ENSMUSG00000074030


Mus musculus

Features
Gene ID: ENSMUSG00000074030
  
Biological name :Exoc8
  
Synonyms : Exoc8 / Exocyst complex component 8 / Q6PGF7
  
Possible biological names infered from orthology : Q8IYI6
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: E2
Gene start: 124893108
Gene end: 124897705
  
Corresponding Affymetrix probe sets: 10582708 (MoGene1.0st)   1436048_at (Mouse Genome 430 2.0 Array)   1458839_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000095915
NCBI entrez gene - 102058     See in Manteia.
MGI - MGI:2142527
RefSeq - NM_198103
RefSeq Peptide - NP_932771
swissprot - Q6PGF7
Ensembl - ENSMUSG00000074030
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 exoc8ENSDARG00000063211Danio rerio
 EXOC8ENSGALG00000043280Gallus gallus
 EXOC8ENSG00000116903Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR016159  Cullin repeat-like-containing domain superfamily
 IPR032403  Exocyst component Exo84, C-terminal
 IPR033961  Exocyst complex component Exo84


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001927 exocyst assembly IBA
 biological_processGO:0006887 exocytosis ISO
 biological_processGO:0007032 endosome organization IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0022617 extracellular matrix disassembly IEA
 biological_processGO:0034613 cellular protein localization IEA
 biological_processGO:0051601 exocyst localization IBA
 cellular_componentGO:0000145 exocyst ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005770 late endosome IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0030426 growth cone IEA
 cellular_componentGO:0031252 cell leading edge IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0017160 Ral GTPase binding IEA
 molecular_functionGO:0035091 phosphatidylinositol binding ISO


Pathways (from Reactome)
Pathway description
Insulin processing
VxPx cargo-targeting to cilium


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001697 abnormal embryo size "anomalous proportions of embryo compared to littermates" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Emx1tm1.1(KOMP)Vlcg/Emx1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Emx1tm1.1(KOMP)Vlcg/Ucd

 MP:0002966 decreased circulating alkaline phosphatase level "reduced activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Emx1tm1.1(KOMP)Vlcg/Emx1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Emx1tm1.1(KOMP)Vlcg/Ucd

 MP:0003720 abnormal neural tube closure "abnormal invagination and fusion of the neuroepithelial layer in early development" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:99099]
Show

Allelic Composition: Emx1tm1.1(KOMP)Vlcg/Emx1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Emx1tm1.1(KOMP)Vlcg/Ucd

 MP:0003864 abnormal midbrain development "anomaly in the formation of or the patterning of the part of the brainstem developing from the middle of the three primary cerebral vesicles of the embryo" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Emx1tm1.1(KOMP)Vlcg/Emx1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Emx1tm1.1(KOMP)Vlcg/Ucd

 MP:0006108 abnormal hindbrain development "anomaly in the formation or pattering of the caudal region of the brain" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93573]
Show

Allelic Composition: Emx1tm1.1(KOMP)Vlcg/Emx1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Emx1tm1.1(KOMP)Vlcg/Ucd

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Xbp1tm1a(EUCOMM)Wtsi/Xbp1+
Genetic Background: C57BL/6N-Xbp1tm1a(EUCOMM)Wtsi/Ics

 MP:0013292 embryonic lethality prior to organogenesis "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]
Show

Allelic Composition: Xbp1tm1a(EUCOMM)Wtsi/Xbp1+
Genetic Background: C57BL/6N-Xbp1tm1a(EUCOMM)Wtsi/Ics

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
Show

Allelic Composition: Xbp1tm1a(EUCOMM)Wtsi/Xbp1+
Genetic Background: C57BL/6N-Xbp1tm1a(EUCOMM)Wtsi/Ics

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr