Manteia - Molecule gene

ENSMUSG00000074221

Mus musculus

Features

Gene ID:	ENSMUSG00000074221

Biological name :	Zfp568

Synonyms :	E9PYI1 / Zfp568 / zinc finger protein 568

Possible biological names infered from orthology :	Q7Z3V5 / zinc finger protein 571 / ZNF571

Species:	Mus musculus

Chr. number:	7
Strand:	1
Band:	B1
Gene start:	29983955
Gene end:	30028282

Corresponding Affymetrix probe sets:	10551803 (MoGene1.0st) 1435091_at (Mouse Genome 430 2.0 Array) 1459929_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000137438 Ensembl peptide - ENSMUSP00000147124 Ensembl peptide - ENSMUSP00000073930 Ensembl peptide - ENSMUSP00000118387 Ensembl peptide - ENSMUSP00000118823 NCBI entrez gene - 243905 See in Manteia. MGI - MGI:2142347 RefSeq - XM_011250569 RefSeq - NM_001033355 RefSeq - NM_001167872 RefSeq - NM_001167873 RefSeq Peptide - NP_001028527 RefSeq Peptide - NP_001161344 RefSeq Peptide - NP_001161345 swissprot - E9PYI1 swissprot - A0A140LJ91 Ensembl - ENSMUSG00000074221

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
Q7Z3V5	ENSG00000180479	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Zfp30 / zinc finger protein 30 / Q9Y2G7* / ZFP30 zinc finger protein*	ENSMUSG00000047473	36
Zfp82 / Q6P9Y7 / zinc finger protein 82 / Q8N141* / ZFP82 zinc finger protein*	ENSMUSG00000098022	35
Zfp790 / zinc finger protein 790 / Q6PG37* / ZNF790*	ENSMUSG00000011427	35
Zfp940 / zinc finger protein 940 / Q6PG37* / ZNF790* / zinc finger protein 790*	ENSMUSG00000050855	34
Zfp28 / P10078 / zinc finger protein 28 / Q8NHY6* / ZFP28 zinc finger protein*	ENSMUSG00000062861	34
Zfp84 / zinc finger protein 84	ENSMUSG00000046185	33
Zfp14 / P10755 / zinc finger protein 14 / Q9HCL3* / ZFP14 zinc finger protein*	ENSMUSG00000053985	33
Zfp454 / zinc finger protein 454 / Q8N9F8* / ZNF454*	ENSMUSG00000048728	32
Zfp383 / zinc finger protein 383 / Q8NA42* / ZNF383*	ENSMUSG00000099689	32
Q3V080 / Zfp583 / zinc finger protein 583 / Q96ND8* / ZNF583*	ENSMUSG00000030443	32
Zfp78 / zinc finger protein 78 / Q9BX82* / ZNF471* / zinc finger protein 471*	ENSMUSG00000055150	31
Gm3854 / Q96NG8* / ZNF582* / zinc finger protein 582*	ENSMUSG00000109398	29
Zfp566 / zinc finger protein 566 / Q969W8* / ZNF566*	ENSMUSG00000078768	24

Protein motifs (from Interpro)

Interpro ID	Name
IPR001909	Krueppel-associated box
IPR013087	Zinc finger C2H2-type
IPR036051	KRAB domain superfamily
IPR036236	Zinc finger C2H2 superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP
biological_process	GO:0001701	in utero embryonic development	IMP
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0007275	multicellular organism development	IEA
biological_process	GO:0010646	regulation of cell communication	IMP
biological_process	GO:0022007	convergent extension involved in neural plate elongation	IMP
biological_process	GO:0045892	negative regulation of transcription, DNA-templated	IDA
biological_process	GO:0060028	convergent extension involved in axis elongation	IMP
biological_process	GO:0060669	embryonic placenta morphogenesis	IMP
cellular_component	GO:0005622	intracellular	IEA
cellular_component	GO:0005634	nucleus	IDA
molecular_function	GO:0000976	transcription regulatory region sequence-specific DNA binding	IMP
molecular_function	GO:0001222	transcription corepressor binding	IPI
molecular_function	GO:0003676	nucleic acid binding	IEA
molecular_function	GO:0003677	DNA binding	IEA
molecular_function	GO:0003700	DNA-binding transcription factor activity	IBA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0046872	metal ion binding	IEA

Pathways (from Reactome)

Pathway description

Generic Transcription Pathway

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000928	incomplete cephalic closure	"arrest of the fusion of the cephalic neural folds" [J:12622]	Show Allelic Composition: Zfp568^chato/Zfp568^chato Genetic Background: either: (involves: 129S1/SvImJ * C57BL/6) or (involves: C3HeB/FeJ * C57BL/6) or (involves: C57BL/6 * CAST/Ei)
MP:0000929	open neural tube	"incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]	Show Allelic Composition: Zfp568^chato/Zfp568^chato Genetic Background: either: (involves: 129S1/SvImJ * C57BL/6) or (involves: C3HeB/FeJ * C57BL/6) or (involves: C57BL/6 * CAST/Ei)
MP:0001385	pup cannibalization	"the killing and eating of newborn mice by the mother; can be a normal response if the mother does not recognize the pups as her own" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Limk2^{Gt(OST80053)Lex}/Limk2^{Gt(OST80053)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
MP:0001672	abnormal embryogenesis/ development	"anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ugdh^lzme/Ugdh^lzme Genetic Background: involves: C3HeB/FeJ * C57BL/6J Allelic Composition: Zfp568^chato/Zfp568^chato Genetic Background: either: (involves: 129S1/SvImJ * C57BL/6) or (involves: C3HeB/FeJ * C57BL/6) or (involves: C57BL/6 * CAST/Ei) Allelic Composition: Zfp568^{Gt(P103E09)Wrst}/Zfp568^{Gt(RRU161)Byg},Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺ Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * CBA Allelic Composition: Meox2^tm1(cre)Sor/Meox2⁺,Zfp568^{Gt(P103E09)Wrst}/Zfp568^{Gt(RRU161)Byg} Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S4/SvJaeSor
MP:0001674	abnormal triploblastic development	"abnormal development of the three primary germ layers" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]	Show Allelic Composition: Zfp568^chato/Zfp568^chato Genetic Background: either: (involves: 129S1/SvImJ * C57BL/6) or (involves: C3HeB/FeJ * C57BL/6) or (involves: C57BL/6 * CAST/Ei)
MP:0001688	abnormal somite development	"anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Zfp568^chato/Zfp568^chato Genetic Background: either: (involves: 129S1/SvImJ * C57BL/6) or (involves: C3HeB/FeJ * C57BL/6) or (involves: C57BL/6 * CAST/Ei)
MP:0001711	abnormal placenta		Show Allelic Composition: Zfp568^chato/Zfp568^chato Genetic Background: either: (involves: 129S1/SvImJ * C57BL/6) or (involves: C3HeB/FeJ * C57BL/6) or (involves: C57BL/6 * CAST/Ei)
MP:0001724	abnormal extraembryonic endoderm formation	"malformation of the endoderm of the extraembryonic tissue that appears prior to gastrulation and performs critical functions during embryogenesis including nutrient uptake and transport from the mother to the embryo" [J:62628]	Show Allelic Composition: Zfp568^chato/Zfp568^chato Genetic Background: either: (involves: 129S1/SvImJ * C57BL/6) or (involves: C3HeB/FeJ * C57BL/6) or (involves: C57BL/6 * CAST/Ei)
MP:0001730	embryonic growth arrest	"the cessation of development beyond a particular stage" [J:17509]	Show Allelic Composition: Ugdh^lzme/Ugdh^lzme Genetic Background: involves: C3HeB/FeJ * C57BL/6J Allelic Composition: Zfp568^chato/Zfp568^chato Genetic Background: either: (involves: 129S1/SvImJ * C57BL/6) or (involves: C3HeB/FeJ * C57BL/6) or (involves: C57BL/6 * CAST/Ei) Allelic Composition: Zfp568^{Gt(RRU161)Byg}/Zfp568^{Gt(RRU161)Byg} Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Zfp568^{Gt(RRU161)Byg}/Zfp568^chato Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0002080	prenatal lethality	"death anytime between fertilization and E18.5" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Zfp568^chato/Zfp568^chato Genetic Background: either: (involves: 129S1/SvImJ * C57BL/6) or (involves: C3HeB/FeJ * C57BL/6) or (involves: C57BL/6 * CAST/Ei)
MP:0002086	abnormal extraembryonic tissue morphology	"structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Zfp568^chato/Zfp568^chato Genetic Background: either: (involves: 129S1/SvImJ * C57BL/6) or (involves: C3HeB/FeJ * C57BL/6) or (involves: C57BL/6 * CAST/Ei) Allelic Composition: Trim28^chatwo/Trim28⁺,Zfp568^chato/Zfp568^chato Genetic Background: involves: C57BL/6J Allelic Composition: Trim28^chatwo/Trim28^chatwo,Zfp568^chato/Zfp568⁺ Genetic Background: involves: C57BL/6J
MP:0002151	abnormal neural tube morphology/development	"anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Zfp568^chato/Zfp568^chato Genetic Background: either: (involves: 129S1/SvImJ * C57BL/6) or (involves: C3HeB/FeJ * C57BL/6) or (involves: C57BL/6 * CAST/Ei)
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Trim28^chatwo/Trim28^tm1.2Ipc Genetic Background: involves: 129S2/SvPas * C57BL/6J
MP:0002175	low brain weight	"lower than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Limk2^{Gt(OST80053)Lex}/Limk2^{Gt(OST80053)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
MP:0002825	abnormal notochord	"malformation or absence of the axial fibrocellular cord in embryos around which develops the vertebral primordia" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Zfp568^chato/Zfp568^chato Genetic Background: either: (involves: 129S1/SvImJ * C57BL/6) or (involves: C3HeB/FeJ * C57BL/6) or (involves: C57BL/6 * CAST/Ei)
MP:0002836	abnormal chorion	"malformations of the outermost extraembryonic membrane" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Zfp568^chato/Zfp568^chato Genetic Background: either: (involves: 129S1/SvImJ * C57BL/6) or (involves: C3HeB/FeJ * C57BL/6) or (involves: C57BL/6 * CAST/Ei)
MP:0003119	abnormal digestive system development	"dysmorphology of the organ system that converts ingested food to nutrients and energy" [smb:Susan M. Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Zfp568^chato/Zfp568^chato Genetic Background: either: (involves: 129S1/SvImJ * C57BL/6) or (involves: C3HeB/FeJ * C57BL/6) or (involves: C57BL/6 * CAST/Ei)
MP:0003229	abnormal vitelline vasculature	"malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]	Show Allelic Composition: Zfp568^chato/Zfp568^chato Genetic Background: either: (involves: 129S1/SvImJ * C57BL/6) or (involves: C3HeB/FeJ * C57BL/6) or (involves: C57BL/6 * CAST/Ei)
MP:0003403	absent placental labyrinth	"malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:73417]	Show Allelic Composition: Zfp568^chato/Zfp568^chato Genetic Background: either: (involves: 129S1/SvImJ * C57BL/6) or (involves: C3HeB/FeJ * C57BL/6) or (involves: C57BL/6 * CAST/Ei)
MP:0004180	failure of initiation of embryo turning	"failure to begin the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Zfp568^chato/Zfp568^chato Genetic Background: either: (involves: 129S1/SvImJ * C57BL/6) or (involves: C3HeB/FeJ * C57BL/6) or (involves: C57BL/6 * CAST/Ei)
MP:0004187	cardia bifida	"failure of the bilateral myocardial cells to coalesce into a single central heart tube resulting in the presence of two independent hearts" [smb:Susan M Bello, Mouse Genome Informatics Curator ""]	Show Allelic Composition: Zfp568^chato/Zfp568^chato Genetic Background: either: (involves: 129S1/SvImJ * C57BL/6) or (involves: C3HeB/FeJ * C57BL/6) or (involves: C57BL/6 * CAST/Ei)
MP:0004264	abnormal extraembryonic tissue physiology	"functional anomaly of the membranes involved with embryonic protection and nutrition" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Zfp568^chato/Zfp568^chato Genetic Background: either: (involves: 129S1/SvImJ * C57BL/6) or (involves: C3HeB/FeJ * C57BL/6) or (involves: C57BL/6 * CAST/Ei)
MP:0004559	small allantois	"reduced size of the fetal membrane which contributes to the formation of the umbilical cord and placental blood vessels" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Zfp568^chato/Zfp568^chato Genetic Background: either: (involves: 129S1/SvImJ * C57BL/6) or (involves: C3HeB/FeJ * C57BL/6) or (involves: C57BL/6 * CAST/Ei)
MP:0004948	abnormal neuronal precursor proliferation	"any anomaly in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Limk2^{Gt(OST80053)Lex}/Limk2^{Gt(OST80053)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
MP:0005655	increased aggression	"when compared to controls, subjects exhibit greater than the normal level of domineering, assaultive posture and/or hostile physical action" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]	Show Allelic Composition: Limk2^{Gt(OST80053)Lex}/Limk2^{Gt(OST80053)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
MP:0006323	abnormal extraembryonic mesoderm development	"malformation of the mesoderm of the extraembryonic tissue that is involved in forming the amnion, chorion,yolk sac, and body stalk" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Zfp568^chato/Zfp568^chato Genetic Background: either: (involves: 129S1/SvImJ * C57BL/6) or (involves: C3HeB/FeJ * C57BL/6) or (involves: C57BL/6 * CAST/Ei)
MP:0008029	abnormal paraxial mesoderm	"failure or abnormality in the formation of the mesoderm lying at either side of the midline embryonic notochord; on segmentation, paraxial mesoderm forms the paired somites" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Zfp568^chato/Zfp568^chato Genetic Background: either: (involves: 129S1/SvImJ * C57BL/6) or (involves: C3HeB/FeJ * C57BL/6) or (involves: C57BL/6 * CAST/Ei)
MP:0008926	abnormal anterior definitive endoderm morphology	"any structural anomaly of the mesendoderm which first migrates from the node and which gives rise to the gut" [PMID:12464432]	Show Allelic Composition: Zfp568^chato/Zfp568^chato Genetic Background: either: (involves: 129S1/SvImJ * C57BL/6) or (involves: C3HeB/FeJ * C57BL/6) or (involves: C57BL/6 * CAST/Ei)
MP:0009657	failure of chorioallantoic fusion	"failure to initiate and/or complete the formation of a highly vascularized extra-embryonic fetal membrane by fusion of the chorion and allantois" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Zfp568^chato/Zfp568^chato Genetic Background: either: (involves: 129S1/SvImJ * C57BL/6) or (involves: C3HeB/FeJ * C57BL/6) or (involves: C57BL/6 * CAST/Ei)
MP:0010117	abnormal lateral plate mesoderm	"anomaly of the portion of the middle of the three primary germ layers of the embryo that resides on the periphery of the embryo, is continuous with the extra-embryonic mesoderm, splits into two layers enclosing the intra-embryonic coelom, and gives rise to body wall structures" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Zfp568^chato/Zfp568^chato Genetic Background: either: (involves: 129S1/SvImJ * C57BL/6) or (involves: C3HeB/FeJ * C57BL/6) or (involves: C57BL/6 * CAST/Ei)
MP:0011097	complete embryonic lethality before turning of embryo	"death of all organisms of a given genotype in a population between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]	Show Allelic Composition: Ugdh^lzme/Ugdh^lzme Genetic Background: involves: C3HeB/FeJ * C57BL/6J
MP:0011205	excessive folding of visceral yolk sac	"the appearance of wrinkles or folds on the surface of the visceral yolk sac" [MGI:csmith, PMID:17881493]	Show Allelic Composition: Zfp568^chato/Zfp568^chato Genetic Background: either: (involves: 129S1/SvImJ * C57BL/6) or (involves: C3HeB/FeJ * C57BL/6) or (involves: C57BL/6 * CAST/Ei)
MP:0012173	short rostral-caudal axis	"length reduction or truncation of the axis that runs from the head to the tail of the body" [MGI:anna]	Show Allelic Composition: Zfp568^chato/Zfp568^chato Genetic Background: either: (involves: 129S1/SvImJ * C57BL/6) or (involves: C3HeB/FeJ * C57BL/6) or (involves: C57BL/6 * CAST/Ei) Allelic Composition: Zfp568^{Gt(RRU161)Byg}/Zfp568^{Gt(RRU161)Byg} Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Zfp568^{Gt(RRU161)Byg}/Zfp568^chato Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

1 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr