ENSMUSG00000074129


Mus musculus

Features
Gene ID: ENSMUSG00000074129
  
Biological name :Rpl13a
  
Synonyms : P19253 / ribosomal protein L13A / Rpl13a
  
Possible biological names infered from orthology :
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: B3
Gene start: 45125558
Gene end: 45128761
  
Corresponding Affymetrix probe sets: 10389522 (MoGene1.0st)   10563101 (MoGene1.0st)   10563108 (MoGene1.0st)   10563110 (MoGene1.0st)   10563112 (MoGene1.0st)   10563114 (MoGene1.0st)   1417608_a_at (Mouse Genome 430 2.0 Array)   1433928_a_at (Mouse Genome 430 2.0 Array)   1435873_a_at (Mouse Genome 430 2.0 Array)   1455001_x_at (Mouse Genome 430 2.0 Array)   1455485_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000115722
Ensembl peptide - ENSMUSP00000148262
Ensembl peptide - ENSMUSP00000148139
Ensembl peptide - ENSMUSP00000148031
Ensembl peptide - ENSMUSP00000147986
Ensembl peptide - ENSMUSP00000147958
Ensembl peptide - ENSMUSP00000147909
Ensembl peptide - ENSMUSP00000147877
Ensembl peptide - ENSMUSP00000147866
Ensembl peptide - ENSMUSP00000147520
Ensembl peptide - ENSMUSP00000147282
NCBI entrez gene - 22121     See in Manteia.
MGI - MGI:1351455
RefSeq - NM_009438
RefSeq Peptide - NP_033464
swissprot - A0A1B0GSL5
swissprot - A0A1B0GSJ2
swissprot - A0A1B0GSF0
swissprot - A0A1B0GSC2
swissprot - A0A1B0GSB2
swissprot - A0A1B0GRH1
swissprot - A0A1B0GQW6
swissprot - P19253
swissprot - A0A1B0GTA1
swissprot - Q5M9M0
swissprot - A0A1B0GT00
swissprot - A0A1B0GSQ6
Ensembl - ENSMUSG00000074129
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rpl13aENSDARG00000044093Danio rerio


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gm45713ENSMUSG0000008998998
Rpl13a-ps1ENSMUSG0000006208392


Protein motifs (from Interpro)
Interpro ID Name
 IPR005755  Ribosomal protein L13, eukaryotic/archaeal
 IPR005822  Ribosomal protein L13
 IPR023563  Ribosomal protein L13, conserved site
 IPR036899  Ribosomal protein L13 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006412 translation IEA
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0017148 negative regulation of translation ISO
 biological_processGO:0032496 response to lipopolysaccharide IMP
 biological_processGO:0048246 macrophage chemotaxis IMP
 biological_processGO:0060425 lung morphogenesis IMP
 biological_processGO:0071346 cellular response to interferon-gamma IDA
 biological_processGO:1901194 negative regulation of formation of translation preinitiation complex ISO
 cellular_componentGO:0005840 ribosome IEA
 cellular_componentGO:0015934 large ribosomal subunit IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0022625 cytosolic large ribosomal subunit IBA
 cellular_componentGO:0097452 GAIT complex IDA
 molecular_functionGO:0003729 mRNA binding IDA
 molecular_functionGO:0003735 structural constituent of ribosome IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000188 abnormal circulating glucose level "anomalous concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: ApcMin/Apc+,Arhgef4tm1Taki/Arhgef4tm1Taki,Spata13tm1Taki/Spata13tm1Taki
Genetic Background: B6J.Cg-Arhgef4tm1Taki Spata13tm1Taki ApcMin

Allelic Composition: Rpl13atm1.1Jesc/Rpl13atm1.1Jesc
Genetic Background: FVB.129S5(Cg)-Rpl13atm1.1Jesc

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
Show

Allelic Composition: Rpl13atm1.1Mazu/Rpl13atm1.1Mazu,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: C57BL/6

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Rpl13atm1.1Mazu/Rpl13atm1.1Mazu,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rpl13atm1.1Mazu/Rpl13atm1.1Mazu,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: C57BL/6

 MP:0003058 increased insulin secretion "greater than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Rpl13atm1.1Jesc/Rpl13atm1.1Jesc
Genetic Background: FVB.129S5(Cg)-Rpl13atm1.1Jesc

 MP:0003186 abnormal redox activity "defect in the processes that maintain the redox environment of a cell or compartment within a cell " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rpl13atm1.1Jesc/Rpl13atm1.1Jesc
Genetic Background: FVB.129S5(Cg)-Rpl13atm1.1Jesc

 MP:0004804 decreased susceptibility to autoimmune diabetes "reduced likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ins2Akita/Ins2Akita,Rpl13atm1.1Jesc/Rpl13atm1.1Jesc
Genetic Background: FVB.Cg-Rpl13atm1.1Jesc Ins2Akita

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Rpl13atm1.1Jesc/Rpl13atm1.1Jesc
Genetic Background: FVB.129S5(Cg)-Rpl13atm1.1Jesc

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Rpl13atm1.1Jesc/Rpl13atm1.1Jesc
Genetic Background: FVB.129S5(Cg)-Rpl13atm1.1Jesc

 MP:0005343 increased circulating aspartate transaminase level "greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
Show

Allelic Composition: Rpl13atm1.1Mazu/Rpl13atm1.1Mazu,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: C57BL/6

 MP:0005426 tachypnea "rapid breathing" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rpl13atm1.1Mazu/Rpl13atm1.1Mazu,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: C57BL/6

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rpl13atm1.1Mazu/Rpl13atm1.1Mazu,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: C57BL/6

 MP:0008553 increased circulating tumor necrosis factor level "greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Rpl13atm1.1Mazu/Rpl13atm1.1Mazu,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: C57BL/6

 MP:0008713 abnormal cytokine level "deviation from the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rpl13atm1.1Mazu/Rpl13atm1.1Mazu,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: C57BL/6

 MP:0010760 abnormal macrophage chemotaxis "anomaly in the movement of a macrophage guided by a specific chemical concentration gradient" [GO:0048246]
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Allelic Composition: Rpl13atm1.1Mazu/Rpl13atm1.1Mazu,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: C57BL/6

 MP:0010959 abnormal oxidative phosphorylation "any anomaly in the process of phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain; oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis" [GO:0006119]
Show

Allelic Composition: Rpl13atm1.1Jesc/Rpl13atm1.1Jesc
Genetic Background: FVB.129S5(Cg)-Rpl13atm1.1Jesc

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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