ENSMUSG00000079037


Mus musculus

Features
Gene ID: ENSMUSG00000079037
  
Biological name :Prnp
  
Synonyms : P04925 / prion protein / Prnp
  
Possible biological names infered from orthology : P04156
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: F2
Gene start: 131909928
Gene end: 131938429
  
Corresponding Affymetrix probe sets: 10476314 (MoGene1.0st)   1416130_at (Mouse Genome 430 2.0 Array)   1448233_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000088833
NCBI entrez gene - 19122     See in Manteia.
MGI - MGI:97769
RefSeq - NM_011170
RefSeq - NM_001278256
RefSeq Peptide - NP_001265185
RefSeq Peptide - NP_035300
swissprot - P04925
swissprot - Q4FJQ7
Ensembl - ENSMUSG00000079037
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PRNPENSGALG00000000209Gallus gallus
 PRNPENSG00000171867Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000817  Prion protein
 IPR022416  Prion/Doppel protein, beta-ribbon domain
 IPR025860  Major prion protein N-terminal domain
 IPR036924  Prion/Doppel beta-ribbon domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001933 negative regulation of protein phosphorylation IMP
 biological_processGO:0006139 nucleobase-containing compound metabolic process TAS
 biological_processGO:0006878 cellular copper ion homeostasis TAS
 biological_processGO:0006979 response to oxidative stress IDA
 biological_processGO:0007611 learning or memory IEA
 biological_processGO:0010942 positive regulation of cell death IGI
 biological_processGO:0031648 protein destabilization IEA
 biological_processGO:0032147 activation of protein kinase activity IGI
 biological_processGO:0032689 negative regulation of interferon-gamma production IMP
 biological_processGO:0032700 negative regulation of interleukin-17 production IMP
 biological_processGO:0032703 negative regulation of interleukin-2 production IMP
 biological_processGO:0032880 regulation of protein localization IMP
 biological_processGO:0035584 calcium-mediated signaling using intracellular calcium source IGI
 biological_processGO:0035690 cellular response to drug IDA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043086 negative regulation of catalytic activity IEA
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity IMP
 biological_processGO:0043525 positive regulation of neuron apoptotic process IEA
 biological_processGO:0046007 negative regulation of activated T cell proliferation IMP
 biological_processGO:0046686 response to cadmium ion IEA
 biological_processGO:0046688 response to copper ion IEA
 biological_processGO:0050730 regulation of peptidyl-tyrosine phosphorylation IGI
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IMP
 biological_processGO:0050860 negative regulation of T cell receptor signaling pathway IMP
 biological_processGO:0051260 protein homooligomerization ISO
 biological_processGO:0061098 positive regulation of protein tyrosine kinase activity IEA
 biological_processGO:0070885 negative regulation of calcineurin-NFAT signaling cascade IMP
 biological_processGO:0071280 cellular response to copper ion IEA
 biological_processGO:0090314 positive regulation of protein targeting to membrane IGI
 biological_processGO:0090647 modulation of age-related behavioral decline IGI
 biological_processGO:1900272 negative regulation of long-term synaptic potentiation IEA
 biological_processGO:1901216 positive regulation of neuron death IGI
 biological_processGO:1901379 regulation of potassium ion transmembrane transport IGI
 biological_processGO:1902430 negative regulation of amyloid-beta formation IGI
 biological_processGO:1902938 regulation of intracellular calcium activated chloride channel activity IEA
 biological_processGO:1902951 negative regulation of dendritic spine maintenance IGI
 biological_processGO:1902992 negative regulation of amyloid precursor protein catabolic process IGI
 biological_processGO:1903078 positive regulation of protein localization to plasma membrane IMP
 biological_processGO:1904645 response to amyloid-beta IGI
 biological_processGO:1904646 cellular response to amyloid-beta IEA
 biological_processGO:1905664 regulation of calcium ion import across plasma membrane IGI
 biological_processGO:1990535 neuron projection maintenance IGI
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005741 mitochondrial outer membrane ISO
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016234 inclusion body IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0031225 anchored component of membrane IEA
 cellular_componentGO:0031965 nuclear membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0045121 membrane raft IMP
 cellular_componentGO:0106003 amyloid-beta complex IEA
 molecular_functionGO:0001540 amyloid-beta binding TAS
 molecular_functionGO:0002020 protease binding IPI
 molecular_functionGO:0004871 obsolete signal transducer activity IGI
 molecular_functionGO:0005507 copper ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005521 lamin binding IEA
 molecular_functionGO:0005539 glycosaminoglycan binding IDA
 molecular_functionGO:0008017 microtubule binding IEA
 molecular_functionGO:0015631 tubulin binding IEA
 molecular_functionGO:0031802 type 5 metabotropic glutamate receptor binding IPI
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0043008 ATP-dependent protein binding IEA
 molecular_functionGO:0044325 ion channel binding IEA
 molecular_functionGO:0044877 protein-containing complex binding IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051087 chaperone binding IEA
 molecular_functionGO:1903135 cupric ion binding IMP
 molecular_functionGO:1903136 cuprous ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp*D177N*M128V)A21Rchi/Tg(Prnp*D177N*M128V)A21Rchi
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp*D177N*M128V)A21Rchi/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp*)#Rgab/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp*S170N*N174T)1020Aag/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000242 impaired fertilization "defect or reduced ability in the process beginning with penetration of the secondary oocyte by the spermatozoon and completed by fusion of the male and female pronucei" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Prnp/Prndtm1Dwm/Prnp/Prndtm1Dwm
Genetic Background: 129P2/OlaHsd-Prnp/Prndtm1Dwm

 MP:0000243 myoclonus "involuntary shock-like contractions, variable in rhythm and amplitude, followed by relaxation, of a muscle or a group of muscles; generally due to a central nervous system lesion" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp*)#Rgab/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Prnptm3(PRNP*129V)Tkit/Prnptm3(PRNP*129V)Tkit,Tg(Prnp-PRNP*129V)139Tkit/?
Genetic Background: Not Specified

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Krastm1Mok/Kras+,Nrastm1Mok/Nrastm1Mok
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: EgfrMhdadsk5/Egfr+
Genetic Background: C3HeB/FeJ-EgfrMhdadsk5/Ieg

Allelic Composition: Prnptm1Cwe/Prnptm2.1Cwe
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Prnptm1Ito/Prnptm1Ito
Genetic Background: involves: C57BL/6J

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp*)#Rgab/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Sprntm1Geno/Sprntm1Geno
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J * FVB/N

 MP:0000749 muscle degeneration "pathological deterioration of muscle tissue, often accompanied by loss of function" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp*S170N*N174T)1020Aag/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000754 partial paralysis "partial loss of power of voluntary movement in a muscle through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp*S170N*N174T)1020Aag/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000755 hindlimb paralysis "loss of power of voluntary movement in the muscles of the hindlimb through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp)a20Cwe/0
Genetic Background: Not Specified

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp*)#Rgab/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0000780 abnormal corpus callosum morphology "malformation or absence of a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres; it consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp*S170N*N174T)1020Aag/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Prnptm2Lnq/Prnptm2Lnq
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0000807 abnormal hippocampus morphology "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]
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Allelic Composition: Prnptm3Lnq/Prnptm3Lnq
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0000819 abnormal olfactory bulb morphology "malformation or absence of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Principles of Neural Science:ISBN 0-8385-8034-3, J:16461]
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Allelic Composition: Prnptm3Lnq/Prnptm3Lnq
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0000832 abnormal thalamus morphology "malformation or absence of the large ovoid mass of paired bodies containing mostly gray matter and forming part of the lateral wall of the third ventricle of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Prnptm2Lnq/Prnptm2Lnq
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Prnptm2.1Cwe/Prnptm2.1Cwe
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Prnptm1Cwe/Prnptm2.1Cwe
Genetic Background: involves: 129P2/OlaHsd

 MP:0000876 Purkinje cell degeneration "a retrogressive impairment of function or destruction of the large neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex" [J:46854]
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Allelic Composition: Pkd2tm2Som/Pkd2+
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp-tTA)F959Sbp/Tg(Prnp-tTA)F959Sbp,Tg(tetO-ATXN3)2904Olri/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp-tTA)F959Sbp/0,Tg(tetO-ATXN3)2904Olri/Tg(tetO-ATXN3)2904Olri
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB

 MP:0000877 abnormal Purkinje cell "any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells" [J:46140, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp-tTA)F959Sbp/Tg(Prnp-tTA)F959Sbp,Tg(tetO-ATXN3)2904Olri/Tg(tetO-ATXN3)2904Olri
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB

 MP:0000880 decreased Purkinje cell number "fewer than normal neuronal cells that are located in the interface of the molecular and granular layers of the cerebellar cortex" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:45302]
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Allelic Composition: Prnptm2.1Cwe/Prnptm2.1Cwe
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Prnptm1Cwe/Prnptm2.1Cwe
Genetic Background: involves: 129P2/OlaHsd

 MP:0000889 abnormal cerebellar molecular layer "any malformation or absence of the outermost layer of the cerebral cortex that contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Prnptm3Lnq/Prnptm3Lnq
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0000890 thin cerebellar molecular layer "reduced width of the outer of the three cortical layers of the cerebellum" [J:46854]
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Allelic Composition: Prnptm2.1Cwe/Prnptm2.1Cwe
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp-tTA)F959Sbp/Tg(Prnp-tTA)F959Sbp,Tg(tetO-ATXN3)2904Olri/Tg(tetO-ATXN3)2904Olri
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp-tTA)F959Sbp/0,Tg(tetO-ATXN3)2904Olri/Tg(tetO-ATXN3)2904Olri
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp-tTA)F959Sbp/Tg(Prnp-tTA)F959Sbp,Tg(tetO-ATXN3)2904Olri/Tg(tetO-ATXN3)2904Olri
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp*S170N*N174T)1020Aag/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prnptm3Lnq/Prnptm3Lnq
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
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Allelic Composition: Eedtm1Sho/Eedtm1Sho,Eportm1(EGFP/cre)Uk/Epor+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sortm1(EYFP)Cos
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp-tTA)F959Sbp/0,Tg(tetO-ATXN3)2904Olri/Tg(tetO-ATXN3)2904Olri
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp-tTA)F959Sbp/Tg(Prnp-tTA)F959Sbp,Tg(tetO-ATXN3)2904Olri/Tg(tetO-ATXN3)2904Olri
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Pkd2tm2Som/Pkd2+
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

Allelic Composition: Prnptm2.1Cwe/Prnptm2.1Cwe
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Prnptm2Rcm/Prnptm2Rcm
Genetic Background: Not Specified

Allelic Composition: Prnptm1Ito/Prnptm1Ito
Genetic Background: involves: C57BL/6J

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp*D177N*M128V)A21Rchi/Tg(Prnp*D177N*M128V)A21Rchi
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp*D177N*M128V)A21Rchi/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp*A116V*M128V)1309Jama/0
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Sprntm1Geno/Sprntm1Geno
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J * FVB/N

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp*S170N*N174T)1020Aag/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001394 circling "repeated, compulsive movement in a circle; often associated with inner ear defects" [MGI:CLS, J:61295]
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Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp*S170N*N174T)1020Aag/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Runx3tm1Itan/Runx3tm1Itan,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp-tTA)F959Sbp/Tg(Prnp-tTA)F959Sbp,Tg(tetO-ATXN3)2904Olri/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp-tTA)F959Sbp/0,Tg(tetO-ATXN3)2904Olri/Tg(tetO-ATXN3)2904Olri
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp-tTA)F959Sbp/Tg(Prnp-tTA)F959Sbp,Tg(tetO-ATXN3)2904Olri/Tg(tetO-ATXN3)2904Olri
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Runx3tm1Itan/Runx3tm1Itan,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Prnptm2Lnq/Prnptm2Lnq
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

Allelic Composition: Prnptm3Lnq/Prnptm3Lnq
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Pkd2tm2Som/Pkd2+
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp-tTA)F959Sbp/Tg(Prnp-tTA)F959Sbp,Tg(tetO-ATXN3)2904Olri/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp-tTA)F959Sbp/0,Tg(tetO-ATXN3)2904Olri/Tg(tetO-ATXN3)2904Olri
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp-tTA)F959Sbp/Tg(Prnp-tTA)F959Sbp,Tg(tetO-ATXN3)2904Olri/Tg(tetO-ATXN3)2904Olri
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB

Allelic Composition: Prnptm2Lnq/Prnptm2Lnq
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

Allelic Composition: Prnptm3Lnq/Prnptm3Lnq
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp*A116V*M128V)1309Jama/0
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp-tTA)F959Sbp/0,Tg(tetO-ATXN3)2904Olri/Tg(tetO-ATXN3)2904Olri
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB

 MP:0001442 decreased grooming behavior "reduced amount of time spent cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Runx3tm1Itan/Runx3tm1Itan,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0001458 abnormal object recognition memory "defects in the ability to recognize objects that the animal has previously encountered; recognition is measured by relative amount of time exploring objects, which should decrease upon subsequent or multiple presentations of the same object when presented with novel objects at the same time" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Runx3tm1Itan/Runx3tm1Itan,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Pkd2tm2Som/Pkd2+
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0001501 abnormal sleep pattern "deviation from the normal wake/sleep cycle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Prnptm1Lnq/Prnptm1Lnq
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Ednratm2Hku/Ednratm3(Ednrb)Hku
Genetic Background: involves: 129 * C57BL/6 * ICR

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp*D177N*M128V)A21Rchi/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp-tTA)F959Sbp/Tg(Prnp-tTA)F959Sbp,Tg(tetO-ATXN3)2904Olri/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp-tTA)F959Sbp/0,Tg(tetO-ATXN3)2904Olri/Tg(tetO-ATXN3)2904Olri
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp-tTA)F959Sbp/Tg(Prnp-tTA)F959Sbp,Tg(tetO-ATXN3)2904Olri/Tg(tetO-ATXN3)2904Olri
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp*)#Rgab/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Sprntm1Geno/Sprntm1Geno
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J * FVB/N

 MP:0001523 impaired righting response "reduced ability or greater amount of time needed to recover from supine position" [J:25565]
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Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp*A116V*M128V)1309Jama/0
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001525 impaired balance "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]
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Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp*D177N*M128V)A21Rchi/Tg(Prnp*D177N*M128V)A21Rchi
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp*D177N*M128V)A21Rchi/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

 MP:0001777 abnormal body temperature regulation "anomalous control of the body s heat" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prnptm1Lnq/Prnptm1Lnq
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0001793 altered susceptibility to infection "a change in the likelihood that an organism will develop ill effects from a pathogenic invasion or from components of or toxins produced by pathogens " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prnptm3(PRNP*129V)Tkit/Prnptm3(PRNP*129V)Tkit,Tg(Prnp-PRNP*129V)144Tkit/?
Genetic Background: Not Specified

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
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Allelic Composition: Egr1tm1Jmi/Egr1tm1Jmi,Tg(Scgb1a1-rtTA,-tTS,tetO-TGFB1*)1Eli/?
Genetic Background: involves: 129 * C57BL/6

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Prnp/Prndtm1Dwm/Prnp/Prndtm1Dwm
Genetic Background: 129P2/OlaHsd-Prnp/Prndtm1Dwm

Allelic Composition: Prnp/Prndtm1Aag/Prnp/Prndtm1Aag
Genetic Background: Not Specified

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Eedtm1Sho/Eedtm1Sho,Eportm1(EGFP/cre)Uk/Epor+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sortm1(EYFP)Cos
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp-tTA)F959Sbp/0,Tg(tetO-ATXN3)2904Olri/Tg(tetO-ATXN3)2904Olri
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp-tTA)F959Sbp/Tg(Prnp-tTA)F959Sbp,Tg(tetO-ATXN3)2904Olri/Tg(tetO-ATXN3)2904Olri
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ednratm2Hku/Ednratm3(Ednrb)Hku
Genetic Background: involves: 129 * C57BL/6 * ICR

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp*D177N*M128V)A21Rchi/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp*A116V*M128V)1309Jama/0
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp*)#Rgab/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp*P101L)2866Sbp/0
Genetic Background: involves: 129S7/SvEvBrd * FVB/N

Allelic Composition: Prnptm3Lnq/Prnptm3Lnq
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0002106 abnormal muscle physiology "anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: EgfrMhdadsk5/Egfr+
Genetic Background: C3HeB/FeJ-EgfrMhdadsk5/Ieg

 MP:0002111 abnormal tail morphology "abnormal development of the tail resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gnl3Gt(S4-4B1)Sor/Gnl3Gt(S4-4B1)Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Krastm1Mok/Kras+,Nrastm1Mok/Nrastm1Mok
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
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Allelic Composition: Prnptm3(PRNP*129V)Tkit/Prnptm3(PRNP*129V)Tkit,Tg(Prnp-PRNP*129V)144Tkit/?
Genetic Background: Not Specified

Allelic Composition: Prnptm3(PRNP*129V)Tkit/Prnptm3(PRNP*129V)Tkit
Genetic Background: Not Specified

Allelic Composition: Prnptm2(PRNP*129M)Tkit/Prnptm2(PRNP*129M)Tkit,Tg(Prnp-PRNP*129M)1Tkit/?
Genetic Background: Not Specified

Allelic Composition: Prnptm5(PRNP*)TKit/Prnptm5(PRNP*)TKit,Tg(Prnp-PRNP*)1Tkit/?
Genetic Background: Not Specified

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp*P101L)2866Sbp/0
Genetic Background: involves: 129S7/SvEvBrd * FVB/N

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp*S170N*N174T)1020Aag/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: EgfrMhdadsk5/Egfr+
Genetic Background: C3HeB/FeJ-EgfrMhdadsk5/Ieg

Allelic Composition: Prnptm1Canc/Prnptm1Canc
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Prnptm2Canc/Prnptm2Canc
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Prnptm3Canc/Prnptm3Canc
Genetic Background: involves: 129P2/OlaHsd

 MP:0002183 gliosis "increased growth pattern of neuroglia in a damaged area of the brain or spinal cord" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Prnp/Prndtm1Aag/Prnp/Prndtm1Aag
Genetic Background: Not Specified

Allelic Composition: Prnptm2Lnq/Prnptm2Lnq
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(PRNP)35Jcol/Tg(PRNP)35Jcol
Genetic Background: involves: 129 * 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pkd2tm2Som/Pkd2+
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0002229 CNS neurodegeneration "a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Prnptm2Lnq/Prnptm2Lnq
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0002269 muscular atrophy "a wasting of muscle tissue resulting in a derangement of the muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp*)#Rgab/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0002410 decreased susceptibility to viral infection "reduced likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Runx3tm1Itan/Runx3tm1Itan,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Nefh-cre)22Jcol/?,Tg(Prnp)37Jcol/?
Genetic Background: involves: 129/Sv * 129S7/SvEvBrd * C57BL/6 * FVB

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Runx3tm1Itan/Runx3tm1Itan,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0002651 abnormal sciatic nerve "malformation, absence or misprojection of the nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp*S170N*N174T)1020Aag/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002654 spongiform encephalopathy "a neurodegenerative state characterized by the appearance of large vacuolated areas in the brain cells, resembling a sponge" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Runx3tm1Itan/Runx3tm1Itan,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Nefh-cre)22Jcol/?,Tg(Prnp)37Jcol/?
Genetic Background: involves: 129/Sv * 129S7/SvEvBrd * C57BL/6 * FVB

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp*P101L)2866Sbp/0
Genetic Background: involves: 129S7/SvEvBrd * FVB/N

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp*P101L)2866Sbp/Tg(Prnp*P101L)2866Sbp
Genetic Background: involves: 129S7/SvEvBrd * FVB/N

Allelic Composition: Prnptm3Lnq/Prnptm3Lnq
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp*S170N*N174T)1020Aag/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(PRNP)35Jcol/Tg(PRNP)35Jcol
Genetic Background: involves: 129 * 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Prnptm2Lnq/Prnptm2Lnq
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0002804 abnormal motor learning "defects in the ability to repeat a motor task requiring well coordinated movements and balance; measures cerebellar dependent learning" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp-tTA)F959Sbp/Tg(Prnp-tTA)F959Sbp,Tg(tetO-ATXN3)2904Olri/Tg(tetO-ATXN3)2904Olri
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB

 MP:0002911 abnormal inhibitory postsynaptic potential "defect in the membrane potential detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Pkd2tm2Som/Pkd2+
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0002912 abnormal excitatory postsynaptic potential "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Runx3tm1Itan/Runx3tm1Itan,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Nefh-cre)22Jcol/?,Tg(Prnp)37Jcol/?
Genetic Background: involves: 129/Sv * 129S7/SvEvBrd * C57BL/6 * FVB

 MP:0002945 abnormal inhibitory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Pkd2tm2Som/Pkd2+
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Prnptm2Lnq/Prnptm2Lnq
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

Allelic Composition: Prnptm3Lnq/Prnptm3Lnq
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0003224 neuron degeneration "a retrogressive impairment of function or destruction of the functional cells of the nervous system that receive, conduct, and transmit impulses " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Prnptm2Lnq/Prnptm2Lnq
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp*)#Rgab/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

Allelic Composition: Prnptm3Lnq/Prnptm3Lnq
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0003314 dysmetria "an inability to control the range of motion, typified by under- or over-shooting the intended position with the hand, arm, leg or eye" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Sprntm1Geno/Sprntm1Geno
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J * FVB/N

 MP:0003329 amyloid beta deposits 
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Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp*A116V*M128V)1309Jama/0
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Prnptm2Edin/Prnptm2Edin,Tg(APPswe,PSEN1dE9)85Dbo/0
Genetic Background: B6.Cg-Prnptm2Edin Tg(APPswe,PSEN1dE9)85Dbo

 MP:0003354 astrocytosis "a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Prnptm2Edin/Prnptm2Edin,Tg(APPswe,PSEN1dE9)85Dbo/0
Genetic Background: B6.Cg-Prnptm2Edin Tg(APPswe,PSEN1dE9)85Dbo

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp*)#Rgab/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp*P101L)2866Sbp/0
Genetic Background: involves: 129S7/SvEvBrd * FVB/N

Allelic Composition: Prnptm3Lnq/Prnptm3Lnq
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp*S170N*N174T)1020Aag/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003412 abnormal afterhyperpolarization "anomaly in the currents that follow an action potential and influence firing frequency and neuronal integration" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94941]
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Allelic Composition: Runx3tm1Itan/Runx3tm1Itan,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0003424 premature neuronal precursor differentiation "earlier than normal transformation of neuronal precursor cells into neurons" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94391]
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Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp)C4Cwe/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003461 abnormal response to novel object "altered investigative behavior from controls in reactions associated with exposing an animal to a novel object" [CFG:Center for Functional Genomics, Northwestern University]
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Allelic Composition: Runx3tm1Itan/Runx3tm1Itan,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Nefh-cre)22Jcol/?,Tg(Prnp)37Jcol/?
Genetic Background: involves: 129/Sv * 129S7/SvEvBrd * C57BL/6 * FVB

 MP:0003491 abnormal voluntary movement "anomalies in coordinated movements executed with a purpose and can be improved by learning and/or experience" [Nmice:Neuromice Consortium Submission]
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Allelic Composition: Prnptm3Lnq/Prnptm3Lnq
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0003632 abnormal nervous system morphology 
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Allelic Composition: Prnptm2Lnq/Prnptm2Lnq
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0003633 abnormal nervous system physiology 
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Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp*P101L)2866Sbp/0
Genetic Background: involves: 129S7/SvEvBrd * FVB/N

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp*P101L)2866Sbp/Tg(Prnp*P101L)2866Sbp
Genetic Background: involves: 129S7/SvEvBrd * FVB/N

 MP:0003644 thymus atrophy "wasting of the thymus resulting in reduced size " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Krastm1Mok/Kras+,Nrastm1Mok/Nrastm1Mok
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2

 MP:0003952 abnormal copper level "anomaly in the concentration in the body with respect to this metallic element that normally occurs in a number of proteins including amine oxidases and chaperone proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Krastm1Mok/Kras+,Nrastm1Mok/Nrastm1Mok
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2

 MP:0004087 abnormal muscle fiber morphology "malformed or poorly developed muscle fibers, the cylindrical multinucleated muscle cells that contract when stimulated" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp*S170N*N174T)1020Aag/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004191 neuronal intranuclear inclusions "presence of aggregates of protein within the nuclei of neurons; frequently seen in Huntington s disease" [acv:Alicia Valenzuela_Genetic Resources Curator]
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Allelic Composition: Eedtm1Sho/Eedtm1Sho,Eportm1(EGFP/cre)Uk/Epor+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sortm1(EYFP)Cos
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp-tTA)F959Sbp/Tg(Prnp-tTA)F959Sbp,Tg(tetO-ATXN3)2904Olri/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp-tTA)F959Sbp/0,Tg(tetO-ATXN3)2904Olri/Tg(tetO-ATXN3)2904Olri
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB

 MP:0004542 impaired acrosome reaction "abnormality in the cellular exocytosis that allows sperm to penetrate the zona pellucida of ovulated eggs" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Prnp/Prndtm1Dwm/Prnp/Prndtm1Dwm
Genetic Background: 129P2/OlaHsd-Prnp/Prndtm1Dwm

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Runx3tm1Itan/Runx3tm1Itan,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Nefh-cre)22Jcol/?,Tg(Prnp)37Jcol/?
Genetic Background: involves: 129/Sv * 129S7/SvEvBrd * C57BL/6 * FVB

Allelic Composition: Prnptm2Lnq/Prnptm2Lnq
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0004939 abnormal B cell morphology "any structural anomaly of lymphocytes that expresses membrane-bound immunoglobulin complexes in the mature form, and differentiate into antibody-secreting plasma cells and memory cells upon interaction with antigen; B cells are the primary lymphocyte responsible for humoral immunity, and are most effective against extracellular pathogens" [CL:0000236, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Krastm1Mok/Kras+,Nrastm1Mok/Nrastm1Mok
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2

 MP:0004948 abnormal neuronal precursor proliferation "any anomaly in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp)C4Cwe/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Prnptm2Edin/Prnptm2Edin
Genetic Background: B6.129P2-Prnptm2Edin

 MP:0005090 increased double-negative T cells count "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Krastm1Mok/Kras+,Nrastm1Mok/Nrastm1Mok
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Krastm1Mok/Kras+,Nrastm1Mok/Nrastm1Mok
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2

 MP:0005202 lethargy "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp*S170N*N174T)1020Aag/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005363 decreased susceptibility to prion infection "reduced likelihood that an organism will develop ill effects from the small proteinaceous infectious particles which are resistant to inactivation by procedures that modify nucleic acids and which contain an abnormal isoform of a cellular protein that is a major and necessary component" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pkd2tm2Som/Pkd2+
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

Allelic Composition: Prnptm1(PRNP)Tkit/Prnptm1(PRNP)Tkit
Genetic Background: Not Specified

Allelic Composition: Prnpb/Prnpb
Genetic Background: I/LnJ

Allelic Composition: Prnpc/Prnpc
Genetic Background: MAI/Pas

Allelic Composition: Prnptm1Tuzi/Prnp+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Prnptm1Tuzi/Prnptm2Edin
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Prnptm1Tuzi/Prnptm2Edin,Tg(CMV-cre)1Cgn/?
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ

Allelic Composition: Prnptm2Tuzi/Prnptm2Edin,Tg(CMV-cre)1Cgn/?
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ

Allelic Composition: Prnptm2Tuzi/Prnp+,Tg(CMV-cre)1Cgn/?
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ

Allelic Composition: Prnptm2Tuzi/Prnptm2Edin
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Prnptm3(PRNP*129V)Tkit/Prnptm3(PRNP*129V)Tkit,Tg(Prnp-PRNP*129V)144Tkit/?
Genetic Background: Not Specified

Allelic Composition: Prnptm3(PRNP*129V)Tkit/Prnptm3(PRNP*129V)Tkit,Tg(Prnp-PRNP*129V)139Tkit/?
Genetic Background: Not Specified

Allelic Composition: Prnptm3(PRNP*129V)Tkit/Prnptm3(PRNP*129V)Tkit
Genetic Background: Not Specified

Allelic Composition: Prnptm2(PRNP*129M)Tkit/Prnptm3(PRNP*129V)Tkit
Genetic Background: Not Specified

Allelic Composition: Prnptm2(PRNP*129M)Tkit/Prnptm2(PRNP*129M)Tkit
Genetic Background: Not Specified

Allelic Composition: Prnptm2(PRNP*129M)Tkit/Prnptm2(PRNP*129M)Tkit,Tg(Prnp-PRNP*129M)1Tkit/?
Genetic Background: Not Specified

Allelic Composition: Prnptm5(PRNP*)TKit/Prnptm5(PRNP*)TKit,Tg(Prnp-PRNP*)1Tkit/?
Genetic Background: Not Specified

Allelic Composition: Prnptm1Lnq/Prnptm1Lnq
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp*S170N*N174T)1020Aag/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005364 increased susceptibility to prion infection "increased likelihood that an organism will develop ill effects from the small proteinaceous infectious particles which are resistant to inactivation by procedures that modify nucleic acids and which contain an abnormal isoform of a cellular protein that is a major and necessary component" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prnptm1(PRNP)Tkit/Prnptm1(PRNP)Tkit
Genetic Background: Not Specified

Allelic Composition: Prnpa/Prnpa
Genetic Background: NZW

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp)a19Cwe/0
Genetic Background: Not Specified

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp)a20Cwe/0
Genetic Background: Not Specified

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp)c35Cwe/0
Genetic Background: Not Specified

Allelic Composition: Prnptm4(PRNP)Tkit/Prnptm4(PRNP)Tkit,Tg(Prnp-PRNP)32Tkit/?
Genetic Background: Not Specified

Allelic Composition: Prnptm4(PRNP)Tkit/Prnptm4(PRNP)Tkit
Genetic Background: Not Specified

Allelic Composition: Prnptm3(PRNP*129V)Tkit/Prnptm3(PRNP*129V)Tkit
Genetic Background: Not Specified

Allelic Composition: Prnptm2(PRNP*129M)Tkit/Prnptm2(PRNP*129M)Tkit
Genetic Background: Not Specified

Allelic Composition: Prnptm2(PRNP*129M)Tkit/Prnptm2(PRNP*129M)Tkit,Tg(Prnp-PRNP*129M)1Tkit/?
Genetic Background: Not Specified

Allelic Composition: Prnptm5(PRNP*)TKit/Prnptm5(PRNP*)TKit,Tg(Prnp-PRNP*)1Tkit/?
Genetic Background: Not Specified

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp)4053Sbp/0
Genetic Background: involves: 129S7/SvEvBrd * FVB/N

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(PRNP)35Jcol/Tg(PRNP)35Jcol
Genetic Background: involves: 129 * 129S7/SvEvBrd * C57BL/6 * FVB/N

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(PRNP)45Jcol/Tg(PRNP)45Jcol
Genetic Background: involves: 129 * 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0005578 teratozoospermia "presence of malformed spermatozoa in the semen; malformations include the physical bending of the sperm to produce kinks or bends" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
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Allelic Composition: Prnp/Prndtm1Aag/Prnp/Prndtm1Aag
Genetic Background: Not Specified

 MP:0008025 brain vacuoles "the abnormal presence of cavities or fluid-filled vesicles in the soma of brain cells, often indicative of spongiosis or other pathological states" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp*A116V*M128V)1309Jama/0
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Prnptm2Lnq/Prnptm2Lnq
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0008026 abnormal brain white matter morphology "any structural anomaly of the regions of the brain that are largely or entirely composed of myelinated nerve cell axons and contain few or no neural cell bodies or dendrites" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prnptm2Lnq/Prnptm2Lnq
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Krastm1Mok/Kras+,Nrastm1Mok/Nrastm1Mok
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Egr1tm1Jmi/Egr1tm1Jmi,Tg(Scgb1a1-rtTA,-tTS,tetO-TGFB1*)1Eli/?
Genetic Background: involves: 129 * C57BL/6

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Krastm1Mok/Kras+,Nrastm1Mok/Nrastm1Mok
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2

 MP:0008232 abnormal cingulum morphology "any structural anomaly of the white matter fiber bundle that projects from the cingulate gyrus to the entorhinal cortex in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp*S170N*N174T)1020Aag/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008263 abnormal hippocampus CA1 region morphology 
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Allelic Composition: Prnptm3Lnq/Prnptm3Lnq
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0008346 increased gamma-delta T cell number "greater number of immature or mature T cells expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]
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Allelic Composition: Krastm1Mok/Kras+,Nrastm1Mok/Nrastm1Mok
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Lck-Prnp)33Cwe/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008918 microgliosis "a proliferation or spread of microglia in the area of a degenerative lesion or damaged tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp*S170N*N174T)1020Aag/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008948 decreased neuron number "fewer than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
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Allelic Composition: Prnptm2Lnq/Prnptm2Lnq
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0009434 paraparesis "a weakness affecting lower limbs" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp*)#Rgab/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Runx3tm1Itan/Runx3tm1Itan,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prnptm2Edin/Prnptm2Edin
Genetic Background: B6.129P2-Prnptm2Edin

 MP:0009967 abnormal neuron proliferation "any anomaly in the ability of a neuron to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prnptm2Lnq/Prnptm2Lnq
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

Allelic Composition: Prnptm3Lnq/Prnptm3Lnq
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0010072 increased pruritus "abnormal presence or increased intensity of an uncomfortable sensation resulting from irritation of the skin or mucous membranes that evokes the desire or reflex to rub or scratch" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp*S170N*N174T)1020Aag/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0010132 decreased DN2 thymocyte number "reduced number of thymocytes that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-positive" [CL:0000806]
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Allelic Composition: Krastm1Mok/Kras+,Nrastm1Mok/Nrastm1Mok
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2

 MP:0010133 increased DN3 thymocyte number "increased number of thymocytes that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-negative and expressing the T cell receptor beta-chain in complex with the pre-T cell receptor alpha chain." [CL:0000807]
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Allelic Composition: Krastm1Mok/Kras+,Nrastm1Mok/Nrastm1Mok
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2

 MP:0010136 decreased DN4 thymocyte number "reduced number of thymocytes that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-negative, CD25-negative, and pre-TCR-positive." [CL:0000808]
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Allelic Composition: Krastm1Mok/Kras+,Nrastm1Mok/Nrastm1Mok
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2

 MP:0011149 abnormal hippocampus stratum lacunosum morphology 
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Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp*S170N*N174T)1020Aag/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011214 increased brain copper level "a greater accumulation of copper in the brain tissue compared to controls" [MGI:llw2]
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Allelic Composition: Krastm1Mok/Kras+,Nrastm1Mok/Nrastm1Mok
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2

 MP:0011215 decreased brain copper level "a reduced amount of copper in the brain tissue compared to controls" [MGI:llw2]
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Allelic Composition: Pkd2tm2Som/Pkd2+
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp)C4Cwe/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011380 enlarged brain ventricle "increased size of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord" [MGI:smb]
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Allelic Composition: Prnptm2Lnq/Prnptm2Lnq
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0011979 abnormal magnesium ion homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of magnesium ions within the body or between a cell and its external environment" [MPD:Molly]
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Allelic Composition: Krastm1Mok/Kras+,Nrastm1Mok/Nrastm1Mok
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2

 MP:0014185 cerebellum atrophy "acquired diminution of the size of the cerebellum associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:Anna]
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Allelic Composition: Prnptm2Lnq/Prnptm2Lnq
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0020187 altered susceptibility to prion infection "altered likelihood that an organism will develop ill effects from the small proteinaceous infectious particles which are resistant to inactivation by procedures that modify nucleic acids and which contain an abnormal isoform of a cellular protein that is a major and necessary component" [GOC:NV]
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Allelic Composition: Pkd2tm2Som/Pkd2+
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

Allelic Composition: Prnptm1Rcm/Prnptm1Rcm
Genetic Background: 129P2/OlaHsd-Prnptm1Rcm

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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