ENSMUSG00000079042


Mus musculus

Features
Gene ID: ENSMUSG00000079042
  
Biological name :Apela
  
Synonyms : Apela / Apelin receptor early endogenous ligand / P0DMC4
  
Possible biological names infered from orthology : P0DMC3
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: B3.1
Gene start: 65028417
Gene end: 65037336
  
Corresponding Affymetrix probe sets: 10578950 (MoGene1.0st)   1436287_at (Mouse Genome 430 2.0 Array)   1442571_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000139425
Ensembl peptide - ENSMUSP00000140510
NCBI entrez gene - 100038489     See in Manteia.
MGI - MGI:3642370
RefSeq - XM_011242247
RefSeq - NM_001297554
RefSeq Peptide - NP_001284483
swissprot - P0DMC4
Ensembl - ENSMUSG00000079042
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 APELAENSGALG00000023444Gallus gallus
 APELAENSG00000248329Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
No match


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001570 vasculogenesis IMP
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007369 gastrulation IEA
 biological_processGO:0007492 endoderm development ISS
 biological_processGO:0007507 heart development ISS
 biological_processGO:0007509 mesoderm migration involved in gastrulation ISS
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0035050 embryonic heart tube development IMP
 biological_processGO:0045766 positive regulation of angiogenesis ISS
 biological_processGO:0045823 positive regulation of heart contraction ISS
 biological_processGO:0060183 apelin receptor signaling pathway ISS
 biological_processGO:0060395 SMAD protein signal transduction IDA
 biological_processGO:0060674 placenta blood vessel development IMP
 biological_processGO:0060976 coronary vasculature development IMP
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade ISS
 biological_processGO:0090133 mesendoderm migration ISS
 biological_processGO:0090134 cell migration involved in mesendoderm migration ISS
 biological_processGO:1901165 positive regulation of trophoblast cell migration ISS
 biological_processGO:1903589 positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis IMP
 biological_processGO:1904022 positive regulation of G-protein coupled receptor internalization IEA
 cellular_componentGO:0005576 extracellular region ISS
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0005179 hormone activity ISS
 molecular_functionGO:0031704 apelin receptor binding ISS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000259 abnormal vascular development "malformation or aberrant differentiation of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17509]
Show

Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: C57BL/6J * SJL/J

 MP:0000260 abnormal angiogenesis "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: C57BL/6J * SJL/J

 MP:0000270 abnormal heart tube morphology "malformed embryonic heart " [J:37888]
Show

Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: C57BL/6J * SJL/J

 MP:0001711 abnormal placenta 
Show

Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: C57BL/6J * SJL/J

 MP:0001718 abnormal yolk sac "malformed extraembryonic tissue which contributes to hematopoietic circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:12623]
Show

Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: C57BL/6J * SJL/J

 MP:0001719 absent vitelline blood vessels "missing vasculature of the yolk sac" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62571, J:12623]
Show

Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: C57BL/6J * SJL/J

 MP:0001722 pale yolk sac "bloodless yolk sac" [J:62571]
Show

Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: C57BL/6J * SJL/J

 MP:0001787 pericardial edema "accumulation of watery fluid in the pericardial sac of the heart" [J:52597]
Show

Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: C57BL/6J * SJL/J

 MP:0001933 abnormal litter size "deviation from the normal number of live born pups in a litter" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: C57BL/6J * SJL/J

Allelic Composition: Apelatm1.2Brre/Apela+
Genetic Background: B6(Cg)-Apelatm1.2Brre

 MP:0002127 abnormal cardiovascular system morphology "abnormal development of the heart or vascular tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: C57BL/6J * SJL/J

 MP:0002842 increased blood pressure "increased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: C57BL/6J * SJL/J

 MP:0002962 increased protein excretion "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: C57BL/6J * SJL/J

 MP:0003718 maternal effect "expression of a phenotypic trait in an female animal s offspring that is dependent on the maternal genotype" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: C57BL/6J * SJL/J

Allelic Composition: Apelatm1.2Brre/Apela+
Genetic Background: B6(Cg)-Apelatm1.2Brre

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: C57BL/6J * SJL/J

 MP:0004787 abnormal dorsal aorta morphology "any structural anomaly of the paired arterial structures of the embryo that supplies each developing somite via efferent segmental arteries; the dorsal aortae articulate with the umbilical arteries, which return mixed blood to the villi of the chorion for reoxygenation" [ISBN:0-914294-08-3 "Gray s Anatomy"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: C57BL/6J * SJL/J

 MP:0008803 abnormal placental labyrinth vasculature morphology "any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: C57BL/6J * SJL/J

 MP:0009429 decreased embryo weight "reduced weight of an embryo compared to littermates or other controls (sensu Mus: up to E14, or the completion of organogenesis)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: C57BL/6J * SJL/J

 MP:0009658 increased placenta apoptosis "increase in the number of cells of the placenta undergoing programmed cell death" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: C57BL/6J * SJL/J

 MP:0010662 abnormal intersomitic artery morphology "any structural anomaly of the small branching sprouts of the dorsal aorta that grow across the medial surface of the somite, turn right angles to grow over that surface and then fuse with other sprouts and form the vertebral arteries adjacent to the neural tube; the intersomitic arteries supply the body wall and persist in the adult as the posterior intercostal, subcostal and the lumbar arteries" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: C57BL/6J * SJL/J

 MP:0010831 partial lethality "the appearance of lower than Mendelian ratios of offspring of a given genotype due to death of some, but not all of the organisms" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: C57BL/6J * SJL/J

 MP:0011433 glomerular capillary congestion "obstruction of the normal flux of blood within the renal glomerular capillaries" [MGI:anna]
Show

Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: C57BL/6J * SJL/J

 MP:0011453 abnormal glomerular capillary endothelium morphology "any structural anomaly of the thin, extremely flattened layer of cells that line the interior surface of glomerular capillaries and is densely perforated by large transcellular pores (aka fenestrae or fenestrations) that, unlike those of other fenestrated capillaries, are generally thought to lack diaphragms" [MGI:anna]
Show

Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: C57BL/6J * SJL/J

 MP:0011455 absent glomerular endothelium fenestra "absence of the large plasma membrane-lined circular pores that normally perforate the flattened glomerular endothelium; loss of fenestrae may lead to a reduction in the glomerular filtration rate or proteinuria" [MGI:anna]
Show

Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: C57BL/6J * SJL/J

 MP:0011523 thin placenta labyrinth "decrease in the width of the structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [MGI:csmith]
Show

Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: C57BL/6J * SJL/J

 MP:0011531 abnormal syncytiotrophoblast morphology "any structural anomaly of the multi-nucleated, terminally differentiated syncytial epithelial layer of the placental villi that forms the major nutrient transport surfaces within the labyrinth layer of the rodent placenta" [ISBN-10:0521851653]
Show

Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: C57BL/6J * SJL/J

 MP:0014044 absent cardiac outflow tract "absence of or complete failure to form the common arterial trunk that normally forms the aorta and pulmonary artery and the ventricular outflow regions" [MGI:anna]
Show

Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: C57BL/6J * SJL/J

 MP:0020518 renal glomerular protein deposits "any anomalous accumulation of protein in the renal glomerulus" [HP:0030949]
Show

Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: C57BL/6J * SJL/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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