ENSDARG00000115463


Danio rerio

Features
Gene ID: ENSDARG00000115463
  
Biological name :tomt
  
Synonyms : A0A193KX02 / tomt / transmembrane O-methyltransferase
  
Possible biological names infered from orthology : A1Y9I9 / AP000812.4 / leucine rich transmembrane and O-methyltransferase domain containing / LRTOMT / Q8WZ04 / Q96E66 / Transmembrane O-methyltransferase homolog
  
Species: Danio rerio
  
Chr. number: 15
Strand: -1
Band:
Gene start: 47808159
Gene end: 47812268
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000145949
NCBI entrez gene - 110437932     See in Manteia.
swissprot - A0A193KX02
ZFIN ID - ZDB-GENE-160629-1
Ensembl - ENSDARG00000115463
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000035375Gallus gallus
 AP000812.4ENSG00000284844Homo sapiens
 LRTOMTENSG00000184154Homo sapiens
 TomtENSMUSG00000078630Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
comtb / catechol-O-methyltransferase b / COMT* / O88587* / P21964* / catechol-O-methyltransferase*ENSDARG0000002567937
comta / catechol-O-methyltransferase a / COMT* / O88587* / P21964* / catechol-O-methyltransferase*ENSDARG0000001533736


Protein motifs (from Interpro)
Interpro ID Name
 IPR002935  O-methyltransferase, family 3
 IPR029063  S-adenosyl-L-methionine-dependent methyltransferase
 IPR033025  Transmembrane O-methyltransferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006584 catecholamine metabolic process IEA
 biological_processGO:0006897 endocytosis IMP
 biological_processGO:0007605 sensory perception of sound IEA
 biological_processGO:0031223 auditory behavior IMP
 biological_processGO:0032259 methylation IEA
 biological_processGO:0035315 hair cell differentiation IMP
 biological_processGO:0042135 neurotransmitter catabolic process IEA
 biological_processGO:0042424 catecholamine catabolic process ISS
 biological_processGO:0048884 neuromast development IMP
 biological_processGO:0050974 detection of mechanical stimulus involved in sensory perception IMP
 biological_processGO:0060122 inner ear receptor cell stereocilium organization IMP
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0008171 O-methyltransferase activity IEA
 molecular_functionGO:0016206 catechol O-methyltransferase activity ISS
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0102084 L-dopa O-methyltransferase activity IEA
 molecular_functionGO:0102938 orcinol O-methyltransferase activity IEA


Pathways (from Reactome)
Pathway description
Enzymatic degradation of dopamine by COMT


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000166 lateral crista lateral crista hair cell decreased functionality , abnormal
lateral crista stereocilium bundle absent , abnormal
lateral crista inner ear receptor cell stereocilium organization decreased process quality , abnormal
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 ZFA:0000217 inner ear inner ear hair cell absent , abnormal
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 ZFA:0000243 neuromast neuromast has fewer parts of type neuromast hair cell , abnormal
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 ZFA:0001094 whole organism whole organism absent , abnormal
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 ZFA:0009367 neuromast hair cell neuromast hair cell response to mechanical stimulus decreased process quality , abnormal
neuromast hair cell stereocilium decreased functionality , abnormal
neuromast hair cell stereocilium functionality , ameliorated
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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