of a ring of 9 outer microtubule doublets surrounding a central pair; inner and outer dynein arms project from each of the outer 9 doublets, and these arms are responsible for generating the motive force of the flagellum; in addition, 9 radial spokes, each of which originates from 1 of the 9 outer microtubular doublet pairs, project inward toward the central pair in a helical fashion" [PMID:14581499]
Show

Allelic Composition: Slc12a6em1Dlp/Slc12a6em1Dlp
Genetic Background: involves: C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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