| MP:0000066 | osteoporosis | "reduction in bone mass or atrophy of skeletal tissue; may lead to skeletal fragility" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315] |
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Allelic Composition: KitW-v/KitW-v,Ly6atm1Pmf/Ly6atm1Pmf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0000218 | increased WBC count | "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Zic4tm2Kjmi/Zic4+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0000219 | increased neutrophil count | "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Zic4tm2Kjmi/Zic4+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0000223 | decreased monocyte count | "fewer than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Pde6brd1/Pde6brd1,Pde6gtm1Goff/Pde6gtm1Goff
Genetic Background: either: (involves: 129S/SvEv * C57BL/6 * MF1 * Swiss Webster) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * MF1 * Swiss Webster)
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| MP:0000239 | deficiency of myeloid colony forming progenitor cells | "lack of precursors of the myeloid cell types" [J:60630, tc:Teresa Chu , Mouse Genome Informatics Curator] |
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Allelic Composition: Zic4tm2Kjmi/Zic4+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0000240 | extramedullary hematopoiesis | "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Zic4tm2Kjmi/Zic4+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0000334 | decreased granulocyte number | "fewer than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Pde6brd1/Pde6brd1,Pde6gtm1Goff/Pde6gtm1Goff
Genetic Background: either: (involves: 129S/SvEv * C57BL/6 * MF1 * Swiss Webster) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * MF1 * Swiss Webster)
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| MP:0000691 | enlarged spleen | "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Zic4tm2Kjmi/Zic4+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0001209 | spontaneous skin ulceration | "unpredictable appearance of skin lesions, usually with inflammation" [J:65302] |
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Allelic Composition: Zic4tm2Kjmi/Zic4+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0001222 | epidermal hyperplasia | "increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146] |
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Allelic Composition: Zic4tm2Kjmi/Zic4+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0001242 | hyperkeratosis | "increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133] |
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Allelic Composition: Zic4tm2Kjmi/Zic4+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0001577 | anemia | "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370] |
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Allelic Composition: KitW-v/KitW-v,Ly6atm1Pmf/Ly6atm1Pmf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0002123 | abnormal hematopoiesis | "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Pde6brd1/Pde6brd1,Pde6gtm1Goff/Pde6gtm1Goff
Genetic Background: either: (involves: 129S/SvEv * C57BL/6 * MF1 * Swiss Webster) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * MF1 * Swiss Webster)
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| MP:0002169 | no phenotype detected | "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Pax3Sp-d/Pax3+
Genetic Background: C57BL/6J-Pax3Sp-d
Allelic Composition: Ly6atm1Grau/Ly6atm1Grau
Genetic Background: involves: 129X1/SvJ * C57BL/6
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| MP:0002490 | abnormal circulating immunoglobulin concentration | "deviation from the normal levels of glycoproteins present in the blood and other tissue, often functioning as antibodies" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Pde6brd1/Pde6brd1,Pde6gtm1Goff/Pde6gtm1Goff
Genetic Background: either: (involves: 129S/SvEv * C57BL/6 * MF1 * Swiss Webster) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * MF1 * Swiss Webster)
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| MP:0003135 | increased erythrocyte precursors | "greater numbers of progenitors of the erythrocyte lineage" [smb:Susan M. Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Zic4tm2Kjmi/Zic4+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0003179 | decreased platelet count | "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052] |
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Allelic Composition: Pde6brd1/Pde6brd1,Pde6gtm1Goff/Pde6gtm1Goff
Genetic Background: either: (involves: 129S/SvEv * C57BL/6 * MF1 * Swiss Webster) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * MF1 * Swiss Webster)
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| MP:0004207 | squamous cell carcinoma | "a carcinoma that arises from stratified squamous epithelium that occurs in sites where glandular or columnar epithelium is normally present, such as the skin, esophagus, lungs and cervix" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Zic4tm2Kjmi/Zic4+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0004985 | decreased osteoclast cell number | "reduced number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: KitW-v/KitW-v,Ly6atm1Pmf/Ly6atm1Pmf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0004991 | decreased bone strength | "reduced ability of bone to endure the application of force without yielding or breaking" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: KitW-v/KitW-v,Ly6atm1Pmf/Ly6atm1Pmf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0005006 | abnormal osteoblast function | "anomalous function of this bone-forming cell, which normally forms an osseous matrix in which it becomes enclosed as an osteocyte " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: KitW-v/KitW-v,Ly6atm1Pmf/Ly6atm1Pmf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0005013 | increased lymphocyte number | "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Pde6brd1/Pde6brd1,Pde6gtm1Goff/Pde6gtm1Goff
Genetic Background: either: (involves: 129S/SvEv * C57BL/6 * MF1 * Swiss Webster) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * MF1 * Swiss Webster)
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| MP:0005094 | abnormal T cell proliferation | "anomaly in the clonal expansion of naive T cells" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Pde6brd1/Pde6brd1,Pde6gtm1Goff/Pde6gtm1Goff
Genetic Background: either: (involves: 129S/SvEv * C57BL/6 * MF1 * Swiss Webster) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * MF1 * Swiss Webster)
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| MP:0005097 | polychromatophilia | "condition characterized by the presence of red blood cells that have an affinity for acid, basic, and neutral stains" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:305] |
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Allelic Composition: Zic4tm2Kjmi/Zic4+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0005606 | increased bleeding time | "greater than the normal duration of blood flow after skin puncture; indicative of platelet and capillary function" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission] |
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Allelic Composition: Pde6brd1/Pde6brd1,Pde6gtm1Goff/Pde6gtm1Goff
Genetic Background: either: (involves: 129S/SvEv * C57BL/6 * MF1 * Swiss Webster) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * MF1 * Swiss Webster)
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| MP:0006410 | abnormal common myeloid progenitor cell morphology | "anomaly in the structure of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Pde6brd1/Pde6brd1,Pde6gtm1Goff/Pde6gtm1Goff
Genetic Background: either: (involves: 129S/SvEv * C57BL/6 * MF1 * Swiss Webster) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * MF1 * Swiss Webster)
Allelic Composition: KitW-v/KitW-v,Ly6atm1Pmf/Ly6atm1Pmf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Ly6atm1Pmf/Ly6atm1Pmf
Genetic Background: C.129P2-Ly6atm1Pmf
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| MP:0008250 | abnormal myeloid leukocyte morphology | "any structural anomaly of a cell of the monocyte, granulocyte, or mast cell lineage" [CL:0000766] |
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Allelic Composition: Pde6brd1/Pde6brd1,Pde6gtm1Goff/Pde6gtm1Goff
Genetic Background: either: (involves: 129S/SvEv * C57BL/6 * MF1 * Swiss Webster) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * MF1 * Swiss Webster)
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| MP:0008255 | decreased megakaryocyte cell number | "reduced number of giant cells 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm" [CL:0000556, ISBN:0721601464] |
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Allelic Composition: Pde6brd1/Pde6brd1,Pde6gtm1Goff/Pde6gtm1Goff
Genetic Background: either: (involves: 129S/SvEv * C57BL/6 * MF1 * Swiss Webster) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * MF1 * Swiss Webster)
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| MP:0008395 | abnormal osteoblast differentiation | "atypical production of or inability to produce bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ly6atm1Pmf/Ly6atm1Pmf
Genetic Background: C.129P2-Ly6atm1Pmf
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| MP:0008396 | abnormal osteoclast differentiation | "atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ly6atm1Pmf/Ly6atm1Pmf
Genetic Background: C.129P2-Ly6atm1Pmf
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| MP:0008470 | abnormal spleen B cell follicle morphology | "any structural anomaly of the area of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur" [PMID:17495967] |
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Allelic Composition: Zic4tm2Kjmi/Zic4+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0009115 | abnormal fat cell morphology | "any structural anomaly of a fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals" [CL:0000449] |
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Allelic Composition: Ly6atm1Pmf/Ly6atm1Pmf
Genetic Background: C.129P2-Ly6atm1Pmf
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| MP:0010124 | decreased bone mineral content | "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ly6atm1Pmf/Ly6atm1Pmf
Genetic Background: C.129P2-Ly6atm1Pmf
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| MP:0010373 | myeloid hyperplasia | "greater than normal number of nucleated cells of the myeloid lineage (a monocyte, granulocyte, or mast cell), found in blood or other tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Zic4tm2Kjmi/Zic4+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0010869 | decreased bone trabecula number | "decreased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ly6atm1Pmf/Ly6atm1Pmf
Genetic Background: C.129P2-Ly6atm1Pmf
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| MP:0010927 | decreased osteoid volume | "reduction in the amount of space occupied by newly formed organic bone matrix secreted by osteoblasts" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Ly6atm1Pmf/Ly6atm1Pmf
Genetic Background: C.129P2-Ly6atm1Pmf
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| MP:0011091 | complete prenatal lethality | "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith] |
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Allelic Composition: Pde6brd1/Pde6brd1,Pde6gtm1Goff/Pde6gtm1Goff
Genetic Background: either: (involves: 129S/SvEv * C57BL/6 * MF1 * Swiss Webster) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * MF1 * Swiss Webster)
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| MP:0011102 | partial embryonic lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith] |
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Allelic Composition: KitW-v/KitW-v,Ly6atm1Pmf/Ly6atm1Pmf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0020040 | decreased bone ossification | "decrease in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [ORCID: orcid.org/0000-0003-4606-0597] |
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Allelic Composition: Ly6atm1Pmf/Ly6atm1Pmf
Genetic Background: C.129P2-Ly6atm1Pmf
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