ENSMUSG00000078630


Mus musculus

Features
Gene ID: ENSMUSG00000078630
  
Biological name :Tomt
  
Synonyms : A1Y9I9 / Tomt / Transmembrane O-methyltransferase homolog
  
Possible biological names infered from orthology : AP000812.4 / leucine rich transmembrane and O-methyltransferase domain containing / LRTOMT / Q8WZ04 / Q96E66
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: E2
Gene start: 101898370
Gene end: 101906359
  
Corresponding Affymetrix probe sets: 10608703 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000102582
Ensembl peptide - ENSMUSP00000102583
NCBI entrez gene - 791260     See in Manteia.
MGI - MGI:3769724
RefSeq - XM_017312403
RefSeq - NM_001081679
RefSeq - NM_001282088
RefSeq Peptide - NP_001075148
RefSeq Peptide - NP_001269017
swissprot - A1Y9I9
Ensembl - ENSMUSG00000078630
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tomtENSDARG00000115463Danio rerio
 ENSGALG00000035375Gallus gallus
 AP000812.4ENSG00000284844Homo sapiens
 LRTOMTENSG00000184154Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Comt / O88587 / Catechol O-methyltransferase / P21964*ENSMUSG0000000032634


Protein motifs (from Interpro)
Interpro ID Name
 IPR002935  O-methyltransferase, family 3
 IPR029063  S-adenosyl-L-methionine-dependent methyltransferase
 IPR033025  Transmembrane O-methyltransferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006584 catecholamine metabolic process IEA
 biological_processGO:0007605 sensory perception of sound IMP
 biological_processGO:0032259 methylation IEA
 biological_processGO:0042135 neurotransmitter catabolic process IEA
 biological_processGO:0042424 catecholamine catabolic process IDA
 biological_processGO:0060117 auditory receptor cell development IMP
 biological_processGO:1904591 positive regulation of protein import IMP
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0045177 apical part of cell IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0008171 O-methyltransferase activity IEA
 molecular_functionGO:0016206 catechol O-methyltransferase activity IDA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0102084 L-dopa O-methyltransferase activity IEA
 molecular_functionGO:0102938 orcinol O-methyltransferase activity IEA


Pathways (from Reactome)
Pathway description
Enzymatic degradation of dopamine by COMT


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000043 organ of Corti degeneration "a retrogressive impairment of function or destruction of the highly specialized epithelium in the floor of the ductus cochlearis" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gp1bbtm2Frla/Gp1bbtm2Frla
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Gp1bbtm2Frla/Gp1bbtm2Frla
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Tomtm1Btlr/Tomtm1Btlr
Genetic Background: involves: C3H/HeN * C57BL/6J

 MP:0001354 increased aggression towards males "when compared to controls, subjects exhibit greater than the normal level of domineering, assaultive posture and/or hostile physical action toward male mice" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Webster s II New College Dictionary:ISBN 0-395-70869-9]
Show

Allelic Composition: Gp1bbtm2Frla/Gp1bbtm2Frla
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Tomtm1Btlr/Tomtm1Btlr
Genetic Background: involves: C3H/HeN * C57BL/6J

 MP:0001395 bi-directional circling "circling behavior exhibited in both clockwise and counterclockwise directions" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gp1bbtm2Frla/Gp1bbtm2Frla
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Tomtm1Btlr/Tomtm1Btlr
Genetic Background: involves: C3H/HeN * C57BL/6J

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Gp1bbtm2Frla/Gp1bbtm2Frla
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Tomtm1Btlr/Tomtm1Btlr
Genetic Background: involves: C3H/HeN * C57BL/6J

 MP:0001525 impaired balance "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]
Show

Allelic Composition: Gp1bbtm2Frla/Gp1bbtm2Frla
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001967 deafness "inability to hear" [J:57651]
Show

Allelic Composition: Gp1bbtm2Frla/Gp1bbtm2Frla
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002857 cochlear ganglion degeneration "loss of neural cell bodies in the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gp1bbtm2Frla/Gp1bbtm2Frla
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004398 cochlear inner hair cell degeneration "degeneration or loss of the single row of flask-shaped inner hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gp1bbtm2Frla/Gp1bbtm2Frla
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004404 cochlear outer hair cell degeneration "degeneration or loss of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gp1bbtm2Frla/Gp1bbtm2Frla
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004522 abnormal orientation of cochlear hair cell stereociliary bundles "misorientation or rotation of inner and/or outer hair cell stereociliary bundles, resulting in defective planar cell polarity of the inner ear sensory epithelium" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Gp1bbtm2Frla/Gp1bbtm2Frla
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004737 absent distortion product otoacoustic emissions "failure to create mechanical distortions in the inner ear when two primary tones are presented, indicating failure of outer hair cells to amplify basilar membrane motion" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gp1bbtm2Frla/Gp1bbtm2Frla
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005307 head tossing "compulsive flailing of the head in multiple directions" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gp1bbtm2Frla/Gp1bbtm2Frla
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Tomtm1Btlr/Tomtm1Btlr
Genetic Background: involves: C3H/HeN * C57BL/6J

 MP:0006359 absent startle reflex "failure to respond to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gp1bbtm2Frla/Gp1bbtm2Frla
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
Show

Allelic Composition: Gp1bbtm2Frla/Gp1bbtm2Frla
Genetic Background: involves: 129S2/SvPas * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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