ENSDARG00000025679


Danio rerio

Features
Gene ID: ENSDARG00000025679
  
Biological name :comtb
  
Synonyms : catechol-O-methyltransferase b / comtb
  
Possible biological names infered from orthology : catechol-O-methyltransferase / COMT / O88587 / P21964
  
Species: Danio rerio
  
Chr. number: 11
Strand: 1
Band:
Gene start: 25619892
Gene end: 25631442
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000038939
Ensembl peptide - ENSDARP00000113393
NCBI entrez gene - 565370     See in Manteia.
RefSeq - NM_001083843
RefSeq Peptide - NP_001077312
swissprot - E9QFY6
swissprot - A4IG53
ZFIN ID - ZDB-GENE-040724-164
Ensembl - ENSDARG00000025679
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 COMTENSGALG00000002024Gallus gallus
 COMTENSG00000093010Homo sapiens
 ComtENSMUSG00000000326Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
comta / catechol-O-methyltransferase a / COMT* / O88587* / P21964* / catechol-O-methyltransferase*ENSDARG0000001533766
tomt / A0A193KX02 / transmembrane O-methyltransferase / LRTOMT* / Q8WZ04* / Q96E66* / AP000812.4* / leucine rich transmembrane and O-methyltransferase domain containing*ENSDARG0000011546336


Protein motifs (from Interpro)
Interpro ID Name
 IPR002935  O-methyltransferase, family 3
 IPR017128  Catechol O-methyltransferase, eukaryotic
 IPR029063  S-adenosyl-L-methionine-dependent methyltransferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006584 catecholamine metabolic process IEA
 biological_processGO:0032259 methylation IEA
 biological_processGO:0042135 neurotransmitter catabolic process IEA
 cellular_componentGO:0005575 cellular_component ND
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0008171 O-methyltransferase activity IEA
 molecular_functionGO:0016206 catechol O-methyltransferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Methylation
Enzymatic degradation of dopamine by COMT
Enzymatic degradation of Dopamine by monoamine oxidase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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contact: otassy@igbmc.fr