Manteia - Molecule gene

ENSMUSG00000074802

Mus musculus

Features

Gene ID:	ENSMUSG00000074802

Biological name :	Gas2l3

Synonyms :	Gas2l3 / growth arrest specific 2 like 3

Possible biological names infered from orthology :	Q86XJ1

Species:	Mus musculus

Chr. number:	10
Strand:	-1
Band:	C2
Gene start:	89408823
Gene end:	89443967

Corresponding Affymetrix probe sets:	10371770 (MoGene1.0st) 1437244_at (Mouse Genome 430 2.0 Array) 1453416_at (Mouse Genome 430 2.0 Array) 1455980_a_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000151238 Ensembl peptide - ENSMUSP00000151992 Ensembl peptide - ENSMUSP00000151428 Ensembl peptide - ENSMUSP00000151247 Ensembl peptide - ENSMUSP00000151240 Ensembl peptide - ENSMUSP00000096973 Ensembl peptide - ENSMUSP00000100935 NCBI entrez gene - 237436 See in Manteia. MGI - MGI:1918780 RefSeq - XM_011243445 RefSeq - NM_001033331 RefSeq - NM_001079876 RefSeq - NM_001284344 RefSeq Peptide - NP_001271273 RefSeq Peptide - NP_001028503 RefSeq Peptide - NP_001073345 swissprot - A0A0R4J1A6 swissprot - A0A1W2P6G4 swissprot - A0A1W2P6G0 swissprot - Q3TPC3 swissprot - A0A1W2P8B3 Ensembl - ENSMUSG00000074802

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
gas2l3	ENSDARG00000045880	Danio rerio
GAS2L3	ENSGALG00000028373	Gallus gallus
GAS2L3	ENSG00000139354	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Gas2 / P11862 / Mus musculus growth arrest specific 2 (Gas2), transcript variant 2, mRNA. / O43903* / growth arrest specific 2*	ENSMUSG00000030498	27
Gas2l2 / Q5SSG4 / GAS2-like protein 2 / Q8NHY3* / growth arrest specific 2 like 2*	ENSMUSG00000020686	24
Gas2l1 / Q8JZP9 / GAS2-like protein 1 / Q99501* / growth arrest specific 2 like 1*	ENSMUSG00000034201	20

Protein motifs (from Interpro)

Interpro ID	Name
IPR001715	Calponin homology domain
IPR003108	GAR domain
IPR029932	GAS2-like protein 3
IPR036534	GAR domain superfamily
IPR036872	CH domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000226	microtubule cytoskeleton organization	IEA
biological_process	GO:0030036	actin cytoskeleton organization	IEA
cellular_component	GO:0005856	cytoskeleton	IEA
cellular_component	GO:0015629	actin cytoskeleton	IEA
cellular_component	GO:0015630	microtubule cytoskeleton	IEA
molecular_function	GO:0003779	actin binding	IEA
molecular_function	GO:0005515	protein binding	IEA
molecular_function	GO:0008017	microtubule binding	IEA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000278	abnormal myocardial fiber morphology	"malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]	Show Allelic Composition: Suz12^Plt8/Suz12⁺ Genetic Background: involves: 129/Sv * C57BL/6
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Suz12^Plt8/Suz12⁺ Genetic Background: involves: 129/Sv * C57BL/6
MP:0002795	dilated cardiomyopathy	"decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Suz12^Plt8/Suz12⁺ Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Gas2l3^{tm1c(EUCOMM)Hmgu}/Gas2l3^{tm1c(EUCOMM)Hmgu},Nkx2-5^tm2(cre)Rph/Nkx2-5⁺ Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6N
MP:0002833	increased heart weight	"greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]	Show Allelic Composition: Suz12^Plt8/Suz12⁺ Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Gas2l3^{tm1c(EUCOMM)Hmgu}/Gas2l3^{tm1c(EUCOMM)Hmgu},Nkx2-5^tm2(cre)Rph/Nkx2-5⁺ Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6N
MP:0003567	abnormal cardiomyocyte proliferation	"anomalous division or replication of cardiac muscle cells" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Suz12^Plt8/Suz12⁺ Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Gas2l3^{tm1d(EUCOMM)Hmgu}/Gas2l3^{tm1d(EUCOMM)Hmgu} Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * C57BL/6N
MP:0004564	enlarged myocardial fiber	"increased size of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gas2l3^{tm1d(EUCOMM)Hmgu}/Gas2l3^{tm1d(EUCOMM)Hmgu} Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * C57BL/6N
MP:0004567	decreased myocardial fiber number	"decreased number of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gas2l3^{tm1d(EUCOMM)Hmgu}/Gas2l3^{tm1d(EUCOMM)Hmgu} Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * C57BL/6N
MP:0004937	dilated heart	"stretched or widened aperture of the luminal spaces of the heart, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gas2l3^{tm1c(EUCOMM)Hmgu}/Gas2l3^{tm1c(EUCOMM)Hmgu},Nkx2-5^tm2(cre)Rph/Nkx2-5⁺ Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6N
MP:0005140	decreased cardiac muscle contractility	"inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Suz12^Plt8/Suz12⁺ Genetic Background: involves: 129/Sv * C57BL/6
MP:0005608	cardiac interstitial fibrosis	"formation of fibrous tissue within the interstices of the heart as a result of repair or a reactive process" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]	Show Allelic Composition: Suz12^Plt8/Suz12⁺ Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Gas2l3^{tm1c(EUCOMM)Hmgu}/Gas2l3^{tm1c(EUCOMM)Hmgu},Nkx2-5^tm2(cre)Rph/Nkx2-5⁺ Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6N
MP:0008022	dilated heart ventricles	"the lumenal space of the lower chambers of the heart is increased in volume or area, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gas2l3^{tm1d(EUCOMM)Hmgu}/Gas2l3^{tm1d(EUCOMM)Hmgu} Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * C57BL/6N
MP:0008788	abnormal fetal cardiomyocyte morphology	"any structural anomaly of fetal and neonatal heart cells that undergo proliferation and are not yet terminally differentiated into binucleate or multinucleate cardiac myocytes" [PMID:17429040]	Show Allelic Composition: Suz12^Plt8/Suz12⁺ Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Gas2l3^{tm1d(EUCOMM)Hmgu}/Gas2l3^{tm1d(EUCOMM)Hmgu} Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * C57BL/6N
MP:0011086	partial postnatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Gas2l3^{tm1d(EUCOMM)Hmgu}/Gas2l3^{tm1d(EUCOMM)Hmgu} Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * C57BL/6N
MP:0013289	abnormal mitotic cytokinesis	"any anomaly in the process that results in the division of the cytoplasm of a cell after mitosis, this process consists of two distinct processes furrowing and abscission" [GO:0000281, MGI:smb]	Show Allelic Composition: Suz12^Plt8/Suz12⁺ Genetic Background: involves: 129/Sv * C57BL/6
MP:0020409	abnormal cardiac thrombosis	"any anomaly in the formation or presence of thrombi in the heart" [PMID:15870284]	Show Allelic Composition: Gas2l3^{tm1d(EUCOMM)Hmgu}/Gas2l3^{tm1d(EUCOMM)Hmgu} Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * C57BL/6N

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr