ENSMUSG00000071657


Mus musculus

Features
Gene ID: ENSMUSG00000071657
  
Biological name :Bscl2
  
Synonyms : Bscl2 / Q9Z2E9 / Seipin
  
Possible biological names infered from orthology : BSCL2, seipin lipid droplet biogenesis associated / Q96G97
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: A
Gene start: 8837467
Gene end: 8848683
  
Corresponding Affymetrix probe sets: 10461237 (MoGene1.0st)   1420632_a_at (Mouse Genome 430 2.0 Array)   1437345_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000125422
Ensembl peptide - ENSMUSP00000125250
Ensembl peptide - ENSMUSP00000127685
Ensembl peptide - ENSMUSP00000083224
Ensembl peptide - ENSMUSP00000123920
Ensembl peptide - ENSMUSP00000123976
NCBI entrez gene - 14705     See in Manteia.
MGI - MGI:1298392
RefSeq - XM_006526691
RefSeq - NM_001136064
RefSeq - NM_001290823
RefSeq - NM_008144
RefSeq Peptide - NP_001277752
RefSeq Peptide - NP_001129536
RefSeq Peptide - NP_032170
swissprot - Q9Z2E9
swissprot - F6US45
swissprot - A0A0R4J225
swissprot - E0CXJ2
Ensembl - ENSMUSG00000071657
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bscl2ENSDARG00000037008Danio rerio
 BSCL2ENSG00000168000Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR009617  Seipin family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:0019915 lipid storage IEA
 biological_processGO:0034389 lipid particle organization IEA
 biological_processGO:0045444 fat cell differentiation IMP
 biological_processGO:0050995 negative regulation of lipid catabolic process IMP
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030176 integral component of endoplasmic reticulum membrane IEA
 molecular_functionGO:0003674 molecular_function ND


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000005 increased brown fat amount "increased amount of thermogenic tissue in the body that is composed of cells containing multiple small fat droplets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:14208]
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Allelic Composition: Bscl2tm1Geno/Bscl2tm1Geno
Genetic Background: B6.129P2-Bscl2tm1Geno

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Bscl2tm1.1Lchan/Bscl2tm1.1Lchan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000477 abnormal intestine morphology "malformation of the digestive tube passing from the stomach to the anus" [J:48968]
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Allelic Composition: Bscl2tm1Geno/Bscl2tm1Geno
Genetic Background: B6.129P2-Bscl2tm1Geno

 MP:0000496 abnormal small intestine morphology "structural or developmental anomalies of the intestinum tenue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bscl2tm1.1Lchan/Bscl2tm1.1Lchan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
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Allelic Composition: Leprtm1.1Chua/Lepr+,Tg(Gh1-cre)bKnmn/0
Genetic Background: involves: 129 * C57BL/6 * FVB

Allelic Composition: Bscl2tm1.1Lchan/Bscl2tm1.1Lchan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Bscl2tm1Geno/Bscl2tm1Geno
Genetic Background: B6.129P2-Bscl2tm1Geno

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Leprtm1.1Chua/Lepr+,Tg(Gh1-cre)bKnmn/0
Genetic Background: involves: 129 * C57BL/6 * FVB

Allelic Composition: Bscl2tm1.1Lchan/Bscl2tm1.1Lchan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001146 abnormal testis morphology "anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Leprtm1.1Chua/Lepr+,Tg(Gh1-cre)bKnmn/0
Genetic Background: involves: 129 * C57BL/6 * FVB

Allelic Composition: Bscl2tm1.1Gliu/Bscl2tm1.1Gliu,Tg(Ddx4-cre)1Dcas/0
Genetic Background: involves: 129 * 129S4/SvJaeSor * FVB/N

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
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Allelic Composition: Leprtm1.1Chua/Lepr+,Tg(Gh1-cre)bKnmn/0
Genetic Background: involves: 129 * C57BL/6 * FVB

Allelic Composition: Bscl2tm1.1Gliu/Bscl2tm1.1Gliu,Tg(Ddx4-cre)1Dcas/0
Genetic Background: involves: 129 * 129S4/SvJaeSor * FVB/N

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Bscl2tm1.1Lchan/Bscl2tm1.1Lchan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Bscl2tm1Geno/Bscl2tm1Geno
Genetic Background: B6.129P2-Bscl2tm1Geno

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Leprtm1.1Chua/Lepr+,Tg(Gh1-cre)bKnmn/0
Genetic Background: involves: 129 * C57BL/6 * FVB

Allelic Composition: Bscl2tm1.1Lchan/Bscl2tm1.1Lchan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001433 polyphagia "eating to excess" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bscl2tm1.1Lchan/Bscl2tm1.1Lchan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
Show

Allelic Composition: Leprtm1.1Chua/Lepr+,Tg(Gh1-cre)bKnmn/0
Genetic Background: involves: 129 * C57BL/6 * FVB

Allelic Composition: Bscl2tm1.1Lchan/Bscl2tm1.1Lchan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001554 increased circulating free fatty acid level "higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
Show

Allelic Composition: Bscl2tm1.1Lchan/Bscl2tm1.1Lchan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001556 increased circulating HDL cholesterol level "higher than average level of high density lipoprotein in the blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47439]
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Allelic Composition: Bscl2tm1Geno/Bscl2tm1Geno
Genetic Background: B6.129P2-Bscl2tm1Geno

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Bscl2tm1Geno/Bscl2tm1Geno
Genetic Background: B6.129P2-Bscl2tm1Geno

 MP:0001780 decreased brown fat amount "reduced quantity of this thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Leprtm1.1Chua/Lepr+,Tg(Gh1-cre)bKnmn/0
Genetic Background: involves: 129 * C57BL/6 * FVB

Allelic Composition: Bscl2tm1.1Lchan/Bscl2tm1.1Lchan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001781 abnormal white fat amount "anomaly in the quantity of the fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Nr1h3tm1.1Djm/Nr1h3tm1.1Djm,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * DBA

 MP:0001783 decreased white fat amount "reduced quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Bscl2tm1.1Lchan/Bscl2tm1.1Lchan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Leprtm1.1Chua/Lepr+,Tg(Gh1-cre)bKnmn/0
Genetic Background: involves: 129 * C57BL/6 * FVB

Allelic Composition: Bscl2tm1Geno/Bscl2tm1Geno
Genetic Background: B6.129P2-Bscl2tm1Geno

Allelic Composition: Bscl2tm1.1Gliu/Bscl2tm1.1Gliu,Tg(Ddx4-cre)1Dcas/0
Genetic Background: involves: 129 * 129S4/SvJaeSor * FVB/N

 MP:0001932 abnormal spermiogenesis "failure of sperm cells to form or differentiate" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Leprtm1.1Chua/Lepr+,Tg(Gh1-cre)bKnmn/0
Genetic Background: involves: 129 * C57BL/6 * FVB

Allelic Composition: Bscl2tm1.1Gliu/Bscl2tm1.1Gliu,Tg(Ddx4-cre)1Dcas/0
Genetic Background: involves: 129 * 129S4/SvJaeSor * FVB/N

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bscl2tm1.1Lchan/Bscl2tm1.1Lchan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Leprtm1.1Chua/Lepr+,Tg(Gh1-cre)bKnmn/0
Genetic Background: involves: 129 * C57BL/6 * FVB

Allelic Composition: Bscl2tm1.1Lchan/Bscl2tm1.1Lchan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Bscl2tm1Geno/Bscl2tm1Geno
Genetic Background: B6.129P2-Bscl2tm1Geno

Allelic Composition: Bscl2tm1.1Gliu/Bscl2tm1.1Gliu,Tg(Fabp4-cre)1Rev/0
Genetic Background: involves: 129 * 129S4/SvJaeSor

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bscl2tm1.1Lchan/Bscl2tm1.1Lchan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Bscl2tm1Geno/Bscl2tm1Geno
Genetic Background: B6.129P2-Bscl2tm1Geno

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Leprtm1.1Chua/Lepr+,Tg(Gh1-cre)bKnmn/0
Genetic Background: involves: 129 * C57BL/6 * FVB

Allelic Composition: Bscl2tm1.1Lchan/Bscl2tm1.1Lchan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Bscl2tm1Geno/Bscl2tm1Geno
Genetic Background: B6.129P2-Bscl2tm1Geno

 MP:0002631 abnormal epididymis morphology "malformation of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Bscl2tm1Geno/Bscl2tm1Geno
Genetic Background: B6.129P2-Bscl2tm1Geno

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bscl2tm1.1Lchan/Bscl2tm1.1Lchan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Bscl2tm1Geno/Bscl2tm1Geno
Genetic Background: B6.129P2-Bscl2tm1Geno

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Leprtm1.1Chua/Lepr+,Tg(Gh1-cre)bKnmn/0
Genetic Background: involves: 129 * C57BL/6 * FVB

Allelic Composition: Bscl2tm1.1Gliu/Bscl2tm1.1Gliu,Tg(Ddx4-cre)1Dcas/0
Genetic Background: involves: 129 * 129S4/SvJaeSor * FVB/N

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
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Allelic Composition: Leprtm1.1Chua/Lepr+,Tg(Gh1-cre)bKnmn/0
Genetic Background: involves: 129 * C57BL/6 * FVB

Allelic Composition: Bscl2tm1.1Gliu/Bscl2tm1.1Gliu,Tg(Ddx4-cre)1Dcas/0
Genetic Background: involves: 129 * 129S4/SvJaeSor * FVB/N

 MP:0002702 decreased circulating free fatty acid level "lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Bscl2tm1.1Lchan/Bscl2tm1.1Lchan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Bscl2tm1Geno/Bscl2tm1Geno
Genetic Background: B6.129P2-Bscl2tm1Geno

 MP:0002970 abnormal white fat morphology "structural aberration in the connective tissue consisting of fat-storing cells and arranged in lobular groups or along minor blood vessels" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Bscl2tm1.1Lchan/Bscl2tm1.1Lchan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Bscl2tm1Geno/Bscl2tm1Geno
Genetic Background: B6.129P2-Bscl2tm1Geno

 MP:0003068 enlarged kidney "larger than average size of the kidney" [J:86005, pvb:Pierre Vanden Borre, Mouse Genome Informatics Curator]
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Allelic Composition: Bscl2tm1.1Lchan/Bscl2tm1.1Lchan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003442 decreased circulating glycerol level "lower than normal concentration of glycerol in the blood" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Bscl2tm1.1Lchan/Bscl2tm1.1Lchan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003443 increased circulating glycerol level "higher than normal concentration of glycerol in the blood" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Bscl2tm1.1Lchan/Bscl2tm1.1Lchan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Bscl2tm1.1Lchan/Bscl2tm1.1Lchan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0004777 abnormal phospholipid level "anomalous concentration of the fat derivatives in which one fatty acid has been replaced by a phosphate group" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprtm1.1Chua/Lepr+,Tg(Gh1-cre)bKnmn/0
Genetic Background: involves: 129 * C57BL/6 * FVB

Allelic Composition: Bscl2tm1.1Gliu/Bscl2tm1.1Gliu,Tg(Ddx4-cre)1Dcas/0
Genetic Background: involves: 129 * 129S4/SvJaeSor * FVB/N

 MP:0004890 decreased energy expenditure "decrease in the number of calories used per unit time or increase in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Bscl2tm1Geno/Bscl2tm1Geno
Genetic Background: B6.129P2-Bscl2tm1Geno

 MP:0004893 decreased adiponectin level "reduced concentration of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprtm1.1Chua/Lepr+,Tg(Gh1-cre)bKnmn/0
Genetic Background: involves: 129 * C57BL/6 * FVB

Allelic Composition: Bscl2tm1.1Lchan/Bscl2tm1.1Lchan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Bscl2tm1Geno/Bscl2tm1Geno
Genetic Background: B6.129P2-Bscl2tm1Geno

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Leprtm1.1Chua/Lepr+,Tg(Gh1-cre)bKnmn/0
Genetic Background: involves: 129 * C57BL/6 * FVB

Allelic Composition: Bscl2tm1.1Gliu/Bscl2tm1.1Gliu,Tg(Fabp4-cre)1Rev/0
Genetic Background: involves: 129 * 129S4/SvJaeSor

 MP:0005290 decreased oxygen consumption "less than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Bscl2tm1Geno/Bscl2tm1Geno
Genetic Background: B6.129P2-Bscl2tm1Geno

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Leprtm1.1Chua/Lepr+,Tg(Gh1-cre)bKnmn/0
Genetic Background: involves: 129 * C57BL/6 * FVB

Allelic Composition: Bscl2tm1Geno/Bscl2tm1Geno
Genetic Background: B6.129P2-Bscl2tm1Geno

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Leprtm1.1Chua/Lepr+,Tg(Gh1-cre)bKnmn/0
Genetic Background: involves: 129 * C57BL/6 * FVB

Allelic Composition: Bscl2tm1.1Lchan/Bscl2tm1.1Lchan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Bscl2tm1Geno/Bscl2tm1Geno
Genetic Background: B6.129P2-Bscl2tm1Geno

 MP:0005334 abnormal fat pad "malformed or aberrant size of the encapsulated adipose tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bscl2tm1.1Lchan/Bscl2tm1.1Lchan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005533 increased body temperature "greater than the level of heat natural to a living being" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Leprtm1.1Chua/Lepr+,Tg(Gh1-cre)bKnmn/0
Genetic Background: involves: 129 * C57BL/6 * FVB

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Leprtm1.1Chua/Lepr+,Tg(Gh1-cre)bKnmn/0
Genetic Background: involves: 129 * C57BL/6 * FVB

Allelic Composition: Bscl2tm1.1Lchan/Bscl2tm1.1Lchan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Bscl2tm1Geno/Bscl2tm1Geno
Genetic Background: B6.129P2-Bscl2tm1Geno

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bscl2tm1.1Lchan/Bscl2tm1.1Lchan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005578 teratozoospermia "presence of malformed spermatozoa in the semen; malformations include the physical bending of the sperm to produce kinks or bends" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
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Allelic Composition: Leprtm1.1Chua/Lepr+,Tg(Gh1-cre)bKnmn/0
Genetic Background: involves: 129 * C57BL/6 * FVB

Allelic Composition: Bscl2tm1.1Gliu/Bscl2tm1.1Gliu,Tg(Ddx4-cre)1Dcas/0
Genetic Background: involves: 129 * 129S4/SvJaeSor * FVB/N

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Leprtm1.1Chua/Lepr+,Tg(Gh1-cre)bKnmn/0
Genetic Background: involves: 129 * C57BL/6 * FVB

Allelic Composition: Bscl2tm1.1Lchan/Bscl2tm1.1Lchan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Bscl2tm1Geno/Bscl2tm1Geno
Genetic Background: B6.129P2-Bscl2tm1Geno

 MP:0005670 abnormal white fat physiology "functional aberration in the connective tissue consisting of fat-storing cells and arranged in lobular groups or along minor blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bscl2tm1.1Lchan/Bscl2tm1.1Lchan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0006319 abnormal epididymal fat pad "any structural anomaly of the encapsulated adipose tissue associated with the epididymis" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprtm1.1Chua/Lepr+,Tg(Gh1-cre)bKnmn/0
Genetic Background: involves: 129 * C57BL/6 * FVB

Allelic Composition: Bscl2tm1.1Lchan/Bscl2tm1.1Lchan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0006362 abnormal male germ cell morphology "any structural anomaly of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprtm1.1Chua/Lepr+,Tg(Gh1-cre)bKnmn/0
Genetic Background: involves: 129 * C57BL/6 * FVB

Allelic Composition: Bscl2tm1.1Gliu/Bscl2tm1.1Gliu,Tg(Ddx4-cre)1Dcas/0
Genetic Background: involves: 129 * 129S4/SvJaeSor * FVB/N

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprtm1.1Chua/Lepr+,Tg(Gh1-cre)bKnmn/0
Genetic Background: involves: 129 * C57BL/6 * FVB

Allelic Composition: Bscl2tm1.1Gliu/Bscl2tm1.1Gliu,Tg(Ddx4-cre)1Dcas/0
Genetic Background: involves: 129 * 129S4/SvJaeSor * FVB/N

 MP:0008034 enhanced lipolysis "increase in the rate of the hydrolysis of fat into free fatty acids " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bscl2tm1.1Lchan/Bscl2tm1.1Lchan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Bscl2tm1Geno/Bscl2tm1Geno
Genetic Background: B6.129P2-Bscl2tm1Geno

 MP:0008844 decreased subcutaneous adipose tissue amount "reduction in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprtm1.1Chua/Lepr+,Tg(Gh1-cre)bKnmn/0
Genetic Background: involves: 129 * C57BL/6 * FVB

Allelic Composition: Bscl2tm1.1Lchan/Bscl2tm1.1Lchan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008892 abnormal sperm flagellum "any strucutral anomaly of the whiplike posterior filiform portion of the spermatozoon that provides sperm motility" [MESH:A05.360.490.890.840]
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Allelic Composition: Leprtm1.1Chua/Lepr+,Tg(Gh1-cre)bKnmn/0
Genetic Background: involves: 129 * C57BL/6 * FVB

Allelic Composition: Bscl2tm1.1Gliu/Bscl2tm1.1Gliu,Tg(Ddx4-cre)1Dcas/0
Genetic Background: involves: 129 * 129S4/SvJaeSor * FVB/N

 MP:0008964 decreased carbon dioxide production "reduction in the rate at which carbon dioxide leaves the blood and enters the alveolar gas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bscl2tm1Geno/Bscl2tm1Geno
Genetic Background: B6.129P2-Bscl2tm1Geno

 MP:0009117 abnormal white fat cell morphology "any structural anomaly of fat cells with light coloration and few mitochondria; these contain a scant ring of cytoplasm surrounding a single large lipid droplet or vacuole" [MESH:A11.329.114.500]
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Allelic Composition: Bscl2tm1.1Lchan/Bscl2tm1.1Lchan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009131 decreased white fat cell number "reduction in the number of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bscl2tm1.1Lchan/Bscl2tm1.1Lchan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009133 decreased white fat cell size "reduction in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bscl2tm1.1Lchan/Bscl2tm1.1Lchan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009230 abnormal sperm head morphology "any structural abnormality of the head segment of the sperm cell which contains the nucleus with densely coiled chromatin fibers, and is surrounded anteriorly by the acrosome which contains enzymes used for penetrating the female egg" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprtm1.1Chua/Lepr+,Tg(Gh1-cre)bKnmn/0
Genetic Background: involves: 129 * C57BL/6 * FVB

Allelic Composition: Bscl2tm1.1Gliu/Bscl2tm1.1Gliu,Tg(Ddx4-cre)1Dcas/0
Genetic Background: involves: 129 * 129S4/SvJaeSor * FVB/N

 MP:0009283 decreased gonadal fat pad weight "less than average weight of the encapsulated adipose tissue associated with the ovaries or testes" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprtm1.1Chua/Lepr+,Tg(Gh1-cre)bKnmn/0
Genetic Background: involves: 129 * C57BL/6 * FVB

Allelic Composition: Bscl2tm1.1Lchan/Bscl2tm1.1Lchan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Bscl2tm1Geno/Bscl2tm1Geno
Genetic Background: B6.129P2-Bscl2tm1Geno

 MP:0009293 decreased inguinal fat pad weight 
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Allelic Composition: Leprtm1.1Chua/Lepr+,Tg(Gh1-cre)bKnmn/0
Genetic Background: involves: 129 * C57BL/6 * FVB

Allelic Composition: Bscl2tm1Geno/Bscl2tm1Geno
Genetic Background: B6.129P2-Bscl2tm1Geno

 MP:0009295 decreased interscapular fat pad weight 
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Allelic Composition: Bscl2tm1.1Lchan/Bscl2tm1.1Lchan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Bscl2tm1Geno/Bscl2tm1Geno
Genetic Background: B6.129P2-Bscl2tm1Geno

 MP:0009299 decreased mesenteric fat pad weight 
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Allelic Composition: Leprtm1.1Chua/Lepr+,Tg(Gh1-cre)bKnmn/0
Genetic Background: involves: 129 * C57BL/6 * FVB

Allelic Composition: Bscl2tm1Geno/Bscl2tm1Geno
Genetic Background: B6.129P2-Bscl2tm1Geno

 MP:0009303 decreased renal fat pad weight 
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Allelic Composition: Bscl2tm1.1Lchan/Bscl2tm1.1Lchan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009305 decreased retroperitoneal fat pad weight 
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Allelic Composition: Leprtm1.1Chua/Lepr+,Tg(Gh1-cre)bKnmn/0
Genetic Background: involves: 129 * C57BL/6 * FVB

 MP:0009355 increased liver triglyceride level "higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprtm1.1Chua/Lepr+,Tg(Gh1-cre)bKnmn/0
Genetic Background: involves: 129 * C57BL/6 * FVB

Allelic Composition: Bscl2tm1Geno/Bscl2tm1Geno
Genetic Background: B6.129P2-Bscl2tm1Geno

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprtm1.1Chua/Lepr+,Tg(Gh1-cre)bKnmn/0
Genetic Background: involves: 129 * C57BL/6 * FVB

Allelic Composition: Bscl2tm1.1Lchan/Bscl2tm1.1Lchan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0010954 abnormal cellular respiration "anomaly in the enzymatic release of energy from organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration)" [GO:0045333]
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Allelic Composition: Bscl2tm1.1Lchan/Bscl2tm1.1Lchan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0010957 abnormal aerobic respiration "any anomaly in the process of enzymatic release of energy from organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor" [GO:0009060]
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Allelic Composition: Bscl2tm1.1Lchan/Bscl2tm1.1Lchan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Bscl2tm1.1Lchan/Bscl2tm1.1Lchan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Bscl2tm1Geno/Bscl2tm1Geno
Genetic Background: B6.129P2-Bscl2tm1Geno

 MP:0011156 abnormal hypodermis fat layer morphology "any structural anomaly of the superficial portion of the subcutaneous tissue which is specialized for fat storage" [ISBN:0-683-40008-8]
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Allelic Composition: Leprtm1.1Chua/Lepr+,Tg(Gh1-cre)bKnmn/0
Genetic Background: involves: 129 * C57BL/6 * FVB

 MP:0011167 abnormal adipose tissue development "anomaly in the process of the formation of the connective tissue composed of fat cells enmeshed in areolar tissue" [MESH:A10.165.114, MGI:csmith]
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Allelic Composition: Bscl2tm1Geno/Bscl2tm1Geno
Genetic Background: B6.129P2-Bscl2tm1Geno

 MP:0011168 abnormal fat cell differentiation "abnormal or arrest of differentiation of fat-storing cells found mostly in the abdominal cavity and subcutaneous tissue of mammals" [CL:0000449, MGI:csmith]
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Allelic Composition: Bscl2tm1.1Lchan/Bscl2tm1.1Lchan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0011169 abnormal white fat cell differentation "abnormal or arrest of differentiation of fat cells with light coloration and few mitochondria; these contain a scant ring of cytoplasm surrounding a single large lipid droplet or vacuole" [MESH:A11.329.114.500, MGI:csmith]
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Allelic Composition: Leprtm1.1Chua/Lepr+,Tg(Gh1-cre)bKnmn/0
Genetic Background: involves: 129 * C57BL/6 * FVB

 MP:0011174 lipodystrophy "abnormal or degenerative conditions of the body s adipose tissue resulting in bodily or focal loss and the appearance of redistribution of fat tissue; adipose tissue loss may be total, partial, or localized" [MGI:csmith]
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Allelic Composition: Leprtm1.1Chua/Lepr+,Tg(Gh1-cre)bKnmn/0
Genetic Background: involves: 129 * C57BL/6 * FVB

Allelic Composition: Bscl2tm1Geno/Bscl2tm1Geno
Genetic Background: B6.129P2-Bscl2tm1Geno

Allelic Composition: Bscl2tm1.1Gliu/Bscl2tm1.1Gliu,Tg(Fabp4-cre)1Rev/0
Genetic Background: involves: 129 * 129S4/SvJaeSor

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Bscl2tm1Geno/Bscl2tm1Geno
Genetic Background: B6.129P2-Bscl2tm1Geno

 MP:0013245 abnormal lipid metabolism "any anomaly in the chemical reactions and pathways involving a lipid, including metabolic, catabolic and biosynthetic processes" [MPD:Molly]
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Allelic Composition: Bscl2tm1.1Lchan/Bscl2tm1.1Lchan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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