ENSMUSG00000079509


Mus musculus

Features
Gene ID: ENSMUSG00000079509
  
Biological name :Zfx
  
Synonyms : P17012 / Zfx / zinc finger protein X-linked
  
Possible biological names infered from orthology : P08048 / P17010 / ZFY / zinc finger protein, Y-linked
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: C3
Gene start: 94074631
Gene end: 94123702
  
Corresponding Affymetrix probe sets: 10605729 (MoGene1.0st)   1419565_a_at (Mouse Genome 430 2.0 Array)   1422249_s_at (Mouse Genome 430 2.0 Array)   1425972_a_at (Mouse Genome 430 2.0 Array)   1428046_a_at (Mouse Genome 430 2.0 Array)   1428047_s_at (Mouse Genome 430 2.0 Array)   1439404_x_at (Mouse Genome 430 2.0 Array)   1449512_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000085423
Ensembl peptide - ENSMUSP00000109559
Ensembl peptide - ENSMUSP00000109560
Ensembl peptide - ENSMUSP00000118903
Ensembl peptide - ENSMUSP00000109558
NCBI entrez gene - 22764     See in Manteia.
MGI - MGI:99211
RefSeq - XM_017318466
RefSeq - XM_006527965
RefSeq - XM_006527966
RefSeq - XM_006527967
RefSeq - XM_011247577
RefSeq - XM_011247578
RefSeq - XM_017318464
RefSeq - XM_017318465
RefSeq - NM_001044386
RefSeq - NM_001358356
RefSeq - NM_011768
RefSeq Peptide - NP_001037851
RefSeq Peptide - NP_001345285
RefSeq Peptide - NP_035898
swissprot - B1ASD2
swissprot - B1ASD1
swissprot - P17012
swissprot - Q8R2L1
Ensembl - ENSMUSG00000079509
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01079241.1ENSDARG00000098424Danio rerio
 zfxENSDARG00000074453Danio rerio
 ZFXENSG00000005889Homo sapiens
 ZFYENSG00000067646Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Zfy2 / P20662 / zinc finger protein 2, Y-linked / ZFY* / ZFX* / P17010* / P08048* / zinc finger protein, X-linked* / zinc finger protein, Y-linked*ENSMUSG0000000010368
Zfy1 / P10925 / zinc finger protein 1, Y-linked / ZFY* / ZFX* / P17010* / P08048* / zinc finger protein, X-linked* / zinc finger protein, Y-linked*ENSMUSG0000005321167
Zfp711 / zinc finger protein 711 / Q9Y462* / ZNF711*ENSMUSG0000002552957
Q99KZ6 / Zfp639 / zinc finger protein 639 / Q9UID6* / ZNF639*ENSMUSG0000002766711


Protein motifs (from Interpro)
Interpro ID Name
 IPR006794  Transcriptional activator, Zfx / Zfy domain
 IPR013087  Zinc finger C2H2-type
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001541 ovarian follicle development IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007281 germ cell development IMP
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0009566 fertilization IMP
 biological_processGO:0009791 post-embryonic development IMP
 biological_processGO:0035264 multicellular organism growth IMP
 biological_processGO:0048599 oocyte development IMP
 biological_processGO:0048872 homeostasis of number of cells IMP
 biological_processGO:0060746 parental behavior IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005730 nucleolus ISO
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: CryaaAey7/Cryaa+
Genetic Background: C3HeB/FeJ-CryaaAey7/Ieg

Allelic Composition: Zfxtm1Dcp/Zfxtm1Dcp
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0001545 abnormal hematopoietic system physiology "anomalous function of the fluid and/or its suspended elements that circulate(s) through the heart, arteries, capillaries, and veins" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Slc30a3tm1Rpa/Slc30a3+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Zfxtm1.1Reiz/Y,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

Allelic Composition: Zfxtm1.1Reiz/Y,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0001606 impaired hematopoiesis "atypical process of blood cell formation with the result of fewer of these cells being formed" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
Show

Allelic Composition: Zfxtm1.1Reiz/Y,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: CryaaAey7/Cryaa+
Genetic Background: C3HeB/FeJ-CryaaAey7/Ieg

Allelic Composition: Zfxtm1Dcp/Zfxtm1Dcp
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Zfxtm1Dcp/Zfxtm1Dcp
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Zfxtm1.1Reiz/Y,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Zfxtm1.2Reiz/Zfxtm1.2Reiz
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0002088 abnormal embryonic growth/weight/body size "limited or accelerated growth or development apparent before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Zfxtm1Dcp/Zfxtm1Dcp
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0002089 abnormal postnatal growth/weight/body size "increased or decreased average body size, weight or growth characteristic abnormalities manifesting after birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Zfxtm1Dcp/Zfxtm1Dcp
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0002161 abnormal fertility/fecundity "reduced ability or inability to produce live offspring" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Zfxtm1Dcp/Zfxtm1Dcp
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0002209 germ cell depletion "reduced numbers of any of the reproductive (generative) cells of a multicellular organism, whether they are undifferentiated or fully differentiated" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Zfxtm1Dcp/Zfx+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002682 reduced number of mature ovarian follicles "fewer than normal numbers of spehroidal cell aggregations in the ovary containing the ovum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Zfxtm1Dcp/Zfxtm1Dcp
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: CryaaAey7/Cryaa+
Genetic Background: C3HeB/FeJ-CryaaAey7/Ieg

 MP:0004810 decreased hematopoietic stem cell number "reduced cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc30a3tm1Rpa/Slc30a3+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Zfxtm1.1Reiz/Y,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

Allelic Composition: Zfxtm1.1Reiz/Y,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Zfxtm1.2Reiz/Y
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

Allelic Composition: Zfxtm1.2Reiz/Zfxtm1.2Reiz
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Zfxtm1.1Reiz/Y,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Zfxtm1.1Reiz/Y,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

 MP:0005431 oocyte depletion "reduced numbers or absence of germ cells in the female" [llw2:Linda Washburn , Mouse Genome Informatics Curator, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Zfxtm1Dcp/Zfx+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Zfxtm1Dcp/Zfxtm1Dcp
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
Show

Allelic Composition: Zfxtm1.1Reiz/Y,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

 MP:0008249 abnormal common lymphocyte progenitor cell morphology "any structural anomaly of a progenitor cell committed to the lymphoid lineage" [CL:0000051, PMID:10407577]
Show

Allelic Composition: Slc30a3tm1Rpa/Slc30a3+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Zfxtm1.1Reiz/Y,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

Allelic Composition: Zfxtm1.1Reiz/Y,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0008392 decreased primordial germ cell number "reduced number of a mesodermally-derived, most primitive undifferentiated sex cell, that originates in the allantois and migrates through the hindgut and into the gonadal ridge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: CryaaAey7/Cryaa+
Genetic Background: C3HeB/FeJ-CryaaAey7/Ieg

Allelic Composition: Zfxtm1Dcp/Zfxtm1Dcp
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: CryaaAey7/Cryaa+
Genetic Background: C3HeB/FeJ-CryaaAey7/Ieg

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Zfxtm1Dcp/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Slc30a3tm1Rpa/Slc30a3+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Zfxtm1.1Reiz/Zfxtm1.1Reiz,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: CryaaAey7/Cryaa+
Genetic Background: C3HeB/FeJ-CryaaAey7/Ieg

Allelic Composition: Zfxtm1Dcp/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Zfxtm1Dcp/Zfx+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Zfxtm1Dcp/Zfx+
Genetic Background: involves: 129S4/SvJae * BALB/c

Allelic Composition: Zfxtm1Dcp/Zfxtm1Dcp
Genetic Background: involves: 129S4/SvJae * BALB/c

Allelic Composition: Zfxtm1Dcp/Zfxtm1Dcp
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Zfxtm1.2Reiz/Y
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

Allelic Composition: Zfxtm1.2Reiz/Zfxtm1.2Reiz
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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