ENSMUSG00000074797


Mus musculus

Features
Gene ID: ENSMUSG00000074797
  
Biological name :Itpa
  
Synonyms : inosine triphosphatase (nucleoside triphosphate pyrophosphatase) / Itpa / Q9D892
  
Possible biological names infered from orthology : inosine triphosphatase / Q9BY32
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: F1
Gene start: 130667610
Gene end: 130681614
  
Corresponding Affymetrix probe sets: 10476197 (MoGene1.0st)   10485340 (MoGene1.0st)   1416448_at (Mouse Genome 430 2.0 Array)   1442353_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000099482
NCBI entrez gene - 16434     See in Manteia.
MGI - MGI:96622
RefSeq - XM_017315731
RefSeq - NM_025922
RefSeq Peptide - NP_080198
swissprot - Q60I30
swissprot - Q9D892
Ensembl - ENSMUSG00000074797
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 itpaENSDARG00000057529Danio rerio
 ITPAENSGALG00000003250Gallus gallus
 ITPAENSG00000125877Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002637  Ham1-like protein
 IPR027502  Inosine triphosphate pyrophosphatase
 IPR029001  Inosine triphosphate pyrophosphatase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006193 ITP catabolic process IMP
 biological_processGO:0009117 nucleotide metabolic process IEA
 biological_processGO:0009143 nucleoside triphosphate catabolic process IEA
 biological_processGO:0009204 deoxyribonucleoside triphosphate catabolic process IEA
 biological_processGO:0051276 chromosome organization IMP
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004551 nucleotide diphosphatase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0035529 NADH pyrophosphatase activity IEA
 molecular_functionGO:0035870 dITP diphosphatase activity ISO
 molecular_functionGO:0036220 ITP diphosphatase activity ISO
 molecular_functionGO:0036222 XTP diphosphatase activity ISO
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0047429 nucleoside-triphosphate diphosphatase activity IDA


Pathways (from Reactome)
Pathway description
Purine catabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Zfp42Gt(XB238)Byg/Zfp42+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Zfp42Gt(XB238)Byg/Zfp42+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
Show

Allelic Composition: Zfp42Gt(XB238)Byg/Zfp42+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
Show

Allelic Composition: Zfp42Gt(XB238)Byg/Zfp42+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
Show

Allelic Composition: Zfp42Gt(XB238)Byg/Zfp42+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000382 underdeveloped hair follicles "arrest of or retarded differentiation of the epidermal invaginations from which the hair shaft develops" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
Show

Allelic Composition: Zfp42Gt(XB238)Byg/Zfp42+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001242 hyperkeratosis "increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]
Show

Allelic Composition: Zfp42Gt(XB238)Byg/Zfp42+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Zfp42Gt(XB238)Byg/Zfp42+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
Show

Allelic Composition: Zfp42Gt(XB238)Byg/Zfp42+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001636 irregular heartbeat "uneven timing of heart contraction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33038]
Show

Allelic Composition: Zfp42Gt(XB238)Byg/Zfp42+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Zfp42Gt(XB238)Byg/Zfp42+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001951 abnormal breathing "irregular or atypical breathing pattern " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:17489]
Show

Allelic Composition: Zfp42Gt(XB238)Byg/Zfp42+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002188 small heart "reduced size of the heart relative to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:67044]
Show

Allelic Composition: Zfp42Gt(XB238)Byg/Zfp42+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002740 heart hypoplasia "decreased cell number in the heart" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:77765]
Show

Allelic Composition: Zfp42Gt(XB238)Byg/Zfp42+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004090 abnormal sarcomere morphology "any structural abnormality in the segment of a myofibril between two Z lines comprised of multi-protein complexes composed of three different filament systems; these systems work together to contract and relax muscle" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Zfp42Gt(XB238)Byg/Zfp42+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004092 absent Z lines "missing the cross-striation bisecting the I band of striated muscle myofibrils and serving as the anchoring point of actin filaments at either end of the sarcomere" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Zfp42Gt(XB238)Byg/Zfp42+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004901 decreased male germ cell number "reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Zfp42Gt(XB238)Byg/Zfp42+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Zfp42Gt(XB238)Byg/Zfp42+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Zfp42Gt(XB238)Byg/Zfp42+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Zfp42Gt(XB238)Byg/Zfp42+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Zfp42Gt(XB238)Byg/Zfp42+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000074797 Itpa / Q9D892 / inosine triphosphatase (nucleoside triphosphate pyrophosphatase) / Q9BY32* / inosine triphosphatase*  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr