ENSMUSG00000090084


Mus musculus

Features
Gene ID: ENSMUSG00000090084
  
Biological name :Srpx
  
Synonyms : Q9R0M3 / Srpx / Sushi-repeat-containing protein SRPX
  
Possible biological names infered from orthology : P78539 / sushi repeat containing protein, X-linked
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: A1.1
Gene start: 10037977
Gene end: 10117709
  
Corresponding Affymetrix probe sets: 10603583 (MoGene1.0st)   1451939_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000111205
Ensembl peptide - ENSMUSP00000111206
Ensembl peptide - ENSMUSP00000047926
NCBI entrez gene - 51795     See in Manteia.
MGI - MGI:1858306
RefSeq - NM_016911
RefSeq Peptide - NP_058607
swissprot - A2BE45
swissprot - Q9R0M3
Ensembl - ENSMUSG00000090084
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 srpxENSDARG00000010318Danio rerio
 SRPXENSGALG00000043100Gallus gallus
 SRPXENSG00000101955Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Srpx2 / Q8R054 / Sushi repeat-containing protein SRPX2 / O60687* / sushi repeat containing protein, X-linked 2*ENSMUSG0000003125346
Ccdc80 / Q8R2G6 / Coiled-coil domain-containing protein 80 / Q76M96* / coiled-coil domain containing 80*ENSMUSG0000002266519


Protein motifs (from Interpro)
Interpro ID Name
 IPR000436  Sushi/SCR/CCP domain
 IPR003410  HYR domain
 IPR013783  Immunoglobulin-like fold
 IPR025232  Domain of unknown function DUF4174
 IPR035976  Sushi/SCR/CCP superfamily
 IPR036981  Sushi repeat-containing protein SRPX


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001845 phagolysosome assembly IMP
 biological_processGO:0006914 autophagy IMP
 biological_processGO:0034976 response to endoplasmic reticulum stress IMP
 biological_processGO:0060244 negative regulation of cell proliferation involved in contact inhibition IDA
 biological_processGO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand IMP
 cellular_componentGO:0005776 autophagosome IDA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Papss2bm/Papss2bm
Genetic Background: B6C3Fe a/a-Papss2bm/J

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
Show

Allelic Composition: Papss2bm/Papss2bm
Genetic Background: B6C3Fe a/a-Papss2bm/J

 MP:0002024 T cell derived lymphoma "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Papss2bm/Papss2bm
Genetic Background: B6C3Fe a/a-Papss2bm/J

 MP:0002027 lung adenocarcinoma "malignant neoplasm of epithelial cells in the lung" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:18542]
Show

Allelic Composition: Papss2bm/Papss2bm
Genetic Background: B6C3Fe a/a-Papss2bm/J

 MP:0002032 sarcoma "connective tissue neoplasm associated with the proliferation of mesodermal cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
Show

Allelic Composition: Papss2bm/Papss2bm
Genetic Background: B6C3Fe a/a-Papss2bm/J

 MP:0002619 abnormal lymphocyte morphology/development "anomalous structure, differentiation, or number of the white blood cells formed in the body s lymphoid tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Papss2bm/Papss2bm
Genetic Background: B6C3Fe a/a-Papss2bm/J

 MP:0010264 increased hepatoma incidence "greater than the expected number of malignant tumors composed of neoplastic liver cells in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Papss2bm/Papss2bm
Genetic Background: B6C3Fe a/a-Papss2bm/J

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
Show

Allelic Composition: Papss2bm/Papss2bm
Genetic Background: B6C3Fe a/a-Papss2bm/J

Allelic Composition: Srpxtm1Hzi/Srpx+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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